{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T02:49:53Z","timestamp":1783392593812,"version":"3.54.6"},"reference-count":42,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.jbc.2022.101818","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T20:44:15Z","timestamp":1646858655000},"page":"101818","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Gonadal white adipose tissue is important for gametogenesis in mice through maintenance of local metabolic and immune niches"],"prefix":"10.1016","volume":"298","author":[{"given":"Chao-Fan","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Wen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9346-9822","authenticated-orcid":false,"given":"Hai-Quan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Le","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Yu","family":"Diao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-Ling","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Jun","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9474-7321","authenticated-orcid":false,"given":"Chao-Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Xiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2022.101818_bib1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nrurol.2010.6","article-title":"The effect of obesity on sperm disorders and male infertility","volume":"7","author":"Du Plessis","year":"2010","journal-title":"Nat. Rev. Urol."},{"key":"10.1016\/j.jbc.2022.101818_bib2","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1093\/humupd\/dmg024","article-title":"Obesity and reproductive disorders in women","volume":"9","author":"Pasquali","year":"2003","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.jbc.2022.101818_bib3","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1210\/en.2017-00371","article-title":"High-fat diet and female fertility","volume":"158","author":"Hohos","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.jbc.2022.101818_bib4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0889-8529(18)30179-8","article-title":"Female hypogonadotropic hypogonadism. Hypothalamic amenorrhea syndrome","volume":"22","author":"Yen","year":"1993","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"10.1016\/j.jbc.2022.101818_bib5","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/0002-9378(69)90266-X","article-title":"Menstruation and fertility in anorexia nervosa","volume":"105","author":"Starkey","year":"1969","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.jbc.2022.101818_bib6","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1210\/jc.2011-1159","article-title":"Clinical review#: Lipodystrophies: Genetic and acquired body fat disorders","volume":"96","author":"Garg","year":"2011","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jbc.2022.101818_bib7","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa040388","article-title":"Recombinant human leptin in women with hypothalamic amenorrhea","volume":"351","author":"Welt","year":"2004","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.jbc.2022.101818_bib8","doi-asserted-by":"crossref","first-page":"7054","DOI":"10.1073\/pnas.1324025111","article-title":"Lack of testicular seipin causes teratozoospermia syndrome in men","volume":"111","author":"Jiang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2022.101818_bib9","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1210\/jc.2007-2521","article-title":"Fertility and obstetrical complications in women with LMNA-related familial partial lipodystrophy","volume":"93","author":"Vantyghem","year":"2008","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jbc.2022.101818_bib10","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1097\/AOG.0b013e31822cecf7","article-title":"Pregnancy in a woman with congenital generalized lipodystrophy: leptin's vital role in reproduction","volume":"119","author":"Maguire","year":"2012","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.jbc.2022.101818_bib11","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/BF00220364","article-title":"The function of fat bodies in relation to the hypothalamo-hypophyseal-gonadal axis in the frog, Rana esculenta","volume":"161","author":"Chieffi","year":"1975","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.jbc.2022.101818_bib12","first-page":"487","article-title":"Effect of removal of epididymal fat on spermatogenesis in albino rats","volume":"24","author":"Srinivasan","year":"1986","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.jbc.2022.101818_bib13","doi-asserted-by":"crossref","first-page":"5669","DOI":"10.1210\/en.2010-0772","article-title":"Epididymal fat is necessary for spermatogenesis, but not testosterone production or copulatory behavior","volume":"151","author":"Chu","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.jbc.2022.101818_bib14","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1530\/JOE-16-0174","article-title":"Removal of mouse ovary fat pad affects sex hormones, folliculogenesis and fertility","volume":"232","author":"Wang","year":"2017","journal-title":"J.\u00a0Endocrinol."},{"key":"10.1016\/j.jbc.2022.101818_bib15","doi-asserted-by":"crossref","first-page":"74","DOI":"10.7150\/ijbs.7.74","article-title":"Lipocalin-2-induced cytokine production enhances endometrial carcinoma cell survival and migration","volume":"7","author":"Lin","year":"2011","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jbc.2022.101818_bib16","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.2337\/db07-0007","article-title":"The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance","volume":"56","author":"Yan","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.jbc.2022.101818_bib17","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.bbrc.2020.05.194","article-title":"Effects of leptin on HPG axis and reproductive function in male rat in simulated altitude of 5500 m hypoxia environment","volume":"529","author":"Liu","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jbc.2022.101818_bib18","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1262\/jrd.2011-012","article-title":"Follicular growth and atresia in mammalian ovaries: Regulation by survival and death of granulosa cells","volume":"58","author":"Matsuda","year":"2012","journal-title":"J.\u00a0Reprod. Dev."},{"key":"10.1016\/j.jbc.2022.101818_bib19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0149-7634(00)00047-6","article-title":"The regulation of total body fat: Lessons learned from lipectomy studies","volume":"25","author":"Mauer","year":"2001","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.jbc.2022.101818_bib20","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1034\/j.1600-0897.2002.01074.x","article-title":"Interleukin 2 receptor gamma chain (gamma c) knockout mice show less regularity in estrous cycle but achieve normal pregnancy without fetal compromise","volume":"47","author":"Miyazaki","year":"2002","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.jbc.2022.101818_bib21","doi-asserted-by":"crossref","first-page":"79","DOI":"10.5173\/ceju.2015.01.435","article-title":"Mechanisms linking obesity to male infertility","volume":"68","author":"Katib","year":"2015","journal-title":"Cent. European J. Urol."},{"key":"10.1016\/j.jbc.2022.101818_bib22","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11695-017-2802-7","article-title":"Massive weight loss obtained by bariatric surgery affects semen quality in morbid male obesity: A preliminary prospective double-armed study","volume":"28","author":"Samavat","year":"2018","journal-title":"Obes. Surg."},{"key":"10.1016\/j.jbc.2022.101818_bib23","first-page":"300","article-title":"Effect of obesity on clinical parameters and pregnancy rates in women with polycystic ovary syndrome undergoing ovulation induction cycles","volume":"62","author":"Tokmak","year":"2017","journal-title":"J.\u00a0Reprod. Med."},{"key":"10.1016\/j.jbc.2022.101818_bib24","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1139\/apnm-2020-0477","article-title":"Dietary restriction and\/or exercise training impairs spermatogenesis in normal rats","volume":"46","author":"Yinlam Li","year":"2021","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"10.1016\/j.jbc.2022.101818_bib25","doi-asserted-by":"crossref","first-page":"568343","DOI":"10.1155\/2010\/568343","article-title":"Role of leptin in the activation of immune cells","volume":"2010","author":"Fernandez-Riejos","year":"2010","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.jbc.2022.101818_bib26","first-page":"429","article-title":"Relation of leptin, adiponectin and insulin resistance to bone mineral density in type 2 diabetic postmenopausal women","volume":"62","author":"Koroglu","year":"2011","journal-title":"Endokrynol. Pol."},{"key":"10.1016\/j.jbc.2022.101818_bib27","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jpeds.2012.01.055","article-title":"Correlates of resistin in children with chronic kidney disease: The chronic kidney disease in children cohort","volume":"161","author":"Nehus","year":"2012","journal-title":"J.\u00a0Pediatr."},{"key":"10.1016\/j.jbc.2022.101818_bib28","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1095\/biolreprod60.2.216","article-title":"Leptin's actions on the reproductive axis: Perspectives and mechanisms","volume":"60","author":"Cunningham","year":"1999","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jbc.2022.101818_bib29","doi-asserted-by":"crossref","first-page":"5162","DOI":"10.4049\/jimmunol.1001958","article-title":"Testosterone replacement effectively inhibits the development of experimental autoimmune orchitis in rats: Evidence for a direct role of testosterone on regulatory T cell expansion","volume":"186","author":"Fijak","year":"2011","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jbc.2022.101818_bib30","first-page":"1","article-title":"Immunologically privileged sites","volume":"25","author":"Barker","year":"1977","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.jbc.2022.101818_bib31","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0070-2153(05)71008-5","article-title":"The blood-testis barrier: Its biology, regulation, and physiological role in spermatogenesis","volume":"71","author":"Wong","year":"2005","journal-title":"Curr. Top Dev. Biol."},{"key":"10.1016\/j.jbc.2022.101818_bib32","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1095\/biolreprod.110.087452","article-title":"The blood-testis and blood-epididymis barriers are more than just their tight junctions","volume":"84","author":"Mital","year":"2011","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jbc.2022.101818_bib33","first-page":"153","article-title":"The Sertoli cell - a hormonal target and \"Super\" nurse for germ cells that determines testicular size","volume":"66","author":"Petersen","year":"2006","journal-title":"Horm. Res."},{"key":"10.1016\/j.jbc.2022.101818_bib34","doi-asserted-by":"crossref","first-page":"105878","DOI":"10.1016\/j.jsbmb.2021.105878","article-title":"Low-fat diets and testosterone in men: Systematic review and meta-analysis of intervention studies","volume":"210","author":"Whittaker","year":"2021","journal-title":"J.\u00a0Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.jbc.2022.101818_bib35","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.clnu.2009.07.008","article-title":"Relationship of omega-3 and omega-6 fatty acids with semen characteristics, and anti-oxidant status of seminal plasma: A comparison between fertile and infertile men","volume":"29","author":"Safarinejad","year":"2010","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.jbc.2022.101818_bib36","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0303-7207(03)00055-8","article-title":"Regulation of the phenotype of ovarian somatic cells by estrogen","volume":"202","author":"Britt","year":"2003","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.jbc.2022.101818_bib37","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1530\/REP-12-0319","article-title":"Estradiol supports in\u00a0vitro development of bovine early antral follicles","volume":"145","author":"Endo","year":"2013","journal-title":"Reproduction"},{"key":"10.1016\/j.jbc.2022.101818_bib38","doi-asserted-by":"crossref","first-page":"4212","DOI":"10.1073\/pnas.1601825113","article-title":"Rethinking progesterone regulation of female reproductive cyclicity","volume":"113","author":"Kubota","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2022.101818_bib39","article-title":"Diet-Induced obesity in male C57BL\/6 mice decreases fertility as a consequence of disrupted blood-testis barrier","volume":"10","author":"Fan","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2022.101818_bib40","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1095\/biolreprod57.5.1233","article-title":"Chronically elevated luteinizing hormone depletes primordial follicles in the mouse ovary","volume":"57","author":"Flaws","year":"1997","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jbc.2022.101818_bib41","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jbc.2022.101818_bib42","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925822002587?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925822002587?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:17:06Z","timestamp":1758241026000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925822002587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S0021925822002587"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2022.101818","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gonadal white adipose tissue is important for gametogenesis in mice through maintenance of local metabolic and immune niches","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2022.101818","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"101818"}}