{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:08:09Z","timestamp":1791526089837,"version":"4.3.4"},"reference-count":67,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001459","name":"Government of Singapore Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001352","name":"National University of Singapore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001352","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009539","name":"Life Sciences Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009539","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001350","name":"Government of Singapore Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001350","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001381","name":"National Research Foundation of Singapore","doi-asserted-by":"publisher","award":["NRF-NRFI2017-05"],"award-info":[{"award-number":["NRF-NRFI2017-05"]}],"id":[{"id":"10.13039\/501100001381","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001381","name":"National Research Foundation of Singapore","doi-asserted-by":"publisher","award":["NRF2017_SISFP08"],"award-info":[{"award-number":["NRF2017_SISFP08"]}],"id":[{"id":"10.13039\/501100001381","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.jbc.2022.101709","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T20:56:05Z","timestamp":1644440165000},"page":"101709","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["The lipid transporter Mfsd2a maintains pulmonary surfactant homeostasis"],"prefix":"10.1016","volume":"298","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8981-1376","authenticated-orcid":false,"given":"Bernice H.","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9763-0652","authenticated-orcid":false,"given":"Geok Lin","family":"Chua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dwight L.","family":"Galam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus R.","family":"Wenk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Torta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7289-9890","authenticated-orcid":false,"given":"David L.","family":"Silver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2022.101709_bib1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1164\/ajrccm.163.1.9903029","article-title":"Alteration of fatty acid profiles in different pulmonary surfactant phospholipids in acute respiratory distress syndrome and severe pneumonia","volume":"163","author":"Schmidt","year":"2001","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jbc.2022.101709_bib2","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1034\/j.1399-3003.1999.14c14.x","article-title":"Surfactant abnormalities in idiopathic pulmonary fibrosis, hypersensitivity pneumonitis and sarcoidosis","volume":"14","author":"Gunther","year":"1999","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jbc.2022.101709_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0228279","article-title":"Decreased surfactant lipids correlate with lung function in chronic obstructive pulmonary disease (COPD)","volume":"15","author":"Agudelo","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2022.101709_bib4","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/s41580-019-0141-3","article-title":"Cellular crosstalk in the development and regeneration of the respiratory system","volume":"20","author":"Zepp","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2022.101709_bib5","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1016\/j.bbamem.2008.05.003","article-title":"Structure of pulmonary surfactant membranes and films: The role of proteins and lipid-protein interactions","volume":"1778","author":"P\u00e9rez-Gil","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbc.2022.101709_bib6","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1056\/NEJMra022387","article-title":"Hydrophobic surfactant proteins in lung function and disease","volume":"347","author":"Whitsett","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jbc.2022.101709_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0203464","article-title":"Quantitative lipidomic analysis of mouse lung during postnatal development by electrospray ionization tandem mass spectrometry","volume":"13","author":"Karnati","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2022.101709_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0117985","article-title":"Surfactant lipidomics in healthy children and childhood interstitial lung disease","volume":"10","author":"Griese","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2022.101709_bib9","doi-asserted-by":"crossref","first-page":"9628","DOI":"10.1074\/jbc.M611767200","article-title":"ABCA3 as a lipid transporter in pulmonary surfactant biogenesis","volume":"282","author":"Ban","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2022.101709_bib10","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0014-5793(01)03056-3","article-title":"ABCA3 is a lamellar body membrane protein in human lung alveolar type II cells","volume":"508","author":"Yamano","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jbc.2022.101709_bib11","first-page":"L472","article-title":"Phagocytosis of surfactant by alveolar macrophages in vitro","volume":"261","author":"Grabner","year":"1991","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.jbc.2022.101709_bib12","first-page":"OL639","article-title":"Interactions between pulmonary surfactant and alveolar macrophages in the pathogenesis of lung disease","volume":"50 Online Pub","author":"Yoshida","year":"2004","journal-title":"Cell Mol. Biol. (Noisy-le-grand)"},{"key":"10.1016\/j.jbc.2022.101709_bib13","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1164\/rccm.200401-089OC","article-title":"Mass spectrometric analysis of surfactant metabolism in human volunteers using deuteriated choline","volume":"170","author":"Bernhard","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jbc.2022.101709_bib14","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1016\/S0021-9258(18)32599-7","article-title":"The significance of reutilization of surfactant phosphatidylcholine","volume":"258","author":"Jacobs","year":"1983","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2022.101709_bib15","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1172\/JCI38061","article-title":"LPCAT1 regulates surfactant phospholipid synthesis and is required for transitioning to air breathing in mice","volume":"120","author":"Bridges","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jbc.2022.101709_bib16","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.cmet.2014.05.019","article-title":"Lysophospholipid acyltransferases mediate phosphatidylcholine diversification to achieve the physical properties required in vivo","volume":"20","author":"Harayama","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbc.2022.101709_bib17","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1152\/jappl.1988.64.5.2017","article-title":"Recycling of surfactant in black and beige mice: Pool sizes and kinetics","volume":"64","author":"Gross","year":"1988","journal-title":"J. Appl. Physiol. (1985)"},{"key":"10.1016\/j.jbc.2022.101709_bib18","first-page":"L1","article-title":"Clearance and recycling of pulmonary surfactant","volume":"259","author":"Wright","year":"1990","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.jbc.2022.101709_bib19","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.97381","article-title":"Alveolar injury and regeneration following deletion of ABCA3","volume":"2","author":"Rindler","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.jbc.2022.101709_bib20","doi-asserted-by":"crossref","first-page":"L543","DOI":"10.1152\/ajplung.00011.2003","article-title":"SP-B deficiency causes respiratory failure in adult mice","volume":"285","author":"Melton","year":"2003","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.jbc.2022.101709_bib21","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1128\/MCB.01512-06","article-title":"Role of phosphocholine cytidylyltransferase alpha in lung development","volume":"27","author":"Tian","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jbc.2022.101709_bib22","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nature13241","article-title":"Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid","volume":"509","author":"Nguyen","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2022.101709_bib23","doi-asserted-by":"crossref","first-page":"10501","DOI":"10.1074\/jbc.M116.721340","article-title":"Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid (DHA) in eye and is important for photoreceptor cell development","volume":"291","author":"Wong","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2022.101709_bib24","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1042\/bj2530693","article-title":"Albumin stimulates the release of lysophosphatidylcholine from cultured rat hepatocytes","volume":"253","author":"Baisted","year":"1988","journal-title":"Biochem. J."},{"key":"10.1016\/j.jbc.2022.101709_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2006443","article-title":"The lysolipid transporter Mfsd2a regulates lipogenesis in the developing brain","volume":"16","author":"Chan","year":"2018","journal-title":"PLoS Biol."},{"key":"10.1016\/j.jbc.2022.101709_bib26","doi-asserted-by":"crossref","first-page":"9689","DOI":"10.1523\/JNEUROSCI.1142-19.2019","article-title":"Disrupted blood-retina lysophosphatidylcholine transport impairs photoreceptor health but not visual signal transduction","volume":"39","author":"Lobanova","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jbc.2022.101709_bib27","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.neuron.2017.03.043","article-title":"Blood-brain barrier permeability is regulated by lipid transport-dependent suppression of caveolae-mediated transcytosis","volume":"94","author":"Andreone","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.jbc.2022.101709_bib28","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/ng.3311","article-title":"Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome","volume":"47","author":"Guemez-Gamboa","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbc.2022.101709_bib29","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/ng.3313","article-title":"A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome","volume":"47","author":"Alakbarzade","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbc.2022.101709_bib30","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s10048-018-0556-6","article-title":"Homozygous mutation in MFSD2A, encoding a lysolipid transporter for docosahexanoic acid, is associated with microcephaly and hypomyelination","volume":"19","author":"Harel","year":"2018","journal-title":"Neurogenetics"},{"key":"10.1016\/j.jbc.2022.101709_bib31","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1038\/s41431-020-0669-x","article-title":"Biallelic MFSD2A variants associated with congenital microcephaly, developmental delay, and recognizable neuroimaging features","volume":"28","author":"Scala","year":"2020","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.jbc.2022.101709_bib32","doi-asserted-by":"crossref","first-page":"9383","DOI":"10.1074\/jbc.M116.721035","article-title":"Structural insights into the transport mechanism of the human sodium-dependent lysophosphatidylcholine transporter Mfsd2a","volume":"291","author":"Quek","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2022.101709_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0050629","article-title":"Major facilitator superfamily domain-containing protein 2a (MFSD2A) has roles in body growth, motor function, and lipid metabolism","volume":"7","author":"Berger","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2022.101709_bib34","doi-asserted-by":"crossref","first-page":"117","DOI":"10.4049\/jimmunol.1801585","article-title":"The lysophosphatidylcholine transporter MFSD2A is essential for CD8(+) memory T cell maintenance and secondary response to infection","volume":"203","author":"Piccirillo","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.jbc.2022.101709_bib35","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1161\/CIRCRESAHA.120.317473","article-title":"Single-cell analysis of blood-brain barrier response to pericyte loss","volume":"128","author":"Mae","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.jbc.2022.101709_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba1983","article-title":"Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis","volume":"6","author":"Adams","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jbc.2022.101709_bib37","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aba1972","article-title":"Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis","volume":"6","author":"Habermann","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jbc.2022.101709_bib38","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.131597","article-title":"Transcriptional regulatory model of fibrosis progression in the human lung","volume":"4","author":"McDonough","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.jbc.2022.101709_bib39","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1165\/rcmb.2020-0095MA","article-title":"Single-nucleus RNA-sequencing profiling of mouse lung. Reduced dissociation bias and improved rare cell-type detection compared with single-cell RNA sequencing","volume":"63","author":"Koenitzer","year":"2020","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.jbc.2022.101709_bib40","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41586-021-03650-9","article-title":"Structural basis of omega-3 fatty acid transport across the blood-brain barrier","volume":"595","author":"Cater","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2022.101709_bib41","doi-asserted-by":"crossref","first-page":"E1475","DOI":"10.1073\/pnas.1117988108","article-title":"Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition","volume":"108","author":"Rock","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2022.101709_bib42","doi-asserted-by":"crossref","first-page":"6366","DOI":"10.1073\/pnas.101500298","article-title":"Altered stability of pulmonary surfactant in SP-C-deficient mice","volume":"98","author":"Glasser","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2022.101709_bib43","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1172\/JCI3236","article-title":"Generation of lyso-phospholipids from surfactant in acute lung injury is mediated by type-II phospholipase A2 and inhibited by a direct surfactant protein A-phospholipase A2 protein interaction","volume":"102","author":"Arbibe","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jbc.2022.101709_bib44","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1194\/jlr.M085431","article-title":"Metabolism of a synthetic compared with a natural therapeutic pulmonary surfactant in adult mice","volume":"59","author":"Madsen","year":"2018","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jbc.2022.101709_bib45","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1203\/00006450-197504000-00011","article-title":"Lamb fetal pulmonary fluid. II. Fate of phosphatidylcholine","volume":"9","author":"Scarpelli","year":"1975","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.jbc.2022.101709_bib46","first-page":"709","article-title":"Ventilation enhances pulmonary alveolar clearance of radioactive dipalmitoyl phosphatidylcholine in liposomes","volume":"121","author":"Oyarzun","year":"1980","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.jbc.2022.101709_bib47","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0005-2760(93)90105-I","article-title":"Synthesis of phosphatidylcholine in Guinea-pig fetal lung involves acyl remodelling and differential turnover of individual molecular species","volume":"1166","author":"Burdge","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbc.2022.101709_bib48","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/0005-2760(83)90205-9","article-title":"Mechanisms involved in the synthesis of disaturated phosphatidylcholine by alveolar type II cells isolated from adult rat lung","volume":"750","author":"Post","year":"1983","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbc.2022.101709_bib49","first-page":"E187","article-title":"Lung surfactant kinetics in conscious pigs","volume":"277","author":"Martini","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.jbc.2022.101709_bib50","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1172\/JCI110310","article-title":"Analysis of labeling and clearance of lung surfactant phospholipids in rabbit. Evidence of bidirectional surfactant flux between lamellar bodies and alveolar lavage","volume":"68","author":"Hallman","year":"1981","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jbc.2022.101709_bib51","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1073\/pnas.0909361107","article-title":"Pulmonary surfactant phosphatidylglycerol inhibits respiratory syncytial virus-induced inflammation and infection","volume":"107","author":"Numata","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2022.101709_bib52","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1165\/rcmb.2011-0194OC","article-title":"Phosphatidylglycerol suppresses influenza A virus infection","volume":"46","author":"Numata","year":"2012","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.jbc.2022.101709_bib53","first-page":"1417","article-title":"Nanodiscs as a therapeutic delivery agent: Inhibition of respiratory syncytial virus infection in the lung","volume":"8","author":"Numata","year":"2013","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jbc.2022.101709_bib54","doi-asserted-by":"crossref","first-page":"25488","DOI":"10.1074\/jbc.M109.040832","article-title":"Anionic pulmonary surfactant phospholipids inhibit inflammatory responses from alveolar macrophages and U937 cells by binding the lipopolysaccharide-interacting proteins CD14 and MD-2","volume":"284","author":"Kuronuma","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2022.101709_bib55","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1194\/jlr.M055723","article-title":"Phosphatidylinositol inhibits respiratory syncytial virus infection","volume":"56","author":"Numata","year":"2015","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jbc.2022.101709_bib56","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1194\/jlr.M065201","article-title":"Structural analogs of pulmonary surfactant phosphatidylglycerol inhibit toll-like receptor 2 and 4 signaling","volume":"57","author":"Kandasamy","year":"2016","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jbc.2022.101709_bib57","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0378-1119(00)00006-8","article-title":"Molecular structure and tissue-specific expression of the mouse pancreatic phospholipase A(2) gene","volume":"244","author":"Richmond","year":"2000","journal-title":"Gene"},{"key":"10.1016\/j.jbc.2022.101709_bib58","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1164\/rccm.200707-1088OC","article-title":"Secreted phospholipase A2 group X overexpression in asthma and bronchial hyperresponsiveness","volume":"176","author":"Hallstrand","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jbc.2022.101709_bib59","doi-asserted-by":"crossref","first-page":"L879","DOI":"10.1152\/ajplung.90580.2008","article-title":"Secretory group V phospholipase A2 regulates acute lung injury and neutrophilic inflammation caused by LPS in mice","volume":"296","author":"Munoz","year":"2009","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.jbc.2022.101709_bib60","doi-asserted-by":"crossref","first-page":"E516","DOI":"10.1073\/pnas.1424651112","article-title":"Membranes serve as allosteric activators of phospholipase A2, enabling it to extract, bind, and hydrolyze phospholipid substrates","volume":"112","author":"Mouchlis","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2022.101709_bib61","doi-asserted-by":"crossref","first-page":"18711","DOI":"10.1074\/jbc.270.32.18711","article-title":"Lipid signaling enzymes and surface dilution kinetics","volume":"270","author":"Carman","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2022.101709_bib62","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1146\/annurev.bi.64.070195.003253","article-title":"Interfacial enzymology of glycerolipid hydrolases: Lessons from secreted phospholipases A2","volume":"64","author":"Gelb","year":"1995","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.jbc.2022.101709_bib63","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nn.2467","article-title":"A robust and high-throughput Cre reporting and characterization system for the whole mouse brain","volume":"13","author":"Madisen","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jbc.2022.101709_bib67","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis.","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jbc.2022.101709_bib64","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.2013","article-title":"Isolation of highly pure primary mouse alveolar epithelial type II cells by flow cytometric cell sorting","volume":"6","author":"Sinha","year":"2016","journal-title":"Bio Protoc."},{"key":"10.1016\/j.jbc.2022.101709_bib65","doi-asserted-by":"crossref","DOI":"10.3791\/1941","article-title":"Direct tracheal instillation of solutes into mouse lung","author":"Helms","year":"2010","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.jbc.2022.101709_bib66","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3390\/metabo9040080","article-title":"Surfactant lipidomics of alveolar lavage fluid in mice based on ultra-high-performance liquid chromatography coupled to hybrid quadrupole-exactive orbitrap mass spectrometry","volume":"9","author":"Yang","year":"2019","journal-title":"Metabolites"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925822001491?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925822001491?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T21:44:21Z","timestamp":1777412661000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925822001491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":67,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S0021925822001491"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2022.101709","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The lipid transporter Mfsd2a maintains pulmonary surfactant homeostasis","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2022.101709","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"101709"}}