{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:49:14Z","timestamp":1772120954011,"version":"3.50.1"},"reference-count":58,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 HL094505"],"award-info":[{"award-number":["RO1 HL094505"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL148333"],"award-info":[{"award-number":["R01 HL148333"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016935","name":"Lisa Dean Moseley Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016935","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017065","name":"University of Michigan Rogel Cancer Center","doi-asserted-by":"publisher","award":["P30CA046592"],"award-info":[{"award-number":["P30CA046592"]}],"id":[{"id":"10.13039\/100017065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860430"],"award-info":[{"award-number":["81860430"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.jbc.2021.101536","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T20:41:14Z","timestamp":1640292074000},"page":"101536","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["A common human missense mutation of vesicle coat protein SEC23B leads to growth restriction and chronic pancreatitis in mice"],"prefix":"10.1016","volume":"298","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4391-6636","authenticated-orcid":false,"given":"Wei","family":"Wei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhigang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rami","family":"Khoriaty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2021.101536_bib1","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nrm2025","article-title":"The COPII cage: Unifying principles of vesicle coat assembly","volume":"7","author":"Gurkan","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2021.101536_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/jcs.069773","article-title":"COPII-mediated vesicle formation at a glance","volume":"124","author":"Jensen","year":"2011","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.jbc.2021.101536_bib3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1146\/annurev.cellbio.20.010403.105307","article-title":"Bi-directional protein transport between the ER and Golgi","volume":"20","author":"Lee","year":"2004","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.jbc.2021.101536_bib4","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/ncb2390","article-title":"COPII and the regulation of protein sorting in mammals","volume":"14","author":"Zanetti","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jbc.2021.101536_bib5","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/nrm3588","article-title":"Organization of the ER-Golgi interface for membrane traffic control","volume":"14","author":"Brandizzi","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2021.101536_bib6","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1016\/j.bbamcr.2013.02.003","article-title":"Vesicle-mediated export from the ER: COPII coat function and regulation","volume":"1833","author":"D'Arcangelo","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbc.2021.101536_bib7","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.semcdb.2007.06.007","article-title":"Molecular mechanisms of COPII vesicle formation","volume":"18","author":"Lee","year":"2007","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.jbc.2021.101536_bib8","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0092-8674(03)00609-3","article-title":"Multiple cargo binding sites on the COPII subunit Sec24p ensure capture of diverse membrane proteins into transport vesicles","volume":"114","author":"Miller","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2021.101536_bib9","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.devcel.2007.10.006","article-title":"Insights into COPII coat nucleation from the structure of Sec23.Sar1 complexed with the active fragment of Sec31","volume":"13","author":"Bi","year":"2007","journal-title":"Dev. Cell"},{"key":"10.1016\/j.jbc.2021.101536_bib10","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/nature04339","article-title":"Structure of the Sec13\/31 COPII coat cage","volume":"439","author":"Stagg","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2021.101536_bib11","doi-asserted-by":"crossref","first-page":"10704","DOI":"10.1073\/pnas.191359398","article-title":"Structure of the Sec23p\/24p and Sec13p\/31p complexes of COPII","volume":"98","author":"Lederkremer","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.\u00a0S. A."},{"key":"10.1016\/j.jbc.2021.101536_bib12","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.cell.2007.05.036","article-title":"Structure and organization of coat proteins in the COPII cage","volume":"129","author":"Fath","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2021.101536_bib13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0092-8674(03)01079-1","article-title":"The mechanisms of vesicle budding and fusion","volume":"116","author":"Bonifacino","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2021.101536_bib14","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1399-0004.2010.01550.x","article-title":"Cranio-lenticulo-sutural dysplasia associated with defects in collagen secretion","volume":"80","author":"Boyadjiev","year":"2010","journal-title":"Clin. Genet."},{"key":"10.1016\/j.jbc.2021.101536_bib15","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1038\/ng1876","article-title":"Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking","volume":"38","author":"Boyadjiev","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbc.2021.101536_bib16","doi-asserted-by":"crossref","first-page":"15471","DOI":"10.1038\/srep15471","article-title":"Neural tube opening and abnormal extraembryonic membrane development in SEC23A deficient mice","volume":"5","author":"Zhu","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2021.101536_bib17","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/ng.405","article-title":"Mutations affecting the secretory COPII coat component SEC23B cause congenital dyserythropoietic anemia type II","volume":"41","author":"Schwarz","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbc.2021.101536_bib18","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1002\/humu.21077","article-title":"Congenital dyserythropoietic anemia type II (CDAII) is caused by mutations in the SEC23B gene","volume":"30","author":"Bianchi","year":"2009","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.jbc.2021.101536_bib19","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.1182\/blood-2003-02-0613","article-title":"Congenital dyserythropoietic anemia type II: Epidemiology, clinical appearance, and prognosis based on long-term observation","volume":"102","author":"Heimpel","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.jbc.2021.101536_bib20","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1182\/blood.2019000948","article-title":"Congenital dyserythropoietic anemias","volume":"136","author":"Iolascon","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.jbc.2021.101536_bib21","doi-asserted-by":"crossref","first-page":"E169","DOI":"10.1002\/ajh.23800","article-title":"Retrospective cohort study of 205 cases with congenital dyserythropoietic anemia type II: Definition of clinical and molecular spectrum and identification of new diagnostic scores","volume":"89","author":"Russo","year":"2014","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.jbc.2021.101536_bib22","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/ajh.22096","article-title":"Two founder mutations in the SEC23B gene account for the relatively high frequency of CDA II in the Italian population","volume":"86","author":"Russo","year":"2011","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.jbc.2021.101536_bib23","doi-asserted-by":"crossref","first-page":"708","DOI":"10.3324\/haematol.2009.014985","article-title":"Molecular analysis of 42 patients with congenital dyserythropoietic anemia type II: New mutations in the SEC23B gene and a search for a genotype-phenotype relationship","volume":"95","author":"Iolascon","year":"2010","journal-title":"Haematologica"},{"key":"10.1016\/j.jbc.2021.101536_bib24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.bcmd.2013.02.003","article-title":"Hypomorphic mutations of SEC23B gene account for mild phenotypes of congenital dyserythropoietic anemia type II","volume":"51","author":"Russo","year":"2013","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.jbc.2021.101536_bib25","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.ajhg.2015.10.001","article-title":"Germline heterozygous variants in SEC23B are associated with Cowden syndrome and enriched in apparently sporadic thyroid cancer","volume":"97","author":"Yehia","year":"2015","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jbc.2021.101536_bib26","doi-asserted-by":"crossref","first-page":"E2001","DOI":"10.1073\/pnas.1209207109","article-title":"SEC23B is required for the maintenance of murine professional secretory tissues","volume":"109","author":"Tao","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.101536_bib27","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1091\/mbc.e17-01-0001","article-title":"SEC23B is required for pancreatic acinar cell function in adult mice","volume":"28","author":"Khoriaty","year":"2017","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.jbc.2021.101536_bib28","doi-asserted-by":"crossref","first-page":"27802","DOI":"10.1038\/srep27802","article-title":"Pancreatic SEC23B deficiency is sufficient to explain the perinatal lethality of germline SEC23B deficiency in mice","volume":"6","author":"Khoriaty","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2021.101536_bib29","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.1128\/MCB.00287-14","article-title":"Absence of a red blood cell phenotype in mice with hematopoietic deficiency of SEC23B","volume":"34","author":"Khoriaty","year":"2014","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2021.101536_bib30","doi-asserted-by":"crossref","first-page":"E7748","DOI":"10.1073\/pnas.1805784115","article-title":"Functions of the COPII gene paralogs SEC23A and SEC23B are interchangeable in\u00a0vivo","volume":"115","author":"Khoriaty","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.101536_bib31","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1034\/j.1600-0854.2001.21112.x","article-title":"The ER to Golgi interface is the major concentration site of secretory proteins in the exocrine pancreatic cell","volume":"2","author":"Oprins","year":"2001","journal-title":"Traffic"},{"key":"10.1016\/j.jbc.2021.101536_bib32","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.3324\/haematol.2013.085522","article-title":"Characteristic phenotypes associated with congenital dyserythropoietic anemia (type II) manifest at different stages of erythropoiesis","volume":"98","author":"Satchwell","year":"2013","journal-title":"Haematologica"},{"key":"10.1016\/j.jbc.2021.101536_bib33","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1136\/gut.2009.198903","article-title":"Pancreatitis-associated chymotrypsinogen C (CTRC) mutant elicits endoplasmic reticulum stress in pancreatic acinar cells","volume":"59","author":"Szmola","year":"2010","journal-title":"Gut"},{"key":"10.1016\/j.jbc.2021.101536_bib34","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/humu.20853","article-title":"Hereditary pancreatitis caused by mutation-induced misfolding of human cationic trypsinogen: A novel disease mechanism","volume":"30","author":"Kereszturi","year":"2009","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.jbc.2021.101536_bib35","doi-asserted-by":"crossref","first-page":"27551","DOI":"10.1074\/jbc.M113.528174","article-title":"Endoplasmic reticulum stress is chronically activated in chronic pancreatitis","volume":"289","author":"Sah","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.101536_bib36","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/ng.2730","article-title":"Variants in CPA1 are strongly associated with early onset chronic pancreatitis","volume":"45","author":"Witt","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbc.2021.101536_bib37","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/76088","article-title":"Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis","volume":"25","author":"Witt","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbc.2021.101536_bib38","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41586-018-0088-0","article-title":"Pancreas regeneration","volume":"557","author":"Zhou","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2021.101536_bib39","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1210\/me.2005-0170","article-title":"Negative regulation of growth hormone receptor signaling","volume":"20","author":"Flores-Morales","year":"2006","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.jbc.2021.101536_bib40","doi-asserted-by":"crossref","first-page":"C1906","DOI":"10.1152\/ajpcell.2000.279.6.C1906","article-title":"Inhibition of growth hormone action in models of inflammation","volume":"279","author":"Bergad","year":"2000","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.jbc.2021.101536_bib41","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.4158\/EP15939.RA","article-title":"Lessons from 50 years of study of Laron syndrome","volume":"21","author":"Laron","year":"2015","journal-title":"Endocr. Pract."},{"key":"10.1016\/j.jbc.2021.101536_bib42","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ghir.2015.08.004","article-title":"Fifty seven years of follow-up of the Israeli cohort of Laron syndrome patients-from discovery to treatment","volume":"28","author":"Laron","year":"2016","journal-title":"Growth Horm. IGF Res."},{"key":"10.1016\/j.jbc.2021.101536_bib43","doi-asserted-by":"crossref","first-page":"19937","DOI":"10.1074\/jbc.M109.014308","article-title":"Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism","volume":"284","author":"Fan","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.101536_bib44","doi-asserted-by":"crossref","first-page":"G646","DOI":"10.1152\/ajpgi.00178.2002","article-title":"Interleukin-6 inhibits hepatic growth hormone signaling via upregulation of Cis and Socs-3","volume":"284","author":"Denson","year":"2003","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.jbc.2021.101536_bib45","first-page":"E565","article-title":"GH insensitivity induced by endotoxin injection is associated with decreased liver GH receptors","volume":"276","author":"Defalque","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.jbc.2021.101536_bib46","first-page":"R371","article-title":"Acute alterations in growth hormone-insulin-like growth factor axis in humans injected with endotoxin","volume":"273","author":"Lang","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.jbc.2021.101536_bib47","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1210\/me.2007-0561","article-title":"Endotoxin-induced proteolytic reduction in hepatic growth hormone (GH) receptor: A novel mechanism for GH insensitivity","volume":"22","author":"Wang","year":"2008","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.jbc.2021.101536_bib48","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1172\/JCI119207","article-title":"Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. A model for stunted growth in children with chronic inflammation","volume":"99","author":"De Benedetti","year":"1997","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.jbc.2021.101536_bib49","doi-asserted-by":"crossref","first-page":"E186","DOI":"10.1152\/ajpendo.00652.2013","article-title":"Distinct mechanisms of induction of hepatic growth hormone resistance by endogenous IL-6, TNF-alpha, and IL-1beta","volume":"307","author":"Zhao","year":"2014","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.jbc.2021.101536_bib50","doi-asserted-by":"crossref","first-page":"531","DOI":"10.3748\/wjg.v8.i3.531","article-title":"The role of endotoxin, TNF-alpha, and IL-6 in inducing the state of growth hormone insensitivity","volume":"8","author":"Wang","year":"2002","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jbc.2021.101536_bib51","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1359\/JBMR.040805","article-title":"Interleukin-1beta and TNF-alpha act in synergy to inhibit longitudinal growth in fetal rat metatarsal bones","volume":"19","author":"Martensson","year":"2004","journal-title":"J.\u00a0Bone Miner. Res."},{"key":"10.1016\/j.jbc.2021.101536_bib52","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3389\/fimmu.2014.00058","article-title":"SOCS3, a major regulator of infection and inflammation","volume":"5","author":"Carow","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jbc.2021.101536_bib53","doi-asserted-by":"crossref","first-page":"35553","DOI":"10.1074\/jbc.274.50.35553","article-title":"SOCS\/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms","volume":"274","author":"Ram","year":"1999","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2021.101536_bib54","doi-asserted-by":"crossref","first-page":"6378","DOI":"10.1210\/en.2007-1574","article-title":"Nuclear factor-kappaB mediates the inhibitory effects of tumor necrosis factor-alpha on growth hormone-inducible gene expression in liver","volume":"149","author":"Buzzelli","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.jbc.2021.101536_bib55","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1172\/JCI10994","article-title":"TNF-alpha downregulates murine hepatic growth hormone receptor expression by inhibiting Sp1 and Sp3 binding","volume":"107","author":"Denson","year":"2001","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.jbc.2021.101536_bib56","doi-asserted-by":"crossref","first-page":"15052","DOI":"10.1073\/pnas.0808097105","article-title":"Pancreatic exocrine insufficiency in LXRbeta-\/- mice is associated with a reduction in aquaporin-1 expression","volume":"105","author":"Gabbi","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2021.101536_bib57","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1042\/BCJ20170884","article-title":"Molecular mechanisms of missense mutations that generate ectopic N-glycosylation sites in coagulation factor VIII","volume":"475","author":"Wei","year":"2018","journal-title":"Biochem. J."},{"key":"10.1016\/j.jbc.2021.101536_bib58","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1182\/blood-2011-05-352815","article-title":"Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of alpha1-antitrypsin","volume":"118","author":"Zhang","year":"2011","journal-title":"Blood"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925821013466?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925821013466?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:14:59Z","timestamp":1758240899000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925821013466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S0021925821013466"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2021.101536","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.05.10.443273","asserted-by":"object"}]},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A common human missense mutation of vesicle coat protein SEC23B leads to growth restriction and chronic pancreatitis in mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2021.101536","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"101536"}}