{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:03:01Z","timestamp":1790420581423,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/igo\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIDCR 1K99DE030124-01A1"],"award-info":[{"award-number":["NIDCR 1K99DE030124-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ZIC DE000729-09"],"award-info":[{"award-number":["ZIC DE000729-09"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ZIC DE000750-01"],"award-info":[{"award-number":["ZIC DE000750-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["686841"],"award-info":[{"award-number":["686841"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.jbc.2021.101467","type":"journal-article","created":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T21:09:13Z","timestamp":1638565753000},"page":"101467","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Imaging of anthrax intoxication in mice reveals shared and individual functions of surface receptors CMG-2 and TEM-8 in cellular toxin entry"],"prefix":"10.1016","volume":"298","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9233-6940","authenticated-orcid":false,"given":"Carly","family":"Merritt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Chun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasem J.","family":"Fattah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6282-2657","authenticated-orcid":false,"given":"Lakmali M.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quinn Q.","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4448-8883","authenticated-orcid":false,"given":"Mahtab","family":"Moayeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0447-6212","authenticated-orcid":false,"given":"Dennis","family":"Paliga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3706-9012","authenticated-orcid":false,"given":"Sebastian","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4364-2655","authenticated-orcid":false,"given":"Rolf","family":"Heumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5233-0501","authenticated-orcid":false,"given":"Stephen H.","family":"Leppla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7046-4060","authenticated-orcid":false,"given":"Thomas H.","family":"Bugge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2021.101467_bib1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1172\/JCI0216204","article-title":"Development of an improved vaccine for anthrax","volume":"110","author":"Leppla","year":"2002","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.jbc.2021.101467_bib2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev.cellbio.19.111301.140655","article-title":"Anthrax toxin","volume":"19","author":"Collier","year":"2003","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.jbc.2021.101467_bib3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/n35101999","article-title":"Identification of the cellular receptor for anthrax toxin","volume":"414","author":"Bradley","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2021.101467_bib4","doi-asserted-by":"crossref","first-page":"5170","DOI":"10.1073\/pnas.0431098100","article-title":"Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor","volume":"100","author":"Scobie","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.101467_bib5","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1128\/iai.63.1.82-87.1995","article-title":"Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteases","volume":"63","author":"Gordon","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jbc.2021.101467_bib6","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1021\/bi015860m","article-title":"Stoichiometry of anthrax toxin complexes","volume":"41","author":"Mogridge","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.jbc.2021.101467_bib7","doi-asserted-by":"crossref","first-page":"7045","DOI":"10.1073\/pnas.052160199","article-title":"The lethal and edema factors of anthrax toxin bind only to oligomeric forms of the protective antigen","volume":"99","author":"Mogridge","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.101467_bib8","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1073\/pnas.79.10.3162","article-title":"Anthrax toxin edema factor: A bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells","volume":"79","author":"Leppla","year":"1982","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.101467_bib9","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1126\/science.280.5364.734","article-title":"Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor","volume":"280","author":"Duesbery","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.jbc.2021.101467_bib10","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1038\/s41564-020-0782-1","article-title":"Anthrax lethal factor cleaves regulatory subunits of phosphoinositide-3 kinase to contribute to toxin lethality","volume":"5","author":"Mendenhall","year":"2020","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.jbc.2021.101467_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002638","article-title":"Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome","volume":"8","author":"Levinsohn","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2021.101467_bib12","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nature12510","article-title":"Key tissue targets responsible for anthrax-toxin-induced lethality","volume":"501","author":"Liu","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2021.101467_bib13","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1146\/annurev-micro-091014-104523","article-title":"Anthrax pathogenesis","volume":"69","author":"Moayeri","year":"2015","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.jbc.2021.101467_bib14","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1016\/S0021-9258(18)53698-X","article-title":"Residues 1-254 of anthrax toxin lethal factor are sufficient to cause cellular uptake of fused polypeptides","volume":"268","author":"Arora","year":"1993","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.101467_bib15","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1046\/j.1365-2672.1999.00890.x","article-title":"Anthrax toxin fusion proteins for intracellular delivery of macromolecules","volume":"87","author":"Leppla","year":"1999","journal-title":"J.\u00a0Appl. Microbiol."},{"key":"10.1016\/j.jbc.2021.101467_bib16","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.1128\/iai.62.11.4955-4961.1994","article-title":"Fusions of anthrax toxin lethal factor with shiga toxin and diphtheria toxin enzymatic domains are toxic to mammalian cells","volume":"62","author":"Arora","year":"1994","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jbc.2021.101467_bib17","doi-asserted-by":"crossref","first-page":"15542","DOI":"10.1016\/S0021-9258(19)49569-0","article-title":"Fusions of anthrax toxin lethal factor to the ADP-ribosylation domain of Pseudomonas exotoxin A are potent cytotoxins which are translocated to the cytosol of mammalian cells","volume":"267","author":"Arora","year":"1992","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.101467_bib18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1042\/BA20000037","article-title":"Anthrax toxin-mediated delivery of cholera toxin-a subunit into the cytosol of mammalian cells","volume":"32","author":"Sharma","year":"2000","journal-title":"Biotechnol. Appl. Biochem."},{"key":"10.1016\/j.jbc.2021.101467_bib19","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nmeth862","article-title":"Imaging specific cell-surface proteolytic activity in single living cells","volume":"3","author":"Hobson","year":"2006","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jbc.2021.101467_bib20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1042\/BA20000072","article-title":"Anthrax-toxin-mediated delivery of a 19 kDa antigen of Mycobacterium tuberculosis into the cytosol of mammalian cells","volume":"33","author":"Mehra","year":"2001","journal-title":"Biotechnol. Appl. Biochem."},{"key":"10.1016\/j.jbc.2021.101467_bib21","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1111\/j.1462-5822.2010.01480.x","article-title":"Imaging the cell entry of the anthrax oedema and lethal toxins with fluorescent protein chimeras","volume":"12","author":"Zornetta","year":"2010","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.jbc.2021.101467_bib22","doi-asserted-by":"crossref","first-page":"12059","DOI":"10.1073\/pnas.94.22.12059","article-title":"Targeting HIV proteins to the major histocompatibility complex class I processing pathway with a novel gp120-anthrax toxin fusion protein","volume":"94","author":"Goletz","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.101467_bib23","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0264-410X(01)00407-8","article-title":"Induction of hepatitis C virus-specific cytotoxic T lymphocytes in mice by immunization with dendritic cells treated with an anthrax toxin fusion protein","volume":"20","author":"Moriya","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.jbc.2021.101467_bib24","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1348-0421.2001.tb01279.x","article-title":"Role of furin in delivery of a CTL epitope of an anthrax toxin-fusion protein","volume":"45","author":"Zhang","year":"2001","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.jbc.2021.101467_bib25","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1128\/IAI.67.7.3290-3296.1999","article-title":"Cytotoxic T-lymphocyte epitopes fused to anthrax toxin induce protective antiviral immunity","volume":"67","author":"Doling","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jbc.2021.101467_bib26","doi-asserted-by":"crossref","first-page":"46326","DOI":"10.1074\/jbc.M108930200","article-title":"Inhibition of axotomy-induced neuronal apoptosis by extracellular delivery of a Bcl-XL fusion protein","volume":"276","author":"Liu","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.101467_bib27","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1128\/IAI.66.2.615-619.1998","article-title":"Anthrax toxin-mediated delivery in\u00a0vivo and in\u00a0vitro of a cytotoxic T- lymphocyte epitope from ovalbumin","volume":"66","author":"Ballard","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jbc.2021.101467_bib28","doi-asserted-by":"crossref","first-page":"15737","DOI":"10.1021\/bi981436i","article-title":"Characterization of membrane translocation by anthrax protective antigen","volume":"37","author":"Wesche","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.jbc.2021.101467_bib29","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1007\/s12035-018-1311-6","article-title":"Lethal factor domain-mediated delivery of Nurr1 transcription factor enhances tyrosine hydroxylase activity and protects from neurotoxin-induced degeneration of dopaminergic cells","volume":"56","author":"Paliga","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jbc.2021.101467_bib30","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1128\/IAI.67.4.1853-1859.1999","article-title":"Oligomerization of anthrax toxin protective antigen and binding of lethal factor during endocytic uptake into mammalian cells","volume":"67","author":"Singh","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jbc.2021.101467_bib31","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.2967\/jnumed.119.226423","article-title":"Tumor imaging using radiolabelled matrix metalloproteinase-activated anthrax proteins","volume":"60","author":"Xavier","year":"2019","journal-title":"J.\u00a0Nucl. Med."},{"key":"10.1016\/j.jbc.2021.101467_bib32","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1128\/IAI.74.2.1084-1090.2006","article-title":"Cre reporter system to monitor the translocation of type III secreted proteins into host cells","volume":"74","author":"Briones","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jbc.2021.101467_bib33","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1158\/1535-7163.MCT-13-0358","article-title":"Receptor-directed chimeric toxins created by sortase-mediated protein fusion","volume":"12","author":"McCluskey","year":"2013","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.jbc.2021.101467_bib34","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.molonc.2012.12.003","article-title":"Targeting HER2-positive cancer cells with receptor-redirected anthrax protective antigen","volume":"7","author":"McCluskey","year":"2013","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.jbc.2021.101467_bib35","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1158\/1541-7786.MCR-08-0451","article-title":"Matrix metalloproteinase-activated anthrax lethal toxin inhibits endothelial invasion and neovasculature formation during in\u00a0vitro morphogenesis","volume":"7","author":"Alfano","year":"2009","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.jbc.2021.101467_bib36","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1158\/1535-7163.MCT-09-0694","article-title":"Inhibition of tumor angiogenesis by the matrix metalloproteinase-activated anthrax lethal toxin in an orthotopic model of anaplastic thyroid carcinoma","volume":"9","author":"Alfano","year":"2010","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.jbc.2021.101467_bib37","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nbt1091","article-title":"Intermolecular complementation achieves high-specificity tumor targeting by anthrax toxin","volume":"23","author":"Liu","year":"2005","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jbc.2021.101467_bib38","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1074\/jbc.M707419200","article-title":"Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature","volume":"283","author":"Liu","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.101467_bib39","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.taap.2014.06.010","article-title":"Comparative toxicity and efficacy of engineered anthrax lethal toxin variants with broad anti-tumor activities","volume":"279","author":"Peters","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jbc.2021.101467_bib40","doi-asserted-by":"crossref","first-page":"9058","DOI":"10.1074\/jbc.M113.452110","article-title":"Engineering anthrax toxin variants that exclusively form octamers and their application to targeting tumors","volume":"288","author":"Phillips","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.101467_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020532","article-title":"Efficient targeting of head and neck squamous cell carcinoma by systemic administration of a dual uPA and MMP-activated engineered anthrax toxin","volume":"6","author":"Schafer","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2021.101467_bib42","first-page":"6061","article-title":"Tumor cell-selective cytotoxicity of matrix metalloproteinase-activated anthrax toxin","volume":"60","author":"Liu","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.jbc.2021.101467_bib43","doi-asserted-by":"crossref","first-page":"7437","DOI":"10.1158\/1078-0432.CCR-06-2019","article-title":"Systemic anthrax lethal toxin therapy produces regressions of subcutaneous human melanoma tumors in athymic nude mice","volume":"12","author":"Abi-Habib","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jbc.2021.101467_bib44","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1073\/pnas.0236849100","article-title":"Potent antitumor activity of a urokinase-activated engineered anthrax toxin","volume":"100","author":"Liu","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.101467_bib45","doi-asserted-by":"crossref","first-page":"17976","DOI":"10.1074\/jbc.M011085200","article-title":"Targeting of tumor cells by cell surface urokinase plasminogen activator-dependent anthrax toxin","volume":"276","author":"Liu","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.101467_bib46","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1158\/1535-7163.MCT-05-0163","article-title":"Antitumor efficacy of a urokinase activation-dependent anthrax toxin","volume":"5","author":"Rono","year":"2006","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.jbc.2021.101467_bib47","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1158\/0008-5472.CAN-06-4642","article-title":"Systematic urokinase-activated anthrax toxin therapy produces regressions of subcutaneous human non-small cell lung tumor in athymic nude mice","volume":"67","author":"Su","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.jbc.2021.101467_bib48","doi-asserted-by":"crossref","first-page":"33534","DOI":"10.18632\/oncotarget.5214","article-title":"Targeting the membrane-anchored serine protease testisin with a novel engineered anthrax toxin prodrug to kill tumor cells and reduce tumor burden","volume":"6","author":"Martin","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.jbc.2021.101467_bib49","doi-asserted-by":"crossref","first-page":"e00201","DOI":"10.1128\/mBio.00201-13","article-title":"Anthrax toxin-mediated delivery of the Pseudomonas exotoxin A enzymatic domain to the cytosol of tumor cells via cleavable ubiquitin fusions","volume":"4","author":"Bachran","year":"2013","journal-title":"mBio"},{"key":"10.1016\/j.jbc.2021.101467_bib50","doi-asserted-by":"crossref","first-page":"4703","DOI":"10.1093\/nar\/27.24.4703","article-title":"Nuclear targeting determinants of the phage P1 cre DNA recombinase","volume":"27","author":"Le","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2021.101467_bib51","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/dvg.20335","article-title":"A\u00a0global double-fluorescent Cre reporter mouse","volume":"45","author":"Muzumdar","year":"2007","journal-title":"Genesis"},{"key":"10.1016\/j.jbc.2021.101467_bib52","doi-asserted-by":"crossref","first-page":"12424","DOI":"10.1073\/pnas.0905409106","article-title":"Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in\u00a0vivo","volume":"106","author":"Liu","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.101467_bib53","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1158\/1535-7163.MCT-06-0315","article-title":"A\u00a0urokinase-activated recombinant anthrax toxin is selectively cytotoxic to many human tumor cell types","volume":"5","author":"Abi-Habib","year":"2006","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.jbc.2021.101467_bib54","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.pep.2015.08.019","article-title":"Tandem SUMO fusion vectors for improving soluble protein expression and purification","volume":"116","author":"Guerrero","year":"2015","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.jbc.2021.101467_bib55","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/dvg.20321","article-title":"Enhanced purification of cell-permeant Cre and germline transmission after transduction into mouse embryonic stem cells","volume":"45","author":"Peitz","year":"2007","journal-title":"Genesis"},{"key":"10.1016\/j.jbc.2021.101467_bib56","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1093\/nar\/24.8.1404","article-title":"Regulation of Cre recombinase activity by the synthetic steroid RU 486","volume":"24","author":"Kellendonk","year":"1996","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2021.101467_bib57","doi-asserted-by":"crossref","first-page":"5395","DOI":"10.1007\/s00216-014-7935-0","article-title":"A\u00a0rapid and sensitive fluorimetric beta-galactosidase assay for coliform detection using chlorophenol red-beta-D-galactopyranoside","volume":"406","author":"Sicard","year":"2014","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.jbc.2021.101467_bib58","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1016\/j.celrep.2017.12.011","article-title":"Tumor-associated macrophages derived from circulating inflammatory monocytes degrade collagen through cellular uptake","volume":"21","author":"Madsen","year":"2017","journal-title":"Cell Rep."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582101276X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582101276X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:07:42Z","timestamp":1758240462000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002192582101276X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S002192582101276X"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2021.101467","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Imaging of anthrax intoxication in mice reveals shared and individual functions of surface receptors CMG-2 and TEM-8 in cellular toxin entry","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2021.101467","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"101467"}}