{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:43:55Z","timestamp":1787064235405,"version":"build-2736575974"},"reference-count":57,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T00:00:00Z","timestamp":1639699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000928","name":"Welch Foundation","doi-asserted-by":"publisher","award":["I-1878"],"award-info":[{"award-number":["I-1878"]}],"id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association Inc","doi-asserted-by":"publisher","award":["19TPA34910171"],"award-info":[{"award-number":["19TPA34910171"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.jbc.2021.101515","type":"journal-article","created":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T10:52:26Z","timestamp":1639824746000},"page":"101515","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Inhibition of Jumonji demethylases reprograms severe dilated cardiomyopathy and prolongs survival"],"prefix":"10.1016","volume":"298","author":[{"given":"Tram Anh","family":"Tran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Gonzales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6688-5281","authenticated-orcid":false,"given":"Luc","family":"Girard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman","family":"May","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gillette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Ping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1131-3689","authenticated-orcid":false,"given":"Elisabeth D.","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2021.101515_bib1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1172\/JCI24178","article-title":"Protein kinase cascades in the regulation of cardiac hypertrophy","volume":"115","author":"Dorn","year":"2005","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.jbc.2021.101515_bib2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev.physiol.65.092101.142243","article-title":"Cardiac hypertrophy: The good, the bad, and the ugly","volume":"65","author":"Frey","year":"2003","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.jbc.2021.101515_bib3","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/nrm3495","article-title":"Molecular basis of physiological heart growth: Fundamental concepts and new players","volume":"14","author":"Maillet","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2021.101515_bib4","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1073\/pnas.1015081108","article-title":"Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagy","volume":"108","author":"Cao","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.101515_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yjmcc.2018.05.013","article-title":"Repressive histone methylation regulates cardiac myocyte cell cycle exit","volume":"121","author":"El-Nachef","year":"2018","journal-title":"J.\u00a0Mol. Cell Cardiol."},{"key":"10.1016\/j.jbc.2021.101515_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2018.05.009","article-title":"JMJD3 inhibition protects against isoproterenol-induced cardiac hypertrophy by suppressing beta-MHC expression","volume":"477","author":"Guo","year":"2018","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.jbc.2021.101515_bib7","doi-asserted-by":"crossref","first-page":"e105416","DOI":"10.1371\/journal.pone.0105416","article-title":"Histone deacetylase 3 promotes RCAN1 stability and nuclear translocation","volume":"9","author":"Han","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2021.101515_bib8","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1172\/JCI61084","article-title":"HDAC4 controls histone methylation in response to elevated cardiac load","volume":"123","author":"Hohl","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.jbc.2021.101515_bib9","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.jacbts.2019.05.011","article-title":"Epigenetics in cardiac hypertrophy and heart failure","volume":"4","author":"Liu","year":"2019","journal-title":"JACC Basic Transl. Sci."},{"key":"10.1016\/j.jbc.2021.101515_bib10","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.cmet.2014.09.011","article-title":"An epigenetic \u201cLINK(RNA)\u201d to pathological cardiac hypertrophy","volume":"20","author":"Liu","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbc.2021.101515_bib11","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.yexcr.2015.04.012","article-title":"The histone demethylase PHF8 represses cardiac hypertrophy upon pressure overload","volume":"335","author":"Liu","year":"2015","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.jbc.2021.101515_bib12","doi-asserted-by":"crossref","first-page":"206","DOI":"10.2459\/JCM.0b013e3283212ecd","article-title":"Jumonji is a potential regulatory factor mediating nitric oxide-induced modulation of cardiac hypertrophy","volume":"10","author":"Rabkin","year":"2009","journal-title":"J.\u00a0Cardiovasc. Med. (Hagerstown)"},{"key":"10.1016\/j.jbc.2021.101515_bib13","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/S0092-8674(02)00861-9","article-title":"Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy","volume":"110","author":"Zhang","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2021.101515_bib14","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1172\/JCI46277","article-title":"The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice","volume":"121","author":"Zhang","year":"2011","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.jbc.2021.101515_bib15","doi-asserted-by":"crossref","first-page":"5230","DOI":"10.1038\/s41467-018-07173-2","article-title":"Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis","volume":"9","author":"Zhang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2021.101515_bib16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1365-2443.2008.01252.x","article-title":"Genome-wide histone methylation profile for heart failure","volume":"14","author":"Kaneda","year":"2009","journal-title":"Genes Cells"},{"key":"10.1016\/j.jbc.2021.101515_bib17","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1161\/CIRCULATIONAHA.111.040071","article-title":"Distinct epigenomic features in end-stage failing human hearts","volume":"124","author":"Movassagh","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jbc.2021.101515_bib18","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s41467-017-02762-z","article-title":"Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in\u00a0vivo","volume":"9","author":"Gilsbach","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2021.101515_bib19","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.yjmcc.2016.12.006","article-title":"Calcineurin signaling in the heart: The importance of time and place","volume":"103","author":"Parra","year":"2017","journal-title":"J.\u00a0Mol. Cell Cardiol."},{"key":"10.1016\/j.jbc.2021.101515_bib20","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3892\/ijmm_00000448","article-title":"Increased expression of calpain and elevated activity of calcineurin in the myocardium of patients with congestive heart failure","volume":"26","author":"Yang","year":"2010","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jbc.2021.101515_bib21","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1159\/000481280","article-title":"Correlation between serum calcineurin activity and left ventricular hypertrophy in hypertensive patients and its clinical significance","volume":"139","author":"Cao","year":"2018","journal-title":"Cardiology"},{"key":"10.1016\/j.jbc.2021.101515_bib22","first-page":"1145","article-title":"Proteolysis by endogenous calpain I leads to the activation of calcineurin in human heart","volume":"58","author":"Wang","year":"2012","journal-title":"Clin. Lab."},{"key":"10.1016\/j.jbc.2021.101515_bib23","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1161\/01.CIR.0000156458.80515.F7","article-title":"Targeted proteolysis sustains calcineurin activation","volume":"111","author":"Burkard","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jbc.2021.101515_bib24","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0092-8674(00)81573-1","article-title":"A\u00a0calcineurin-dependent transcriptional pathway for cardiac hypertrophy","volume":"93","author":"Molkentin","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2021.101515_bib25","doi-asserted-by":"crossref","first-page":"H425","DOI":"10.1152\/ajpheart.00546.2002","article-title":"Time-dependent systolic and diastolic function in mice overexpressing calcineurin","volume":"284","author":"Semeniuk","year":"2003","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.jbc.2021.101515_bib26","doi-asserted-by":"crossref","first-page":"22295","DOI":"10.1074\/jbc.M801296200","article-title":"NFATc2 is a necessary mediator of calcineurin-dependent cardiac hypertrophy and heart failure","volume":"283","author":"Bourajjaj","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.101515_bib27","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/1440-1681.12318","article-title":"Novel mouse model of left ventricular pressure overload and infarction causing predictable ventricular remodelling and progression to heart failure","volume":"42","author":"Weinheimer","year":"2015","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.jbc.2021.101515_bib28","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0008-6363(02)00661-2","article-title":"Overexpression of calcineurin in mouse causes sudden cardiac death associated with decreased density of K+ channels","volume":"57","author":"Dong","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jbc.2021.101515_bib29","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1161\/CIRCEP.108.789081","article-title":"Cardiac ion channels","volume":"2","author":"Grant","year":"2009","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"10.1016\/j.jbc.2021.101515_bib30","series-title":"Cardiac Electrophysiology: From Cell to Bedside","first-page":"25","article-title":"Voltage-gated potassium channels","author":"Outdit","year":"2018"},{"key":"10.1016\/j.jbc.2021.101515_bib31","series-title":"Cardiac Electrophysiology","first-page":"12","article-title":"Voltage-gated calcium channels","author":"Kushnir","year":"2018"},{"key":"10.1016\/j.jbc.2021.101515_bib32","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1194\/jlr.M044784","article-title":"Fibroblast growth factor 21 is induced upon cardiac stress and alters cardiac lipid homeostasis","volume":"55","author":"Brahma","year":"2014","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.jbc.2021.101515_bib33","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1038\/ncomms3019","article-title":"Fibroblast growth factor 21 protects against cardiac hypertrophy in mice","volume":"4","author":"Planavila","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2021.101515_bib34","doi-asserted-by":"crossref","first-page":"539","DOI":"10.3389\/fphys.2020.00539","article-title":"The histone demethylase JMJD1C regulates CAMKK2-AMPK signaling to participate in cardiac hypertrophy","volume":"11","author":"Yu","year":"2020","journal-title":"Front Physiol."},{"key":"10.1016\/j.jbc.2021.101515_bib35","doi-asserted-by":"crossref","first-page":"3870","DOI":"10.1172\/JCI34472","article-title":"An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice","volume":"118","author":"Sheikh","year":"2008","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.jbc.2021.101515_bib36","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1038\/ncomms3035","article-title":"A\u00a0small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth","volume":"4","author":"Wang","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2021.101515_bib37","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.celrep.2018.09.081","article-title":"Jumonji inhibitors overcome radioresistance in cancer through changes in H3K4 methylation at double-strand breaks","volume":"25","author":"Bayo","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2021.101515_bib38","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1016\/j.celrep.2017.04.077","article-title":"Taxane-platin-resistant lung cancers co-develop hypersensitivity to JumonjiC demethylase inhibitors","volume":"19","author":"Dalvi","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2021.101515_bib39","doi-asserted-by":"crossref","first-page":"18481","DOI":"10.1073\/pnas.1013555107","article-title":"Constitutively active calcineurin induces cardiac endoplasmic reticulum stress and protects against apoptosis that is mediated by alpha-crystallin-B","volume":"107","author":"Bousette","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.101515_bib40","doi-asserted-by":"crossref","first-page":"e0184724","DOI":"10.1371\/journal.pone.0184724","article-title":"The cardiac calsequestrin gene transcription is modulated at the promoter by NFAT and MEF-2 transcription factors","volume":"12","author":"Estrada-Aviles","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2021.101515_bib41","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1161\/CIRCGENETICS.108.816686","article-title":"Evidence for coregulation of myocardial gene expression by MEF2 and NFAT in human heart failure","volume":"2","author":"Putt","year":"2009","journal-title":"Circ. Cardiovasc. Genet."},{"key":"10.1016\/j.jbc.2021.101515_bib42","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1146\/annurev.immunol.15.1.707","article-title":"Transcription factors of the NFAT family: Regulation and function","volume":"15","author":"Rao","year":"1997","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jbc.2021.101515_bib43","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1128\/MCB.00864-13","article-title":"The demethylase JMJD2C localizes to H3K4me3-positive transcription start sites and is dispensable for embryonic development","volume":"34","author":"Pedersen","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jbc.2021.101515_bib44","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1161\/CIRCULATIONAHA.111.040352","article-title":"Epithelial-to-mesenchymal and endothelial-to-mesenchymal transition: From cardiovascular development to disease","volume":"125","author":"Kovacic","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jbc.2021.101515_bib45","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jacc.2018.09.089","article-title":"Endothelial to mesenchymal transition in cardiovascular disease: JACC state-of-the-art review","volume":"73","author":"Kovacic","year":"2019","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.jbc.2021.101515_bib46","doi-asserted-by":"crossref","first-page":"43625","DOI":"10.1074\/jbc.M408391200","article-title":"E2F-1 regulates the expression of a subset of target genes during skeletal myoblast hypertrophy","volume":"279","author":"Hlaing","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.101515_bib47","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1161\/CIRCRESAHA.114.302022","article-title":"Mammalian target of rapamycin signaling in cardiac physiology and disease","volume":"114","author":"Sciarretta","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.jbc.2021.101515_bib48","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1536\/ihj.20-439","article-title":"Identification of SLED1 as a potential predictive biomarker and therapeutic target of post-infarct heart failure by bioinformatics analyses","volume":"62","author":"Zhang","year":"2021","journal-title":"Int. Heart J."},{"key":"10.1016\/j.jbc.2021.101515_bib49","doi-asserted-by":"crossref","first-page":"114597","DOI":"10.1016\/j.bcp.2021.114597","article-title":"Pharmacological inhibition of GLUT1 as a new immunotherapeutic approach after myocardial infarction","volume":"190","author":"Chen","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jbc.2021.101515_bib50","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1016\/j.jacc.2021.02.057","article-title":"Therapeutic manipulation of myocardial metabolism: JACC state-of-the-art review","volume":"77","author":"Honka","year":"2021","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.jbc.2021.101515_bib51","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1097\/HJH.0000000000002456","article-title":"Adaptive immune disorders in hypertension and heart failure: Focusing on T-cell subset activation and clinical implications","volume":"38","author":"Rai","year":"2020","journal-title":"J.\u00a0Hypertens."},{"key":"10.1016\/j.jbc.2021.101515_bib52","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1161\/CIRCULATIONAHA.118.036065","article-title":"Dysfunctional and proinflammatory regulatory T-lymphocytes are essential for adverse cardiac remodeling in ischemic cardiomyopathy","volume":"139","author":"Bansal","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.jbc.2021.101515_bib53","first-page":"5063","article-title":"Systemic inflammation is associated with myocardial fibrosis, diastolic dysfunction, and cardiac hypertrophy in patients with hypertrophic cardiomyopathy","volume":"9","author":"Fang","year":"2017","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.jbc.2021.101515_bib56","doi-asserted-by":"crossref","first-page":"e015690","DOI":"10.1161\/JAHA.119.015690","article-title":"Identification of genes and pathways regulated by lamin A in heart","volume":"9","author":"Coste Pradas","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.jbc.2021.101515_bib57","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1038\/s41598-019-39445-2","article-title":"Transcriptomics of cardiac biopsies reveals differences in patients with or without diagnostic parameters for heart failure with preserved ejection fraction","volume":"9","author":"Das","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2021.101515_bib54","doi-asserted-by":"crossref","DOI":"10.1002\/0471142727.mb1508s73","article-title":"High-throughput real-time quantitative reverse transcription PCR","author":"Bookout","year":"2006","journal-title":"Curr. Protoc. Mol. Biol."},{"key":"10.1016\/j.jbc.2021.101515_bib55","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1186\/1471-2164-9-488","article-title":"BioVenn - A web application for the comparison and visualization of biological lists using area-proportional Venn diagrams","volume":"9","author":"Hulsen","year":"2008","journal-title":"BMC Genomics"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925821013259?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925821013259?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:09:51Z","timestamp":1758240591000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925821013259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":57,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["S0021925821013259"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2021.101515","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of Jumonji demethylases reprograms severe dilated cardiomyopathy and prolongs survival","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2021.101515","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"101515"}}