{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T15:40:12Z","timestamp":1783957212882,"version":"3.55.0"},"reference-count":72,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T00:00:00Z","timestamp":1653350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01GM065204"],"award-info":[{"award-number":["R01GM065204"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01HD096745"],"award-info":[{"award-number":["R01HD096745"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007184","name":"Yale School of Medicine","doi-asserted-by":"publisher","award":["R01HD096745"],"award-info":[{"award-number":["R01HD096745"]}],"id":[{"id":"10.13039\/100007184","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006691","name":"Harvard Medical School","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014281","name":"Society for Experimental Mechanics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.jbc.2022.102077","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T17:37:53Z","timestamp":1653500273000},"page":"102077","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Redox regulation by TXNRD3 during epididymal maturation underlies capacitation-associated mitochondrial activity and sperm motility in mice"],"prefix":"10.1016","volume":"298","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7326-4379","authenticated-orcid":false,"given":"Huafeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianhui","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5210-9962","authenticated-orcid":false,"given":"Kyung Jo","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8614-0973","authenticated-orcid":false,"given":"Jungmin","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vadim N.","family":"Gladyshev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8018-1355","authenticated-orcid":false,"given":"Jean-Ju","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2022.102077_bib1","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1093\/humupd\/dmw015","article-title":"The human epididymis: its function in sperm maturation","volume":"22","author":"Sullivan","year":"2016","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.jbc.2022.102077_bib2","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/andr.12320","article-title":"Molecular changes and signaling events occurring in spermatozoa during epididymal maturation","volume":"5","author":"Gervasi","year":"2017","journal-title":"Andrology"},{"key":"10.1016\/j.jbc.2022.102077_bib3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.mce.2003.10.069","article-title":"Antioxidant strategies in the epididymis","volume":"216","author":"Vernet","year":"2004","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.jbc.2022.102077_bib4","first-page":"2074","article-title":"Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice","volume":"119","author":"Chabory","year":"2009","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.jbc.2022.102077_bib5","doi-asserted-by":"crossref","first-page":"583","DOI":"10.4103\/1008-682X.153303","article-title":"Redox regulation of mammalian sperm capacitation","volume":"17","author":"O'Flaherty","year":"2015","journal-title":"Asian J. Androl."},{"key":"10.1016\/j.jbc.2022.102077_bib6","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1530\/ror.0.0020048","article-title":"Reactive oxygen species and sperm physiology","volume":"2","author":"de Lamirande","year":"1997","journal-title":"Rev. Reprod."},{"key":"10.1016\/j.jbc.2022.102077_bib7","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.fertnstert.2007.05.029","article-title":"Increase of oxidative stress in human sperm with lower motility","volume":"89","author":"Kao","year":"2008","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jbc.2022.102077_bib8","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.fertnstert.2004.11.022","article-title":"Effect of reactive oxygen species produced by spermatozoa and leukocytes on sperm functions in non-leukocytospermic patients","volume":"83","author":"Henkel","year":"2005","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jbc.2022.102077_bib9","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/978-3-0348-5419-1_5","article-title":"Pyridine nucleotide - disulfide oxidoreductases","volume":"36","author":"Holmgren","year":"1980","journal-title":"Experientia Suppl."},{"key":"10.1016\/j.jbc.2022.102077_bib10","first-page":"1","article-title":"Thioredoxin reductase","volume":"346 Pt 1","author":"Mustacich","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.jbc.2022.102077_bib11","doi-asserted-by":"crossref","first-page":"24522","DOI":"10.1074\/jbc.274.35.24522","article-title":"Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases","volume":"274","author":"Sun","year":"1999","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2022.102077_bib12","doi-asserted-by":"crossref","first-page":"3673","DOI":"10.1073\/pnas.051454398","article-title":"Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems","volume":"98","author":"Sun","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2022.102077_bib13","doi-asserted-by":"crossref","first-page":"6102","DOI":"10.1046\/j.1432-1327.2000.01701.x","article-title":"Physiological functions of thioredoxin and thioredoxin reductase","volume":"267","author":"Arn\u00e9r","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.jbc.2022.102077_bib14","doi-asserted-by":"crossref","first-page":"54510","DOI":"10.1074\/jbc.M408494200","article-title":"Overexpression of enzymatically active human cytosolic and mitochondrial thioredoxin reductase in HEK-293 cells. Effect on cell growth and differentiation","volume":"279","author":"Nalvarte","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2022.102077_bib15","doi-asserted-by":"crossref","first-page":"9414","DOI":"10.1128\/MCB.24.21.9414-9423.2004","article-title":"Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function","volume":"24","author":"Conrad","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jbc.2022.102077_bib16","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1128\/MCB.25.5.1980-1988.2005","article-title":"Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development","volume":"25","author":"Jakupoglu","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jbc.2022.102077_bib17","doi-asserted-by":"crossref","first-page":"26491","DOI":"10.1074\/jbc.M503638200","article-title":"Mammalian selenoprotein thioredoxin-glutathione reductase. Roles in disulfide bond formation and sperm maturation","volume":"280","author":"Su","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2022.102077_bib18","article-title":"TXNRD3 supports male fertility via the redox control of spermatogenesis","author":"Dou","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.jbc.2022.102077_bib19","doi-asserted-by":"crossref","first-page":"4578","DOI":"10.1093\/bioinformatics\/btab503","article-title":"UCSC cell browser: visualize your single-cell data","volume":"37","author":"Speir","year":"2021","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jbc.2022.102077_bib20","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.anireprosci.2013.12.007","article-title":"Thiol-disulfide proteins of stallion epididymal spermatozoa","volume":"145","author":"Dias","year":"2014","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.jbc.2022.102077_bib21","series-title":"Encyclopedia of Reproduction","author":"Skinner","year":"2018"},{"key":"10.1016\/j.jbc.2022.102077_bib22","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1126\/science.285.5432.1393","article-title":"Dual function of the selenoprotein PHGPx during sperm maturation","volume":"285","author":"Ursini","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.jbc.2022.102077_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.201800311","article-title":"GPX4 at the crossroads of lipid homeostasis and ferroptosis","volume":"19","author":"Forcina","year":"2019","journal-title":"Proteomics"},{"key":"10.1016\/j.jbc.2022.102077_bib24","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.cell.2017.11.048","article-title":"Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis","volume":"172","author":"Ingold","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2022.102077_bib25","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1365-2605.1993.tb01148.x","article-title":"A\u00a0positive role for the superoxide anion in triggering hyperactivation and capacitation of human spermatozoa","volume":"16","author":"de Lamirande","year":"1993","journal-title":"Int. J. Androl."},{"key":"10.1016\/j.jbc.2022.102077_bib26","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/mrd.22871","article-title":"Reactive oxygen species as mediators of sperm capacitation and pathological damage","volume":"84","author":"Aitken","year":"2017","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.jbc.2022.102077_bib27","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2164\/jandrol.05068","article-title":"Comparison of chromatin assays for DNA fragmentation evaluation in human sperm","volume":"27","author":"Chohan","year":"2006","journal-title":"J.\u00a0Androl."},{"key":"10.1016\/j.jbc.2022.102077_bib28","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1111\/j.2047-2927.2014.00234.x","article-title":"Sperm DNA integrity testing: big halo is a good predictor of embryo quality and pregnancy after conventional IVF","volume":"2","author":"Tandara","year":"2014","journal-title":"Andrology"},{"key":"10.1016\/j.jbc.2022.102077_bib29","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/j.1939-4640.2003.tb02641.x","article-title":"The sperm chromatin dispersion test: a simple method for the determination of sperm DNA fragmentation","volume":"24","author":"Fern\u00e1ndez","year":"2003","journal-title":"J.\u00a0Androl."},{"key":"10.1016\/j.jbc.2022.102077_bib30","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1093\/oxfordjournals.humrep.a019255","article-title":"The acridine orange test: a clinically relevant screening method for sperm quality during infertility investigation?","volume":"11","author":"Eggert-Kruse","year":"1996","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jbc.2022.102077_bib31","series-title":"Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction","first-page":"189","article-title":"Acridine orange test for assessment of human sperm DNA integrity","author":"Varghese","year":"2011"},{"key":"10.1016\/j.jbc.2022.102077_bib32","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1095\/biolreprod.112.104109","article-title":"Sperm bioenergetics in a nutshell","volume":"87","author":"Visconti","year":"2012","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jbc.2022.102077_bib33","doi-asserted-by":"crossref","first-page":"7630","DOI":"10.1074\/jbc.M006217200","article-title":"Functional relationships between capacitation-dependent cell signaling and compartmentalized metabolic pathways in murine spermatozoa","volume":"276","author":"Travis","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2022.102077_bib34","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1095\/biolreprod.103.026054","article-title":"Glycolysis plays a major role for adenosine triphosphate supplementation in mouse sperm flagellar movement","volume":"71","author":"Mukai","year":"2004","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jbc.2022.102077_bib35","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1095\/biolreprod.112.102673","article-title":"Metabolic substrates exhibit differential effects on functional parameters of mouse sperm capacitation","volume":"87","author":"Goodson","year":"2012","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jbc.2022.102077_bib36","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1093\/biolre\/ioaa114","article-title":"Metabolic changes in mouse sperm during capacitation\u2020","volume":"103","author":"Balbach","year":"2020","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jbc.2022.102077_bib37","doi-asserted-by":"crossref","first-page":"102176","DOI":"10.1016\/j.redox.2021.102176","article-title":"Increased mitochondrial activity upon CatSper channel activation is required for mouse sperm capacitation","volume":"48","author":"Ferreira","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.jbc.2022.102077_bib38","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1016\/j.febslet.2006.04.097","article-title":"Characterization of dimeric ATP synthase and cristae membrane ultrastructure from Saccharomyces and Polytomella mitochondria","volume":"580","author":"Dudkina","year":"2006","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jbc.2022.102077_bib39","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/emboj.2008.35","article-title":"Dimer ribbons of ATP synthase shape the inner mitochondrial membrane","volume":"27","author":"Strauss","year":"2008","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2022.102077_bib40","doi-asserted-by":"crossref","first-page":"4250","DOI":"10.1073\/pnas.1816556116","article-title":"Dimers of mitochondrial ATP synthase induce membrane curvature and self-assemble into rows","volume":"116","author":"Blum","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2022.102077_bib41","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.cell.2013.08.032","article-title":"Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency","volume":"155","author":"Cogliati","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2022.102077_bib42","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ab.2017.07.009","article-title":"Mitochondrial membrane potential","volume":"552","author":"Zorova","year":"2018","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jbc.2022.102077_bib43","doi-asserted-by":"crossref","first-page":"781558","DOI":"10.3389\/fcell.2022.781558","article-title":"Genes involved in maintaining mitochondrial membrane potential upon electron transport chain disruption","volume":"10","author":"Vasan","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jbc.2022.102077_bib44","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/cyto.a.20188","article-title":"Characterization of cells with different mitochondrial membrane potential during apoptosis","volume":"68","author":"Lugli","year":"2005","journal-title":"Cytometry A"},{"key":"10.1016\/j.jbc.2022.102077_bib45","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A\u00a0role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2022.102077_bib46","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/embor.2012.14","article-title":"Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment","volume":"13","author":"Greene","year":"2012","journal-title":"EMBO Rep."},{"key":"10.1016\/j.jbc.2022.102077_bib47","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3390\/cells11020220","article-title":"Energy metabolism and hyperactivation of spermatozoa from three mouse species under capacitating conditions","volume":"11","author":"Sansegundo","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.jbc.2022.102077_bib48","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1093\/humrep\/deg202","article-title":"Oxidative DNA damage in human sperm influences time to pregnancy","volume":"18","author":"Loft","year":"2003","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jbc.2022.102077_bib49","doi-asserted-by":"crossref","first-page":"31567","DOI":"10.1074\/jbc.M101760200","article-title":"Characterization of Sptrx, a novel member of the thioredoxin family specifically expressed in human spermatozoa","volume":"276","author":"Miranda-Vizuete","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2022.102077_bib50","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.freeradbiomed.2013.05.021","article-title":"Functional deletion of Txndc2 and Txndc3 increases the susceptibility of spermatozoa to age-related oxidative stress","volume":"65","author":"Smith","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jbc.2022.102077_bib51","doi-asserted-by":"crossref","first-page":"44874","DOI":"10.1074\/jbc.M305475200","article-title":"Cloning and developmental analysis of murid spermatid-specific thioredoxin-2 (SPTRX-2), a novel sperm fibrous sheath protein and autoantigen","volume":"278","author":"Miranda-Vizuete","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2022.102077_bib52","doi-asserted-by":"crossref","first-page":"34971","DOI":"10.1074\/jbc.M404192200","article-title":"Spermatocyte\/spermatid-specific thioredoxin-3, a novel Golgi apparatus-associated thioredoxin, is a specific marker of aberrant spermatogenesis","volume":"279","author":"Jim\u00e9nez","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2022.102077_bib53","doi-asserted-by":"crossref","first-page":"16501","DOI":"10.1073\/pnas.0407708101","article-title":"Glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme, is required for sperm motility and male fertility","volume":"101","author":"Miki","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2022.102077_bib54","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1095\/biolreprod.109.079699","article-title":"Phosphoglycerate kinase 2 (PGK2) is essential for sperm function and male fertility in mice","volume":"82","author":"Danshina","year":"2010","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jbc.2022.102077_bib55","doi-asserted-by":"crossref","first-page":"20613","DOI":"10.1074\/jbc.M115.664813","article-title":"Differences in ATP generation via glycolysis and oxidative phosphorylation and relationships with sperm motility in mouse species","volume":"290","author":"Tourmente","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2022.102077_bib56","doi-asserted-by":"crossref","first-page":"995","DOI":"10.3390\/antiox9100995","article-title":"Western diet causes obesity-induced nonalcoholic fatty liver disease development by differentially compromising the autophagic response","volume":"9","author":"Simoes","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jbc.2022.102077_bib57","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/jb\/mvr049","article-title":"Rotation and structure of FoF1-ATP synthase","volume":"149","author":"Okuno","year":"2011","journal-title":"J.\u00a0Biochem."},{"key":"10.1016\/j.jbc.2022.102077_bib58","doi-asserted-by":"crossref","first-page":"33742","DOI":"10.1074\/jbc.M404628200","article-title":"Targeted ablation of plasma membrane Ca2+-ATPase (PMCA) 1 and 4 indicates a major housekeeping function for PMCA1 and a critical role in hyperactivated sperm motility and male fertility for PMCA4","volume":"279","author":"Okunade","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2022.102077_bib59","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.cell.2019.03.047","article-title":"Dual sensing of physiologic pH and calcium by EFCAB9 regulates sperm motility","volume":"177","author":"Hwang","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2022.102077_bib60","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/toxsci\/kfw070","article-title":"Bisphenol A impairs mature sperm functions by a CatSper-relevant mechanism","volume":"152","author":"Wang","year":"2016","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.jbc.2022.102077_bib61","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/j.celrep.2018.10.026","article-title":"The mammalian spermatogenesis single-cell transcriptome, from spermatogonial stem cells to spermatids","volume":"25","author":"Hermann","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2022.102077_bib62","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2022.102077_bib63","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1186\/s13059-015-0844-5","article-title":"Mast: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data","volume":"16","author":"Finak","year":"2015","journal-title":"Genome Biol."},{"key":"10.1016\/j.jbc.2022.102077_bib64","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jbc.2022.102077_bib65","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.cell.2018.05.061","article-title":"Recovering gene interactions from single-cell data using data diffusion","volume":"174","author":"van Dijk","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2022.102077_bib66","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.cell.2014.02.056","article-title":"Structurally distinct Ca2+ signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility","volume":"157","author":"Chung","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2022.102077_bib67","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/ncomms1153","article-title":"A\u00a0novel gene required for male fertility and functional CATSPER channel formation in spermatozoa","volume":"2","author":"Chung","year":"2011","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2022.102077_bib68","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.23082","article-title":"CatSper\u03b6 regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility","volume":"6","author":"Chung","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.jbc.2022.102077_bib69","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.cell.2020.02.012","article-title":"A\u00a0quantitative tissue-specific landscape of protein redox regulation during aging","volume":"180","author":"Xiao","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2022.102077_bib70","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jbc.2022.102077_bib71","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1159\/000369703","article-title":"Matrine inhibits mouse sperm function by reducing sperm [Ca2+]i and phospho-ERK1\/2","volume":"35","author":"Luo","year":"2015","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.jbc.2022.102077_bib72","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1095\/biolreprod.107.061358","article-title":"CATSPER channel-mediated Ca2+ entry into mouse sperm triggers a tail-to-head propagation","volume":"77","author":"Xia","year":"2007","journal-title":"Biol. Reprod."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925822005178?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925822005178?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T22:59:19Z","timestamp":1778626759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925822005178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":72,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S0021925822005178"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2022.102077","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.07.19.452987","asserted-by":"object"}]},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Redox regulation by TXNRD3 during epididymal maturation underlies capacitation-associated mitochondrial activity and sperm motility in mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2022.102077","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"102077"}}