{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T09:03:09Z","timestamp":1792746189376,"version":"4.5.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008394","name":"Natur og Univers, Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008394","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015223","name":"Danish Diabetes Academy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015223","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004836","name":"Independent Research Fund Denmark","doi-asserted-by":"publisher","award":["0134-00217B"],"award-info":[{"award-number":["0134-00217B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF14OC0009315"],"award-info":[{"award-number":["NNF14OC0009315"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF15CC0001"],"award-info":[{"award-number":["NNF15CC0001"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF18CC0034900"],"award-info":[{"award-number":["NNF18CC0034900"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011958","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","award":["4004-00235"],"award-info":[{"award-number":["4004-00235"]}],"id":[{"id":"10.13039\/501100011958","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.jbc.2021.101388","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T10:40:20Z","timestamp":1636368020000},"page":"101388","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Hepatocyte-specific perturbation of NAD+ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis\u2013like phenotypes"],"prefix":"10.1016","volume":"297","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8577-3162","authenticated-orcid":false,"given":"Morten","family":"Dall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1650-8784","authenticated-orcid":false,"given":"Anna S.","family":"Hassing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4571-4368","authenticated-orcid":false,"given":"Lili","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9457-8000","authenticated-orcid":false,"given":"Thomas S.","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4164-7690","authenticated-orcid":false,"given":"Lars R.","family":"Ingerslev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Sulek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5941-4094","authenticated-orcid":false,"given":"Samuel A.J.","family":"Trammell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew P.","family":"Gillum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Barr\u00e8s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen S.","family":"Poulsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1292-4799","authenticated-orcid":false,"given":"Matthias","family":"Mann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathrine","family":"\u00d8rskov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1488-7012","authenticated-orcid":false,"given":"Jonas T.","family":"Treebak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2021.101388_bib1","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/nrgastro.2013.171","article-title":"The global NAFLD epidemic","volume":"10","author":"Loomba","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jbc.2021.101388_bib2","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1002\/hep.28245","article-title":"Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice","volume":"63","author":"Gariani","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jbc.2021.101388_bib3","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1111\/acel.12135","article-title":"Elevated microRNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT","volume":"12","author":"Choi","year":"2013","journal-title":"Aging Cell"},{"key":"10.1016\/j.jbc.2021.101388_bib4","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.bcp.2014.07.002","article-title":"Troxerutin improves hepatic lipid homeostasis by restoring NAD+-depletion-mediated dysfunction of lipin 1 signaling in high-fat diet-treated mice","volume":"91","author":"Zhang","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jbc.2021.101388_bib5","doi-asserted-by":"crossref","first-page":"15063","DOI":"10.1038\/s41598-017-14866-z","article-title":"Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: Comparison with exercise","volume":"7","author":"Uddin","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2021.101388_bib6","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1111\/bph.13513","article-title":"Hepatic NAD+ deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing","volume":"173","author":"Zhou","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jbc.2021.101388_bib7","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.3390\/molecules22081315","article-title":"The inhibitory effects of purple sweet potato color on hepatic inflammation is associated with restoration of NAD+ levels and attenuation of NLRP3 inflammasome activation in high-fat-diet-treated mice","volume":"22","author":"Wang","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.jbc.2021.101388_bib8","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.cmet.2012.04.022","article-title":"The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet induced obesity","volume":"15","author":"Canto","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbc.2021.101388_bib9","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/ajcn\/nqy132","article-title":"A\u00a0randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: Safety, insulin-sensitivity, and lipid-mobilizing effects","volume":"108","author":"Dollerup","year":"2018","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jbc.2021.101388_bib10","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.cmet.2018.03.018","article-title":"Quantitative analysis of NAD synthesis-breakdown fluxes","volume":"27","author":"Liu","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbc.2021.101388_bib11","doi-asserted-by":"crossref","first-page":"50754","DOI":"10.1074\/jbc.M408388200","article-title":"The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells","volume":"279","author":"Revollo","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.101388_bib12","doi-asserted-by":"crossref","first-page":"36334","DOI":"10.1074\/jbc.M508660200","article-title":"Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms","volume":"280","author":"Berger","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.101388_bib13","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0092-8674(04)00416-7","article-title":"Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans","volume":"117","author":"Bieganowski","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2021.101388_bib14","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/S0021-9258(18)64789-1","article-title":"Biosynthesis of diphosphopyridine nucleotide: I. Identification of intermediates","volume":"233","author":"Preiss","year":"1958","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.101388_bib15","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1515\/med-2021-0286","article-title":"A\u00a0nomogram for predicting metabolic steatohepatitis: The combination of NAMPT, RALGDS, GADD45B, FOSL2, RTP3, and RASD1","volume":"16","author":"Liao","year":"2021","journal-title":"Open Med."},{"key":"10.1016\/j.jbc.2021.101388_bib16","doi-asserted-by":"crossref","first-page":"13304","DOI":"10.1074\/jbc.RA118.006756","article-title":"Mitochondrial function in liver cells is resistant to perturbations in NAD\u00a0+ salvage capacity","volume":"294","author":"Dall","year":"2019","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.101388_bib17","doi-asserted-by":"crossref","first-page":"1243417","DOI":"10.1126\/science.1243417","article-title":"Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice","volume":"342","author":"Peek","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.jbc.2021.101388_bib18","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12944-017-0464-z","article-title":"Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1\/AMPK\u03b1\/SREBP1 signaling pathway","volume":"16","author":"Wang","year":"2017","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.jbc.2021.101388_bib19","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/hep.28912","article-title":"Nicotinamide adenine dinucleotide biosynthesis promotes liver regeneration","volume":"65","author":"Mukherjee","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jbc.2021.101388_bib20","doi-asserted-by":"crossref","DOI":"10.15252\/msb.20188793","article-title":"Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease","volume":"15","author":"Niu","year":"2019","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.jbc.2021.101388_bib21","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/hep.30150","article-title":"Ductular reaction in liver diseases: Pathological mechanisms and translational significances","volume":"69","author":"Sato","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.jbc.2021.101388_bib22","doi-asserted-by":"crossref","DOI":"10.3791\/52438-v","article-title":"Bile duct ligation in mice: Induction of inflammatory liver injury and fibrosis by obstructive cholestasis","author":"Tag","year":"2015","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.jbc.2021.101388_bib23","doi-asserted-by":"crossref","first-page":"D480","DOI":"10.1093\/nar\/gkaa1100","article-title":"UniProt: The universal protein knowledgebase in 2021","volume":"49","author":"Consortium","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2021.101388_bib24","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/s42255-019-0109-9","article-title":"Spatial sorting enables comprehensive characterization of liver zonation","volume":"1","author":"Ben-Moshe","year":"2019","journal-title":"Nat. Metab."},{"key":"10.1016\/j.jbc.2021.101388_bib25","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.lfs.2019.03.064","article-title":"Nicotinamide riboside protects against liver fibrosis induced by CCl4 via regulating the acetylation of Smads signaling pathway","volume":"225","author":"Jiang","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.jbc.2021.101388_bib26","doi-asserted-by":"crossref","DOI":"10.1093\/cdn\/nzaa031","article-title":"Choice of laboratory rodent diet may confound data interpretation and reproducibility","volume":"4","author":"Pellizzon","year":"2020","journal-title":"Curr. Dev. Nutr."},{"key":"10.1016\/j.jbc.2021.101388_bib27","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1023\/A:1020884312053","article-title":"Food intake, water intake, and drinking spout side preference of 28 mouse strains","volume":"32","author":"Bachmanov","year":"2002","journal-title":"Behav. Genet."},{"key":"10.1016\/j.jbc.2021.101388_bib28","article-title":"Instability in NAD\u00a0+ metabolism leads to impaired cardiac mitochondrial function and communication","volume":"10","author":"KH","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.jbc.2021.101388_bib29","doi-asserted-by":"crossref","first-page":"1600878","DOI":"10.1002\/mnfr.201600878","article-title":"Effects of a wide range of dietary nicotinamide riboside (NR) concentrations on metabolic flexibility and white adipose tissue (WAT) of mice fed a mildly obesogenic diet","volume":"61","author":"Shi","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.jbc.2021.101388_bib30","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1177\/0023677215571192","article-title":"The carbon tetrachloride model in mice","volume":"49","author":"Scholten","year":"2015","journal-title":"Lab. Anim."},{"key":"10.1016\/j.jbc.2021.101388_bib31","doi-asserted-by":"crossref","first-page":"4291","DOI":"10.1038\/s41467-019-12262-x","article-title":"Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage","volume":"10","author":"Sambeat","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2021.101388_bib32","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature21065","article-title":"Single-cell spatial reconstruction reveals global division of labour in the mammalian liver","volume":"542","author":"Halpern","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2021.101388_bib33","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.molcel.2011.07.019","article-title":"SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome","volume":"44","author":"Hirschey","year":"2011","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2021.101388_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011707","article-title":"Sirtuin 3, a new target of PGC-1\u03b1, plays an important role in the suppression of ROS and mitochondrial biogenesis","volume":"5","author":"Kong","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2021.101388_bib35","doi-asserted-by":"crossref","first-page":"291","DOI":"10.7150\/ijbs.4.291","article-title":"SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression","volume":"4","author":"Jacobs","year":"2008","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jbc.2021.101388_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0045098","article-title":"Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition","volume":"7","author":"Fischer","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2021.101388_bib37","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.147193","article-title":"SIRT3 is required for liver regeneration but not for the beneficial effect of nicotinamide riboside","volume":"6","author":"Mukherjee","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.jbc.2021.101388_bib38","first-page":"E377","article-title":"Perturbations of NAD + salvage systems impact mitochondrial function and energy homeostasis in mouse myoblasts and intact skeletal muscle","volume":"314","author":"Agerholm","year":"2018","journal-title":"Am. J. Physiol. Metab."},{"key":"10.1016\/j.jbc.2021.101388_bib39","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/iep.12008","article-title":"An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis","volume":"94","author":"Matsumoto","year":"2013","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.jbc.2021.101388_bib40","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3109\/10520295.2011.570277","article-title":"Certification procedures for sirius red F3B (CI 35780, Direct red 80)","volume":"86","author":"Dapson","year":"2011","journal-title":"Biotech. Histochem."},{"key":"10.1016\/j.jbc.2021.101388_bib41","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.mce.2018.01.025","article-title":"Hepatic NAD\u00a0+ levels and NAMPT abundance are unaffected during prolonged high-fat diet consumption in C57BL\/6JBomTac mice","volume":"473","author":"Dall","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jbc.2021.101388_bib42","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1194\/jlr.M040451","article-title":"Contrasting metabolic effects of medium- versus long-chain fatty acids in skeletal muscle [S]","volume":"54","author":"Montgomery","year":"2013","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jbc.2021.101388_bib43","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: Ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jbc.2021.101388_bib44","doi-asserted-by":"crossref","first-page":"D766","DOI":"10.1093\/nar\/gky955","article-title":"GENCODE reference annotation for the human and mouse genomes","volume":"47","author":"Frankish","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2021.101388_bib45","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: An efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jbc.2021.101388_bib46","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: A bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jbc.2021.101388_bib47","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: An R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"10.1016\/j.jbc.2021.101388_bib48","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s13059-018-1603-1","article-title":"Cell hashing with barcoded antibodies enables multiplexing and doublet detection for single cell genomics","volume":"19","author":"Stoeckius","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.jbc.2021.101388_bib49","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13059-019-1670-y","article-title":"Alevin efficiently estimates accurate gene abundances from dscRNA-seq data","volume":"20","author":"Srivastava","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.jbc.2021.101388_bib50","article-title":"Integrated analysis of multimodal single-cell data","author":"Hao","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.jbc.2021.101388_bib51","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1038\/s41598-020-58059-7","article-title":"Multi-omics characterization of a diet-induced obese model of non-alcoholic steatohepatitis","volume":"10","author":"\u00c6gidius","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2021.101388_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-018-06318-7","article-title":"Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations","volume":"9","author":"MacParland","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2021.101388_bib53","doi-asserted-by":"crossref","DOI":"10.1126\/science.1260419","article-title":"Tissue-based map of the human proteome","author":"Uhl\u00e9n","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.jbc.2021.101388_bib54","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.cels.2016.02.015","article-title":"Plasma proteome profiling to assess human health and disease","volume":"2","author":"Geyer","year":"2016","journal-title":"Cell Syst."},{"key":"10.1016\/j.jbc.2021.101388_bib55","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nmeth.2834","article-title":"Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells","volume":"11","author":"Kulak","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jbc.2021.101388_bib56","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1074\/mcp.M114.044305","article-title":"Extending the limits of quantitative proteome profiling with data-independent acquisition and application to acetaminophen-treated three-dimensional liver microtissues","volume":"14","author":"Bruderer","year":"2015","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.jbc.2021.101388_bib57","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1002\/pmic.201500488","article-title":"High-precision iRT prediction in the targeted analysis of data-independent acquisition and its impact on identification and quantitation","volume":"16","author":"Bruderer","year":"2016","journal-title":"Proteomics"},{"key":"10.1016\/j.jbc.2021.101388_bib58","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1073\/pnas.1530509100","article-title":"Statistical significance for genomewide studies","volume":"100","author":"Storey","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.101388_bib59","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2021.101388_bib60","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.freeradbiomed.2015.11.011","article-title":"Carboxylesterase converts Amplex red to resorufin: Implications for mitochondrial H2O2 release assays","volume":"90","author":"Miwa","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jbc.2021.101388_bib61","doi-asserted-by":"crossref","first-page":"D447","DOI":"10.1093\/nar\/gkv1145","article-title":"2016 update of the PRIDE database and its related tools","volume":"44","author":"Vizca\u00edno","year":"2016","journal-title":"Nucleic Acids Res."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925821011947?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925821011947?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:09:05Z","timestamp":1758240545000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925821011947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":61,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S0021925821011947"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2021.101388","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatocyte-specific perturbation of NAD+ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis\u2013like phenotypes","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2021.101388","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"101388"}}