{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:47:47Z","timestamp":1789152467455,"version":"build-2803163510"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T00:00:00Z","timestamp":1614124800000},"content-version":"vor","delay-in-days":54,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-19-1-0442"],"award-info":[{"award-number":["W81XWH-19-1-0442"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["T32 AI07485"],"award-info":[{"award-number":["T32 AI07485"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA086862"],"award-info":[{"award-number":["P30CA086862"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA97274"],"award-info":[{"award-number":["CA97274"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG065532"],"award-info":[{"award-number":["AG065532"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01 BX001702"],"award-info":[{"award-number":["I01 BX001702"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007217","name":"Health Services Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007217","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006379","name":"Office of Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006379","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008893","name":"University of Iowa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008893","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.jbc.2021.100465","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T21:55:18Z","timestamp":1614203718000},"page":"100465","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["TNF receptor-associated factor 3 restrains B-cell receptor signaling in normal and malignant B cells"],"prefix":"10.1016","volume":"296","author":[{"given":"Amy L.","family":"Whillock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany K.","family":"Ybarra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1291-5078","authenticated-orcid":false,"given":"Gail A.","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2021.100465_bib1","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.3389\/fimmu.2018.02161","article-title":"TRAF3 as a Multifaceted regulator of B lymphocyte survival and activation","volume":"9","author":"Bishop","year":"2018","journal-title":"Front Immunol."},{"key":"10.1016\/j.jbc.2021.100465_bib2","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S1074-7613(00)80497-5","article-title":"Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses","volume":"5","author":"Xu","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/j.jbc.2021.100465_bib3","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.immuni.2007.07.012","article-title":"Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs","volume":"27","author":"Xie","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.jbc.2021.100465_bib4","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.immuni.2008.01.009","article-title":"TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor","volume":"28","author":"Gardam","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.jbc.2021.100465_bib5","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/leu.2011.309","article-title":"Specific deletion of TRAF3 in B lymphocytes leads to B-lymphoma development in mice","volume":"26","author":"Moore","year":"2012","journal-title":"Leukemia"},{"key":"10.1016\/j.jbc.2021.100465_bib6","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.3389\/fimmu.2018.02111","article-title":"Genetic alterations of TRAF proteins in human cancers","volume":"9","author":"Zhu","year":"2018","journal-title":"Front Immunol."},{"key":"10.1016\/j.jbc.2021.100465_bib7","article-title":"Genomic and transcriptomic correlates of Richter's transformation in chronic lymphocytic leukemia","author":"Klintman","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.jbc.2021.100465_bib8","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1182\/blood-2014-10-602714","article-title":"Genetic inactivation of TRAF3 in canine and human B-cell lymphoma","volume":"125","author":"Bushell","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.jbc.2021.100465_bib9","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.celrep.2015.03.059","article-title":"An oncogenic role for alternative NF-kappaB signaling in DLBCL revealed upon deregulated BCL6 expression","volume":"11","author":"Zhang","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2021.100465_bib10","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1182\/blood-2015-01-613596","article-title":"Introduction to a series of reviews on multiple myeloma","volume":"125","author":"San Miguel","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.jbc.2021.100465_bib11","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1182\/bloodadvances.2017009670","article-title":"The oncogenic membrane protein LMP1 sequesters TRAF3 in B-cell lymphoma cells to produce functional TRAF3 deficiency","volume":"1","author":"Bangalore-Prakash","year":"2017","journal-title":"Blood Adv."},{"key":"10.1016\/j.jbc.2021.100465_bib12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1146\/annurev.immunol.021908.132541","article-title":"B\u00a0cell signaling and fate decision","volume":"28","author":"Kurosaki","year":"2010","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jbc.2021.100465_bib13","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.molimm.2010.12.007","article-title":"Regulation of BCR signaling","volume":"48","author":"Kurosaki","year":"2011","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.jbc.2021.100465_bib14","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nri2765","article-title":"The SYK tyrosine kinase: A crucial player in diverse biological functions","volume":"10","author":"Mocsai","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jbc.2021.100465_bib15","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/nrc.2017.121","article-title":"Targeting B cell receptor signalling in cancer: Preclinical and clinical advances","volume":"18","author":"Burger","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jbc.2021.100465_bib16","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrc1589","article-title":"Mechanisms of B-cell lymphoma pathogenesis","volume":"5","author":"Kuppers","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jbc.2021.100465_bib17","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nature08638","article-title":"Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma","volume":"463","author":"Davis","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2021.100465_bib18","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ctrv.2018.01.002","article-title":"Targeting the B-cell receptor pathway in diffuse large B-cell lymphoma","volume":"65","author":"Dunleavy","year":"2018","journal-title":"Cancer Treat Rev."},{"key":"10.1016\/j.jbc.2021.100465_bib19","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.1158\/1078-0432.CCR-14-2225","article-title":"FDA approval: Ibrutinib for Patients with previously treated mantle cell lymphoma and previously treated chronic lymphocytic leukemia","volume":"21","author":"de Claro","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jbc.2021.100465_bib20","doi-asserted-by":"crossref","first-page":"615","DOI":"10.2147\/CMAR.S133291","article-title":"Management of relapsed\/refractory marginal zone lymphoma: Focus on ibrutinib","volume":"10","author":"Denlinger","year":"2018","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.jbc.2021.100465_bib21","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2147\/JBM.S183997","article-title":"Evaluating ibrutinib in the treatment of symptomatic Waldenstrom's macroglobulinemia","volume":"10","author":"Papanota","year":"2019","journal-title":"J.\u00a0Blood Med."},{"key":"10.1016\/j.jbc.2021.100465_bib22","doi-asserted-by":"crossref","first-page":"103010","DOI":"10.1016\/j.critrevonc.2020.103010","article-title":"Efficacy and safety of ibrutinib in diffuse large B-cell lymphoma: A single-arm meta-analysis","volume":"152","author":"Hou","year":"2020","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.jbc.2021.100465_bib23","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.3390\/cancers12051328","article-title":"Ibrutinib resistance mechanisms and treatment Strategies for B-cell lymphomas","volume":"12","author":"George","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jbc.2021.100465_bib24","doi-asserted-by":"crossref","first-page":"591577","DOI":"10.3389\/fonc.2020.591577","article-title":"Genetic and non-genetic mechanisms of resistance to BCR signaling inhibitors in B cell malignancies","volume":"10","author":"Ondrisova","year":"2020","journal-title":"Front Oncol."},{"key":"10.1016\/j.jbc.2021.100465_bib25","doi-asserted-by":"crossref","first-page":"6307","DOI":"10.4049\/jimmunol.162.11.6307","article-title":"Cutting edge: Contrasting roles of TNF receptor-associated factor 2 (TRAF2) and TRAF3 in CD40-activated B lymphocyte differentiation","volume":"162","author":"Hostager","year":"1999","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jbc.2021.100465_bib26","doi-asserted-by":"crossref","first-page":"15392","DOI":"10.1074\/jbc.M909520199","article-title":"Recruitment of CD40 and tumor necrosis factor receptor-associated factors 2 and 3 to membrane microdomains during CD40 signaling","volume":"275","author":"Hostager","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100465_bib27","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1385\/IR:24:2:097","article-title":"Signaling by CD40 and its mimics in B cell activation","volume":"24","author":"Bishop","year":"2001","journal-title":"Immunol. Res."},{"key":"10.1016\/j.jbc.2021.100465_bib28","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1189\/jlb.0111044","article-title":"Enhanced Toll-like receptor (TLR) responses of TNFR-associated factor 3 (TRAF3)-deficient B lymphocytes","volume":"90","author":"Xie","year":"2011","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.jbc.2021.100465_bib29","doi-asserted-by":"crossref","first-page":"7410","DOI":"10.1073\/pnas.83.19.7410","article-title":"Induced differentiation of a transformed clone of Ly-1+ B cells by clonal T cells and antigen","volume":"83","author":"Bishop","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.100465_bib30","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1074\/jbc.M310628200","article-title":"Synergistic B cell activation by CD40 and the B cell antigen receptor: role of B lymphocyte antigen receptor-mediated kinase activation and tumor necrosis factor receptor-associated factor regulation","volume":"279","author":"Haxhinasto","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100465_bib31","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.4049\/jimmunol.169.3.1145","article-title":"Cutting edge: Molecular mechanisms of synergy between CD40 and the B cell antigen receptor: Role for TNF receptor-associated factor 2 in receptor interaction","volume":"169","author":"Haxhinasto","year":"2002","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jbc.2021.100465_bib32","doi-asserted-by":"crossref","first-page":"ra71","DOI":"10.1126\/scisignal.2003973","article-title":"The tyrosine kinase Syk differentially regulates Toll-like receptor signaling downstream of the adaptor molecules TRAF6 and TRAF3","volume":"6","author":"Lin","year":"2013","journal-title":"Sci. Signal"},{"key":"10.1016\/j.jbc.2021.100465_bib33","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.3324\/haematol.2017.170571","article-title":"SYK inhibition thwarts the BAFF - B-cell receptor crosstalk and thereby antagonizes Mcl-1 in chronic lymphocytic leukemia","volume":"102","author":"Paiva","year":"2017","journal-title":"Haematologica"},{"key":"10.1016\/j.jbc.2021.100465_bib34","doi-asserted-by":"crossref","first-page":"830","DOI":"10.4049\/jimmunol.2000322","article-title":"TRAF3 Acts as a Checkpoint of B cell receptor signaling to control antibody class switch recombination and Anergy","volume":"205","author":"Chen","year":"2020","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jbc.2021.100465_bib35","doi-asserted-by":"crossref","first-page":"143","DOI":"10.4049\/jimmunol.1000290","article-title":"TNF receptor-associated factor 3 is required for T cell-mediated immunity and TCR\/CD28 signaling","volume":"186","author":"Xie","year":"2011","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jbc.2021.100465_bib36","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1038\/s41598-017-02280-4","article-title":"TRAF3 enhances TCR signaling by regulating the inhibitors Csk and PTPN22","volume":"7","author":"Wallis","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2021.100465_bib37","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1002\/JLB.2MR1119-397R","article-title":"TRAF family molecules in T cells: Multiple receptors and functions","volume":"107","author":"Arkee","year":"2020","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.jbc.2021.100465_bib38","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1002\/eji.1830270935","article-title":"Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses","volume":"27","author":"Oliver","year":"1997","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jbc.2021.100465_bib39","doi-asserted-by":"crossref","first-page":"7198","DOI":"10.4049\/jimmunol.162.12.7198","article-title":"IgMhighCD21high lymphocytes enriched in the splenic marginal zone generate effector cells more rapidly than the bulk of follicular B cells","volume":"162","author":"Oliver","year":"1999","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jbc.2021.100465_bib40","doi-asserted-by":"crossref","first-page":"13075","DOI":"10.1073\/pnas.1004594107","article-title":"The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy","volume":"107","author":"Honigberg","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.100465_bib41","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1124\/jpet.106.109058","article-title":"R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation","volume":"319","author":"Braselmann","year":"2006","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jbc.2021.100465_bib42","doi-asserted-by":"crossref","first-page":"4894","DOI":"10.1182\/blood-2010-03-275180","article-title":"The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the E\u03bc- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling","volume":"116","author":"Suljagic","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jbc.2021.100465_bib43","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1084\/jem.188.7.1297","article-title":"Different protein tyrosine kinases are required for B cell antigen receptor-mediated activation of extracellular signal-regulated kinase, c-Jun NH2-terminal kinase 1, and p38 mitogen-activated protein kinase","volume":"188","author":"Jiang","year":"1998","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.jbc.2021.100465_bib44","first-page":"D296","article-title":"ELM-the eukaryotic linear motif resource in 2020","volume":"48","author":"Kumar","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2021.100465_bib45","doi-asserted-by":"crossref","first-page":"45382","DOI":"10.1074\/jbc.M306708200","article-title":"Tumor necrosis factor receptor-associated factor 2 (TRAF2)-deficient B lymphocytes reveal novel roles for TRAF2 in CD40 signaling","volume":"278","author":"Hostager","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100465_bib46","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1084\/jem.20031255","article-title":"Requirement for TRAF3 in signaling by LMP1 but not CD40 in B lymphocytes","volume":"199","author":"Xie","year":"2004","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.jbc.2021.100465_bib47","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00005-008-0014-5","article-title":"The role of B lymphocytes as antigen-presenting cells","volume":"56","author":"Chen","year":"2008","journal-title":"Arch. Immunol. Ther. Exp. (Warsz)"},{"key":"10.1016\/j.jbc.2021.100465_bib48","doi-asserted-by":"crossref","first-page":"107474","DOI":"10.1016\/j.celrep.2020.03.038","article-title":"BCR-induced Ca(2+) signals Dynamically Tune survival, Metabolic Reprogramming, and proliferation of Naive B cells","volume":"31","author":"Berry","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2021.100465_bib49","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/S0092-8674(00)80373-6","article-title":"In\u00a0vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death","volume":"90","author":"Lam","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2021.100465_bib50","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.cell.2004.05.014","article-title":"Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha\/beta heterodimer","volume":"117","author":"Kraus","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2021.100465_bib51","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1158\/0008-5472.CAN-07-3293","article-title":"Oncogene addiction","volume":"68","author":"Weinstein","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.jbc.2021.100465_bib52","doi-asserted-by":"crossref","first-page":"280","DOI":"10.15252\/embr.201439949","article-title":"Oncogene addiction: Pathways of therapeutic response, resistance, and road maps toward a cure","volume":"16","author":"Pagliarini","year":"2015","journal-title":"EMBO Rep."},{"key":"10.1016\/j.jbc.2021.100465_bib53","doi-asserted-by":"crossref","first-page":"12884","DOI":"10.1038\/s41598-019-49390-9","article-title":"TRAF3 regulates the oncogenic proteins Pim2 and c-Myc to restrain survival in normal and malignant B cells","volume":"9","author":"Whillock","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2021.100465_bib54","doi-asserted-by":"crossref","first-page":"6321","DOI":"10.1182\/blood-2010-12-325944","article-title":"CD19-independent instruction of murine marginal zone B-cell development by constitutive Notch2 signaling","volume":"118","author":"Hampel","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jbc.2021.100465_bib55","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/1476-4598-8-132","article-title":"Anomalous constitutive Src kinase activity promotes B lymphoma survival and growth","volume":"8","author":"Ke","year":"2009","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jbc.2021.100465_bib56","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nri3383","article-title":"Marginal zone B cells: Virtues of innate-like antibody-producing lymphocytes","volume":"13","author":"Cerutti","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jbc.2021.100465_bib57","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nri799","article-title":"Marginal-zone B cells","volume":"2","author":"Martin","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jbc.2021.100465_bib58","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/s41590-020-0687-4","article-title":"ImmGen at 15","volume":"21","author":"Project","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jbc.2021.100465_bib59","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/1074-7613(95)90075-6","article-title":"Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection","volume":"2","author":"Cyster","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/j.jbc.2021.100465_bib60","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.immuni.2007.04.016","article-title":"B\u00a0cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity","volume":"27","author":"Pao","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.jbc.2021.100465_bib61","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1084\/jem.20021686","article-title":"Cbl-b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk","volume":"197","author":"Sohn","year":"2003","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.jbc.2021.100465_bib62","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.immuni.2007.03.015","article-title":"Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b","volume":"26","author":"Kitaura","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.jbc.2021.100465_bib63","doi-asserted-by":"crossref","first-page":"16636","DOI":"10.1074\/jbc.M112.357640","article-title":"The Syk-binding ubiquitin ligase c-Cbl mediates signaling-dependent B cell receptor ubiquitination and B cell receptor-mediated antigen processing and presentation","volume":"287","author":"Katkere","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100465_bib64","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/sj.emboj.7600966","article-title":"Transcription regulation from a TATA and INR-less promoter: Spatial segregation of promoter function","volume":"25","author":"George","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2021.100465_bib65","doi-asserted-by":"crossref","first-page":"6386","DOI":"10.4049\/jimmunol.163.12.6386","article-title":"T\u00a0suppressor lymphocytes inhibit NF-kappa B-mediated transcription of CD86 gene in APC","volume":"163","author":"Li","year":"1999","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jbc.2021.100465_bib66","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1073\/pnas.1514586113","article-title":"Nuclear TRAF3 is a negative regulator of CREB in B cells","volume":"113","author":"Mambetsariev","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.100465_bib67","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1074-7613(00)80015-1","article-title":"CREB regulates MHC class II expression in a CIITA-dependent manner","volume":"10","author":"Moreno","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.jbc.2021.100465_bib68","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.coi.2010.09.007","article-title":"Regulation of major histocompatibility complex class II genes","volume":"23","author":"Choi","year":"2011","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.jbc.2021.100465_bib69","first-page":"276","article-title":"Establishment and characterization of an Epstein-Barr virus (EBC)-negative lymphoblastoid B cell line (BJA-B) from an exceptional, EBV-genome-negative African Burkitt's lymphoma","volume":"22","author":"Menezes","year":"1975","journal-title":"Biomedicine"},{"key":"10.1016\/j.jbc.2021.100465_bib70","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1182\/blood.V75.3.709.709","article-title":"A\u00a0new human B-cell non-Hodgkin's lymphoma cell line (Karpas 422) exhibiting both t (14;18) and t(4;11) chromosomal translocations","volume":"75","author":"Dyer","year":"1990","journal-title":"Blood"},{"key":"10.1016\/j.jbc.2021.100465_bib71","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1182\/blood.V69.5.1307.1307","article-title":"The presence of clonogenic cells in high-grade malignant lymphoma: A prognostic factor","volume":"69","author":"Tweeddale","year":"1987","journal-title":"Blood"},{"key":"10.1016\/j.jbc.2021.100465_bib72","first-page":"1300","article-title":"Surface IgM-kappa specificity on a Burkitt lymphoma cell in\u00a0vivo and in derived culture lines","volume":"28","author":"Klein","year":"1968","journal-title":"Cancer Res."},{"key":"10.1016\/j.jbc.2021.100465_bib73","doi-asserted-by":"crossref","first-page":"e76889","DOI":"10.1371\/journal.pone.0076889","article-title":"Identification of Candidate B-lymphoma genes by Cross-Species gene expression Profiling","volume":"8","author":"Tompkins","year":"2013","journal-title":"Plos One"},{"key":"10.1016\/j.jbc.2021.100465_bib74","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.1073\/pnas.71.8.3283","article-title":"Continuous lymphoid cell lines with characteristics of B cells (bone-marrow-derived), lacking the Epstein-Barr virus genome and derived from three human lymphomas","volume":"71","author":"Klein","year":"1974","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.100465_bib75","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925821002386?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925821002386?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T20:54:34Z","timestamp":1777409674000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925821002386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":75,"alternative-id":["S0021925821002386"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2021.100465","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TNF receptor-associated factor 3 restrains B-cell receptor signaling in normal and malignant B cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2021.100465","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"100465"}}