{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:31:56Z","timestamp":1786991516552,"version":"build-2736575974"},"reference-count":45,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T00:00:00Z","timestamp":1625788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["826245"],"award-info":[{"award-number":["826245"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007270","name":"University of Michigan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008510","name":"University of Maryland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008510","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM130183"],"award-info":[{"award-number":["GM130183"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.jbc.2021.100950","type":"journal-article","created":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T00:00:06Z","timestamp":1625875206000},"page":"100950","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Hydrogen sulfide stimulates lipid biogenesis from glutamine that is dependent on the mitochondrial NAD(P)H pool"],"prefix":"10.1016","volume":"297","author":[{"given":"Sebastian","family":"Carballal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Vitvitsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshan","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0726-8707","authenticated-orcid":false,"given":"David A.","family":"Hanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marouane","family":"Libiad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0460-0380","authenticated-orcid":false,"given":"Jace W.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8332-3275","authenticated-orcid":false,"given":"Ruma","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2021.100950_bib1","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.bbapap.2011.02.004","article-title":"PLP-dependent H2S biogenesis","volume":"1814","author":"Singh","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbc.2021.100950_bib2","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1021\/acs.chemrev.7b00205","article-title":"Chemical biology of H2S signaling through persulfidation","volume":"118","author":"Filipovic","year":"2018","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jbc.2021.100950_bib3","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev-nutr-071813-105654","article-title":"Sulfur as a signaling nutrient through hydrogen sulfide","volume":"34","author":"Kabil","year":"2014","journal-title":"Ann. Rev. Nutr."},{"key":"10.1016\/j.jbc.2021.100950_bib4","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/10409238.2021.1893641","article-title":"Regulation of the redox metabolome and thiol proteome by hydrogen sulfide","volume":"56","author":"Kumar","year":"2021","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.jbc.2021.100950_bib5","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1139\/o82-076","article-title":"Sulphide as an inhibitor and electron donor for the cytochrome c oxidase system","volume":"60","author":"Nicholls","year":"1982","journal-title":"Can. J. Biochem."},{"key":"10.1016\/j.jbc.2021.100950_bib6","doi-asserted-by":"crossref","first-page":"R1479","DOI":"10.1152\/ajpregu.90566.2008","article-title":"Whole tissue hydrogen sulfide concentrations are orders of magnitude lower than presently accepted values","volume":"295","author":"Furne","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.jbc.2021.100950_bib7","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1089\/ars.2011.4310","article-title":"High turnover rates for hydrogen sulfide allow for rapid regulation of its tissue concentrations","volume":"17","author":"Vitvitsky","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.jbc.2021.100950_bib8","doi-asserted-by":"crossref","first-page":"22457","DOI":"10.1074\/jbc.M109.010868","article-title":"Relative contributions of cystathionine beta-synthase and gamma-cystathionase to H2S biogenesis via alternative trans-sulfuration reactions","volume":"284","author":"Singh","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100950_bib9","doi-asserted-by":"crossref","first-page":"11601","DOI":"10.1074\/jbc.M808026200","article-title":"H2S biogenesis by human cystathionine \u03b3-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia","volume":"284","author":"Chiku","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100950_bib10","doi-asserted-by":"crossref","first-page":"6299","DOI":"10.1074\/jbc.RA120.012616","article-title":"Thioredoxin regulates human mercaptopyruvate sulfurtransferase at physiologically-relevant concentrations","volume":"295","author":"Yadav","year":"2020","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100950_bib11","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1111\/j.1742-4658.2008.06482.x","article-title":"Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria","volume":"275","author":"Hildebrandt","year":"2008","journal-title":"FEBS J."},{"key":"10.1016\/j.jbc.2021.100950_bib12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1365-2672.1992.tb05187.x","article-title":"Comparison of fermentation reactions in different regions of the human colon","volume":"72","author":"Macfarlane","year":"1992","journal-title":"J.\u00a0Appl. Bacteriol."},{"key":"10.1016\/j.jbc.2021.100950_bib13","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1177\/153537020322800413","article-title":"Gastrointestinal and microbial responses to sulfate-supplemented drinking water in mice","volume":"228","author":"Deplancke","year":"2003","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.jbc.2021.100950_bib14","doi-asserted-by":"crossref","first-page":"30901","DOI":"10.1074\/jbc.M114.602664","article-title":"Organization of the human mitochondrial sulfide oxidation pathway","volume":"289","author":"Libiad","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100950_bib15","doi-asserted-by":"crossref","first-page":"11641","DOI":"10.1074\/jbc.M117.788547","article-title":"H2S oxidation by nanodisc-embedded human sulfide quinone oxidoreductase","volume":"292","author":"Landry","year":"2017","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100950_bib16","doi-asserted-by":"crossref","first-page":"25072","DOI":"10.1074\/jbc.M115.682369","article-title":"Transient kinetic analysis of hydrogen sulfide oxidation catalyzed by human sulfide quinone oxidoreductase","volume":"290","author":"Mishanina","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100950_bib17","doi-asserted-by":"crossref","first-page":"12429","DOI":"10.1074\/jbc.RA118.004096","article-title":"Mechanism-based inhibition of human persulfide dioxygenase by gamma-glutamyl-homocysteinyl-glycine","volume":"293","author":"Kabil","year":"2018","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100950_bib18","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/cbic.202000661","article-title":"Hydrogen sulfide oxidation by sulfide quinone oxidoreductase","volume":"22","author":"Landry","year":"2021","journal-title":"Chembiochem"},{"key":"10.1016\/j.jbc.2021.100950_bib19","doi-asserted-by":"crossref","first-page":"12077","DOI":"10.1074\/jbc.RA119.009442","article-title":"Hydrogen sulfide perturbs mitochondrial bioenergetics and triggers metabolic reprogramming in colon cells","volume":"294","author":"Libiad","year":"2019","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100950_bib20","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1002\/jimd.12232","article-title":"Pathogenic variants in SQOR encoding sulfide:quinone oxidoreductase are a potentially treatable cause of Leigh disease","volume":"43","author":"Friederich","year":"2020","journal-title":"J.\u00a0Inherit. Metab. Dis."},{"key":"10.1016\/j.jbc.2021.100950_bib21","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/path.4659","article-title":"Cysteine and hydrogen sulphide in the regulation of metabolism: Insights from genetics and pharmacology","volume":"238","author":"Carter","year":"2016","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.jbc.2021.100950_bib22","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1093\/ajcn\/88.3.738","article-title":"Homocysteine, cysteine, and body composition in the Hordaland Homocysteine Study: Does cysteine link amino acid and lipid metabolism?","volume":"88","author":"Elshorbagy","year":"2008","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jbc.2021.100950_bib23","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1017\/S0007114511000201","article-title":"Effect of bariatric surgery on sulphur amino acids and glutamate","volume":"106","author":"Aasheim","year":"2011","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.jbc.2021.100950_bib24","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.atherosclerosis.2012.08.036","article-title":"Relationship between hydrogen sulfide levels and HDL-cholesterol, adiponectin, and potassium levels in the blood of healthy subjects","volume":"225","author":"Jain","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jbc.2021.100950_bib25","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.freeradbiomed.2011.01.038","article-title":"A\u00a0critical life-supporting role for cystathionine gamma-lyase in the absence of dietary cysteine supply","volume":"50","author":"Mani","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jbc.2021.100950_bib26","article-title":"Hydrogen sulfide promotes adipogenesis in 3T3L1 cells","volume":"10","author":"Tsai","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2021.100950_bib27","doi-asserted-by":"crossref","first-page":"100736","DOI":"10.1016\/j.jbc.2021.100736","article-title":"The mitochondrial NADH pool is involved in hydrogen sulfide signaling and stimulation of aerobic glycolysis","volume":"296","author":"Vitvitsky","year":"2021","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100950_bib28","doi-asserted-by":"crossref","first-page":"19611","DOI":"10.1073\/pnas.1117773108","article-title":"Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of alpha-ketoglutarate to citrate to support cell growth and viability","volume":"108","author":"Wise","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.100950_bib29","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1126\/science.aad4017","article-title":"Complementation of mitochondrial electron transport chain by manipulation of the NAD+\/NADH ratio","volume":"352","author":"Titov","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.jbc.2021.100950_bib30","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/nchembio.2454","article-title":"A\u00a0genetically encoded tool for manipulation of NADP(+)\/NADPH in living cells","volume":"13","author":"Cracan","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jbc.2021.100950_bib31","doi-asserted-by":"crossref","first-page":"7593","DOI":"10.1038\/srep07593","article-title":"Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion","volume":"4","author":"Warita","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2021.100950_bib32","first-page":"1189","article-title":"Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer","volume":"56","author":"Pizer","year":"1996","journal-title":"Cancer Res."},{"key":"10.1016\/j.jbc.2021.100950_bib33","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.bbrc.2009.05.045","article-title":"Acetyl-CoA carboxylase-alpha inhibitor TOFA induces human cancer cell apoptosis","volume":"385","author":"Wang","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jbc.2021.100950_bib34","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/nm.4181","article-title":"Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models","volume":"22","author":"Svensson","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.jbc.2021.100950_bib35","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.10067","article-title":"Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response","volume":"4","author":"Gao","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.jbc.2021.100950_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1500968","article-title":"A\u00a0novel persulfide detection method reveals protein persulfide- and polysulfide-reducing functions of thioredoxin and glutathione systems","volume":"2","author":"Doka","year":"2016","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jbc.2021.100950_bib37","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1021\/acssuschemeng.9b06748","article-title":"Hydrogen sulfide improves lipid accumulation in nannochloropsis oceanica through metabolic regulation of carbon allocation and energy supply","volume":"8","author":"Cheng","year":"2020","journal-title":"ACS Sustainable Chem. Eng."},{"key":"10.1016\/j.jbc.2021.100950_bib38","doi-asserted-by":"crossref","first-page":"12967","DOI":"10.1074\/jbc.M112.396796","article-title":"Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycle","volume":"288","author":"Gameiro","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.100950_bib39","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nature10642","article-title":"Reductive carboxylation supports growth in tumour cells with defective mitochondria","volume":"481","author":"Mullen","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2021.100950_bib40","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.58041","article-title":"Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria","volume":"9","author":"Nowinski","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.jbc.2021.100950_bib41","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nature10602","article-title":"Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia","volume":"481","author":"Metallo","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2021.100950_bib42","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cmet.2013.11.022","article-title":"Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth","volume":"19","author":"Sun","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbc.2021.100950_bib43","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/nprot.2017.013","article-title":"Metabolomics and lipidomics using traveling-wave ion mobility mass spectrometry","volume":"12","author":"Paglia","year":"2017","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jbc.2021.100950_bib44","doi-asserted-by":"crossref","first-page":"W251","DOI":"10.1093\/nar\/gkv380","article-title":"MetaboAnalyst 3.0--making metabolomics more meaningful","volume":"43","author":"Xia","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2021.100950_bib45","doi-asserted-by":"crossref","first-page":"14.10.1","DOI":"10.1002\/cpbi.11","article-title":"Using MetaboAnalyst 3.0 for comprehensive metabolomics data analysis","volume":"55","author":"Xia","year":"2016","journal-title":"Curr. Protoc. Bioinformatics"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582100750X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582100750X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T16:35:34Z","timestamp":1762187734000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002192582100750X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S002192582100750X"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2021.100950","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hydrogen sulfide stimulates lipid biogenesis from glutamine that is dependent on the mitochondrial NAD(P)H pool","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2021.100950","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"100950"}}