{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:34:01Z","timestamp":1793129641668,"version":"4.5.0"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T00:00:00Z","timestamp":1620259200000},"content-version":"vor","delay-in-days":125,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007428","name":"Naito Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008667","name":"SENSHIN Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008667","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.jbc.2021.100761","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T00:14:29Z","timestamp":1620432869000},"page":"100761","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Cardio- and reno-protective effects of dipeptidyl peptidase III in diabetic mice"],"prefix":"10.1016","volume":"296","author":[{"given":"Masahiro","family":"Komeno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3393-6193","authenticated-orcid":false,"given":"Akio","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Rasel","family":"Molla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mako","family":"Yasuda-Yamahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Kume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nor Idayu A.","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne Ern Chi","family":"Soh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Kim Chi","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Khusni B.","family":"Ahmat Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nao","family":"Kokami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Asano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Maegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6750-1668","authenticated-orcid":false,"given":"Hisakazu","family":"Ogita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2021.100761_bib1","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1055\/a-1018-9078","article-title":"Definition, classification and diagnosis of diabetes mellitus","volume":"127","author":"Petersmann","year":"2019","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.jbc.2021.100761_bib2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2337\/db16-0806","article-title":"Differentiation of diabetes by pathophysiology, natural history, and prognosis","volume":"66","author":"Skyler","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.jbc.2021.100761_bib3","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.diabres.2017.03.024","article-title":"IDF diabetes atlas: Global estimates for the prevalence of diabetes for 2015 and 2040","volume":"128","author":"Ogurtsova","year":"2017","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.jbc.2021.100761_bib4","doi-asserted-by":"crossref","first-page":"359","DOI":"10.15585\/mmwr.mm6712a2","article-title":"Prevalence of diagnosed diabetes in adults by diabetes type - United States, 2016","volume":"67","author":"Bullard","year":"2018","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.jbc.2021.100761_bib5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00125-018-4711-2","article-title":"Global trends in diabetes complications: A review of current evidence","volume":"62","author":"Harding","year":"2019","journal-title":"Diabetologia"},{"key":"10.1016\/j.jbc.2021.100761_bib6","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1056\/NEJMoa1608664","article-title":"Mortality and cardiovascular disease in type 1 and type 2 diabetes","volume":"376","author":"Rawshani","year":"2017","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.jbc.2021.100761_bib7","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.2337\/dc12-2455","article-title":"Long-term complications and mortality in young-onset diabetes: Type 2 diabetes is more hazardous and lethal than type 1 diabetes","volume":"36","author":"Constantino","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jbc.2021.100761_bib8","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00125-017-4390-4","article-title":"Diabetic cardiomyopathy: A hyperglycaemia- and insulin-resistance-induced heart disease","volume":"61","author":"Jia","year":"2018","journal-title":"Diabetologia"},{"key":"10.1016\/j.jbc.2021.100761_bib9","first-page":"4626125","article-title":"Urinary biomarkers in the assessment of early diabetic nephropathy","volume":"2016","author":"Gluhovschi","year":"2016","journal-title":"J.\u00a0Diabetes Res."},{"key":"10.1016\/j.jbc.2021.100761_bib10","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1093\/eurheartj\/eht108","volume":"34","author":"Ryd\u00e9n","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.jbc.2021.100761_bib11","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11154-010-9131-7","article-title":"Diabetic cardiomyopathy, causes and effects","volume":"11","author":"Boudina","year":"2010","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.jbc.2021.100761_bib12","doi-asserted-by":"crossref","first-page":"183","DOI":"10.4314\/ahs.v16i1.25","article-title":"Prevalence, types and factors associated with echocardiographic abnormalities among newly diagnosed diabetic patients at Mulago Hospital","volume":"16","author":"Muddu","year":"2016","journal-title":"Afr. Health Sci."},{"key":"10.1016\/j.jbc.2021.100761_bib13","first-page":"212","article-title":"Prevalence of diastolic dysfunction in type 2 diabetes mellitus","volume":"15","author":"Yadava","year":"2017","journal-title":"Kathmandu Univ. Med. J. (KUMJ)"},{"key":"10.1016\/j.jbc.2021.100761_bib14","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.2337\/dc14-1296","article-title":"Diabetic kidney disease: A report from an ADA consensus conference","volume":"37","author":"Tuttle","year":"2014","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jbc.2021.100761_bib15","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41581-018-0001-y","article-title":"CKD in diabetes: Diabetic kidney disease versus nondiabetic kidney disease","volume":"14","author":"Anders","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.jbc.2021.100761_bib16","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.jfma.2018.02.007","article-title":"Update of pathophysiology and management of diabetic kidney disease","volume":"117","author":"Lin","year":"2018","journal-title":"J.\u00a0Formos. Med. Assoc."},{"key":"10.1016\/j.jbc.2021.100761_bib17","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3390\/jcm9020472","article-title":"Matrix metalloproteinases in diabetic kidney disease","volume":"9","author":"Garcia-Fernandez","year":"2020","journal-title":"J.\u00a0Clin. Med."},{"key":"10.1016\/j.jbc.2021.100761_bib18","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1038\/sj.ki.5000377","article-title":"Prevalence and risk factors for microalbuminuria in a referred cohort of type II diabetic patients: A global perspective","volume":"69","author":"Parving","year":"2006","journal-title":"Kidney Int."},{"key":"10.1016\/j.jbc.2021.100761_bib19","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.2337\/db05-1423","article-title":"The 30-year natural history of type 1 diabetes complications: The Pittsburgh Epidemiology of Diabetes Complications Study experience","volume":"55","author":"Pambianco","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.jbc.2021.100761_bib20","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0140-6736(98)07019-6","article-title":"Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)","volume":"352","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.jbc.2021.100761_bib21","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1001\/jama.290.16.2159","article-title":"Sustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy: The Epidemiology of Diabetes Interventions and Complications (EDIC) study","volume":"290","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.jbc.2021.100761_bib22","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1056\/NEJMoa052187","article-title":"Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes","volume":"353","author":"Nathan","year":"2005","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.jbc.2021.100761_bib23","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1056\/NEJMoa0808431","article-title":"Glucose control and vascular complications in veterans with type 2 diabetes","volume":"360","author":"Duckworth","year":"2009","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.jbc.2021.100761_bib24","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1753-0407.2011.00148.x","article-title":"Trends in the control of risk factors for cardiovascular disease among adults with diagnosed diabetes: Findings from the National Health and Nutrition Examination survey 1999-2008","volume":"3","author":"Ford","year":"2011","journal-title":"J.\u00a0Diabetes"},{"key":"10.1016\/j.jbc.2021.100761_bib25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2337\/dc13-2112","article-title":"The diabetes control and complications trial\/epidemiology of diabetes interventions and complications study at 30 years: Overview","volume":"37","author":"Nathan","year":"2014","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jbc.2021.100761_bib26","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1074\/mcp.M600229-MCP200","article-title":"Serum peptidome patterns that distinguish metastatic thyroid carcinoma from cancer-free controls are unbiased by gender and age","volume":"5","author":"Villanueva","year":"2006","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.jbc.2021.100761_bib27","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1002\/art.30560","article-title":"AC13, a C-terminal fragment of apolipoprotein A-I, is a candidate biomarker for microscopic polyangiitis","volume":"63","author":"Takakuwa","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jbc.2021.100761_bib28","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1111\/j.1742-4658.2011.08275.x","article-title":"Dipeptidyl peptidase III: A multifaceted oligopeptide N-end cutter","volume":"278","author":"Prajapati","year":"2011","journal-title":"FEBS J."},{"key":"10.1016\/j.jbc.2021.100761_bib29","doi-asserted-by":"crossref","first-page":"12043","DOI":"10.1016\/S0021-9258(18)33674-3","article-title":"Dipeptidyl-aminopeptidase III of rat brain. Selective affinity for enkephalin and angiotensin","volume":"257","author":"Lee","year":"1982","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100761_bib30","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1161\/HYPERTENSIONAHA.116.07357","article-title":"Novel therapeutic role for dipeptidyl peptidase III in the treatment of hypertension","volume":"68","author":"Pang","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.jbc.2021.100761_bib31","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/BF01222201","article-title":"Studies with the mutation, diabetes, in the mouse","volume":"3","author":"Coleman","year":"1967","journal-title":"Diabetologia"},{"key":"10.1016\/j.jbc.2021.100761_bib32","doi-asserted-by":"crossref","first-page":"H934","DOI":"10.1152\/ajpheart.00238.2018","article-title":"Characterization of a mouse model of obesity-related fibrotic cardiomyopathy that recapitulates features of human heart failure with preserved ejection fraction","volume":"315","author":"Alex","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.jbc.2021.100761_bib33","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1093\/cvr\/cvx100","article-title":"Diabetic db\/db mice do not develop heart failure upon pressure overload: A longitudinal in\u00a0vivo PET, MRI, and MRS study on cardiac metabolic, structural, and functional adaptations","volume":"113","author":"Abdurrachim","year":"2017","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jbc.2021.100761_bib34","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1253\/circj.CJ-18-0063","article-title":"Inflammatory mechanisms of cardiovascular remodeling","volume":"82","author":"Anzai","year":"2018","journal-title":"Circ. J."},{"key":"10.1016\/j.jbc.2021.100761_bib35","doi-asserted-by":"crossref","first-page":"15018","DOI":"10.1038\/nrdp.2015.18","article-title":"Diabetic kidney disease","volume":"1","author":"Thomas","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.jbc.2021.100761_bib36","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/0161-5890(89)90112-0","article-title":"Factor C3f is a spasmogenic fragment released from C3b by factors I and H: The heptadeca-peptide C3f was synthesized and characterized","volume":"26","author":"Ganu","year":"1989","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.jbc.2021.100761_bib37","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/S0955-0674(02)00373-3","article-title":"Cell-cell adhesion and signalling","volume":"14","author":"Braga","year":"2002","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.jbc.2021.100761_bib38","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S1537-1891(03)00008-9","article-title":"Rho GTPases and the regulation of endothelial permeability","volume":"39","author":"Wojciak-Stothard","year":"2002","journal-title":"Vascul. Pharmacol."},{"key":"10.1016\/j.jbc.2021.100761_bib39","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1126\/science.279.5350.509","article-title":"Rho GTPases and the actin cytoskeleton","volume":"279","author":"Hall","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.jbc.2021.100761_bib40","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/2193-1801-1-63","article-title":"Complement anaphylatoxins C3a and C5a induce a failing regenerative program in cardiac resident cells. Evidence of a role for cardiac resident stem cells other than cardiomyocyte renewal","volume":"1","author":"Lara-Astiaso","year":"2012","journal-title":"Springerplus"},{"key":"10.1016\/j.jbc.2021.100761_bib41","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0162-3109(94)90025-6","article-title":"Anaphylatoxin C3a induces rapid protein phosphorylation in Guinea pig platelets","volume":"28","author":"Fukuoka","year":"1994","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.jbc.2021.100761_bib42","doi-asserted-by":"crossref","first-page":"22614","DOI":"10.1074\/jbc.M101927200","article-title":"Protein kinase C-alpha signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function","volume":"276","author":"Mehta","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100761_bib43","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.amjcard.2019.10.024","article-title":"Heart failure and diabetes mellitus: Defining the problem and exploring the interrelationship","volume":"124","author":"Wilkinson","year":"2019","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.jbc.2021.100761_bib44","doi-asserted-by":"crossref","first-page":"e840","DOI":"10.1161\/CIR.0000000000000664","article-title":"Cardiorenal syndrome: Classification, pathophysiology, diagnosis, and treatment strategies: A scientific statement from the American Heart Association","volume":"139","author":"Rangaswami","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.jbc.2021.100761_bib45","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1056\/NEJMoa1611925","article-title":"Canagliflozin and cardiovascular and renal events in type 2 diabetes","volume":"377","author":"Neal","year":"2017","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.jbc.2021.100761_bib46","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1056\/NEJMoa1811744","article-title":"Canagliflozin and renal outcomes in type 2 diabetes and nephropathy","volume":"380","author":"Perkovic","year":"2019","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.jbc.2021.100761_bib47","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S1357-2725(03)00267-X","article-title":"Highly reactive cysteine residues are part of the substrate binding site of mammalian dipeptidyl peptidases III","volume":"36","author":"Abrami\u0107","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.jbc.2021.100761_bib48","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1158\/0008-5472.CAN-12-4400","article-title":"Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination","volume":"73","author":"Hast","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.jbc.2021.100761_bib49","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.4049\/jimmunol.165.6.3393","article-title":"Induction of heme oxygenase-1 expression in macrophages by diesel exhaust particle chemicals and quinones via the antioxidant-responsive element","volume":"165","author":"Li","year":"2000","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jbc.2021.100761_bib50","doi-asserted-by":"crossref","first-page":"21592","DOI":"10.1074\/jbc.M300931200","article-title":"Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression","volume":"278","author":"McMahon","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100761_bib51","doi-asserted-by":"crossref","first-page":"4755","DOI":"10.1172\/JCI65698","article-title":"Peptidases released by necrotic cells control CD8+ T cell cross-priming","volume":"123","author":"Gamrekelashvili","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.jbc.2021.100761_bib52","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s13054-020-02888-5","article-title":"Circulating dipeptidyl peptidase-3 at admission is associated with circulatory failure, acute kidney injury and death in severely ill burn patients","volume":"24","author":"D\u00e9pret","year":"2020","journal-title":"Crit. Care"},{"key":"10.1016\/j.jbc.2021.100761_bib53","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/ejhf.1601","article-title":"Circulating dipeptidyl peptidase 3 is a myocardial depressant factor: Dipeptidyl peptidase 3 inhibition rapidly and sustainably improves haemodynamics","volume":"22","author":"Deniau","year":"2020","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.jbc.2021.100761_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0238039","article-title":"Inhibition of circulating dipeptidyl-peptidase 3 restores cardiac function in a sepsis-induced model in rats: A proof of concept study","volume":"15","author":"Deniau","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2021.100761_bib55","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/S0140-6736(18)31808-7","article-title":"Heart failure drug treatment","volume":"393","author":"Rossignol","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.jbc.2021.100761_bib56","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/ki.2013.355","article-title":"Aggressive blood pressure reduction and renin-angiotensin system blockade in chronic kidney disease: Time for re-evaluation","volume":"85","author":"Sarafidis","year":"2014","journal-title":"Kidney Int."},{"key":"10.1016\/j.jbc.2021.100761_bib57","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1080\/10739680701283091","article-title":"Microvascular permeability in diabetes and insulin resistance","volume":"14","author":"Yuan","year":"2007","journal-title":"Microcirculation"},{"key":"10.1016\/j.jbc.2021.100761_bib58","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cmet.2012.11.012","article-title":"Vascular complications of diabetes: Mechanisms of injury and protective factors","volume":"17","author":"Rask-Madsen","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbc.2021.100761_bib59","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00011-018-1129-8","article-title":"Vascular endothelium dysfunction: A conservative target in metabolic disorders","volume":"67","author":"Jamwal","year":"2018","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.jbc.2021.100761_bib60","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.4049\/jimmunol.169.4.2102","article-title":"Complement c3a and c5a induce different signal transduction cascades in endothelial cells","volume":"169","author":"Schraufstatter","year":"2002","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jbc.2021.100761_bib61","doi-asserted-by":"crossref","DOI":"10.1136\/bmjdrc-2019-000817","article-title":"Deficiency of C3a receptor attenuates the development of diabetic nephropathy","volume":"7","author":"Li","year":"2019","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"10.1016\/j.jbc.2021.100761_bib62","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.131849","article-title":"C3a receptor blockade protects podocytes from injury in diabetic nephropathy","volume":"5","author":"Morigi","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.jbc.2021.100761_bib63","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev.bi.57.070188.001541","article-title":"Molecular organization and function of the complement system","volume":"57","author":"M\u00fcller-Eberhard","year":"1988","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.jbc.2021.100761_bib64","doi-asserted-by":"crossref","first-page":"F1171","DOI":"10.1152\/ajprenal.00165.2019","article-title":"Complement C3 exacerbates renal interstitial fibrosis by facilitating the M1 macrophage phenotype in a mouse model of unilateral ureteral obstruction","volume":"317","author":"Cui","year":"2019","journal-title":"Am. J. Physiol. Renal Physiol"},{"key":"10.1016\/j.jbc.2021.100761_bib65","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s00392-012-0432-6","article-title":"Complement anaphylatoxin C3a as a novel independent prognostic marker in heart failure","volume":"101","author":"Gombos","year":"2012","journal-title":"Clin. Res. Cardiol."},{"key":"10.1016\/j.jbc.2021.100761_bib66","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.3389\/fimmu.2019.02166","article-title":"Complement inhibitors in clinical trials for glomerular diseases","volume":"10","author":"Zipfel","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jbc.2021.100761_bib67","doi-asserted-by":"crossref","first-page":"39335","DOI":"10.1038\/srep39335","article-title":"Protective effects of intercalated disk protein afadin on chronic pressure overload-induced myocardial damage","volume":"7","author":"Zankov","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2021.100761_bib68","first-page":"4553","article-title":"Alamandine attenuates long-term hypertension-induced cardiac fibrosis independent of blood pressure","volume":"19","author":"Wang","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jbc.2021.100761_bib69","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1113\/jphysiol.1952.sp004789","article-title":"Vascular reactions to histamine, histamine-liberator and leukotaxine in the skin of Guinea-pigs","volume":"118","author":"Miles","year":"1952","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.jbc.2021.100761_bib70","doi-asserted-by":"crossref","first-page":"5416","DOI":"10.1038\/s41388-018-0286-0","article-title":"Epithelial membrane protein 1 promotes tumor metastasis by enhancing cell migration via copine-III and Rac1","volume":"37","author":"Ahmat Amin","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.jbc.2021.100761_bib71","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0068134","article-title":"An adaptor molecule afadin regulates lymphangiogenesis by modulating RhoA activity in the developing mouse embryo","volume":"8","author":"Majima","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2021.100761_bib72","doi-asserted-by":"crossref","first-page":"D442","DOI":"10.1093\/nar\/gky1106","article-title":"The PRIDE database and related tools and resources in 2019: Improving support for quantification data","volume":"47","author":"Perez-Riverol","year":"2019","journal-title":"Nucleic Acids Res."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925821005548?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925821005548?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:17:24Z","timestamp":1758241044000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925821005548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":72,"alternative-id":["S0021925821005548"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2021.100761","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardio- and reno-protective effects of dipeptidyl peptidase III in diabetic mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2021.100761","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"100761"}}