{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T14:23:03Z","timestamp":1780755783620,"version":"3.54.1"},"reference-count":23,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biochemical and Biophysical Methods"],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1016\/j.jbbm.2006.05.011","type":"journal-article","created":{"date-parts":[[2006,6,15]],"date-time":"2006-06-15T09:22:19Z","timestamp":1150363339000},"page":"175-187","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["Preparation of UHMWPE particles and establishment of inverted macrophage cell model to investigate wear particles induced bioactivites"],"prefix":"10.1016","volume":"68","author":[{"given":"Hsu-Wei","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ching","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charng-Bin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsuan-Liang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Yuan","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Chang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hon-Ming","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hsiung","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbbm.2006.05.011_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/00003086-199203000-00003","article-title":"Mechanism and clinical significance of wear debris-induced osteolysis","volume":"276","author":"Amstutz","year":"1992","journal-title":"Clin Orthop Res"},{"key":"10.1016\/j.jbbm.2006.05.011_bib2","first-page":"46","article-title":"The problem is osteolysis","volume":"311","author":"Harris","year":"1995","journal-title":"Clin Orthop Res"},{"key":"10.1016\/j.jbbm.2006.05.011_bib3","series-title":"American Academy of Orthopaedic Surgeons","first-page":"3","article-title":"Implant wear in total joint replacement: clinical and biologic issues, material and design considerations","author":"Wright","year":"2001"},{"key":"10.1016\/j.jbbm.2006.05.011_bib4","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.2106\/00004623-199509000-00022","article-title":"Periprosthetic osteolysis in total hip arthroplasty: the role of particulate wear debris","volume":"77A","author":"Maloney","year":"1995","journal-title":"J Bone Joint Surg"},{"key":"10.1016\/j.jbbm.2006.05.011_bib5","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.1016\/j.biomaterials.2003.10.054","article-title":"The influence of molecular weight, crosslinking and counterface roughness on TNF-\u03b1 production by macrophages in response to ultra high molecular weight polyethylene particles","volume":"25","author":"Ingram","year":"2004","journal-title":"Biomaterials"},{"key":"10.1016\/j.jbbm.2006.05.011_bib6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/1097-4636(200011)52:2<239::AID-JBM1>3.0.CO;2-R","article-title":"The effect of polyethylene particle chemistry on human monocyte-macrophage function in vitro","volume":"52","author":"Boynton","year":"2000","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.jbbm.2006.05.011_bib7","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1016\/S0142-9612(98)00140-9","article-title":"Polyethylene particles of a \u2018critical size\u2019 are necessary for the induction of cytokines by macrophages in vitro","volume":"19","author":"Green","year":"1998","journal-title":"Biomaterials"},{"key":"10.1016\/j.jbbm.2006.05.011_bib8","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1302\/0301-620X.78B1.0780032","article-title":"The effects of particulate polyethylene at a weight bearing bone-implant interface","volume":"78B","author":"Allen","year":"1996","journal-title":"J Bone Joint Surg"},{"key":"10.1016\/j.jbbm.2006.05.011_bib9","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/(SICI)1097-4636(19980915)41:4<600::AID-JBM12>3.0.CO;2-I","article-title":"Flow cytometric analysis of macrophage response to ceramic and polyethylene particles: effects of size, concentration, and composition","volume":"41","author":"Catelas","year":"1998","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.jbbm.2006.05.011_bib10","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1016\/0142-9612(96)00013-0","article-title":"Histomorphological reaction of bone to different concentrations of phagocytosable particles of high-density polyethylene and Ti-6Al-4V alloy in vivo","volume":"17","author":"Goodman","year":"1996","journal-title":"Biomaterials"},{"key":"10.1016\/j.jbbm.2006.05.011_bib11","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/jor.1100150108","article-title":"Effect of polyethylene on macrophages","volume":"15","author":"Horowitz","year":"1997","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jbbm.2006.05.011_bib12","first-page":"257","article-title":"A rat model of resorption of bone at the cement\u2013bone interface in the presence of polyethylene wear particles","volume":"70A","author":"Howie","year":"1998","journal-title":"J Bone Joint Surg"},{"key":"10.1016\/j.jbbm.2006.05.011_bib13","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0142-9612(97)00250-0","article-title":"Effect of polyethylene particles on human osteoblastic cell growth","volume":"19","author":"Martinez","year":"1998","journal-title":"Biomaterials"},{"key":"10.1016\/j.jbbm.2006.05.011_bib14","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1302\/0301-620X.72B6.2246303","article-title":"Macrophages stimulate bone resorption when they phagocytose particles","volume":"72B","author":"Murray","year":"1990","journal-title":"J Bone Joint Surg"},{"key":"10.1016\/j.jbbm.2006.05.011_bib15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/jbm.820280111","article-title":"Macrophage\/particle interactions: effect of size, composition, and surface area","volume":"28","author":"Shanbhag","year":"1994","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.jbbm.2006.05.011_bib16","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/(SICI)1097-4636(199801)39:1<40::AID-JBM6>3.0.CO;2-I","article-title":"Macrophage phagocytosis of polyethylene particulate in vitro","volume":"9","author":"Voronov","year":"1998","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.jbbm.2006.05.011_bib17","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/jbm.b.10067","article-title":"Generation of narrowly distributed ultra-high molecular weight polyethylene particles by surface texturing techniques","volume":"67B","author":"Fang","year":"2003","journal-title":"J Biomed Mater Res, B Appl Biomater"},{"key":"10.1016\/j.jbbm.2006.05.011_bib18","article-title":"Ultra-high molecular weight polyethylene wear particle effects on bioactivity","author":"Fang","year":"2003","journal-title":"NIST SP 1002"},{"key":"10.1016\/j.jbbm.2006.05.011_bib19","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.matchemphys.2005.06.020","article-title":"Influence of biological lubricant on the morphology of UHMWPE wear particles generated with microfabricated surface textures","volume":"95","author":"Fang","year":"2006","journal-title":"Mater Chem Phys"},{"key":"10.1016\/j.jbbm.2006.05.011_bib20","first-page":"976","article-title":"Surface texture design to generate specific sizes and shapes of UHMWPE wear particles","volume":"34","author":"Fang","year":"2003","journal-title":"Mater Wiss Werkst Tech (Mat Sci and Eng Tech)"},{"key":"10.1016\/j.jbbm.2006.05.011_bib21","unstructured":"ASTM F732, American Standards Of Testing Materials 1996."},{"key":"10.1016\/j.jbbm.2006.05.011_bib22","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/S0142-9612(02)00531-8","article-title":"Metal ions induce bone-resorbing cytokine production through the redox pathway in synoviocytes and bone marrow macrophages","volume":"24","author":"Niki","year":"2003","journal-title":"Biomaterials"},{"key":"10.1016\/j.jbbm.2006.05.011_bib23","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.1016\/S0142-9612(03)00246-1","article-title":"Flow cytometric technique for the detection of phagocytosed wear particles in patients with total joint arthroplasty","volume":"24","author":"Niki","year":"2003","journal-title":"Biomaterials"}],"container-title":["Journal of Biochemical and Biophysical Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165022X06001023?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165022X06001023?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T23:56:28Z","timestamp":1759017388000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165022X06001023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["S0165022X06001023"],"URL":"https:\/\/doi.org\/10.1016\/j.jbbm.2006.05.011","relation":{},"ISSN":["0165-022X"],"issn-type":[{"value":"0165-022X","type":"print"}],"subject":[],"published":{"date-parts":[[2006,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preparation of UHMWPE particles and establishment of inverted macrophage cell model to investigate wear particles induced bioactivites","name":"articletitle","label":"Article Title"},{"value":"Journal of Biochemical and Biophysical Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbbm.2006.05.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}