{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T04:40:54Z","timestamp":1787805654085,"version":"build-2784847793"},"reference-count":93,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.jbc.2021.100313","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T04:22:56Z","timestamp":1611116576000},"page":"100313","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["A disorder-related variant (E420K) of a PP2A-regulatory subunit (PPP2R5D) causes constitutively active AKT-mTOR signaling and uncoordinated cell growth"],"prefix":"10.1016","volume":"296","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0719-2642","authenticated-orcid":false,"given":"Cinta M.","family":"Papke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kali A.","family":"Smolen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Swingle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Cressey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Heng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mourad","family":"Toporsian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyong","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Hagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy K.","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3979-4576","authenticated-orcid":false,"given":"Arminja N.","family":"Kettenbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8487-8571","authenticated-orcid":false,"given":"Richard E.","family":"Honkanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2021.100313_bib1","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1172\/JCI79860","article-title":"B56delta-related protein phosphatase 2A dysfunction identified in patients with intellectual disability","volume":"125","author":"Houge","year":"2015","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.jbc.2021.100313_bib2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s10048-015-0466-9","article-title":"De novo missense variants in PPP2R5D are associated with intellectual disability, macrocephaly, hypotonia, and autism","volume":"17","author":"Shang","year":"2016","journal-title":"Neurogenetics"},{"key":"10.1016\/j.jbc.2021.100313_bib3","doi-asserted-by":"crossref","first-page":"4775","DOI":"10.1093\/hmg\/ddv182","article-title":"Mutations in the PP2A regulatory subunit B family genes PPP2R5B, PPP2R5C and PPP2R5D cause human overgrowth","volume":"24","author":"Loveday","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jbc.2021.100313_bib4","series-title":"GeneReviews [Internet]","first-page":"1193","article-title":"PPP2R5D-Related neurodevelopmental disorder","author":"Mirzaa","year":"2019"},{"key":"10.1016\/j.jbc.2021.100313_bib5","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature14135","article-title":"Large-scale discovery of novel genetic causes of developmental disorders","volume":"519","author":"Fitzgerald","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2021.100313_bib6","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.molcel.2009.02.015","article-title":"From promiscuity to precision: Protein phosphatases get a makeover","volume":"33","author":"Virshup","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2021.100313_bib7","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.tibs.2007.12.004","article-title":"PP2A holoenzyme assembly: In cauda venenum (the sting is in the tail)","volume":"33","author":"Janssens","year":"2008","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jbc.2021.100313_bib8","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1742-4658.2012.08609.x","article-title":"Protein Ser\/Thr phosphatases\u2013the ugly ducklings of cell signalling","volume":"280","author":"Brautigan","year":"2013","journal-title":"FEBS J."},{"key":"10.1016\/j.jbc.2021.100313_bib9","doi-asserted-by":"crossref","first-page":"6349","DOI":"10.1074\/jbc.M507760200","article-title":"The protein phosphatase 2A phosphatase activator is a novel peptidyl-prolyl cis\/trans-isomerase","volume":"281","author":"Jordens","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100313_bib10","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1038\/s41467-017-02405-3","article-title":"Methylation-regulated decommissioning of multimeric PP2A complexes","volume":"8","author":"Wu","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2021.100313_bib11","doi-asserted-by":"crossref","first-page":"D1271","DOI":"10.1093\/nar\/gkx1029","article-title":"ProteomicsDB","volume":"46","author":"Schmidt","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2021.100313_bib12","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nature13319","article-title":"Mass-spectrometry-based draft of the human proteome","volume":"509","author":"Wilhelm","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2021.100313_bib13","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1006\/geno.1996.0438","article-title":"Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2--> p12","volume":"36","author":"McCright","year":"1996","journal-title":"Genomics"},{"key":"10.1016\/j.jbc.2021.100313_bib14","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1042\/bj2560283","article-title":"Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics","volume":"256","author":"Bialojan","year":"1988","journal-title":"Biochem. J."},{"key":"10.1016\/j.jbc.2021.100313_bib15","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0014-5793(97)01210-6","article-title":"Fostriecin, an antitumor antibiotic with inhibitory activity against serine\/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A","volume":"416","author":"Walsh","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jbc.2021.100313_bib16","doi-asserted-by":"crossref","first-page":"15694","DOI":"10.1021\/ja038672n","article-title":"Fundamental role of the fostriecin unsaturated lactone and implications for selective protein phosphatase inhibition","volume":"125","author":"Buck","year":"2003","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.jbc.2021.100313_bib17","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0014-5793(93)80889-3","article-title":"Cantharidin, another natural toxin that inhibits the activity of serine\/threonine protein phosphatases types 1 and 2A","volume":"330","author":"Honkanen","year":"1993","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jbc.2021.100313_bib18","doi-asserted-by":"crossref","first-page":"11867","DOI":"10.1073\/pnas.89.24.11867","article-title":"Cantharidin-binding protein: Identification as protein phosphatase 2A","volume":"89","author":"Li","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.100313_bib19","first-page":"23","article-title":"Small-molecule inhibitors of ser\/thr protein phosphatases: Specificity, use and common forms of abuse","volume":"365","author":"Swingle","year":"2007","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jbc.2021.100313_bib20","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.2174\/0929867325666180508095242","article-title":"Inhibitors of serine\/threonine protein phosphatases: Biochemical and structural studies provide insight for further development","volume":"26","author":"Swingle","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.jbc.2021.100313_bib21","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.2337\/db17-1342","article-title":"Membrane-initiated estrogen receptor signaling mediates metabolic homeostasis via central activation of protein phosphatase 2A","volume":"67","author":"Ueda","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.jbc.2021.100313_bib22","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1016\/j.celrep.2019.07.067","article-title":"PP1 and PP2A use opposite phospho-dependencies to control distinct processes at the kinetochore","volume":"28","author":"Smith","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.jbc.2021.100313_bib23","doi-asserted-by":"crossref","first-page":"80770","DOI":"10.18632\/oncotarget.20415","article-title":"PP2A mediates apoptosis or autophagic cell death in multiple myeloma cell lines","volume":"8","author":"Zhou","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jbc.2021.100313_bib24","doi-asserted-by":"crossref","first-page":"21567","DOI":"10.1074\/jbc.M109.094953","article-title":"The B56gamma3 regulatory subunit of protein phosphatase 2A (PP2A) regulates S phase-specific nuclear accumulation of PP2A and the G1 to S transition","volume":"285","author":"Lee","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100313_bib25","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nature17946","article-title":"Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage","volume":"533","author":"Komor","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2021.100313_bib26","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aao4774","article-title":"Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C: G-to-T: A base editors with higher efficiency and product purity","volume":"3","author":"Komor","year":"2017","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jbc.2021.100313_bib27","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1089\/adt.2007.079","article-title":"High yield expression of serine\/threonine protein phosphatase type 5, and a fluorescent assay suitable for use in the detection of catalytic inhibitors","volume":"5","author":"Ni","year":"2007","journal-title":"Assay Drug Dev. Technol."},{"key":"10.1016\/j.jbc.2021.100313_bib28","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bcp.2016.03.011","article-title":"Crystal structures and mutagenesis of PPP-family ser\/thr protein\u00a0phosphatases elucidate the selectivity of cantharidin and novel\u00a0norcantharidin-based inhibitors of PP5C","volume":"109","author":"Chattopadhyay","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jbc.2021.100313_bib29","doi-asserted-by":"crossref","first-page":"17703","DOI":"10.1021\/jacs.7b09368","article-title":"PP1:Tautomycetin complex reveals a path toward the development of PP1-specific inhibitors","volume":"139","author":"Choy","year":"2017","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.jbc.2021.100313_bib30","first-page":"61","article-title":"An automated fluorescence-based method for continuous assay of PP2A activity","volume":"365","author":"Wegner","year":"2007","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jbc.2021.100313_bib31","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2019103695","article-title":"Mechanisms of site-specific dephosphorylation and kinase opposition imposed by PP2A regulatory subunits","volume":"39","author":"Kruse","year":"2020","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2021.100313_bib32","doi-asserted-by":"crossref","first-page":"5654","DOI":"10.1074\/jbc.RA119.011270","article-title":"Reduction of protein phosphatase 2A (PP2A) complexity reveals cellular functions and dephosphorylation motifs of the PP2A\/B'delta holoenzyme","volume":"295","author":"Jong","year":"2020","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100313_bib33","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.bbrc.2009.06.062","article-title":"The Balpha and Bdelta regulatory subunits of PP2A are necessary for assembly of the CaMKIV.PP2A signaling complex","volume":"386","author":"Reece","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jbc.2021.100313_bib34","doi-asserted-by":"crossref","first-page":"22081","DOI":"10.1074\/jbc.271.36.22081","article-title":"The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm","volume":"271","author":"McCright","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100313_bib35","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1242\/bio.20134051","article-title":"BUBR1 recruits PP2A via the B56 family of targeting subunits to promote chromosome congression","volume":"2","author":"Xu","year":"2013","journal-title":"Biol. Open"},{"key":"10.1016\/j.jbc.2021.100313_bib36","doi-asserted-by":"crossref","first-page":"398751","DOI":"10.4061\/2011\/398751","article-title":"Determinants for substrate specificity of protein phosphatase 2A","volume":"2011","author":"Slupe","year":"2011","journal-title":"Enzyme Res."},{"key":"10.1016\/j.jbc.2021.100313_bib37","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1021\/cb200171d","article-title":"Kinase consensus sequences: A breeding ground for crosstalk","volume":"6","author":"Rust","year":"2011","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.jbc.2021.100313_bib38","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.neulet.2012.10.052","article-title":"Okadaic acid induces Akt hyperphosphorylation and an oxidative stress-mediated cell death in serum starved SK-N-SH human neuroblastoma cells that are augmented by rapamycin","volume":"531","author":"Edelstein","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jbc.2021.100313_bib39","doi-asserted-by":"crossref","first-page":"30503","DOI":"10.1074\/jbc.M601054200","article-title":"The alpha4 regulatory subunit exerts opposing allosteric effects on protein phosphatases PP6 and PP2A","volume":"281","author":"Prickett","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100313_bib40","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2121-2-6","article-title":"Serine\/threonine protein phosphatase 5 (PP5) participates in the regulation of glucocorticoid receptor nucleocytoplasmic shuttling","volume":"2","author":"Dean","year":"2001","journal-title":"BMC Cell Biol"},{"key":"10.1016\/j.jbc.2021.100313_bib41","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0014-5793(98)00775-3","article-title":"Purification of protein phosphatase 4 catalytic subunit: Inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters","volume":"431","author":"Hastie","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jbc.2021.100313_bib42","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.cell.2019.12.036","article-title":"Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism","volume":"180","author":"Satterstrom","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2021.100313_bib43","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/2040-2392-4-36","article-title":"SFARI Gene 2.0: A community-driven knowledgebase for the autism spectrum disorders (ASDs)","volume":"4","author":"Abrahams","year":"2013","journal-title":"Mol. Autism"},{"key":"10.1016\/j.jbc.2021.100313_bib44","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1101\/gr.239756.118","article-title":"Exome-wide assessment of the functional impact and pathogenicity of multinucleotide mutations","volume":"29","author":"Kaplanis","year":"2019","journal-title":"Genome Res."},{"key":"10.1016\/j.jbc.2021.100313_bib45","doi-asserted-by":"crossref","first-page":"6541","DOI":"10.1002\/j.1460-2075.1996.tb01045.x","article-title":"Mechanism of activation of protein kinase B by insulin and IGF-1","volume":"15","author":"Alessi","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2021.100313_bib46","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.drudis.2016.04.005","article-title":"Targeting PRAS40 for multiple diseases","volume":"21","author":"Chong","year":"2016","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.jbc.2021.100313_bib47","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1083\/jcb.200507119","article-title":"Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning","volume":"173","author":"Cai","year":"2006","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.jbc.2021.100313_bib48","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/378785a0","article-title":"Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B","volume":"378","author":"Cross","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2021.100313_bib49","doi-asserted-by":"crossref","first-page":"8832","DOI":"10.1073\/pnas.1405723111","article-title":"Contact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence program","volume":"111","author":"Leontieva","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.100313_bib50","doi-asserted-by":"crossref","first-page":"5995","DOI":"10.1016\/S0021-9258(18)91112-9","article-title":"An activated S6 kinase in extracts from serum- and epidermal growth factor-stimulated Swiss 3T3 cells","volume":"259","author":"Novak-Hofer","year":"1984","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100313_bib51","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1101\/gad.995802","article-title":"Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1\/eIF4E","volume":"16","author":"Fingar","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.jbc.2021.100313_bib52","first-page":"4282","article-title":"Constant expression and activity of protein phosphatase 2A in synchronized cells","volume":"11","author":"Ruediger","year":"1991","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2021.100313_bib53","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.1038\/onc.2010.187","article-title":"Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2\/M checkpoint response","volume":"29","author":"Yan","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.jbc.2021.100313_bib54","doi-asserted-by":"crossref","first-page":"e27424","DOI":"10.1371\/journal.pone.0027424","article-title":"Free fatty acid-induced PP2A hyperactivity selectively impairs hepatic insulin action on glucose metabolism","volume":"6","author":"Galbo","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2021.100313_bib55","doi-asserted-by":"crossref","first-page":"e5920","DOI":"10.1590\/1414-431x20175920","article-title":"Cantharidin suppressed breast cancer MDA-MB-231 cell growth and migration by inhibiting MAPK signaling pathway","volume":"50","author":"Gu","year":"2017","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.jbc.2021.100313_bib56","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1111\/j.1349-7006.2010.01523.x","article-title":"Cantharidin, a potent and selective PP2A inhibitor, induces an oxidative stress-independent growth inhibition of pancreatic cancer cells through G2\/M cell-cycle arrest and apoptosis","volume":"101","author":"Li","year":"2010","journal-title":"Cancer Sci."},{"key":"10.1016\/j.jbc.2021.100313_bib57","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0002-9440(10)63445-1","article-title":"Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1\/2, MEK1\/2, and p70 S6, similar to that in Alzheimer's disease","volume":"163","author":"Pei","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jbc.2021.100313_bib58","doi-asserted-by":"crossref","first-page":"31091","DOI":"10.1074\/jbc.M503041200","article-title":"Protein phosphatase 2A regulates apoptosis in intestinal epithelial cells","volume":"280","author":"Ray","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100313_bib59","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1161\/01.CIR.98.9.899","article-title":"Fostriecin, an inhibitor of protein phosphatase 2A, limits myocardial infarct size even when administered after onset of ischemia","volume":"98","author":"Weinbrenner","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jbc.2021.100313_bib60","doi-asserted-by":"crossref","first-page":"31917","DOI":"10.1074\/jbc.274.45.31917","article-title":"Distinct roles for PP1 and PP2A in phosphorylation of the retinoblastoma protein. PP2a regulates the activities of G(1) cyclin-dependent kinases","volume":"274","author":"Yan","year":"1999","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100313_bib61","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1073\/pnas.0611532104","article-title":"Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56delta subunit","volume":"104","author":"Ahn","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.100313_bib62","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.molmet.2019.07.009","article-title":"Dysregulation of PP2A-Akt interaction contributes to Sucrose non-fermenting related kinase (SNRK) deficiency induced insulin resistance in adipose tissue","volume":"28","author":"Li","year":"2019","journal-title":"Mol. Metab."},{"key":"10.1016\/j.jbc.2021.100313_bib63","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.cell.2005.05.012","article-title":"An Akt\/beta-arrestin 2\/PP2A signaling complex mediates dopaminergic neurotransmission and behavior","volume":"122","author":"Beaulieu","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2021.100313_bib64","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1074\/jbc.M709585200","article-title":"Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt","volume":"283","author":"Kuo","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100313_bib65","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.molcel.2011.02.007","article-title":"Clk2 and B56beta mediate insulin-regulated assembly of the PP2A phosphatase holoenzyme complex on Akt","volume":"41","author":"Rodgers","year":"2011","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2021.100313_bib66","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1083\/jcb.201606033","article-title":"A\u00a0PP2A-B55 recognition signal controls substrate dephosphorylation kinetics during mitotic exit","volume":"214","author":"Cundell","year":"2016","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.jbc.2021.100313_bib67","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ccr.2010.10.031","article-title":"AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity","volume":"19","author":"Chandarlapaty","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jbc.2021.100313_bib68","doi-asserted-by":"crossref","first-page":"35375","DOI":"10.1074\/jbc.M806480200","article-title":"S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2","volume":"283","author":"Zhang","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100313_bib69","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.molcel.2008.10.023","article-title":"APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase","volume":"32","author":"Su","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2021.100313_bib70","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1126\/science.283.5410.2089","article-title":"Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A","volume":"283","author":"Seeling","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.jbc.2021.100313_bib71","doi-asserted-by":"crossref","first-page":"22649","DOI":"10.1074\/jbc.M109.013698","article-title":"PR55 alpha, a regulatory subunit of PP2A, specifically regulates PP2A-mediated beta-catenin dephosphorylation","volume":"284","author":"Zhang","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100313_bib72","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1093\/brain\/awx203","article-title":"Mutations of AKT3 are associated with a wide spectrum of developmental disorders including extreme megalencephaly","volume":"140","author":"Alcantara","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.jbc.2021.100313_bib73","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13229-017-0182-4","article-title":"Identification of mutations in the PI3K-AKT-mTOR signalling pathway in patients with macrocephaly and developmental delay and\/or autism","volume":"8","author":"Yeung","year":"2017","journal-title":"Mol. Autism"},{"key":"10.1016\/j.jbc.2021.100313_bib74","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/s13023-015-0371-1","article-title":"Autism spectrum disorder in tuberous sclerosis complex: Searching for risk markers","volume":"10","author":"Vignoli","year":"2015","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.jbc.2021.100313_bib75","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3389\/fped.2017.00043","article-title":"Dynamic Akt\/mTOR signaling in children with autism spectrum disorder","volume":"5","author":"Onore","year":"2017","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.jbc.2021.100313_bib76","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.molmed.2010.10.002","article-title":"Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders","volume":"17","author":"Ehninger","year":"2011","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.jbc.2021.100313_bib77","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1523\/JNEUROSCI.5685-08.2009","article-title":"Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice","volume":"29","author":"Zhou","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.jbc.2021.100313_bib78","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1089\/adt.2014.603","article-title":"Development and validation of a robust and sensitive assay for the discovery of selective inhibitors for serine\/threonine protein phosphatases PP1alpha (PPP1C) and PP5 (PPP5C)","volume":"12","author":"Swingle","year":"2014","journal-title":"Assay Drug Dev. Technol."},{"key":"10.1016\/j.jbc.2021.100313_bib79","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1007\/s00216-017-0407-6","article-title":"Offline pentafluorophenyl (PFP)-RP prefractionation as an alternative to high-pH RP for comprehensive LC-MS\/MS proteomics and phosphoproteomics","volume":"409","author":"Grassetti","year":"2017","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jbc.2021.100313_bib80","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/nmeth.1714","article-title":"MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics","volume":"8","author":"Ting","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jbc.2021.100313_bib81","doi-asserted-by":"crossref","first-page":"7150","DOI":"10.1021\/ac502040v","article-title":"MultiNotch MS3 enables accurate, sensitive, and multiplexed detection of differential expression across cancer cell line proteomes","volume":"86","author":"McAlister","year":"2014","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jbc.2021.100313_bib82","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/978-1-60761-444-9_5","article-title":"Target-decoy search strategy for mass spectrometry-based proteomics","volume":"604","author":"Elias","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jbc.2021.100313_bib83","doi-asserted-by":"crossref","first-page":"5354","DOI":"10.1021\/pr200611n","article-title":"Universal and confident phosphorylation site localization using phosphoRS","volume":"10","author":"Taus","year":"2011","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.jbc.2021.100313_bib84","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nmeth1109-786","article-title":"Improved visualization of protein consensus sequences by iceLogo","volume":"6","author":"Colaert","year":"2009","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jbc.2021.100313_bib85","doi-asserted-by":"crossref","first-page":"W199","DOI":"10.1093\/nar\/gkz401","article-title":"WebGestalt 2019: Gene set analysis toolkit with revamped UIs and APIs","volume":"47","author":"Liao","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2021.100313_bib86","doi-asserted-by":"crossref","first-page":"D512","DOI":"10.1093\/nar\/gku1267","article-title":"PhosphoSitePlus, 2014: Mutations, PTMs and recalibrations","volume":"43","author":"Hornbeck","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2021.100313_bib87","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nmeth.2968","article-title":"KinomeXplorer: An integrated platform for kinome biology studies","volume":"11","author":"Horn","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jbc.2021.100313_bib88","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: A software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.jbc.2021.100313_bib89","doi-asserted-by":"crossref","first-page":"D362","DOI":"10.1093\/nar\/gkw937","article-title":"The STRING database in 2017: Quality-controlled protein-protein association networks, made broadly accessible","volume":"45","author":"Szklarczyk","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2021.100313_bib90","doi-asserted-by":"crossref","first-page":"e1007822","DOI":"10.1371\/journal.pgen.1007822","article-title":"De novo variants in congenital diaphragmatic hernia identify MYRF as a new syndrome and reveal genetic overlaps with other developmental disorders","volume":"14","author":"Qi","year":"2018","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jbc.2021.100313_bib91","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jbc.2021.100313_bib92","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1101\/gr.107524.110","article-title":"The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data","volume":"20","author":"McKenna","year":"2010","journal-title":"Genome Res."},{"key":"10.1016\/j.jbc.2021.100313_bib93","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13059-016-0974-4","article-title":"The Ensembl variant effect predictor","volume":"17","author":"McLaren","year":"2016","journal-title":"Genome Biol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582100082X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582100082X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T03:22:27Z","timestamp":1634440947000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002192582100082X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":93,"alternative-id":["S002192582100082X"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2021.100313","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A disorder-related variant (E420K) of a PP2A-regulatory subunit (PPP2R5D) causes constitutively active AKT-mTOR signaling and uncoordinated cell growth","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2021.100313","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"100313"}}