{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:14:30Z","timestamp":1788491670120,"version":"build-2803163510"},"reference-count":69,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T00:00:00Z","timestamp":1626739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BE2016718"],"award-info":[{"award-number":["BE2016718"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20160013"],"award-info":[{"award-number":["BK20160013"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31771521"],"award-info":[{"award-number":["31771521"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672582"],"award-info":[{"award-number":["81672582"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.jbc.2021.100996","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T18:55:55Z","timestamp":1626893755000},"page":"100996","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["HSP90 inhibition downregulates DNA replication and repair genes via E2F1 repression"],"prefix":"10.1016","volume":"297","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7984-6305","authenticated-orcid":false,"given":"Hanqing","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanlan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peishan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica A.","family":"Golemis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9844-3245","authenticated-orcid":false,"given":"Zhigang","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2021.100996_bib1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/carcin\/bgp220","article-title":"Epigenetics in cancer","volume":"31","author":"Sharma","year":"2010","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jbc.2021.100996_bib2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1365-2141.2008.07124.x","article-title":"Advances in the understanding of mantle cell lymphoma","volume":"142","author":"Jares","year":"2008","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.jbc.2021.100996_bib3","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1182\/blood-2010-04-189977","article-title":"Mantle cell lymphoma: Biology, pathogenesis, and the molecular basis of treatment in the genomic era","volume":"117","author":"Perez-Galan","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jbc.2021.100996_bib4","doi-asserted-by":"crossref","first-page":"12866","DOI":"10.1073\/pnas.1203617109","article-title":"Heat shock protein 90alpha (HSP90alpha), a substrate and chaperone of DNA-PK necessary for the apoptotic response","volume":"109","author":"Solier","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.100996_bib5","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/ijc.2910510418","article-title":"Unusual expression and localization of heat-shock proteins in human tumor cells","volume":"51","author":"Ferrarini","year":"1992","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.jbc.2021.100996_bib6","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1111\/j.1349-7006.2007.00561.x","article-title":"Extracellular heat shock protein 90: A role for a molecular chaperone in cell motility and cancer metastasis","volume":"98","author":"Tsutsumi","year":"2007","journal-title":"Cancer Sci."},{"key":"10.1016\/j.jbc.2021.100996_bib7","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nature01913","article-title":"A\u00a0high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors","volume":"425","author":"Kamal","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2021.100996_bib8","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1038\/nm.2059","article-title":"A\u00a0purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6-dependent B cell lymphomas","volume":"15","author":"Cerchietti","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.jbc.2021.100996_bib9","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1158\/1078-0432.CCR-11-1000","article-title":"Hsp90 molecular chaperone inhibitors: Are we there yet?","volume":"18","author":"Neckers","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jbc.2021.100996_bib10","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/nrc2887","article-title":"Targeting the dynamic HSP90 complex in cancer","volume":"10","author":"Trepel","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jbc.2021.100996_bib11","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1038\/modpathol.3800459","article-title":"Expression of heat-shock protein-90 in non-Hodgkin's lymphomas","volume":"18","author":"Valbuena","year":"2005","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.jbc.2021.100996_bib12","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1182\/blood-2010-04-278853","article-title":"The Hsp90 inhibitor IPI-504 overcomes bortezomib resistance in mantle cell lymphoma in\u00a0vitro and in\u00a0vivo by down-regulation of the prosurvival ER chaperone BiP\/Grp78","volume":"117","author":"Roue","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jbc.2021.100996_bib13","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1182\/blood-2016-04-711176","article-title":"HSP90 inhibition overcomes ibrutinib resistance in mantle cell lymphoma","volume":"128","author":"Jacobson","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.jbc.2021.100996_bib14","doi-asserted-by":"crossref","first-page":"5053","DOI":"10.1158\/1078-0432.CCR-13-1115","article-title":"Network analysis identifies an HSP90-central hub susceptible in ovarian cancer","volume":"19","author":"Liu","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jbc.2021.100996_bib15","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1158\/0008-5472.CAN-13-3263","article-title":"Ganetespib and HSP90: Translating preclinical hypotheses into clinical promise","volume":"74","author":"Proia","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.jbc.2021.100996_bib16","first-page":"1849","article-title":"Ganetespib: Research and clinical development","volume":"8","author":"Jhaveri","year":"2015","journal-title":"Onco Targets Ther."},{"key":"10.1016\/j.jbc.2021.100996_bib17","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1158\/1535-7163.MCT-11-0755","article-title":"Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy","volume":"11","author":"Ying","year":"2012","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.jbc.2021.100996_bib18","doi-asserted-by":"crossref","first-page":"4973","DOI":"10.1158\/1078-0432.CCR-11-2967","article-title":"Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in\u00a0vitro and in\u00a0vivo models of non-small cell lung cancer","volume":"18","author":"Shimamura","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jbc.2021.100996_bib19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1182\/blood-2010-01-263756","article-title":"17-DMAG targets the nuclear factor-kappaB family of proteins to induce apoptosis in chronic lymphocytic leukemia: Clinical implications of HSP90 inhibition","volume":"116","author":"Hertlein","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jbc.2021.100996_bib20","doi-asserted-by":"crossref","first-page":"5016","DOI":"10.1158\/1078-0432.CCR-12-3510","article-title":"A\u00a0purine scaffold HSP90 inhibitor BIIB021 has selective activity against KSHV-associated primary effusion lymphoma and blocks vFLIP K13-induced NF-kappaB","volume":"19","author":"Gopalakrishnan","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jbc.2021.100996_bib21","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3389\/fmicb.2015.00280","article-title":"The heat shock protein 90 inhibitor BIIB021 suppresses the growth of T and natural killer cell lymphomas","volume":"6","author":"Suzuki","year":"2015","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jbc.2021.100996_bib22","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/sj.bjc.6606007","article-title":"Antiproliferative and proapoptotic activity of GUT-70 mediated through potent inhibition of Hsp90 in mantle cell lymphoma","volume":"104","author":"Jin","year":"2011","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.jbc.2021.100996_bib23","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1038\/leu.2016.357","article-title":"Histone deacetylase inhibitors interrupt HSP90\u2217RASGRP1 and HSP90\u2217CRAF interactions to upregulate BIM and circumvent drug resistance in lymphoma cells","volume":"31","author":"Ding","year":"2017","journal-title":"Leukemia"},{"key":"10.1016\/j.jbc.2021.100996_bib24","doi-asserted-by":"crossref","first-page":"5014","DOI":"10.1158\/0008-5472.CAN-12-0635","article-title":"FLT-PET is superior to FDG-PET for very early response prediction in NPM-ALK-positive lymphoma treated with targeted therapy","volume":"72","author":"Li","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.jbc.2021.100996_bib25","doi-asserted-by":"crossref","first-page":"6697","DOI":"10.1093\/nar\/gky487","article-title":"An Orc1\/Cdc6 ortholog functions as a key regulator in the DNA damage response in Archaea","volume":"46","author":"Sun","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2021.100996_bib26","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1101\/gr.195248.115","article-title":"Concerted activities of Mcm4, Sld3, and Dbf4 in control of origin activation and DNA replication fork progression","volume":"26","author":"Sheu","year":"2016","journal-title":"Genome Res."},{"key":"10.1016\/j.jbc.2021.100996_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006483","article-title":"Loss of RMI2 increases genome instability and causes a Bloom-Like syndrome","volume":"12","author":"Hudson","year":"2016","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jbc.2021.100996_bib28","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1093\/nar\/gkg605","article-title":"Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN","volume":"31","author":"Farre","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2021.100996_bib29","doi-asserted-by":"crossref","first-page":"424","DOI":"10.5858\/2003-127-0424-COMCLC","article-title":"Characterization of 4 mantle cell lymphoma cell lines","volume":"127","author":"Amin","year":"2003","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.jbc.2021.100996_bib30","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/leu.2008.348","article-title":"Stabilization and activation of p53 downregulates mTOR signaling through AMPK in mantle cell lymphoma","volume":"23","author":"Drakos","year":"2009","journal-title":"Leukemia"},{"key":"10.1016\/j.jbc.2021.100996_bib31","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nrclinonc.2010.21","article-title":"mTOR signaling and drug development in cancer","volume":"7","author":"Dancey","year":"2010","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.jbc.2021.100996_bib32","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.cmet.2014.01.001","article-title":"Rapamycin: One drug, many effects","volume":"19","author":"Li","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbc.2021.100996_bib33","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.semcancer.2011.09.008","article-title":"New molecular targets in mantle cell lymphoma","volume":"21","author":"Parekh","year":"2011","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.jbc.2021.100996_bib34","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/bjh.12780","article-title":"Everolimus for patients with mantle cell lymphoma refractory to or intolerant of bortezomib: Multicentre, single-arm, phase 2 study","volume":"165","author":"Wang","year":"2014","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.jbc.2021.100996_bib35","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/leu.2010.226","article-title":"A\u00a0phase II trial of the oral mTOR inhibitor everolimus in relapsed aggressive lymphoma","volume":"25","author":"Witzig","year":"2011","journal-title":"Leukemia"},{"key":"10.1016\/j.jbc.2021.100996_bib36","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nrclinonc.2016.26","article-title":"Treating cancer with selective CDK4\/6 inhibitors","volume":"13","author":"O'Leary","year":"2016","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.jbc.2021.100996_bib37","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/leu.2015.185","article-title":"Dual inhibition of CDK4\/Rb and PI3K\/AKT\/mTOR pathways by ON123300 induces synthetic lethality in mantle cell lymphomas","volume":"30","author":"Divakar","year":"2016","journal-title":"Leukemia"},{"key":"10.1016\/j.jbc.2021.100996_bib38","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1158\/1535-7163.MCT-16-0848","article-title":"Inhibition of Hsp90 suppresses PI3K\/AKT\/mTOR signaling and has antitumor activity in Burkitt lymphoma","volume":"16","author":"Giulino-Roth","year":"2017","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.jbc.2021.100996_bib39","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1091\/mbc.e06-09-0792","article-title":"Nascent transcription of MCM2-7 is important for nuclear localization of the minichromosome maintenance complex in G1","volume":"18","author":"Braun","year":"2007","journal-title":"Mol. Biol. Cel."},{"key":"10.1016\/j.jbc.2021.100996_bib40","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/ng1936","article-title":"A\u00a0viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice","volume":"39","author":"Shima","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbc.2021.100996_bib41","doi-asserted-by":"crossref","first-page":"8548","DOI":"10.1038\/ncomms9548","article-title":"Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality","volume":"6","author":"Alvarez","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2021.100996_bib42","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1101\/gad.1725108","article-title":"BLAP18\/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome","volume":"22","author":"Singh","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.jbc.2021.100996_bib43","doi-asserted-by":"crossref","first-page":"4437","DOI":"10.1073\/pnas.1117279109","article-title":"Defining the molecular interface that connects the Fanconi anemia protein FANCM to the Bloom syndrome dissolvasome","volume":"109","author":"Hoadley","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.100996_bib44","doi-asserted-by":"crossref","first-page":"e1595","DOI":"10.1038\/cddis.2014.555","article-title":"Targeting heat-shock protein 90 with ganetespib for molecularly targeted therapy of gastric cancer","volume":"6","author":"Liu","year":"2015","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jbc.2021.100996_bib45","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.2147\/OTT.S245813","article-title":"HSP90 inhibitor ganetespib (STA-9090) inhibits tumor growth in c-Myc-dependent esophageal squamous cell carcinoma","volume":"13","author":"Guan","year":"2020","journal-title":"Onco Targets Ther."},{"key":"10.1016\/j.jbc.2021.100996_bib46","doi-asserted-by":"crossref","first-page":"41294","DOI":"10.18632\/oncotarget.17180","article-title":"Efficacy of an HSP90 inhibitor, ganetespib, in preclinical thyroid cancer models","volume":"8","author":"Lin","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.jbc.2021.100996_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0018552","article-title":"Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK\/STAT signaling","volume":"6","author":"Proia","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2021.100996_bib48","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1080\/15384047.2019.1595279","article-title":"Targeted blockade of HSP90 impairs DNA-damage response proteins and increases the sensitivity of ovarian carcinoma cells to PARP inhibition","volume":"20","author":"Gabbasov","year":"2019","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.jbc.2021.100996_bib49","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s10637-014-0095-4","article-title":"The HSP90 inhibitor ganetespib has chemosensitizer and radiosensitizer activity in colorectal cancer","volume":"32","author":"He","year":"2014","journal-title":"Invest. New Drugs"},{"key":"10.1016\/j.jbc.2021.100996_bib50","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1038\/sj.onc.1202544","article-title":"Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F","volume":"18","author":"Ohtani","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.jbc.2021.100996_bib51","doi-asserted-by":"crossref","first-page":"3802","DOI":"10.1038\/sj.onc.1207488","article-title":"Regulation of Geminin and Cdt1 expression by E2F transcription factors","volume":"23","author":"Yoshida","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.jbc.2021.100996_bib52","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.gene.2005.10.002","article-title":"Comparative genomics on MCM8 orthologous genes reveals the transcriptional regulation by transcription factor E2F","volume":"367","author":"Hayashi","year":"2006","journal-title":"Gene"},{"key":"10.1016\/j.jbc.2021.100996_bib53","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1073\/pnas.95.7.3603","article-title":"Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells","volume":"95","author":"Yan","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.100996_bib54","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1182\/blood.V95.2.619","article-title":"Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma","volume":"95","author":"Chiarle","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.jbc.2021.100996_bib55","doi-asserted-by":"crossref","first-page":"4554","DOI":"10.1182\/blood.V99.12.4554","article-title":"Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes","volume":"99","author":"Korz","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.jbc.2021.100996_bib56","doi-asserted-by":"crossref","first-page":"151148","DOI":"10.1016\/j.ejcb.2020.151148","article-title":"Hsp90 chaperone facilitates E2F1\/2-dependent gene transcription in human breast cancer cells","volume":"100","author":"Kotwal","year":"2021","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.jbc.2021.100996_bib57","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1182\/blood-2006-04-016634","article-title":"Mantle cell lymphoma cells express predominantly cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity","volume":"108","author":"Marzec","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.jbc.2021.100996_bib58","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1200\/JCO.19.00816","article-title":"Randomized phase III study of ganetespib, a heat shock protein 90 inhibitor, with docetaxel versus docetaxel in advanced non-small-cell lung cancer (GALAXY-2)","volume":"38","author":"Pillai","year":"2020","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.jbc.2021.100996_bib59","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1007\/s10456-013-9373-6","article-title":"Antiangiogenic effects of ganetespib in colorectal cancer mediated through inhibition of HIF-1alpha and STAT-3","volume":"16","author":"Nagaraju","year":"2013","journal-title":"Angiogenesis"},{"key":"10.1016\/j.jbc.2021.100996_bib60","doi-asserted-by":"crossref","first-page":"12910","DOI":"10.1038\/ncomms12910","article-title":"Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration","volume":"7","author":"Smid","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2021.100996_bib61","doi-asserted-by":"crossref","first-page":"15081","DOI":"10.1038\/ncomms15081","article-title":"Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer","volume":"8","author":"Chung","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2021.100996_bib62","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jbc.2021.100996_bib63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang da","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2021.100996_bib64","doi-asserted-by":"crossref","first-page":"D649","DOI":"10.1093\/nar\/gkx1132","article-title":"The reactome pathway Knowledgebase","volume":"46","author":"Fabregat","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2021.100996_bib65","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1109\/TBCAS.2014.2315532","article-title":"Respiration detection chip with integrated temperature-insensitive MEMS sensors and CMOS signal processing circuits","volume":"9","author":"Wei","year":"2015","journal-title":"IEEE Trans. Biomed. Circuits Syst."},{"key":"10.1016\/j.jbc.2021.100996_bib66","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2144\/05392ST02","article-title":"Comparison of the responsiveness of the pGL3 and pGL4 luciferase reporter vectors to steroid hormones","volume":"39","author":"Dougherty","year":"2005","journal-title":"BioTechniques"},{"key":"10.1016\/j.jbc.2021.100996_bib67","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.devcel.2011.10.010","article-title":"Oncogenic RAS regulates BRIP1 expression to induce dissociation of BRCA1 from chromatin, inhibit DNA repair, and promote senescence","volume":"21","author":"Tu","year":"2011","journal-title":"Dev. Cell"},{"key":"10.1016\/j.jbc.2021.100996_bib68","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1128\/MCB.01744-12","article-title":"BRG1 is required for formation of senescence-associated heterochromatin foci induced by oncogenic RAS or BRCA1 loss","volume":"33","author":"Tu","year":"2013","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2021.100996_bib69","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/1440-1681.12891","article-title":"Identification of a pyridine derivative inducing senescence in ovarian cancer cell lines via P21 activation","volume":"45","author":"Shang","year":"2018","journal-title":"Clin. Exp. Pharmacol. Physiol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925821007985?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925821007985?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T16:34:38Z","timestamp":1762187678000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925821007985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":69,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S0021925821007985"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2021.100996","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HSP90 inhibition downregulates DNA replication and repair genes via E2F1 repression","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2021.100996","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"100996"}}