{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:10:24Z","timestamp":1777601424714,"version":"3.51.4"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T00:00:00Z","timestamp":1621209600000},"content-version":"vor","delay-in-days":136,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["CA163069"],"award-info":[{"award-number":["CA163069"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["GM059994"],"award-info":[{"award-number":["GM059994"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["DA036420"],"award-info":[{"award-number":["DA036420"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000102","name":"Health Resources and Services Administration","doi-asserted-by":"publisher","award":["D34HP16299-10-00"],"award-info":[{"award-number":["D34HP16299-10-00"]}],"id":[{"id":"10.13039\/100000102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.jbc.2021.100787","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T07:57:00Z","timestamp":1621324620000},"page":"100787","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Optogenetically-induced multimerization of the dopamine transporter increases uptake and trafficking to the plasma membrane"],"prefix":"10.1016","volume":"296","author":[{"given":"Shalonda M.","family":"Ingram","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanu","family":"Rana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley M.","family":"Manson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal M.","family":"Yayah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan G.B.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benem-Orom","family":"Davids","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Shawn","family":"Goodwin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2021.100787_bib1","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/379606a0","article-title":"Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter","volume":"379","author":"Giros","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2021.100787_bib2","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1124\/pr.108.000869","article-title":"SLC6 neurotransmitter transporters: Structure, function, and regulation","volume":"63","author":"Kristensen","year":"2011","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jbc.2021.100787_bib3","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/S0022-3565(24)36858-2","article-title":"Rapid and reversible effects of methamphetamine on dopamine transporters","volume":"282","author":"Fleckenstein","year":"1997","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jbc.2021.100787_bib4","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2210-6-6","article-title":"Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs","volume":"6","author":"Han","year":"2006","journal-title":"BMC Pharmacol."},{"key":"10.1016\/j.jbc.2021.100787_bib5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ejphar.2003.08.054","article-title":"Monoamine transporters and psychostimulant drugs","volume":"479","author":"Rothman","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jbc.2021.100787_bib6","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nn.2146","article-title":"The binding sites for cocaine and dopamine in the dopamine transporter overlap","volume":"11","author":"Beuming","year":"2008","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jbc.2021.100787_bib7","doi-asserted-by":"crossref","first-page":"393","DOI":"10.2174\/187152708786927877","article-title":"Role of dopamine transporter in the action of psychostimulants, nicotine, and other drugs of abuse","volume":"7","author":"Zhu","year":"2008","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.jbc.2021.100787_bib8","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1074\/jbc.M201926200","article-title":"Oligomerization and trafficking of the human dopamine transporter: Mutational analysis identifies critical domains important for the functional expression of the transporter","volume":"278","author":"Torres","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100787_bib9","doi-asserted-by":"crossref","first-page":"28274","DOI":"10.1074\/jbc.M210652200","article-title":"Oligomerization of dopamine transporters visualized in living cells by fluorescence resonance energy transfer microscopy","volume":"278","author":"Sorkina","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100787_bib10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1471-4159.2006.03719.x","article-title":"The dopamine transporter proteome","volume":"97","author":"Torres","year":"2006","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.jbc.2021.100787_bib11","doi-asserted-by":"crossref","first-page":"5632","DOI":"10.1074\/jbc.RA118.006178","article-title":"Dopamine transporter forms stable dimers in the live cell plasma membrane in a phosphatidylinositol-4,5-bisphosphate independent manner","volume":"294","author":"Das","year":"2019","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100787_bib12","doi-asserted-by":"crossref","first-page":"10055","DOI":"10.1073\/pnas.181344298","article-title":"Symmetrical dimer of the human dopamine transporter revealed by cross-linking Cys-306 at the extracellular end of the sixth transmembrane segment","volume":"98","author":"Hastrup","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jbc.2021.100787_bib13","doi-asserted-by":"crossref","first-page":"8919","DOI":"10.1523\/JNEUROSCI.0048-12.2012","article-title":"Single molecule analysis of serotonin transporter regulation using antagonist-conjugated quantum dots reveals restricted, p38 MAPK-dependent mobilization underlying uptake activation","volume":"32","author":"Chang","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.jbc.2021.100787_bib14","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1006\/bbrc.2002.6384","article-title":"Cocaine increases dopamine uptake and cell surface expression of dopamine transporters","volume":"290","author":"Daws","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jbc.2021.100787_bib15","doi-asserted-by":"crossref","first-page":"45045","DOI":"10.1074\/jbc.C300349200","article-title":"The human dopamine transporter forms a tetramer in the plasma membrane: Cross-linking of a cysteine in the fourth transmembrane segment is sensitive to cocaine analogs","volume":"278","author":"Hastrup","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100787_bib16","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1111\/j.1471-4159.2007.05195.x","article-title":"Substrates dissociate dopamine transporter oligomers","volume":"105","author":"Chen","year":"2008","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.jbc.2021.100787_bib17","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1111\/j.1471-4159.2010.06818.x","article-title":"Interrelation of dopamine transporter oligomerization and surface presence as studied with mutant transporter proteins and amphetamine","volume":"114","author":"Li","year":"2010","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.jbc.2021.100787_bib18","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1523\/JNEUROSCI.2604-17.2017","article-title":"Amphetamine reverses escalated cocaine intake via restoration of dopamine transporter conformation","volume":"38","author":"Siciliano","year":"2018","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.jbc.2021.100787_bib19","doi-asserted-by":"crossref","first-page":"12471","DOI":"10.1074\/jbc.M116.763565","article-title":"Allosteric modulation of human dopamine transporter activity under conditions promoting its dimerization","volume":"292","author":"Cheng","year":"2017","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100787_bib20","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.tplants.2011.09.002","article-title":"The action mechanisms of plant cryptochromes","volume":"16","author":"Liu","year":"2011","journal-title":"Trends Plant Sci."},{"key":"10.1016\/j.jbc.2021.100787_bib21","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/j.febslet.2009.03.040","article-title":"Conformational change induced by ATP binding correlates with enhanced biological function of Arabidopsis cryptochrome","volume":"583","author":"Burney","year":"2009","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jbc.2021.100787_bib22","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1021\/bi047545g","article-title":"Role of structural plasticity in signal transduction by the cryptochrome blue-light photoreceptor\u2020","volume":"44","author":"Partch","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.jbc.2021.100787_bib23","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0092-8674(00)00184-7","article-title":"The C termini of arabidopsis cryptochromes mediate a constitutive light response","volume":"103","author":"Yang","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2021.100787_bib24","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1105\/tpc.010367","article-title":"The signaling mechanism of arabidopsis CRY1 involves direct interaction with COP1","volume":"13","author":"Yang","year":"2001","journal-title":"Plant Cell"},{"key":"10.1016\/j.jbc.2021.100787_bib25","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1126\/science.282.5393.1488","article-title":"Phytochromes and cryptochromes in the entrainment of the arabidopsis circadian clock","volume":"282","author":"Somers","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.jbc.2021.100787_bib26","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1177\/074873001129002213","article-title":"Resetting of the circadian clock by phytochromes and cryptochromes in arabidopsis","volume":"16","author":"Yanovsky","year":"2001","journal-title":"J.\u00a0Biol. Rhythms"},{"key":"10.1016\/j.jbc.2021.100787_bib27","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/mp\/ssm018","article-title":"Blue-light-independent activity of arabidopsis cryptochromes in the regulation of steady-state levels of protein and mRNA expression","volume":"1","author":"Yang","year":"2008","journal-title":"Mol. Plant"},{"key":"10.1016\/j.jbc.2021.100787_bib28","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1105\/tpc.12.12.2499","article-title":"Cryptochromes are required for phytochrome signaling to the circadian clock but not for rhythmicity","volume":"12","author":"Devlin","year":"2000","journal-title":"Plant Cell"},{"key":"10.1016\/j.jbc.2021.100787_bib29","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.1038\/ncomms5925","article-title":"An optimized optogenetic clustering tool for probing protein interaction and function","volume":"5","author":"Taslimi","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2021.100787_bib30","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nchembio.2063","article-title":"Optimized second generation CRY2\/CIB dimerizers and photoactivatable Cre recombinase","volume":"12","author":"Taslimi","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jbc.2021.100787_bib31","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.bbamcr.2016.11.009","article-title":"Optogenetics - Bringing light into the darkness of mammalian signal transduction","volume":"1864","author":"M\u00fchlh\u00e4user","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbc.2021.100787_bib32","doi-asserted-by":"crossref","first-page":"8966","DOI":"10.1074\/jbc.M303976200","article-title":"Amphetamine regulation of dopamine transport: Combined measurements OF transporter currents and transporter imaging support the endocytosis of an active carrier","volume":"279","author":"Kahlig","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100787_bib33","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1074\/jbc.M805298200","article-title":"Amphetamine and methamphetamine differentially affect dopamine transporters in\u00a0vitro and in\u00a0vivo","volume":"284","author":"Goodwin","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100787_bib34","doi-asserted-by":"crossref","first-page":"43933","DOI":"10.1074\/jbc.M111.241232","article-title":"\u03b1-Synuclein stimulates a dopamine transporter-dependent chloride current and modulates the activity of the transporter","volume":"286","author":"Swant","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100787_bib35","doi-asserted-by":"crossref","first-page":"6957","DOI":"10.1074\/jbc.RA119.007441","article-title":"Clustered Kv2.1 decreases dopamine transporter activity and internalization","volume":"294","author":"Lebowitz","year":"2019","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100787_bib36","doi-asserted-by":"crossref","first-page":"29542","DOI":"10.1074\/jbc.M115.691592","article-title":"Dopamine transporter activity is modulated by \u03b1-synuclein","volume":"290","author":"Butler","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100787_bib37","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/jnc.14259","article-title":"Functional properties of dopamine transporter oligomers after copper linking","volume":"144","author":"Zhen","year":"2018","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.jbc.2021.100787_bib38","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/jnc.13025","article-title":"Dopamine transporter oligomerization: Impact of combining protomers with differential cocaine analog binding affinities","volume":"133","author":"Zhen","year":"2015","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.jbc.2021.100787_bib39","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1471-4159.2012.07875.x","article-title":"Amphetamine and methamphetamine reduce striatal dopamine transporter function without concurrent dopamine transporter relocalization","volume":"123","author":"German","year":"2012","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.jbc.2021.100787_bib40","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/S0026-895X(24)12877-5","article-title":"Cocaine induction of dopamine transporter trafficking to the plasma membrane","volume":"61","author":"Little","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.jbc.2021.100787_bib41","doi-asserted-by":"crossref","first-page":"40442","DOI":"10.1074\/jbc.M501969200","article-title":"Psychoactive substrates stimulate dopamine transporter phosphorylation and down-regulation by cocaine-sensitive and protein kinase C-dependent mechanisms","volume":"280","author":"Cervinski","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100787_bib42","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1096\/fj.12-218727","article-title":"Differential targeting of the dopamine transporter to recycling or degradative pathways during amphetamine- or PKC-regulated endocytosis in dopamine neurons","volume":"27","author":"Hong","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.jbc.2021.100787_bib43","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1021\/cn400038u","article-title":"APP+, a fluorescent analogue of the neurotoxin MPP+, is a marker of catecholamine neurons in brain tissue, but not a fluorescent false neurotransmitter","volume":"4","author":"Karpowicz","year":"2013","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.jbc.2021.100787_bib44","doi-asserted-by":"crossref","first-page":"6794","DOI":"10.1523\/JNEUROSCI.4177-08.2009","article-title":"Visualization of dopamine transporter trafficking in live neurons by use of fluorescent cocaine analogs","volume":"29","author":"Eriksen","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.jbc.2021.100787_bib45","doi-asserted-by":"crossref","first-page":"27289","DOI":"10.1074\/jbc.M110.131003","article-title":"Postendocytic sorting of constitutively internalized dopamine transporter in cell lines and dopaminergic neurons","volume":"285","author":"Eriksen","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100787_bib46","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0304-4157(90)90008-Z","article-title":"Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity","volume":"1031","author":"Mollenhauer","year":"1990","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbc.2021.100787_bib47","doi-asserted-by":"crossref","first-page":"17836","DOI":"10.1523\/JNEUROSCI.3284-13.2013","article-title":"Dopamine transporter endocytic trafficking in striatal dopaminergic neurons: Differential dependence on dynamin and the actin cytoskeleton","volume":"33","author":"Gabriel","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.jbc.2021.100787_bib48","doi-asserted-by":"crossref","first-page":"9645","DOI":"10.1128\/JVI.72.12.9645-9655.1998","article-title":"Effect of bafilomycin A1 and nocodazole on endocytic transport in HeLa cells: Implications for viral uncoating and infection","volume":"72","author":"Bayer","year":"1998","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.jbc.2021.100787_bib49","doi-asserted-by":"crossref","first-page":"4198","DOI":"10.1128\/JVI.02179-10","article-title":"Role of endosomes in simian virus 40 entry and infection","volume":"85","author":"Engel","year":"2011","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.jbc.2021.100787_bib50","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1523\/JNEUROSCI.5386-08.2009","article-title":"Dopamine and amphetamine rapidly increase dopamine transporter trafficking to the surface: Live-cell imaging using total internal reflection fluorescence microscopy","volume":"29","author":"Furman","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.jbc.2021.100787_bib51","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.32293","article-title":"Small molecule induced oligomerization, clustering and clathrin-independent endocytosis of the dopamine transporter","volume":"7","author":"Sorkina","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.jbc.2021.100787_bib52","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1523\/JNEUROSCI.0387-04.2004","article-title":"Methamphetamine increases dopamine transporter higher molecular weight complex formation via a dopamine- and hyperthermia-associated mechanism","volume":"24","author":"Baucum","year":"2004","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.jbc.2021.100787_bib53","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1124\/jpet.103.055095","article-title":"Substrate-induced trafficking of the dopamine transporter in heterologously expressing cells and in rat striatal synaptosomal preparations","volume":"307","author":"Reith","year":"2003","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jbc.2021.100787_bib54","doi-asserted-by":"crossref","first-page":"6850","DOI":"10.1073\/pnas.110035297","article-title":"Amphetamine-induced loss of human dopamine transporter activity: An internalization-dependent and cocaine-sensitive mechanism","volume":"97","author":"Saunders","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.100787_bib55","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ejphar.2003.08.064","article-title":"Rapid regulation of dopamine transporter function by substrates, blockers and presynaptic receptor ligands","volume":"479","author":"Gulley","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jbc.2021.100787_bib56","doi-asserted-by":"crossref","first-page":"9238","DOI":"10.1073\/pnas.95.16.9238","article-title":"Cocaine alters the accessibility of endogenous cysteines in putative extracellular and intracellular loops of the human dopamine transporter","volume":"95","author":"Ferrer","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.100787_bib57","doi-asserted-by":"crossref","first-page":"15480","DOI":"10.1073\/pnas.1512957112","article-title":"Ack1 is a dopamine transporter endocytic brake that rescues a trafficking-dysregulated ADHD coding variant","volume":"112","author":"Wu","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.100787_bib58","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1749-6632.2009.05148.x","article-title":"Regulation of the dopamine transporter: Aspects relevant to psychostimulant drugs of abuse","volume":"1187","author":"Schmitt","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jbc.2021.100787_bib59","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ymeth.2005.05.013","article-title":"Photobleaching approaches to investigate diffusional mobility and trafficking of Ras in living cells","volume":"37","author":"Goodwin","year":"2005","journal-title":"Methods (San Diego, Calif.)"},{"key":"10.1016\/j.jbc.2021.100787_bib60","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1529\/biophysj.104.055640","article-title":"Ras diffusion is sensitive to plasma membrane viscosity","volume":"89","author":"Goodwin","year":"2005","journal-title":"Biophys. J."},{"key":"10.1016\/j.jbc.2021.100787_bib61","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1360-0443.2007.01771.x","article-title":"Methamphetamine-induced alterations in monoamine transport: Implications for neurotoxicity, neuroprotection and treatment","volume":"102","author":"Volz","year":"2007","journal-title":"Addiction"},{"key":"10.1016\/j.jbc.2021.100787_bib62","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1124\/jpet.109.153775","article-title":"A\u00a0receptor mechanism for methamphetamine action in dopamine transporter regulation in brain","volume":"330","author":"Xie","year":"2009","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jbc.2021.100787_bib63","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.neuroscience.2011.03.017","article-title":"Low and high affinity dopamine transporter inhibitors block dopamine uptake within 5 sec of intravenous injection","volume":"182","author":"Yorgason","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.jbc.2021.100787_bib64","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.neuropharm.2005.08.018","article-title":"Rapid delivery of the dopamine transporter to the plasmalemmal membrane upon amphetamine stimulation","volume":"49","author":"Johnson","year":"2005","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jbc.2021.100787_bib65","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1073\/pnas.95.7.4029","article-title":"Profound neuronal plasticity in response to inactivation of the dopamine transporter","volume":"95","author":"Jones","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.100787_bib66","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.neulet.2009.07.049","article-title":"Rab 11 regulates constitutive dopamine transporter trafficking and function in N2A neuroblastoma cells","volume":"463","author":"Furman","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jbc.2021.100787_bib67","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1124\/jpet.108.147959","article-title":"Protein kinase Cbeta is a critical regulator of dopamine transporter trafficking and regulates the behavioral response to amphetamine in mice","volume":"328","author":"Chen","year":"2009","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jbc.2021.100787_bib68","doi-asserted-by":"crossref","first-page":"9438","DOI":"10.1523\/JNEUROSCI.3885-16.2017","article-title":"The dopamine transporter recycles via a retromer-dependent postendocytic mechanism: Tracking studies using a novel fluorophore-coupling approach","volume":"37","author":"Wu","year":"2017","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.jbc.2021.100787_bib69","doi-asserted-by":"crossref","first-page":"22168","DOI":"10.1074\/jbc.M301845200","article-title":"The dopamine transporter constitutively internalizes and recycles in a protein kinase C-regulated manner in stably transfected PC12 cell lines","volume":"278","author":"Loder","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100787_bib70","first-page":"53193","article-title":"Differentiation of the SH-SY5Y human neuroblastoma cell line","author":"Shipley","year":"2016","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.jbc.2021.100787_bib71","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1124\/dmd.115.064824","article-title":"Potent and selective inhibition of plasma membrane monoamine transporter by HIV protease inhibitors","volume":"43","author":"Duan","year":"2015","journal-title":"Drug Metab. Dispos."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925821005809?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925821005809?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T20:55:26Z","timestamp":1777409726000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925821005809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":71,"alternative-id":["S0021925821005809"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2021.100787","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Optogenetically-induced multimerization of the dopamine transporter increases uptake and trafficking to the plasma membrane","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2021.100787","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"100787"}}