{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:13:43Z","timestamp":1778656423987,"version":"3.51.4"},"reference-count":57,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RR160101"],"award-info":[{"award-number":["RR160101"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["ES07266"],"award-info":[{"award-number":["ES07266"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.jbc.2021.101144","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T01:34:00Z","timestamp":1630287240000},"page":"101144","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["DNA polymerase \u03b8 promotes CAG\u2022CTG repeat expansions in Huntington\u2019s disease via insertion sequences of its catalytic domain"],"prefix":"10.1016","volume":"297","author":[{"given":"Kara Y.","family":"Chan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice","family":"Ortega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liya","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9842-4578","authenticated-orcid":false,"given":"Guo-Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2021.101144_bib1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/nrm2854","article-title":"Repeat instability as the basis for human diseases and as a potential target for therapy","volume":"11","author":"Lopez Castel","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2021.101144_bib2","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nature05977","article-title":"Expandable DNA repeats and human disease","volume":"447","author":"Mirkin","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2021.101144_bib3","doi-asserted-by":"crossref","first-page":"4134","DOI":"10.1074\/jbc.REV119.007678","article-title":"On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability","volume":"295","author":"Khristich","year":"2020","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.101144_bib4","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.dnarep.2015.11.008","article-title":"Disease-associated repeat instability and mismatch repair","volume":"38","author":"Schmidt","year":"2016","journal-title":"DNA Repair"},{"key":"10.1016\/j.jbc.2021.101144_bib5","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/nchembio.416","article-title":"Replication-dependent instability at (CTG) x (CAG) repeat hairpins in human cells","volume":"6","author":"Liu","year":"2010","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jbc.2021.101144_bib6","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/70598","article-title":"Msh2 deficiency prevents in\u00a0vivo somatic instability of the CAG repeat in Huntington disease transgenic mice","volume":"23","author":"Manley","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbc.2021.101144_bib7","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nrg2828","article-title":"Mechanisms of trinucleotide repeat instability during human development","volume":"11","author":"McMurray","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.jbc.2021.101144_bib8","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1007\/PL00000734","article-title":"DNA repeat expansions and human disease","volume":"57","author":"Usdin","year":"2000","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.jbc.2021.101144_bib9","doi-asserted-by":"crossref","first-page":"20452","DOI":"10.1074\/jbc.C109.014977","article-title":"Mismatch recognition protein MutSbeta does not hijack (CAG)n hairpin repair in\u00a0vitro","volume":"284","author":"Tian","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.101144_bib10","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s11427-017-9186-7","article-title":"DNA mismatch repair in trinucleotide repeat instability","volume":"60","author":"Guo","year":"2017","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.jbc.2021.101144_bib11","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/0092-8674(95)90074-8","article-title":"Trinucleotide repeats that expand in human disease form hairpin structures in\u00a0vitro","volume":"81","author":"Gacy","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2021.101144_bib12","doi-asserted-by":"crossref","first-page":"9426","DOI":"10.1021\/bi980157s","article-title":"Influence of hairpins on template reannealing at trinucleotide repeat duplexes: A model for slipped DNA","volume":"37","author":"Gacy","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.jbc.2021.101144_bib13","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/nsmb.1638","article-title":"Incision-dependent and error-free repair of (CAG)(n)\/(CTG)(n) hairpins in human cell extracts","volume":"16","author":"Hou","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.jbc.2021.101144_bib14","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nsmb959","article-title":"Slipped (CTG)\u2217(CAG) repeats can be correctly repaired, escape repair or undergo error-prone repair","volume":"12","author":"Panigrahi","year":"2005","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.jbc.2021.101144_bib15","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.neuron.2014.06.034","article-title":"DNA damage and its links to neurodegeneration","volume":"83","author":"Madabhushi","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.jbc.2021.101144_bib16","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nature05778","article-title":"OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells","volume":"447","author":"Kovtun","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2021.101144_bib17","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/35002510","article-title":"Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA","volume":"403","author":"Bruner","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2021.101144_bib18","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/cr.2010.15","article-title":"Novel molecular insights into the mechanism of GO removal by MutM","volume":"20","author":"Li","year":"2010","journal-title":"Cell Res."},{"key":"10.1016\/j.jbc.2021.101144_bib19","series-title":"DNA Repair and Mutagenesis","author":"Friedberg","year":"2006"},{"key":"10.1016\/j.jbc.2021.101144_bib20","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1021\/bi701619u","article-title":"Efficient removal of formamidopyrimidines by 8-oxoguanine glycosylases","volume":"47","author":"Krishnamurthy","year":"2008","journal-title":"Biochemistry"},{"key":"10.1016\/j.jbc.2021.101144_bib21","doi-asserted-by":"crossref","first-page":"40479","DOI":"10.1074\/jbc.M110.155267","article-title":"Substrate channeling in mammalian base excision repair pathways: Passing the baton","volume":"285","author":"Prasad","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.101144_bib22","doi-asserted-by":"crossref","first-page":"28352","DOI":"10.1074\/jbc.M109.050286","article-title":"Coordination between polymerase beta and FEN1 can modulate CAG repeat expansion","volume":"284","author":"Liu","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.101144_bib23","doi-asserted-by":"crossref","first-page":"15015","DOI":"10.1074\/jbc.M113.464370","article-title":"Coordinated processing of 3' slipped (CAG)n\/(CTG)n hairpins by DNA polymerases beta and delta preferentially induces repeat expansions","volume":"288","author":"Chan","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.101144_bib24","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1046\/j.1471-4159.2001.00689.x","article-title":"Increased oxidative damage to DNA in a transgenic mouse model of Huntington's disease","volume":"79","author":"Bogdanov","year":"2001","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.jbc.2021.101144_bib25","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1093\/hmg\/9.17.2539","article-title":"Dramatic mutation instability in HD mouse striatum: Does polyglutamine load contribute to cell-specific vulnerability in Huntington's disease?","volume":"9","author":"Kennedy","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jbc.2021.101144_bib26","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.dnarep.2015.01.005","article-title":"Expansion of CAG triplet repeats by human DNA polymerases lambda and beta in\u00a0vitro, is regulated by flap endonuclease 1 and DNA ligase 1","volume":"29","author":"Crespan","year":"2015","journal-title":"DNA Repair"},{"key":"10.1016\/j.jbc.2021.101144_bib27","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.tibs.2011.12.002","article-title":"DNA base excision repair: A mechanism of trinucleotide repeat expansion","volume":"37","author":"Liu","year":"2012","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jbc.2021.101144_bib28","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.dnarep.2016.05.003","article-title":"DNA polymerase theta (POLQ), double-strand break repair, and cancer","volume":"44","author":"Wood","year":"2016","journal-title":"DNA Repair"},{"key":"10.1016\/j.jbc.2021.101144_bib29","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.molcel.2006.07.032","article-title":"Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage","volume":"24","author":"Yoshimura","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2021.101144_bib30","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1093\/nar\/gkn310","article-title":"Low-fidelity DNA synthesis by human DNA polymerase theta","volume":"36","author":"Arana","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2021.101144_bib31","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.jmb.2010.10.041","article-title":"Lesion bypass activity of DNA polymerase theta (POLQ) is an intrinsic property of the pol domain and depends on unique sequence inserts","volume":"405","author":"Hogg","year":"2011","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.jbc.2021.101144_bib32","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nsmb.2985","article-title":"How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis","volume":"22","author":"Lee","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.jbc.2021.101144_bib33","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/nsmb.2993","article-title":"Human DNA polymerase theta grasps the primer terminus to mediate DNA repair","volume":"22","author":"Zahn","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.jbc.2021.101144_bib34","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/cr.2016.66","article-title":"MutSbeta promotes trinucleotide repeat expansion by recruiting DNA polymerase beta to nascent (CAG)n or (CTG)n hairpins for error-prone DNA synthesis","volume":"26","author":"Guo","year":"2016","journal-title":"Cell Res."},{"key":"10.1016\/j.jbc.2021.101144_bib35","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nsmb.2961","article-title":"Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase theta","volume":"22","author":"Kent","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.jbc.2021.101144_bib36","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1128\/MCB.22.7.2037-2046.2002","article-title":"Partial reconstitution of human DNA mismatch repair in\u00a0vitro: Characterization of the role of human replication protein A","volume":"22","author":"Ramilo","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jbc.2021.101144_bib37","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.13740","article-title":"Polymerase theta is a robust terminal transferase that oscillates between three different mechanisms during end-joining","volume":"5","author":"Kent","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.jbc.2021.101144_bib38","doi-asserted-by":"crossref","first-page":"4534","DOI":"10.1093\/nar\/gkf572","article-title":"Slipped-strand DNAs formed by long (CAG)\u2217(CTG) repeats: Slipped-out repeats and slip-out junctions","volume":"30","author":"Pearson","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2021.101144_bib39","doi-asserted-by":"crossref","first-page":"11019","DOI":"10.1073\/pnas.92.24.11019","article-title":"Mismatch repair in Escherichia coli enhances instability of (CTG)n triplet repeats from human hereditary diseases","volume":"92","author":"Jaworski","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.101144_bib40","doi-asserted-by":"crossref","first-page":"6633","DOI":"10.1093\/nar\/gkn632","article-title":"Structural explanation for the role of Mn2+ in the activity of phi6 RNA-dependent RNA polymerase","volume":"36","author":"Poranen","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2021.101144_bib41","doi-asserted-by":"crossref","first-page":"20869","DOI":"10.1074\/jbc.R116.742494","article-title":"Different divalent cations alter the kinetics and fidelity of DNA polymerases","volume":"291","author":"Vashishtha","year":"2016","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.101144_bib42","doi-asserted-by":"crossref","first-page":"24689","DOI":"10.1074\/jbc.M702159200","article-title":"Increased catalytic activity and altered fidelity of human DNA polymerase iota in the presence of manganese","volume":"282","author":"Frank","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.101144_bib43","doi-asserted-by":"crossref","first-page":"0068","DOI":"10.1038\/s41570-017-0068","article-title":"How DNA polymerases catalyse replication and repair with contrasting fidelity","volume":"1","author":"Wu","year":"2017","journal-title":"Nat. Rev. Chem."},{"key":"10.1016\/j.jbc.2021.101144_bib44","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/306234a0","article-title":"A\u00a0polymorphic DNA marker genetically linked to Huntington's disease","volume":"306","author":"Gusella","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2021.101144_bib45","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3810\/pgm.2011.09.2466","article-title":"Exploring the correlates of intermediate CAG repeats in Huntington disease","volume":"123","author":"Ha","year":"2011","journal-title":"Postgrad. Med."},{"key":"10.1016\/j.jbc.2021.101144_bib46","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/ajmg.b.30970","article-title":"Unstable familial transmissions of Huntington disease alleles with 27-35 CAG repeats (intermediate alleles)","volume":"153B","author":"Semaka","year":"2010","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.jbc.2021.101144_bib47","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3233\/JHD-160205","article-title":"Oxidative stress and Huntington's disease: The good, the bad, and the ugly","volume":"5","author":"Kumar","year":"2016","journal-title":"J.\u00a0Huntingtons Dis."},{"key":"10.1016\/j.jbc.2021.101144_bib48","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/ajmg.b.30826","article-title":"Repeat instability in the 27-39 CAG range of the HD gene in the Venezuelan kindreds: Counseling implications","volume":"150B","author":"Brocklebank","year":"2009","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.jbc.2021.101144_bib49","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/s41422-021-00468-y","article-title":"Mispair-bound human MutS-MutL complex triggers DNA incisions and activates mismatch repair","volume":"31","author":"Ortega","year":"2021","journal-title":"Cell Res."},{"key":"10.1016\/j.jbc.2021.101144_bib50","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2005.06.027","article-title":"Reconstitution of 5'-directed human mismatch repair in a purified system","volume":"122","author":"Zhang","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2021.101144_bib51","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.dnarep.2011.10.020","article-title":"In\u00a0vitro repair of DNA hairpins containing various numbers of CAG\/CTG trinucleotide repeats","volume":"11","author":"Zhang","year":"2012","journal-title":"DNA Repair"},{"key":"10.1016\/j.jbc.2021.101144_bib52","doi-asserted-by":"crossref","first-page":"9598","DOI":"10.1073\/pnas.1806355115","article-title":"Cancer-driving H3G34V\/R\/D mutations block H3K36 methylation and H3K36me3-MutSalpha interaction","volume":"115","author":"Fang","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.101144_bib53","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1007\/s12035-019-01839-8","article-title":"Progerin-induced transcriptional changes in Huntington\u2019s disease human pluripotent stem cell-derived neurons","volume":"57","author":"Cohen-Carmon","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jbc.2021.101144_bib54","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1093\/nar\/gkq1323","article-title":"Mutant CAG repeats of Huntingtin transcript fold into hairpins, form nuclear foci and are targets for RNA interference","volume":"39","author":"de Mezer","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2021.101144_bib55","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41593-018-0075-7","article-title":"Striatal neurons directly converted from Huntington\u2019s disease patient fibroblasts recapitulate age-associated disease phenotypes","volume":"21","author":"Victor","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jbc.2021.101144_bib56","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1007\/s12035-013-8591-7","article-title":"Mutations of the Huntington\u2019s disease protein impact on the ATM-dependent signaling and repair pathways of the radiation-induced DNA double-strand breaks: corrective effect of statins and bisphosphonates","volume":"49","author":"Ferlazzo","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jbc.2021.101144_bib57","series-title":"DNA Repair Deficiency in Huntington\u2019s Disease Fibroblasts and Induced Pluripotent Stem Cells","author":"Mollica","year":"2015"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925821009455?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925821009455?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T06:47:32Z","timestamp":1778654852000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925821009455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["S0021925821009455"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2021.101144","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.740745445.793590520","asserted-by":"object"}]},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DNA polymerase \u03b8 promotes CAG\u2022CTG repeat expansions in Huntington\u2019s disease via insertion sequences of its catalytic domain","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2021.101144","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"101144"}}