{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:41:57Z","timestamp":1790203317360,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.jbc.2022.102265","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T02:10:30Z","timestamp":1657851030000},"page":"102265","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["An antagonistic monoclonal anti\u2013Plexin-B1 antibody exerts therapeutic effects in mouse models of postmenopausal osteoporosis and multiple sclerosis"],"prefix":"10.1016","volume":"298","author":[{"given":"Melanie","family":"Vogler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arkadiusz","family":"Oleksy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Schulze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Fedorova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baktybek","family":"Kojonazarov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharandip","family":"Nijjar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0447-5030","authenticated-orcid":false,"given":"Sian","family":"Jossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8536-6102","authenticated-orcid":false,"given":"Kovilen","family":"Sawmynaden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maud","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Matthews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Offermanns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Worzfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2022.102265_bib1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0092-8674(00)80063-X","article-title":"Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates","volume":"99","author":"Tamagnone","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2022.102265_bib2","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0092-8674(00)81715-8","article-title":"Plexin A is a neuronal semaphorin receptor that controls axon guidance","volume":"95","author":"Winberg","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2022.102265_bib3","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrd4337","article-title":"Semaphorins and plexins as therapeutic targets","volume":"13","author":"Worzfeld","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jbc.2022.102265_bib4","doi-asserted-by":"crossref","first-page":"311","DOI":"10.5607\/en.2019.28.3.311","article-title":"Axon guidance molecules guiding neuroinflammation","volume":"28","author":"Lee","year":"2019","journal-title":"Exp. Neurobiol."},{"key":"10.1016\/j.jbc.2022.102265_bib5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nrrheum.2017.201","article-title":"The role of semaphorins in immune responses and autoimmune rheumatic diseases","volume":"14","author":"Nishide","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jbc.2022.102265_bib6","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.mce.2015.09.009","article-title":"Semaphorin signaling in bone","volume":"432","author":"Verlinden","year":"2016","journal-title":"Mol. Cell Endocrinol"},{"key":"10.1016\/j.jbc.2022.102265_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4939-6448-2_1","article-title":"Semaphorins and their signaling mechanisms","volume":"1493","author":"Alto","year":"2017","journal-title":"Met. Mol. Biol."},{"key":"10.1016\/j.jbc.2022.102265_bib8","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/nature09468","article-title":"Structural basis of semaphorin-plexin signalling","volume":"467","author":"Janssen","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2022.102265_bib9","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.cell.2010.07.040","article-title":"Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1","volume":"142","author":"Liu","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2022.102265_bib10","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/nature09473","article-title":"Structural basis for semaphorin signalling through the plexin receptor","volume":"467","author":"Nogi","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2022.102265_bib11","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1056\/NEJMcp1513724","article-title":"Postmenopausal osteoporosis","volume":"374","author":"Black","year":"2016","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.jbc.2022.102265_bib12","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/03008207.2017.1290085","article-title":"Osteoblast-osteoclast interactions","volume":"59","author":"Chen","year":"2018","journal-title":"Connect Tissue Res."},{"key":"10.1016\/j.jbc.2022.102265_bib13","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/S2213-8587(17)30188-2","article-title":"Osteoporosis treatment: recent developments and ongoing challenges","volume":"5","author":"Khosla","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.jbc.2022.102265_bib14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41574-020-00426-5","article-title":"Emerging insights into the comparative effectiveness of anabolic therapies for osteoporosis","volume":"17","author":"Estell","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jbc.2022.102265_bib15","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1038\/nm.2489","article-title":"Suppression of bone formation by osteoclastic expression of semaphorin 4D","volume":"17","author":"Negishi-Koga","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.jbc.2022.102265_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026627","article-title":"Control of bone resorption by semaphorin 4D is dependent on ovarian function","volume":"6","author":"Dacquin","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2022.102265_bib17","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1056\/NEJMra1401483","article-title":"Multiple sclerosis","volume":"378","author":"Reich","year":"2018","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.jbc.2022.102265_bib18","series-title":"StatPearls [Internet]","article-title":"Multiple sclerosis","author":"Tafti","year":"2022"},{"key":"10.1016\/j.jbc.2022.102265_bib19","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s40120-018-0112-1","article-title":"European and American guidelines for multiple sclerosis treatment","volume":"7","author":"Ghezzi","year":"2018","journal-title":"Neurol. Ther."},{"key":"10.1016\/j.jbc.2022.102265_bib20","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1177\/1352458517751049","article-title":"ECTRIMS\/EAN Guideline on the pharmacological treatment of people with multiple sclerosis","volume":"24","author":"Montalban","year":"2018","journal-title":"Mult. Scler."},{"key":"10.1016\/j.jbc.2022.102265_bib21","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1212\/WNL.0000000000005345","article-title":"Comprehensive systematic review summary: disease-modifying therapies for adults with multiple sclerosis: report of the guideline development, dissemination, and implementation subcommittee of the American academy of neurology","volume":"90","author":"Rae-Grant","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.jbc.2022.102265_bib22","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.amjmed.2020.05.049","article-title":"Treatment of multiple sclerosis: a review","volume":"133","author":"Hauser","year":"2020","journal-title":"Am. J. Med."},{"key":"10.1016\/j.jbc.2022.102265_bib23","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3389\/fphar.2019.00286","article-title":"Targeting microglia and macrophages: a potential treatment strategy for multiple sclerosis","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jbc.2022.102265_bib24","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.4049\/jimmunol.0903302","article-title":"Roles of Sema4D-plexin-B1 interactions in the central nervous system for pathogenesis of experimental autoimmune encephalomyelitis","volume":"184","author":"Okuno","year":"2010","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jbc.2022.102265_bib25","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.molmed.2018.11.005","article-title":"Microglia in central nervous system inflammation and multiple sclerosis pathology","volume":"25","author":"Voet","year":"2019","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.jbc.2022.102265_bib26","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/348552a0","article-title":"Phage antibodies: Filamentous phage displaying antibody variable domains","volume":"348","author":"McCafferty","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2022.102265_bib27","doi-asserted-by":"crossref","first-page":"e305","DOI":"10.1038\/emm.2017.23","article-title":"From rabbit antibody repertoires to rabbit monoclonal antibodies","volume":"49","author":"Weber","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.jbc.2022.102265_bib28","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0076-6879(06)06052-6","article-title":"Plexin-induced collapse assay in COS cells","volume":"406","author":"Turner","year":"2006","journal-title":"Met. Enzymol."},{"key":"10.1016\/j.jbc.2022.102265_bib29","doi-asserted-by":"crossref","first-page":"6333","DOI":"10.1523\/JNEUROSCI.5381-06.2007","article-title":"Plexin-B2, but not Plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system in\u00a0vivo","volume":"27","author":"Deng","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.jbc.2022.102265_bib30","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.neuron.2018.01.021","article-title":"Multiple sclerosis: mechanisms and immunotherapy","volume":"97","author":"Baecher-Allan","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.jbc.2022.102265_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneuroim.2018.02.015","article-title":"The roles of macrophages and microglia in multiple sclerosis and experimental autoimmune encephalomyelitis","volume":"318","author":"Chu","year":"2018","journal-title":"J.\u00a0Neuroimmunol."},{"key":"10.1016\/j.jbc.2022.102265_bib32","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/s41582-019-0253-6","article-title":"When encephalitogenic T cells collaborate with microglia in multiple sclerosis","volume":"15","author":"Dong","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jbc.2022.102265_bib33","article-title":"Microglial phenotypes and functions in multiple sclerosis","volume":"8","author":"O'Loughlin","year":"2018","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.jbc.2022.102265_bib34","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.imbio.2018.01.002","article-title":"T\u00a0cell deficiencies as a common risk factor for drug associated progressive multifocal leukoencephalopathy","volume":"223","author":"Pavlovic","year":"2018","journal-title":"Immunobiology"},{"key":"10.1016\/j.jbc.2022.102265_bib35","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41582-020-00427-y","article-title":"Progressive multifocal leukoencephalopathy and the spectrum of JC virus-related disease","volume":"17","author":"Cortese","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jbc.2022.102265_bib36","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/nri3545","article-title":"Immunological functions of the neuropilins and plexins as receptors for semaphorins","volume":"13","author":"Kumanogoh","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jbc.2022.102265_bib37","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S1074-7613(00)00062-5","article-title":"Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling","volume":"13","author":"Kumanogoh","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.jbc.2022.102265_bib38","doi-asserted-by":"crossref","first-page":"31070","DOI":"10.1073\/pnas.2012266117","article-title":"Development of cyclic peptides with potent in\u00a0vivo osteogenic activity through RaPID-based affinity maturation","volume":"117","author":"Bashiruddin","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2022.102265_bib39","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/j.chembiol.2016.09.015","article-title":"Allosteric inhibition of a semaphorin 4D receptor plexin B1 by a high-affinity macrocyclic peptide","volume":"23","author":"Matsunaga","year":"2016","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.jbc.2022.102265_bib40","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/ane.12884","article-title":"Bone microarchitecture and bone mineral density in multiple sclerosis","volume":"137","author":"Olsson","year":"2018","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.jbc.2022.102265_bib41","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s40263-014-0173-3","article-title":"Osteoporosis and multiple sclerosis: risk factors, pathophysiology, and therapeutic interventions","volume":"28","author":"Gupta","year":"2014","journal-title":"CNS Drugs"},{"key":"10.1016\/j.jbc.2022.102265_bib42","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41574-020-0341-0","article-title":"Pathogenesis of glucocorticoid-induced osteoporosis and options for treatment","volume":"16","author":"Chotiyarnwong","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jbc.2022.102265_bib43","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF02207242","article-title":"Immobilization osteoporosis: A review","volume":"8","author":"Minaire","year":"1989","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.jbc.2022.102265_bib44","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/bonekey.2013.227","article-title":"Vitamin D endocrine system and osteoblasts","volume":"3","author":"van Driel","year":"2014","journal-title":"Bonekey Rep."},{"key":"10.1016\/j.jbc.2022.102265_bib45","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.nbd.2014.10.008","article-title":"SEMA4D compromises blood-brain barrier, activates microglia, and inhibits remyelination in neurodegenerative disease","volume":"73","author":"Smith","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jbc.2022.102265_bib46","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.devcel.2015.02.001","article-title":"Semaphorin-plexin signaling controls mitotic spindle orientation during epithelial morphogenesis and repair","volume":"33","author":"Xia","year":"2015","journal-title":"Dev. Cell"},{"key":"10.1016\/j.jbc.2022.102265_bib47","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1016\/j.yexcr.2010.05.007","article-title":"A\u00a0systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system","volume":"316","author":"Zielonka","year":"2010","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.jbc.2022.102265_bib48","doi-asserted-by":"crossref","first-page":"219","DOI":"10.15252\/emmm.201707689","article-title":"SEMA3C drives cancer growth by transactivating multiple receptor tyrosine kinases via Plexin B1","volume":"10","author":"Peacock","year":"2018","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.jbc.2022.102265_bib49","first-page":"225","article-title":"Sema4A induces cell morphological changes through B-type plexin-mediated signaling","volume":"25","author":"Yukawa","year":"2010","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jbc.2022.102265_bib50","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1083\/jcb.201602002","article-title":"A\u00a0reverse signaling pathway downstream of Sema4A controls cell migration via Scrib","volume":"216","author":"Sun","year":"2017","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.jbc.2022.102265_bib51","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.3390\/ijms23063024","article-title":"Identifying function determining residues in neuroimmune semaphorin 4A","volume":"23","author":"Chapoval","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbc.2022.102265_bib52","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201810154","article-title":"Inhibition of Sema4D\/PlexinB1 signaling alleviates vascular dysfunction in diabetic retinopathy","volume":"12","author":"Wu","year":"2020","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.jbc.2022.102265_bib53","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1182\/blood-2002-05-1339","article-title":"CD100\/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes","volume":"101","author":"Granziero","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.jbc.2022.102265_bib54","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1111\/j.1349-7006.2011.02053.x","article-title":"Semaphorin 4D, a lymphocyte semaphorin, enhances tumor cell motility through binding its receptor, plexinB1, in pancreatic cancer","volume":"102","author":"Kato","year":"2011","journal-title":"Cancer Sci."},{"key":"10.1016\/j.jbc.2022.102265_bib55","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1084\/jem.20072602","article-title":"Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages","volume":"205","author":"Sierra","year":"2008","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.jbc.2022.102265_bib56","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1038\/jid.2011.414","article-title":"Sema4D, the ligand for Plexin B1, suppresses c-Met activation and migration and promotes melanocyte survival and growth","volume":"132","author":"Soong","year":"2012","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.jbc.2022.102265_bib57","first-page":"59","article-title":"Standard protocols for the construction of scFv libraries","volume":"178","author":"Lennard","year":"2002","journal-title":"Met. Mol. Biol."},{"key":"10.1016\/j.jbc.2022.102265_bib58","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1172\/JCI60568","article-title":"ErbB-2 signals through Plexin-B1 to promote breast cancer metastasis","volume":"122","author":"Worzfeld","year":"2012","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.jbc.2022.102265_bib59","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1073\/pnas.1308418111","article-title":"Genetic dissection of plexin signaling in\u00a0vivo","volume":"111","author":"Worzfeld","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2022.102265_bib60","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1093\/gerona\/glt046","article-title":"The relevance of mouse models for investigating age-related bone loss in humans","volume":"68","author":"Jilka","year":"2013","journal-title":"J.\u00a0Gerontol. A. Biol. Sci. Med. Sci."},{"key":"10.1016\/j.jbc.2022.102265_bib61","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ejphar.2015.03.028","article-title":"Animal models for osteoporosis","volume":"759","author":"Komori","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jbc.2022.102265_bib62","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.ejphar.2015.03.042","article-title":"Animal models of multiple sclerosis","volume":"759","author":"Procaccini","year":"2015","journal-title":"Eur. J. Pharmacol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925822007074?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925822007074?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T16:33:48Z","timestamp":1762187628000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925822007074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":62,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S0021925822007074"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2022.102265","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An antagonistic monoclonal anti\u2013Plexin-B1 antibody exerts therapeutic effects in mouse models of postmenopausal osteoporosis and multiple sclerosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2022.102265","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"102265"}}