{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:20:44Z","timestamp":1777602044123,"version":"3.51.4"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"vor","delay-in-days":53,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["963552"],"award-info":[{"award-number":["963552"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1103013"],"award-info":[{"award-number":["1103013"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1138585"],"award-info":[{"award-number":["1138585"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["19ek0109282h0003"],"award-info":[{"award-number":["19ek0109282h0003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001134","name":"Australia-India Strategic Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001134","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007727","name":"Department of Industry, Innovation and Science, Australian Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007727","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.jbc.2021.100456","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T22:51:59Z","timestamp":1614120719000},"page":"100456","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Binding of Gtf2i-\u03b2\/\u03b4 transcription factors to the ARMS2 gene leads to increased circulating HTRA1 in AMD patients and in\u00a0vitro"],"prefix":"10.1016","volume":"296","author":[{"given":"Yang","family":"Pan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Iejima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Suga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Noda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inderjeet","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taraprasad","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3717-4963","authenticated-orcid":false,"given":"Subhabrata","family":"Chakrabarti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn H.","family":"Guymer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret M.","family":"DeAngelis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul N.","family":"Baird","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1447-0081","authenticated-orcid":false,"given":"Takeshi","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2021.100456_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/S2214-109X(13)70145-1","article-title":"Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: A systematic review and meta-analysis","volume":"2","author":"Wong","year":"2014","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.jbc.2021.100456_bib2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/01.APO.0000656976.47696.7d","article-title":"Genetic association of age-related macular degeneration and polypoidal choroidal vasculopathy","volume":"9","author":"Chen","year":"2020","journal-title":"Asia Pacific J. Ophthalmol."},{"key":"10.1016\/j.jbc.2021.100456_bib3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nature08151","article-title":"CCR3 is a target for age-related macular degeneration diagnosis and therapy","volume":"460","author":"Takeda","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2021.100456_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40662-016-0063-5","article-title":"Epidemiology of age-related macular degeneration (AMD): Associations with cardiovascular disease phenotypes and lipid factors","volume":"3","author":"Pennington","year":"2016","journal-title":"Eye Vis."},{"key":"10.1016\/j.jbc.2021.100456_bib5","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1126\/science.1133811","article-title":"A\u00a0variant of the HTRA1 gene increases susceptibility to age-related macular degeneration","volume":"314","author":"Yang","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.jbc.2021.100456_bib6","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/ng.2578","article-title":"Seven new loci associated with age-related macular degeneration","volume":"45","author":"Fritsche","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbc.2021.100456_bib7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev-genom-090413-025610","article-title":"Age-related macular degeneration: Genetics and biology coming together","volume":"15","author":"Fritsche","year":"2014","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"10.1016\/j.jbc.2021.100456_bib8","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nature10449","article-title":"Complement factor H binds malondialdehyde epitopes and protects from oxidative stress","volume":"478","author":"Weismann","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2021.100456_bib9","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/ng.2640","article-title":"A\u00a0functional variant in the CFI gene confers a high risk of age-related macular degeneration","volume":"45","author":"van de Ven","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbc.2021.100456_bib10","doi-asserted-by":"crossref","first-page":"4366","DOI":"10.1073\/pnas.0812584106","article-title":"Functional basis of protection against age-related macular degeneration conferred by a common polymorphism in complement factor B","volume":"106","author":"Montes","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.100456_bib11","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1038\/ng.2758","article-title":"Identification of a rare coding variant in complement 3 associated with age-related macular degeneration","volume":"45","author":"Zhan","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbc.2021.100456_bib12","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s00439-010-0805-8","article-title":"Analysis of the indel at the ARMS2 3\u2019UTR in age-related macular degeneration","volume":"127","author":"Wang","year":"2010","journal-title":"Hum. Genet."},{"key":"10.1016\/j.jbc.2021.100456_bib13","first-page":"822","article-title":"Association of the del443ins54 at the ARMS2 locus in Indian and Australian cohorts with age-related macular degeneration","volume":"19","author":"Kaur","year":"2013","journal-title":"Mol. Vis."},{"key":"10.1016\/j.jbc.2021.100456_bib14","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/ng.170","article-title":"Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA","volume":"40","author":"Fritsche","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbc.2021.100456_bib15","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1074\/jbc.M114.593384","volume":"290","author":"Iejima","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100456_bib16","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1016\/j.ajpath.2018.08.012","article-title":"High-temperature requirement A 1 causes photoreceptor cell death in Zebrafish disease models","volume":"188","author":"Oura","year":"2018","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jbc.2021.100456_bib17","doi-asserted-by":"crossref","first-page":"6514","DOI":"10.1167\/iovs.14-14453","article-title":"Overexpression of HtrA1 and exposure to mainstream cigarette smoke leads to choroidal neovascularization and subretinal deposits in aged mice","volume":"55","author":"Nakayama","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jbc.2021.100456_bib18","doi-asserted-by":"crossref","first-page":"14578","DOI":"10.1073\/pnas.1102853108","article-title":"Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice","volume":"108","author":"Jones","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.100456_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0022959","article-title":"Overexpression of HTRA1 leads to ultrastructural changes in the elastic layer of Bruch\u2019s membrane via cleavage of extracellular matrix components","volume":"6","author":"Vierkotten","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2021.100456_bib20","article-title":"TGF-\u03b2 concentrations and activity are down-regulated in the aqueous humor of patients with neovascular age-related macular degeneration","volume":"8","author":"Tosi","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2021.100456_bib21","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1006\/dbio.2001.0480","article-title":"Tgf\u03b22 in corneal morphogenesis during mouse embryonic development","volume":"240","author":"Saika","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.jbc.2021.100456_bib22","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1128\/MCB.20.4.1140-1148.2000","article-title":"Extracellular signal-regulated kinase binds to TFII-I and regulates its activation of the c-fos promoter","volume":"20","author":"Kim","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jbc.2021.100456_bib23","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1128\/MCB.21.10.3387-3397.2000","article-title":"JAK2 activates TFII-I and regulates its interaction with extracellular signal-regulated kinase","volume":"21","author":"Kim","year":"2001","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2021.100456_bib24","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1101\/gad.11.19.2482","article-title":"A\u00a0multifunctional DNA-binding protein that promotes the formation of serum response factor\/homeodomain complexes: Identity to TFII-I","volume":"11","author":"Grueneberg","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.jbc.2021.100456_bib25","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1002\/eji.200839031","article-title":"Characterization of a novel interaction between transcription factor TFII-I and the inducible tyrosine kinase in T cells","volume":"39","author":"Sacrist\u00e1n","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jbc.2021.100456_bib26","doi-asserted-by":"crossref","first-page":"26300","DOI":"10.1074\/jbc.M002980200","article-title":"Alternatively spliced isoforms of TFII-I: Complex formation, nuclear translocation, and differential gene regulation","volume":"275","author":"Cheriyath","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100456_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000836","article-title":"Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration","volume":"6","author":"Yang","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jbc.2021.100456_bib28","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1093\/emboj\/21.7.1743","article-title":"Balancing the activation state of the endothelium via two distinct TGF-\u03b2 type I receptors","volume":"21","author":"Goumans","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2021.100456_bib29","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S1097-2765(03)00386-1","article-title":"Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGF\u03b2\/ALK5 signaling","volume":"12","author":"Goumans","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2021.100456_bib30","doi-asserted-by":"crossref","first-page":"5320","DOI":"10.1182\/blood-2011-12-395772","article-title":"Smad2\/Smad3 in endothelium is indispensable for vascular stability via S1PR1 and N-cadherin expressions","volume":"119","author":"Itoh","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jbc.2021.100456_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005149","article-title":"TGF-\u03b2 is required for vascular barrier function, endothelial survival and homeostasis of the adult microvasculature","volume":"4","author":"Walshe","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2021.100456_bib32","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1136\/bjo.2006.098426","article-title":"Vascular endothelial growth factor biology: Clinical implications for ocular treatments","volume":"90","author":"Bhisitkul","year":"2006","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.jbc.2021.100456_bib33","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/sj.ejhg.5201174","article-title":"Isolation and characterisation of GTF21RD2, a novel fusion gene and member of the TFII-I family of transcription factors, deleted in Williams-Beuren syndrome","volume":"12","author":"Tipney","year":"2004","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.jbc.2021.100456_bib34","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.molmed.2017.04.002","article-title":"Pathophysiology of TFII-I: Old guard wearing new hats","volume":"23","author":"Roy","year":"2017","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.jbc.2021.100456_bib35","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mcp.2017.12.005","article-title":"The contribution of GTF2I haploinsufficiency to Williams syndrome","volume":"40","author":"Chailangkarn","year":"2018","journal-title":"Mol. Cell Probes"},{"key":"10.1016\/j.jbc.2021.100456_bib36","doi-asserted-by":"crossref","first-page":"5014","DOI":"10.1128\/MCB.19.7.5014","article-title":"Regulation of nuclear localization and transcriptional activity of TFII-I by Bruton\u2019s tyrosine kinase","volume":"19","author":"Novina","year":"1999","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2021.100456_bib37","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1073\/pnas.94.2.604","article-title":"Bap-135, a target for Bruton\u2019s tyrosine kinase in response to B cell receptor engagement","volume":"94","author":"Yang","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.100456_bib38","doi-asserted-by":"crossref","first-page":"7144","DOI":"10.1128\/MCB.25.16.7144-7157.2005","article-title":"Positive and negative regulation of the transforming growth factor\/activin target gene goosecoid by the TFII-I family of transcription factors","volume":"25","author":"Ku","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2021.100456_bib39","doi-asserted-by":"crossref","first-page":"16821","DOI":"10.1074\/jbc.M413753200","article-title":"Transcriptional regulation of the Grp78 promoter by endoplasmic reticulum stress: Role of TFII-I and its tyrosine phosphorylation","volume":"280","author":"Hong","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100456_bib40","doi-asserted-by":"crossref","first-page":"3220","DOI":"10.1128\/MCB.21.9.3220-3233.2001","article-title":"Identification of TFII-I as the endoplasmic reticulum stress response element binding factor ERSF: Its autoregulation by stress and interaction with ATF6","volume":"21","author":"Parker","year":"2001","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2021.100456_bib41","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/jcb.22016","article-title":"Transcription factor TFII-I causes transcriptional upregulation of GRP78 synthesis in prostate cancer cells","volume":"106","author":"Misra","year":"2009","journal-title":"J.\u00a0Cell Biochem."},{"key":"10.1016\/j.jbc.2021.100456_bib42","doi-asserted-by":"crossref","first-page":"4396","DOI":"10.1128\/JVI.79.7.4396-4406.2005","article-title":"TFII-I regulates induction of chromosomally integrated human immunodeficiency virus type 1 long terminal repeat in cooperation with USF","volume":"79","author":"Chen","year":"2005","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.jbc.2021.100456_bib43","first-page":"E677","article-title":"Genome-wide targeting of the epigenetic regulatory protein ctcf to gene promoters by the transcription factor TFII-I","volume":"112","author":"Pe\u00f1 A-Hern\u00e1ndez","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.100456_bib44","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1073\/pnas.0811531106","article-title":"Essential functions of the Williams-Beuren syndrome-associated TFII-I genes in embryonic development","volume":"106","author":"Enkhmandakh","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.100456_bib45","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1038\/nature07765","article-title":"A\u00a0mechanosensitive transcriptional mechanism that controls angiogenesis","volume":"457","author":"Mammoto","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2021.100456_bib46","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.gene.2008.11.027","article-title":"Alternative splicing and promoter use in TFII-I genes","volume":"433","author":"Makeyev","year":"2009","journal-title":"Gene"},{"key":"10.1016\/j.jbc.2021.100456_bib47","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.cytogfr.2009.10.005","article-title":"Transforming Growth Factor type beta and Smad family signaling in stem cell function","volume":"20","author":"Seuntjens","year":"2009","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.jbc.2021.100456_bib48","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s12177-009-9047-1","article-title":"Genetic analysis of typical wet-type age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese population","volume":"2","author":"Goto","year":"2009","journal-title":"J.\u00a0Ocul. Biol. Dis. Inform."},{"key":"10.1016\/j.jbc.2021.100456_bib49","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/j.ophtha.2012.09.006","article-title":"Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration","volume":"119","author":"Heier","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jbc.2021.100456_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19113363","article-title":"The controversial role of TGF-\u03b2 in neovascular age-related macular degeneration pathogenesis","volume":"19","author":"Tosi","year":"2018","journal-title":"Int. J. Mol. Sci."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925821002295?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925821002295?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T20:57:07Z","timestamp":1777409827000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925821002295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":50,"alternative-id":["S0021925821002295"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2021.100456","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Binding of Gtf2i-\u03b2\/\u03b4 transcription factors to the ARMS2 gene leads to increased circulating HTRA1 in AMD patients and in\u00a0vitro","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2021.100456","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"100456"}}