{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T13:34:21Z","timestamp":1785159261116,"version":"3.55.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T00:00:00Z","timestamp":1611273600000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.jbc.2021.100326","type":"journal-article","created":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T06:49:22Z","timestamp":1611384562000},"page":"100326","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Engineering of highly potent and selective HNTX-III mutant against hNav1.7 sodium channel for treatment of pain"],"prefix":"10.1016","volume":"296","author":[{"given":"Yunxiao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dezheng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuchu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongfang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minzhi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songping","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2021.100326_bib1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1124\/pr.57.4.13","article-title":"Overview of molecular relationships in the voltage-gated ion channel superfamily","volume":"57","author":"Yu","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jbc.2021.100326_bib2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(00)81133-2","article-title":"From ionic currents to molecular mechanisms: The structure and function of voltage-gated sodium channels","volume":"26","author":"Catterall","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.jbc.2021.100326_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0173551","article-title":"The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant","volume":"12","author":"Rahnama","year":"2017","journal-title":"PLoS one"},{"key":"10.1016\/j.jbc.2021.100326_bib4","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1146\/annurev-neuro-060909-153234","article-title":"Sodium channels in normal and pathological pain","volume":"33","author":"Dib-Hajj","year":"2010","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.jbc.2021.100326_bib5","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1111\/j.1526-4637.2009.00719.x","article-title":"Voltage-gated sodium channels: Therapeutic targets for pain","volume":"10","author":"Dib-Hajj","year":"2009","journal-title":"Pain Med."},{"key":"10.1016\/j.jbc.2021.100326_bib6","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1186\/1471-2458-11-770","article-title":"Pain as a global public health priority","volume":"11","author":"Goldberg","year":"2011","journal-title":"BMC public health"},{"key":"10.1016\/j.jbc.2021.100326_bib7","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/444831a","article-title":"Neurobiology: A channel sets the gain on pain","volume":"444","author":"Waxman","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2021.100326_bib8","doi-asserted-by":"crossref","first-page":"7511","DOI":"10.1523\/JNEUROSCI.0462-16.2016","article-title":"Nav1.7-A1632G mutation from a family with inherited erythromelalgia: Enhanced firing of dorsal root ganglia neurons evoked by thermal stimuli","volume":"36","author":"Yang","year":"2016","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.jbc.2021.100326_bib9","first-page":"450","article-title":"A\u00a0novel SCN9A mutation (F826Y) in primary erythromelalgia alters the excitability of Nav1.7","volume":"17","author":"Wu","year":"2017","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.jbc.2021.100326_bib10","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1097\/ALN.0000000000000476","article-title":"L1612P, a novel voltage-gated sodium channel Nav1.7 mutation inducing a cold sensitive paroxysmal extreme pain disorder","volume":"122","author":"Suter","year":"2015","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jbc.2021.100326_bib11","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1016\/j.pain.2014.05.006","article-title":"Paroxysmal itch caused by gain-of-function Nav1.7 mutation","volume":"155","author":"Devigili","year":"2014","journal-title":"Pain"},{"key":"10.1016\/j.jbc.2021.100326_bib12","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature05413","article-title":"An SCN9A channelopathy causes congenital inability to experience pain","volume":"444","author":"Cox","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2021.100326_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0105895","article-title":"Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain","volume":"9","author":"Gingras","year":"2014","journal-title":"PLoS one"},{"key":"10.1016\/j.jbc.2021.100326_bib14","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0304-3959(00)00229-3","article-title":"Systemic lidocaine for neuropathic pain relief","volume":"87","author":"Mao","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.jbc.2021.100326_bib15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1053\/eujp.2001.0324","article-title":"Anticonvulsants in neuropathic pain: Rationale and clinical evidence","volume":"6 Suppl A","author":"Jensen","year":"2002","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.jbc.2021.100326_bib16","doi-asserted-by":"crossref","first-page":"8695","DOI":"10.1021\/acs.jmedchem.8b01906","article-title":"Challenges and opportunities for therapeutics targeting the voltage-gated sodium channel isoform NaV1.7","volume":"62","author":"Mulcahy","year":"2019","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.jbc.2021.100326_bib17","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.1016\/j.bmcl.2014.06.038","article-title":"Recent progress in sodium channel modulators for pain","volume":"24","author":"Bagal","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.jbc.2021.100326_bib18","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.toxicon.2012.04.337","article-title":"Spider-venom peptides that target voltage-gated sodium channels: Pharmacological tools and potential therapeutic leads","volume":"60","author":"Klint","year":"2012","journal-title":"Toxicon"},{"key":"10.1016\/j.jbc.2021.100326_bib19","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1517\/14712598.2011.621940","article-title":"Venoms as a platform for human drugs: Translating toxins into therapeutics","volume":"11","author":"King","year":"2011","journal-title":"Expert Opin. Biol. Ther."},{"key":"10.1016\/j.jbc.2021.100326_bib20","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.tips.2009.12.007","article-title":"Targeting voltage sensors in sodium channels with spider toxins","volume":"31","author":"Bosmans","year":"2010","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.jbc.2021.100326_bib21","doi-asserted-by":"crossref","first-page":"40883","DOI":"10.1038\/srep40883","article-title":"Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a","volume":"7","author":"Deuis","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2021.100326_bib22","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.3390\/toxins7072494","article-title":"Three peptide modulators of the human voltage-gated sodium channel 1.7, an important analgesic target, from the venom of an Australian tarantula","volume":"7","author":"Chow","year":"2015","journal-title":"Toxins"},{"key":"10.1016\/j.jbc.2021.100326_bib23","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1124\/mol.115.098178","article-title":"Identification and characterization of ProTx-III [mu-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula Thrixopelma pruriens","volume":"88","author":"Cardoso","year":"2015","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.jbc.2021.100326_bib24","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1111\/bph.13081","article-title":"Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach","volume":"172","author":"Klint","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jbc.2021.100326_bib25","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1021\/acs.jmedchem.9b00141","article-title":"Structure- and ligand-based discovery of chromane arylsulfonamide Nav1.7 inhibitors for the treatment of chronic pain","volume":"62","author":"McKerrall","year":"2019","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.jbc.2021.100326_bib26","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.peptides.2013.03.011","article-title":"Potency optimization of Huwentoxin-IV on hNav1.7: A neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena","volume":"44","author":"Revell","year":"2013","journal-title":"Peptides"},{"key":"10.1016\/j.jbc.2021.100326_bib27","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1021\/jm501765v","article-title":"Engineering potent and selective analogues of GpTx-1, a tarantula venom peptide antagonist of the Na(V)1.7 sodium channel","volume":"58","author":"Murray","year":"2015","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.jbc.2021.100326_bib28","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1021\/acs.jmedchem.5b01947","article-title":"Single residue substitutions that confer voltage-gated sodium ion channel subtype selectivity in the NaV1.7 inhibitory peptide GpTx-1","volume":"59","author":"Murray","year":"2016","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.jbc.2021.100326_bib29","doi-asserted-by":"crossref","first-page":"13974","DOI":"10.1074\/jbc.M116.725978","article-title":"Engineering highly potent and selective microproteins against Nav1.7 sodium channel for treatment of pain","volume":"291","author":"Shcherbatko","year":"2016","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100326_bib30","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1126\/science.aaw2493","article-title":"Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins","volume":"363","author":"Shen","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.jbc.2021.100326_bib31","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.cell.2018.12.018","article-title":"Structural basis of Nav1.7 inhibition by a gating-modifier spider toxin","volume":"176","author":"Xu","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2021.100326_bib32","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.coph.2009.05.004","article-title":"Biological diversity and therapeutic potential of natural and engineered cystine knot miniproteins","volume":"9","author":"Kolmar","year":"2009","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.jbc.2021.100326_bib33","doi-asserted-by":"crossref","first-page":"20392","DOI":"10.1074\/jbc.M112.426627","article-title":"Structure and function of hainantoxin-III, a selective antagonist of neuronal tetrodotoxin-sensitive voltage-gated sodium channels isolated from the Chinese bird spider Ornithoctonus hainana","volume":"288","author":"Liu","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100326_bib34","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/bph.13644","article-title":"Histamine H4 receptor agonist-induced relief from painful peripheral neuropathy is mediated by inhibition of spinal neuroinflammation and oxidative stress","volume":"174","author":"Sanna","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jbc.2021.100326_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152405","article-title":"Subtype-selective small molecule inhibitors reveal a fundamental role for Nav1.7 in nociceptor electrogenesis, axonal conduction and presynaptic release","volume":"11","author":"Alexandrou","year":"2016","journal-title":"PLoS one"},{"key":"10.1016\/j.jbc.2021.100326_bib36","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1085\/jgp.112.5.577","article-title":"Mechanism of peptide-induced mast cell degranulation. Translocation and patch-clamp studies","volume":"112","author":"Lorenz","year":"1998","journal-title":"J.\u00a0Gen. Physiol."},{"key":"10.1016\/j.jbc.2021.100326_bib37","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1097\/00128488-200109000-00003","article-title":"The American Society of Health System Pharmacists","volume":"3","author":"Beard","year":"2001","journal-title":"JONA'S Healthc. Law Ethics Regul."},{"key":"10.1016\/j.jbc.2021.100326_bib38","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1111\/bph.13865","article-title":"Modulatory features of the novel spider toxin mu-TRTX-Df1a isolated from the venom of the spider Davus fasciatus","volume":"174","author":"Cardoso","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jbc.2021.100326_bib39","doi-asserted-by":"crossref","first-page":"aac5464","DOI":"10.1126\/science.aac5464","article-title":"Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist","volume":"350","author":"Ahuja","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.jbc.2021.100326_bib40","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1124\/jpet.116.239590","article-title":"Pharmacologic characterization of AMG8379, a potent and selective small molecule sulfonamide antagonist of the voltage-gated sodium channel NaV1.7","volume":"362","author":"Kornecook","year":"2017","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jbc.2021.100326_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0196791","article-title":"Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V","volume":"13","author":"Moyer","year":"2018","journal-title":"PLoS one"},{"key":"10.1016\/j.jbc.2021.100326_bib42","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.1016\/j.bmcl.2015.06.033","article-title":"Sustained inhibition of the NaV1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1","volume":"25","author":"Murray","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.jbc.2021.100326_bib43","doi-asserted-by":"crossref","first-page":"6384","DOI":"10.1073\/pnas.111065098","article-title":"A\u00a0missense mutation of the Na+ channel alpha II subunit gene Na(v)1.2 in a patient with febrile and afebrile seizures causes channel dysfunction","volume":"98","author":"Sugawara","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.100326_bib44","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/nature17976","article-title":"Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain","volume":"534","author":"Osteen","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2021.100326_bib45","doi-asserted-by":"crossref","first-page":"S93","DOI":"10.1111\/j.1526-4637.2011.01158.x","article-title":"The roles of sodium channels in nociception: Implications for mechanisms of neuropathic pain","volume":"12 Suppl 3","author":"Liu","year":"2011","journal-title":"Pain Med."},{"key":"10.1016\/j.jbc.2021.100326_bib46","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1136\/jmedgenet-2014-102813","article-title":"De novo gain-of-function and loss-of-function mutations of SCN8A in patients with intellectual disabilities and epilepsy","volume":"52","author":"Blanchard","year":"2015","journal-title":"J.\u00a0Med. Genet."},{"key":"10.1016\/j.jbc.2021.100326_bib47","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.nbd.2014.05.017","article-title":"A\u00a0novel de novo mutation of SCN8A (Nav1.6) with enhanced channel activation in a child with epileptic encephalopathy","volume":"69","author":"Estacion","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jbc.2021.100326_bib48","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.ajhg.2012.01.006","article-title":"De novo pathogenic SCN8A mutation identified by whole-genome sequencing of a family quartet affected by infantile epileptic encephalopathy and SUDEP","volume":"90","author":"Veeramah","year":"2012","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jbc.2021.100326_bib49","doi-asserted-by":"crossref","DOI":"10.2119\/molmed.2016.00131","article-title":"A\u00a0gain-of-function mutation in Nav1.6 in a case of trigeminal neuralgia","volume":"22","author":"Tanaka","year":"2016","journal-title":"Mol. Med."},{"key":"10.1016\/j.jbc.2021.100326_bib50","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.pain.2013.02.027","article-title":"Knockdown of sodium channel NaV1.6 blocks mechanical pain and abnormal bursting activity of afferent neurons in inflamed sensory ganglia","volume":"154","author":"Xie","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.jbc.2021.100326_bib51","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.neuroscience.2015.02.010","article-title":"Local knockdown of the NaV1.6 sodium channel reduces pain behaviors, sensory neuron excitability, and sympathetic sprouting in rat models of neuropathic pain","volume":"291","author":"Xie","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.jbc.2021.100326_bib52","first-page":"399","article-title":"[Solid-phase chemical synthesis and oxidative refolding of Hainantoxin-III]","volume":"25","author":"Pi","year":"2007","journal-title":"Se Pu"},{"key":"10.1016\/j.jbc.2021.100326_bib53","doi-asserted-by":"crossref","first-page":"852","DOI":"10.3389\/fphar.2017.00852","article-title":"Electrophysiological and pharmacological analyses of Nav1.9 voltage-gated sodium channel by establishing a heterologous expression system","volume":"8","author":"Zhou","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jbc.2021.100326_bib54","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.biochi.2013.10.017","article-title":"Novel analgesic peptides from the tree frog of Hyla japonica","volume":"99","author":"Zhu","year":"2014","journal-title":"Biochimie"},{"key":"10.1016\/j.jbc.2021.100326_bib55","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.3390\/toxins6082363","article-title":"Synthesis and analgesic effects of mu-TRTX-Hhn1b on models of inflammatory and neuropathic pain","volume":"6","author":"Liu","year":"2014","journal-title":"Toxins"},{"key":"10.1016\/j.jbc.2021.100326_bib56","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1163\/156856005774649386","article-title":"Anti-inflammatory activity of aqueous leaf extract of Chromolaena odorata","volume":"13","author":"Owoyele","year":"2005","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jbc.2021.100326_bib57","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1124\/jpet.117.244376","article-title":"Treatment with sulforaphane produces antinociception and improves morphine effects during inflammatory pain in mice","volume":"363","author":"Redondo","year":"2017","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jbc.2021.100326_bib58","doi-asserted-by":"crossref","first-page":"14.e11","DOI":"10.1016\/j.pain.2005.10.036","article-title":"Assessment and analysis of mechanical allodynia-like behavior induced by spared nerve injury (SNI) in the mouse","volume":"122","author":"Bourquin","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.jbc.2021.100326_bib59","article-title":"Liquiritigenin alleviates mechanical and cold hyperalgesia in a rat neuropathic pain model","volume":"4","author":"Chen","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2021.100326_bib60","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.pnpbp.2013.10.014","article-title":"Novel action of metformin in the prevention of haloperidol-induced catalepsy in mice: Potential in the treatment of Parkinson's disease?","volume":"48","author":"Adedeji","year":"2014","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.jbc.2021.100326_bib61","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.bcp.2019.02.015","article-title":"Inhibition of mast cell degranulation by melanin","volume":"163","author":"Kawamoto","year":"2019","journal-title":"Biochem. Pharmacol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925821000971?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925821000971?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T03:30:34Z","timestamp":1634441434000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925821000971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":61,"alternative-id":["S0021925821000971"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2021.100326","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineering of highly potent and selective HNTX-III mutant against hNav1.7 sodium channel for treatment of pain","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2021.100326","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"100326"}}