{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T10:02:46Z","timestamp":1791453766018,"version":"4.3.3"},"reference-count":85,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017923","name":"Alliance Fran\u00e7aise contre les Maladies Parasitaires","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-11-LABX-0024"],"award-info":[{"award-number":["ANR-11-LABX-0024"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-19-CE15\u20130023"],"award-info":[{"award-number":["ANR-19-CE15\u20130023"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-21-CE44-0010"],"award-info":[{"award-number":["ANR-21-CE44-0010"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004962","name":"R\u00e9gion Auvergne-Rh\u00f4ne-Alpes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004962","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010115","name":"R\u00e9gion Auvergne-Rh\u00f4ne-Alpes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010115","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.jbc.2022.102243","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T01:12:07Z","timestamp":1657242727000},"page":"102243","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Disrupting the plastidic iron-sulfur cluster biogenesis pathway in Toxoplasma gondii has pleiotropic effects irreversibly impacting parasite viability"],"prefix":"10.1016","volume":"298","author":[{"given":"El\u00e9a A.","family":"Renaud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Pamukcu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2838-5021","authenticated-orcid":false,"given":"Aude","family":"Cerutti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Berry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Lemaire-Vieille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Yamaryo-Bott\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrille Y.","family":"Bott\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Besteiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2022.102243_bib1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0140-6736(13)60024-0","article-title":"Malaria","volume":"383","author":"White","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.jbc.2022.102243_bib2","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1080\/21505594.2021.2012346","article-title":"The pathogenicity and virulence of Toxoplasma gondii","volume":"12","author":"Sanchez","year":"2021","journal-title":"Virulence"},{"key":"10.1016\/j.jbc.2022.102243_bib3","doi-asserted-by":"crossref","first-page":"10949","DOI":"10.1073\/pnas.1003335107","article-title":"A common red algal origin of the apicomplexan, dinoflagellate, and heterokont plastids","volume":"107","author":"Janouskovec","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2022.102243_bib4","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1146\/annurev-micro-092412-155741","article-title":"The algal past and parasite present of the apicoplast","volume":"67","author":"van Dooren","year":"2013","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.jbc.2022.102243_bib5","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/bs.abr.2017.06.007","article-title":"The dark side of the chloroplast: biogenesis, metabolism and membrane biology of the apicoplast","volume":"84","author":"van Dooren","year":"2017","journal-title":"Adv. Bot. Res."},{"key":"10.1016\/j.jbc.2022.102243_bib6","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1937-6448(10)81005-6","article-title":"Metabolic pathways in the apicoplast of apicomplexa","volume":"281","author":"Seeber","year":"2010","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.jbc.2022.102243_bib7","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1042\/BST20170563","article-title":"Targeting the apicoplast in malaria","volume":"47","author":"Biddau","year":"2019","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.jbc.2022.102243_bib8","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.pt.2019.07.010","article-title":"Delayed death by plastid inhibition in apicomplexan parasites","volume":"35","author":"Kennedy","year":"2019","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.jbc.2022.102243_bib9","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01161-17","article-title":"Validation of putative apicoplast-targeting drugs using a chemical supplementation assay in cultured human malaria parasites","volume":"62","author":"Uddin","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jbc.2022.102243_bib10","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1111\/j.1365-2958.2006.05028.x","article-title":"Iron-sulphur clusters and the problem with oxygen","volume":"59","author":"Imlay","year":"2006","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jbc.2022.102243_bib11","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/nature08301","article-title":"Function and biogenesis of iron\u2013sulphur proteins","volume":"460","author":"Lill","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2022.102243_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2020.118863","article-title":"Mechanistic concepts of iron-sulfur protein biogenesis in Biology","volume":"1868","author":"Braymer","year":"2021","journal-title":"Biochim. Biophys. Acta (Bba) - Mol. Cell Res."},{"key":"10.1016\/j.jbc.2022.102243_bib13","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1111\/mmi.14651","article-title":"A key cytosolic iron-sulfur cluster synthesis protein localises to the mitochondrion of Toxoplasma gondii","volume":"115","author":"Aw","year":"2020","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jbc.2022.102243_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010096","article-title":"Differential contribution of two organelles of endosymbiotic origin to iron-sulfur cluster synthesis and overall fitness in Toxoplasma","volume":"17","author":"Pamukcu","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2022.102243_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003655","article-title":"The Suf iron-sulfur cluster synthesis pathway is required for apicoplast maintenance in malaria parasites","volume":"9","author":"Gisselberg","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2022.102243_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0089718","article-title":"Identification of vital and dispensable sulfur utilization factors in the Plasmodium apicoplast","volume":"9","author":"Haussig","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2022.102243_bib17","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.ijpara.2011.05.006","article-title":"Interaction between sulphur mobilisation proteins SufB and SufC: evidence for an iron\u2013sulphur cluster biogenesis pathway in the apicoplast of Plasmodium falciparum","volume":"41","author":"Kumar","year":"2011","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.jbc.2022.102243_bib18","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1128\/AAC.02711-13","article-title":"Sulfur mobilization for Fe-S cluster assembly by the essential SUF pathway in the Plasmodium falciparum apicoplast and its inhibition","volume":"58","author":"Charan","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jbc.2022.102243_bib19","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1111\/febs.14159","article-title":"[Fe-S] cluster assembly in the apicoplast and its indispensability in mosquito stages of the malaria parasite","volume":"284","author":"Charan","year":"2017","journal-title":"FEBS J."},{"key":"10.1016\/j.jbc.2022.102243_bib20","doi-asserted-by":"crossref","first-page":"28380","DOI":"10.1074\/jbc.C200365200","article-title":"A third bacterial system for the assembly of iron-sulfur clusters with homologs in archaea and plastids","volume":"277","author":"Takahashi","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2022.102243_bib21","doi-asserted-by":"crossref","first-page":"29717","DOI":"10.1074\/jbc.M115.680934","article-title":"Functional dynamics revealed by the structure of the SufBCD complex, a novel ATP-binding cassette (ABC) protein that serves as a scaffold for Iron-Sulfur cluster biogenesis","volume":"290","author":"Hirabayashi","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2022.102243_bib22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/978-1-4939-9857-9_2","article-title":"ToxoDB: functional genomics resource for Toxoplasma and related organisms","volume":"2071","author":"Harb","year":"2020","journal-title":"Met. Mol. Biol."},{"key":"10.1016\/j.jbc.2022.102243_bib23","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1093\/bioinformatics\/btx431","article-title":"DeepLoc: prediction of protein subcellular localization using deep learning","volume":"33","author":"Almagro Armenteros","year":"2017","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jbc.2022.102243_bib24","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.chom.2020.09.011","article-title":"A comprehensive subcellular atlas of the Toxoplasma proteome via hyperLOPIT provides spatial context for protein functions","volume":"28","author":"Barylyuk","year":"2020","journal-title":"Cell Host & Microbe"},{"key":"10.1016\/j.jbc.2022.102243_bib25","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1111\/j.1365-2958.2004.04025.x","article-title":"A suf operon requirement for Fe-S cluster assembly during iron starvation in Escherichia coli: suf operon role during iron starvation","volume":"52","author":"Outten","year":"2004","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jbc.2022.102243_bib26","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1128\/EC.00357-08","article-title":"Efficient gene replacements in Toxoplasma gondii strains deficient for nonhomologous end joining","volume":"8","author":"Fox","year":"2009","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.jbc.2022.102243_bib27","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1128\/EC.00358-08","article-title":"Tagging of endogenous genes in a Toxoplasma gondii strain lacking Ku80","volume":"8","author":"Huynh","year":"2009","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.jbc.2022.102243_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002392","article-title":"A systematic screen to discover and analyze apicoplast proteins identifies a conserved and essential protein import factor","volume":"7","author":"Sheiner","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2022.102243_bib29","doi-asserted-by":"crossref","first-page":"E115","DOI":"10.1093\/nar\/29.22.e115","article-title":"Modulation of myosin A expression by a newly established tetracycline repressor-based inducible system in Toxoplasma gondii","volume":"29","author":"Meissner","year":"2001","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.jbc.2022.102243_bib30","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0166-6851(96)02598-4","article-title":"A novel epitope tag system to study protein targeting and organelle biogenesis in Trypanosoma brucei","volume":"77","author":"Bastin","year":"1996","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.jbc.2022.102243_bib31","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/nrmicro3184","article-title":"Cell division in apicomplexan parasites","volume":"12","author":"Francia","year":"2014","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.jbc.2022.102243_bib32","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/cmi.12285","article-title":"The inner membrane complex through development of Toxoplasma gondii and Plasmodium","volume":"16","author":"Harding","year":"2014","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.jbc.2022.102243_bib33","first-page":"3320","article-title":"Dynamics of the Toxoplasma gondii inner membrane complex","volume":"127","author":"Ouologuem","year":"2014","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.jbc.2022.102243_bib34","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.molbiopara.2004.05.007","article-title":"Fluorescent protein tagging in Toxoplasma gondii: identification of a novel inner membrane complex component conserved among apicomplexa","volume":"137","author":"Gubbels","year":"2004","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.jbc.2022.102243_bib35","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s40588-014-0006-7","article-title":"Isoprenoid metabolism in apicomplexan parasites","volume":"1","author":"Imlay","year":"2014","journal-title":"Curr. Clin. Microbiol. Rep."},{"key":"10.1016\/j.jbc.2022.102243_bib36","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0014-5793(03)00673-2","article-title":"Apicomplexan parasites contain a single lipoic acid synthase located in the plastid","volume":"547","author":"Thomsen-Zieger","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jbc.2022.102243_bib37","doi-asserted-by":"crossref","first-page":"47555","DOI":"10.1074\/jbc.M408562200","article-title":"MiaB protein is a bifunctional radical-S-adenosylmethionine enzyme involved in thiolation and methylation of tRNA","volume":"279","author":"Pierrel","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2022.102243_bib38","doi-asserted-by":"crossref","first-page":"101468","DOI":"10.1016\/j.jbc.2021.101468","article-title":"Toxoplasma gondii apicoplast-resident ferredoxin is an essential electron transfer protein for the MEP isoprenoid-biosynthetic pathway","volume":"298","author":"Henkel","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2022.102243_bib39","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.febslet.2014.11.020","article-title":"Protein\u2013protein interaction studies provide evidence for electron transfer from ferredoxin to lipoic acid synthase in Toxoplasma gondii","volume":"589","author":"Frohnecke","year":"2015","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jbc.2022.102243_bib40","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.03023-21","article-title":"Roles of ferredoxin-dependent proteins in the apicoplast of Plasmodium falciparum parasites","volume":"13","author":"Swift","year":"2022","journal-title":"mBio"},{"key":"10.1016\/j.jbc.2022.102243_bib41","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.cell.2016.08.019","article-title":"A genome-wide CRISPR screen in Toxoplasma identifies essential apicomplexan genes","volume":"166","author":"Sidik","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2022.102243_bib42","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1073\/pnas.051629998","article-title":"Subcellular localization of acetyl-CoA carboxylase in the apicomplexan parasite Toxoplasma gondii","volume":"98","author":"Jelenska","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2022.102243_bib43","doi-asserted-by":"crossref","first-page":"13192","DOI":"10.1073\/pnas.0603391103","article-title":"Apicoplast fatty acid synthesis is essential for organelle biogenesis and parasite survival in Toxoplasma gondii","volume":"103","author":"Mazumdar","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2022.102243_bib44","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.1074\/jbc.M111.310144","article-title":"Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii","volume":"287","author":"Ramakrishnan","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2022.102243_bib45","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1194\/jlr.M082891","article-title":"Toxoplasma gondii acetyl-CoA synthetase is involved in fatty acid elongation (of long fatty acid chains) during tachyzoite life stages","volume":"59","author":"Dubois","year":"2018","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.jbc.2022.102243_bib46","doi-asserted-by":"crossref","first-page":"3778","DOI":"10.1016\/j.celrep.2020.02.072","article-title":"Division and adaptation to host environment of apicomplexan parasites depend on apicoplast lipid metabolic plasticity and host organelle remodeling","volume":"30","author":"Amiar","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2022.102243_bib47","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1038\/s41467-021-22956-w","article-title":"Toxoplasma LIPIN is essential in channeling host lipid fluxes through membrane biogenesis and lipid storage","volume":"12","author":"Dass","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2022.102243_bib48","doi-asserted-by":"crossref","first-page":"7743","DOI":"10.1074\/jbc.RA120.013004","article-title":"Acquisition of exogenous fatty acids renders apicoplast-based biosynthesis dispensable in tachyzoites of Toxoplasma","volume":"295","author":"Liang","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2022.102243_bib49","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1242\/jcs.185223","article-title":"Apicoplast fatty acid synthesis is essential for pellicle formation at the end of cytokinesis in Toxoplasma gondii","volume":"129","author":"Martins-Duarte","year":"2016","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.jbc.2022.102243_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001138","article-title":"Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum","volume":"9","author":"Yeh","year":"2011","journal-title":"PLoS Biol."},{"key":"10.1016\/j.jbc.2022.102243_bib51","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1084\/jem.20110039","article-title":"Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii","volume":"208","author":"Nair","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jbc.2022.102243_bib52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003665","article-title":"Toxoplasma gondii relies on both host and parasite isoprenoids and can be rendered sensitive to Atorvastatin","volume":"9","author":"Li","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2022.102243_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000376","article-title":"Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking","volume":"17","author":"Kennedy","year":"2019","journal-title":"PLoS Biol."},{"key":"10.1016\/j.jbc.2022.102243_bib54","doi-asserted-by":"crossref","first-page":"5802","DOI":"10.1038\/s41467-021-25987-5","article-title":"A plastid two-pore channel essential for inter-organelle communication and growth of Toxoplasma gondii","volume":"12","author":"Li","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2022.102243_bib55","doi-asserted-by":"crossref","first-page":"38615","DOI":"10.1038\/srep38615","article-title":"Global proteomic analysis of prenylated proteins in Plasmodium falciparum using an alkyne-modified isoprenoid analogue","volume":"6","author":"Suazo","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2022.102243_bib56","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.1074\/mcp.M116.064550","article-title":"The prenylated proteome of Plasmodium falciparum reveals pathogen-specific prenylation activity and drug mechanism-of-action","volume":"16","author":"Gisselberg","year":"2017","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.jbc.2022.102243_bib57","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ijpara.2003.12.004","article-title":"The SRS superfamily of Toxoplasma surface proteins","volume":"34","author":"Jung","year":"2004","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.jbc.2022.102243_bib58","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0166-6851(98)00011-5","article-title":"Expression, selection, and organellar targeting of the green fluorescent protein in Toxoplasma gondii","volume":"92","author":"Striepen","year":"1998","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.jbc.2022.102243_bib59","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1074\/mcp.M700391-MCP200","article-title":"Proteomics and glycomics analyses of N-glycosylated structures involved in Toxoplasma gondii-host cell interactions","volume":"7","author":"Fauquenoy","year":"2008","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.jbc.2022.102243_bib60","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.molbiopara.2007.10.012","article-title":"N-linked glycosylation of proteins in the protozoan parasite Toxoplasma gondii","volume":"157","author":"Luk","year":"2008","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.jbc.2022.102243_bib61","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/S0021-9258(17)49916-9","article-title":"C-Mannosylation of Toxoplasma gondii proteins promotes attachment to host cells and parasite virulence","volume":"295","author":"Albuquerque-Wendt","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2022.102243_bib62","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1091\/mbc.10.11.3539","article-title":"Time-lapse video microscopy of gliding motility in Toxoplasma gondii reveals a novel, biphasic mechanism of cell locomotion","volume":"10","author":"H\u00e5kansson","year":"1999","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.jbc.2022.102243_bib63","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1462-5822.2008.01270.x","article-title":"Type II fatty acid synthesis is essential only for malaria parasite late liver stage development","volume":"11","author":"Vaughan","year":"2009","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.jbc.2022.102243_bib64","doi-asserted-by":"crossref","DOI":"10.1128\/mSystems.01196-21","article-title":"The extracellular milieu of Toxoplasma\u2019s lytic cycle drives lab adaptation, primarily by transcriptional reprogramming","volume":"6","author":"Primo","year":"2021","journal-title":"mSystems"},{"key":"10.1016\/j.jbc.2022.102243_bib65","article-title":"The role of type II fatty acid synthesis enzymes FabZ, ODSCI, and ODSCII in the pathogenesis of Toxoplasma gondii infection","volume":"12","author":"Xu","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jbc.2022.102243_bib66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010313","article-title":"The flexibility of Apicomplexa parasites in lipid metabolism","volume":"18","author":"Shunmugam","year":"2022","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2022.102243_bib67","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.chom.2020.01.002","article-title":"Functional and computational genomics reveal unprecedented flexibility in stage-specific Toxoplasma metabolism","volume":"27","author":"Krishnan","year":"2020","journal-title":"Cell Host & Microbe"},{"key":"10.1016\/j.jbc.2022.102243_bib68","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01646-18","article-title":"Host cell metabolism contributes to delayed-death kinetics of apicoplast inhibitors in Toxoplasma gondii","volume":"63","author":"Amberg-Johnson","year":"2019","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jbc.2022.102243_bib69","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1128\/AAC.46.5.1163-1173.2002","article-title":"Antiparasitic agent atovaquone","volume":"46","author":"Baggish","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jbc.2022.102243_bib70","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.38097","article-title":"Identification of cryptic subunits from an apicomplexan ATP synthase","volume":"7","author":"Huet","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.jbc.2022.102243_bib71","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.38131","article-title":"Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presence of a divergent cytochrome c oxidase","volume":"7","author":"Seidi","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.jbc.2022.102243_bib72","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009211","article-title":"Divergent features of the coenzyme Q:cytochrome c oxidoreductase complex in Toxoplasma gondii parasites","volume":"17","author":"Hayward","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2022.102243_bib73","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009301","article-title":"Complexome profile of Toxoplasma gondii mitochondria identifies divergent subunits of respiratory chain complexes including new subunits of cytochrome bc1 complex","volume":"17","author":"Maclean","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2022.102243_bib74","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000270","article-title":"Rab11A-controlled assembly of the inner membrane complex is required for completion of apicomplexan cytokinesis","volume":"5","author":"Agop-Nersesian","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2022.102243_bib75","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008106","article-title":"Rab11A regulates dense granule transport and secretion during Toxoplasma gondii invasion of host cells and parasite replication","volume":"16","author":"Venugopal","year":"2020","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2022.102243_bib76","article-title":"Critical role for isoprenoids in apicoplast biogenesis by malaria parasites","volume":"11","author":"Okada","year":"2021","journal-title":"Microbiology"},{"key":"10.1016\/j.jbc.2022.102243_bib77","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005403","article-title":"Gliding associated proteins play essential roles during the formation of the inner membrane complex of Toxoplasma gondii","volume":"12","author":"Harding","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2022.102243_bib78","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1128\/EC.2.5.1132-1136.2003","article-title":"Biosynthesis of glycosylphosphatidylinositol Is essential to the survival of the protozoan parasite Toxoplasma gondii","volume":"2","author":"Wichroski","year":"2003","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.jbc.2022.102243_bib79","first-page":"4576","article-title":"Evidence for glycosyl-phosphatidylinositol anchoring of Toxoplasma gondii major surface antigens","volume":"9","author":"Tomavo","year":"1989","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jbc.2022.102243_bib80","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/cmi.12186","article-title":"The Toxoplasma gondii calcium-dependent protein kinase 7 is involved in early steps of parasite division and is crucial for parasite survival","volume":"16","author":"Morlon-Guyot","year":"2014","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.jbc.2022.102243_bib81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0031182000066695","article-title":"Surface antigens of Toxoplasma gondii","volume":"97","author":"Couvreur","year":"1988","journal-title":"Parasitology"},{"key":"10.1016\/j.jbc.2022.102243_bib82","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1093\/emboj\/21.9.2149","article-title":"Toxoplasma gondii myosin A and its light chain: a fast, single-headed, plus-end-directed motor","volume":"21","author":"Herm-Gotz","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2022.102243_bib83","doi-asserted-by":"crossref","first-page":"33683","DOI":"10.1074\/jbc.M109.044024","article-title":"Genetic evidence that an endosymbiont-derived endoplasmic reticulum-associated protein degradation (ERAD) system functions in import of apicoplast proteins","volume":"284","author":"Agrawal","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2022.102243_bib84","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1462-5822.2010.01514.x","article-title":"A family of intermediate filament-like proteins is sequentially assembled into the cytoskeleton of Toxoplasma gondii","volume":"13","author":"Anderson-White","year":"2011","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.jbc.2022.102243_bib85","doi-asserted-by":"crossref","first-page":"16217","DOI":"10.1016\/S0021-9258(17)33995-9","article-title":"Similarities between the primary structures of two distinct major surface proteins of Toxoplasma gondii","volume":"269","author":"Cesbron-Delauw","year":"1994","journal-title":"J. Biol. Chem."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925822006858?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925822006858?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:32:01Z","timestamp":1758241921000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925822006858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":85,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S0021925822006858"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2022.102243","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.03.18.484844","asserted-by":"object"}]},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disrupting the plastidic iron-sulfur cluster biogenesis pathway in Toxoplasma gondii has pleiotropic effects irreversibly impacting parasite viability","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2022.102243","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"102243"}}