{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:35:41Z","timestamp":1780580141239,"version":"3.54.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T00:00:00Z","timestamp":1614384000000},"content-version":"vor","delay-in-days":57,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002426","name":"Telethon Italy","doi-asserted-by":"publisher","award":["GGP10208"],"award-info":[{"award-number":["GGP10208"]}],"id":[{"id":"10.13039\/501100002426","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002426","name":"Telethon Italy","doi-asserted-by":"publisher","award":["GGP12115"],"award-info":[{"award-number":["GGP12115"]}],"id":[{"id":"10.13039\/501100002426","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002426","name":"Telethon Italy","doi-asserted-by":"publisher","award":["TCR08005"],"award-info":[{"award-number":["TCR08005"]}],"id":[{"id":"10.13039\/501100002426","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002803","name":"Fondazione Cariplo","doi-asserted-by":"publisher","award":["2012-0560"],"award-info":[{"award-number":["2012-0560"]}],"id":[{"id":"10.13039\/501100002803","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RF-2010-2314035"],"award-info":[{"award-number":["RF-2010-2314035"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.jbc.2021.100490","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T01:51:10Z","timestamp":1614563470000},"page":"100490","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Activation of Src family kinase ameliorates secretory trafficking in mutant prion protein cells"],"prefix":"10.1016","volume":"296","author":[{"given":"Elena","family":"Restelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Capone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Pozzoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Ortolan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Quaglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Corbelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Fiordaliso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galina V.","family":"Beznoussenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimiro","family":"Artuso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignazio","family":"Roiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Sallese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3842-3733","authenticated-orcid":false,"given":"Roberto","family":"Chiesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2021.100490_bib1","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a033134","article-title":"Genetic PrP prion diseases","volume":"10","author":"Kim","year":"2018","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.jbc.2021.100490_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004745","article-title":"The elusive role of the prion protein and the mechanism of toxicity in prion disease","volume":"11","author":"Chiesa","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2021.100490_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004796","article-title":"Transgenic fatal familial insomnia mice indicate prion infectivity-independent mechanisms of pathogenesis and phenotypic expression of disease","volume":"11","author":"Bouybayoune","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2021.100490_bib4","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.neuron.2008.09.008","article-title":"Mutant prion protein expression causes motor and memory deficits and abnormal sleep patterns in a transgenic mouse model","volume":"60","author":"Dossena","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.jbc.2021.100490_bib5","doi-asserted-by":"crossref","first-page":"21732","DOI":"10.1074\/jbc.M213247200","article-title":"Mutant PrP is delayed in its exit from the endoplasmic reticulum, but neither wild-type nor mutant PrP undergoes retrotranslocation prior to proteasomal degradation","volume":"278","author":"Drisaldi","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100490_bib6","doi-asserted-by":"crossref","first-page":"11320","DOI":"10.1074\/jbc.M412441200","article-title":"Cytosolic prion protein (PrP) is not toxic in N2a cells and primary neurons expressing pathogenic PrP mutations","volume":"280","author":"Fioriti","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100490_bib7","doi-asserted-by":"crossref","first-page":"42409","DOI":"10.1074\/jbc.M106928200","article-title":"Mutant prion proteins are partially retained in the endoplasmic reticulum","volume":"276","author":"Ivanova","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100490_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019339","article-title":"Expression of mutant or cytosolic PrP in transgenic mice and cells is not associated with endoplasmic reticulum stress or proteasome dysfunction","volume":"6","author":"Quaglio","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2021.100490_bib9","doi-asserted-by":"crossref","first-page":"543803","DOI":"10.1155\/2013\/543803","article-title":"Synaptic dysfunction in prion diseases: A trafficking problem?","volume":"2013","author":"Senatore","year":"2013","journal-title":"Int. J. Cell Biol."},{"key":"10.1016\/j.jbc.2021.100490_bib10","article-title":"Mutant prion proteins increase calcium permeability of AMPA receptors, exacerbating excitotoxicity","volume":"16","author":"Ghirardini","year":"2020","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2021.100490_bib11","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.neuron.2012.02.027","article-title":"Mutant PrP suppresses glutamatergic neurotransmission in cerebellar granule neurons by impairing membrane delivery of VGCC alpha(2)delta-1 subunit","volume":"74","author":"Senatore","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.jbc.2021.100490_bib12","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1074\/mcp.M900271-MCP200","article-title":"Mutant prion protein expression is associated with an alteration of the Rab GDP dissociation inhibitor alpha (GDI)\/Rab11 pathway","volume":"9","author":"Massignan","year":"2010","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.jbc.2021.100490_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000479","article-title":"Selective processing and metabolism of disease-causing mutant prion proteins","volume":"5","author":"Ashok","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2021.100490_bib14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0092-8674(90)90240-F","article-title":"Polarized sorting of viral glycoproteins to the axon and dendrites of hippocampal neurons in culture","volume":"62","author":"Dotti","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2021.100490_bib15","doi-asserted-by":"crossref","first-page":"28461","DOI":"10.1074\/jbc.272.45.28461","article-title":"Prion protein aggregation reverted by low temperature in transfected cells carrying a prion protein gene mutation","volume":"272","author":"Singh","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100490_bib16","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1083\/jcb.153.3.529","article-title":"Rapid cycling of lipid raft markers between the cell surface and Golgi complex","volume":"153","author":"Nichols","year":"2001","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.jbc.2021.100490_bib17","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1042\/BJ20100615","article-title":"The hydrophobic core region governs mutant prion protein aggregation and intracellular retention","volume":"430","author":"Biasini","year":"2010","journal-title":"Biochem. J."},{"key":"10.1016\/j.jbc.2021.100490_bib18","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1074\/jbc.271.3.1633","article-title":"Mutant and infectious prion proteins display common biochemical properties in cultured cells","volume":"271","author":"Lehmann","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100490_bib19","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/S0896-6273(00)80653-4","article-title":"Neurological illness in transgenic mice expressing a prion protein with an insertional mutation","volume":"21","author":"Chiesa","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.jbc.2021.100490_bib20","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1016\/j.bbamcr.2013.04.008","article-title":"A\u00a0molecular ensemble in the rER for procollagen maturation","volume":"1833","author":"Ishikawa","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbc.2021.100490_bib21","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1083\/jcb.131.6.1715","article-title":"Characterization of a cis-Golgi matrix protein, GM130","volume":"131","author":"Nakamura","year":"1995","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.jbc.2021.100490_bib22","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1016\/j.bbadis.2018.07.003","article-title":"PERK inhibition attenuates the abnormalities of the secretory pathway and the increased apoptotic rate induced by SIL1 knockdown in HeLa cells","volume":"1864","author":"Capone","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.jbc.2021.100490_bib23","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/ncb1751","article-title":"A\u00a0traffic-activated Golgi-based signalling circuit coordinates the secretory pathway","volume":"10","author":"Pulvirenti","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jbc.2021.100490_bib24","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1126\/science.289.5486.1925","article-title":"Signal transduction through prion protein","volume":"289","author":"Mouillet-Richard","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.jbc.2021.100490_bib25","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nature14457","article-title":"Coordinated regulation of bidirectional COPI transport at the Golgi by CDC42","volume":"521","author":"Park","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2021.100490_bib26","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1038\/ncomms2873","article-title":"Prions disturb post-Golgi trafficking of membrane proteins","volume":"4","author":"Uchiyama","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2021.100490_bib27","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.46740","article-title":"Misfolded GPI-anchored proteins are escorted through the secretory pathway by ER-derived factors","volume":"8","author":"Zavodszky","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.jbc.2021.100490_bib28","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1042\/BJ20061592","article-title":"Aggregation of prion protein with insertion mutations is proportional to the number of inserts","volume":"403","author":"Yu","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.jbc.2021.100490_bib29","doi-asserted-by":"crossref","first-page":"15880","DOI":"10.1021\/bi051455+","article-title":"Polymorphism at residue 129 modulates the conformational conversion of the D178N variant of human prion protein 90-231","volume":"44","author":"Apetri","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.jbc.2021.100490_bib30","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1110\/ps.051822606","article-title":"Octapeptide repeat insertions increase the rate of protease-resistant prion protein formation","volume":"15","author":"Moore","year":"2006","journal-title":"Protein Sci."},{"key":"10.1016\/j.jbc.2021.100490_bib31","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/emboj.2009.333","article-title":"Conformational diversity in prion protein variants influences intermolecular beta-sheet formation","volume":"29","author":"Lee","year":"2010","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2021.100490_bib32","doi-asserted-by":"crossref","first-page":"11667","DOI":"10.1073\/pnas.95.20.11667","article-title":"Prion protein NMR structure and familial human spongiform encephalopathies","volume":"95","author":"Riek","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.100490_bib33","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1042\/BJ20130563","article-title":"Epitope scanning indicates structural differences in brain-derived monomeric and aggregated mutant prion proteins related to genetic prion diseases","volume":"454","author":"Tapella","year":"2013","journal-title":"Biochem. J."},{"key":"10.1016\/j.jbc.2021.100490_bib34","doi-asserted-by":"crossref","first-page":"11980","DOI":"10.1074\/jbc.273.19.11980","article-title":"Abnormal properties of prion protein with insertional mutations in different cell types","volume":"273","author":"Priola","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100490_bib35","doi-asserted-by":"crossref","first-page":"11604","DOI":"10.1074\/jbc.272.17.11604","article-title":"Identification of intermediate steps in the conversion of a mutant prion protein to a scrapie-like form in cultured cells","volume":"272","author":"Daude","year":"1997","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100490_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000055","article-title":"Regulation of embryonic cell adhesion by the prion protein","volume":"7","author":"Malaga-Trillo","year":"2009","journal-title":"PLoS Biol."},{"key":"10.1016\/j.jbc.2021.100490_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000075","article-title":"Fishing for prion protein function","volume":"7","author":"Chiesa","year":"2009","journal-title":"PLoS Biol."},{"key":"10.1016\/j.jbc.2021.100490_bib38","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1080\/19336896.2016.1221873","article-title":"Uncontrolled SFK-mediated protein trafficking in prion and Alzheimer\u2019s disease","volume":"10","author":"M\u00e1laga-Trillo","year":"2016","journal-title":"Prion"},{"key":"10.1016\/j.jbc.2021.100490_bib39","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.semcdb.2009.04.004","article-title":"Coordination of the secretory compartments via inter-organelle signalling","volume":"20","author":"Sallese","year":"2009","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.jbc.2021.100490_bib40","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nature19312","article-title":"The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6","volume":"536","author":"K\u00fcffer","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2021.100490_bib41","first-page":"e125","article-title":"Age of onset in genetic prion disease and the design of preventive clinical trials","volume":"93","author":"Minikel","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.jbc.2021.100490_bib42","doi-asserted-by":"crossref","first-page":"5574","DOI":"10.1073\/pnas.97.10.5574","article-title":"Accumulation of protease-resistant prion protein (PrP) and apoptosis of cerebellar granule cells in transgenic mice expressing a PrP insertional mutation","volume":"97","author":"Chiesa","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.100490_bib43","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1242\/dev.115.1.117","article-title":"The prion protein gene: A role in mouse embryogenesis?","volume":"115","author":"Manson","year":"1992","journal-title":"Development"},{"key":"10.1016\/j.jbc.2021.100490_bib44","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0012-1606(87)90143-6","article-title":"Developmental expression of prion protein gene in brain","volume":"121","author":"McKinley","year":"1987","journal-title":"Dev. Biol."},{"key":"10.1016\/j.jbc.2021.100490_bib45","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1006\/nbdi.2001.0433","article-title":"Prion diseases: What is the neurotoxic molecule?","volume":"8","author":"Chiesa","year":"2001","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jbc.2021.100490_bib46","doi-asserted-by":"crossref","first-page":"7611","DOI":"10.1128\/JVI.77.13.7611-7622.2003","article-title":"Molecular distinction between pathogenic and infectious properties of the prion protein","volume":"77","author":"Chiesa","year":"2003","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.jbc.2021.100490_bib47","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1111\/j.1471-4159.2007.05082.x","article-title":"Multiple biochemical similarities between infectious and non-infectious aggregates of a prion protein carrying an octapeptide insertion","volume":"104","author":"Biasini","year":"2008","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.jbc.2021.100490_bib48","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41580-019-0101-y","article-title":"The proteostasis network and its decline in ageing","volume":"20","author":"Hipp","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2021.100490_bib49","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.exger.2005.07.005","article-title":"Protein degradation and aging","volume":"40","author":"Martinez-Vicente","year":"2005","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.jbc.2021.100490_bib50","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/356577a0","article-title":"Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein","volume":"356","author":"Bueler","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2021.100490_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013725","article-title":"Cell type-specific neuroprotective activity of untranslocated prion protein","volume":"5","author":"Restelli","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2021.100490_bib52","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/ncb1109","article-title":"Delivery of raft-associated, GPI-anchored proteins to the apical surface of polarized MDCK cells by a transcytotic pathway","volume":"6","author":"Polishchuk","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jbc.2021.100490_bib53","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1083\/jcb.200108073","article-title":"Small cargo proteins and large aggregates can traverse the Golgi by a common mechanism without leaving the lumen of cisternae","volume":"155","author":"Mironov","year":"2001","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.jbc.2021.100490_bib54","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/0962-8924(93)90106-B","article-title":"Unbiased 3-D quantitation of ultrastructure in cell biology","volume":"3","author":"Lucocq","year":"1993","journal-title":"Trends Cell Biol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925821002659?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925821002659?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T23:35:32Z","timestamp":1758238532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925821002659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":54,"alternative-id":["S0021925821002659"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2021.100490","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of Src family kinase ameliorates secretory trafficking in mutant prion protein cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2021.100490","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"100490"}}