{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T06:22:35Z","timestamp":1781418155940,"version":"3.54.1"},"reference-count":73,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010127","name":"J\u00fcrgen Manchot Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010127","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SPP2225"],"award-info":[{"award-number":["SPP2225"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.jbc.2022.102360","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T11:45:45Z","timestamp":1660131945000},"page":"102360","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Functional inactivation of Plasmodium falciparum glycogen synthase kinase GSK3 modulates erythrocyte invasion and blocks gametocyte maturation"],"prefix":"10.1016","volume":"298","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4918-4640","authenticated-orcid":false,"given":"Arne","family":"Alder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3572-272X","authenticated-orcid":false,"given":"Louisa","family":"Wilcke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4744-1666","authenticated-orcid":false,"given":"Emma","family":"Pietsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidrun","family":"von Thien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4674-9784","authenticated-orcid":false,"given":"Samuel","family":"Pazicky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0764-7483","authenticated-orcid":false,"given":"Christian","family":"L\u00f6w","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7842-5867","authenticated-orcid":false,"given":"Paolo","family":"Mesen-Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8397-7308","authenticated-orcid":false,"given":"Anna","family":"Bachmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul-Christian","family":"Burda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7041-5322","authenticated-orcid":false,"given":"Conrad","family":"Kunick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Sondermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5073-1405","authenticated-orcid":false,"given":"Danny","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim-Wolf","family":"Gilberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2022.102360_bib1","series-title":"World Malaria Report 2020","year":"2021"},{"key":"10.1016\/j.jbc.2022.102360_bib2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature15535","article-title":"The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015","volume":"526","author":"Bhatt","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2022.102360_bib3","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1056\/NEJMoa1314981","article-title":"Spread of artemisinin resistance in Plasmodium falciparum malaria","volume":"371","author":"Ashley","year":"2014","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.jbc.2022.102360_bib4","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/femsre\/fuz005","article-title":"Targeting malaria parasite invasion of red blood cells as an antimalarial strategy","volume":"43","author":"Burns","year":"2019","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.jbc.2022.102360_bib5","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.pt.2021.01.002","article-title":"Parasite and host erythrocyte kinomics of Plasmodium infection","volume":"37","author":"Adderley","year":"2021","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.jbc.2022.102360_bib6","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1042\/BJ20121694","article-title":"Specific phosphorylation of the PfRh2b invasion ligand of Plasmodium falciparum","volume":"452","author":"Engelberg","year":"2013","journal-title":"Biochem. J."},{"key":"10.1016\/j.jbc.2022.102360_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000322","article-title":"Functional analysis of the leading malaria vaccine candidate AMA-1 reveals an essential role for the cytoplasmic domain in the invasion process","volume":"5","author":"Treeck","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2022.102360_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000941","article-title":"Protein kinase a dependent phosphorylation of apical membrane antigen 1 plays an important role in erythrocyte invasion by the malaria parasite","volume":"6","author":"Leykauf","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2022.102360_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000264","article-title":"Cyclic AMP signalling controls key components\u00a0of malaria parasite host cell invasion machinery","volume":"17","author":"Patel","year":"2019","journal-title":"PLoS Biol."},{"key":"10.1016\/j.jbc.2022.102360_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/srep34479","article-title":"Hierarchical phosphorylation of apical membrane antigen 1 is required for efficient red blood cell invasion by malaria parasites","volume":"6","author":"Prinz","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2022.102360_bib11","doi-asserted-by":"crossref","first-page":"7285","DOI":"10.1038\/ncomms8285","article-title":"Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion","volume":"6","author":"Alam","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2022.102360_bib12","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41467-017-00053-1","article-title":"PfCDPK1 mediated signaling in erythrocytic stages of Plasmodium falciparum","volume":"8","author":"Kumar","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2022.102360_bib13","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1074\/jbc.M112.411934","article-title":"Characterization of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) and its role in microneme secretion during erythrocyte invasion","volume":"288","author":"Bansal","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2022.102360_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003344","article-title":"Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress","volume":"9","author":"Collins","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2022.102360_bib15","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01287-20","article-title":"Phosphorylation-dependent assembly of a 14-3-3 mediated signaling complex during red blood cell invasion by Plasmodium falciparum merozoites","volume":"11","author":"More","year":"2020","journal-title":"mBio"},{"key":"10.1016\/j.jbc.2022.102360_bib16","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01972-19","article-title":"Protein kinase A is essential for invasion of Plasmodium falciparum into human erythrocytes","volume":"10","author":"Wilde","year":"2019","journal-title":"mBio"},{"key":"10.1016\/j.jbc.2022.102360_bib17","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/s42003-021-01873-0","article-title":"The catalytic subunit of Plasmodium falciparum casein kinase 2 is essential for gametocytogenesis","volume":"4","author":"Hitz","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.jbc.2022.102360_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005343","article-title":"Plasmodium falciparum adhesins play an essential role in signalling and activation of invasion into human erythrocytes","volume":"11","author":"Tham","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2022.102360_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3001483","article-title":"The 3-phosphoinositide-dependent protein kinase 1 is an essential upstream activator of protein kinase A in malaria parasites","volume":"19","author":"Hitz","year":"2021","journal-title":"PLoS Biol."},{"key":"10.1016\/j.jbc.2022.102360_bib20","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.2174\/1568026620666200516153136","article-title":"Glycogen synthase kinase 3 (GSK3): its role and inhibitors","volume":"20","author":"Wadhwa","year":"2020","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.jbc.2022.102360_bib21","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/med.21867","article-title":"Glycogen synthesis and beyond, a comprehensive review of GSK3 as a key regulator of metabolic pathways and a therapeutic target for treating metabolic diseases","volume":"42","author":"Wang","year":"2022","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.jbc.2022.102360_bib22","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1471-2164-5-79","article-title":"Protein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryote","volume":"5","author":"Ward","year":"2004","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jbc.2022.102360_bib23","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01500-19","article-title":"Dissecting the gene expression, localization, membrane topology, and function of the Plasmodium falciparum STEVOR protein family","volume":"10","author":"Wichers","year":"2019","journal-title":"mBio"},{"key":"10.1016\/j.jbc.2022.102360_bib24","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1093\/nar\/gkj517","article-title":"Comparative whole genome transcriptome analysis of three Plasmodium falciparum strains","volume":"34","author":"Llin\u00e1s","year":"2006","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.jbc.2022.102360_bib25","doi-asserted-by":"crossref","first-page":"E5","DOI":"10.1371\/journal.pbio.0000005","article-title":"The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum","volume":"1","author":"Bozdech","year":"2003","journal-title":"PLoS Biol."},{"key":"10.1016\/j.jbc.2022.102360_bib26","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1186\/1471-2164-12-587","article-title":"Directional gene expression and antisense transcripts in sexual and asexual stages of Plasmodium falciparum","volume":"12","author":"L\u00f3pez-Barrag\u00e1n","year":"2011","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jbc.2022.102360_bib27","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/ncomms1558","article-title":"Global kinomic and localiza-proteomic analyses of the human malaria parasite Plasmodium falciparum","volume":"2","author":"Solyakov","year":"2011","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2022.102360_bib28","doi-asserted-by":"crossref","DOI":"10.1126\/science.aap7847","article-title":"Uncovering the essential genes of the human malaria parasite Plasmodium falciparum by saturation mutagenesis","volume":"360","author":"Zhang","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.jbc.2022.102360_bib29","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1021\/jm301575n","article-title":"3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles are selective inhibitors of Plasmodium falciparum glycogen synthase kinase-3","volume":"56","author":"Fugel","year":"2013","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.jbc.2022.102360_bib30","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12936-019-2725-y","article-title":"Structure-activity relationships in a series of antiplasmodial thieno[2,3-b]pyridines","volume":"18","author":"Masch","year":"2019","journal-title":"Malar. J."},{"key":"10.1016\/j.jbc.2022.102360_bib31","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1080\/1062936X.2015.1104518","article-title":"First report on exploring classification and regression based QSAR modelling of Plasmodium falciparum glycogen synthase kinase (PfGSK-3) inhibitors","volume":"26","author":"Balasaheb Aher","year":"2015","journal-title":"SAR QSAR Environ. Res."},{"key":"10.1016\/j.jbc.2022.102360_bib32","doi-asserted-by":"crossref","first-page":"4739","DOI":"10.3390\/molecules26164739","article-title":"Synthesis and antiplasmodial activity of bisindolylcyclobutenediones","volume":"26","author":"Lande","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.jbc.2022.102360_bib33","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.bbapap.2003.11.023","article-title":"Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localization and selective inhibitors","volume":"1697","author":"Droucheau","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbc.2022.102360_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.104839","article-title":"Exploration of benzofuran-based compounds as potent and selective Plasmodium falciparum glycogen synthase kinase-3 (PfGSK-3) inhibitors","volume":"112","author":"Moolman","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.jbc.2022.102360_bib35","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1046\/j.1365-2958.2000.02175.x","article-title":"Apical membrane antigen 1 plays a central role in\u00a0erythrocyte invasion by Plasmodium species","volume":"38","author":"Triglia","year":"2000","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jbc.2022.102360_bib36","doi-asserted-by":"crossref","first-page":"4617","DOI":"10.1039\/C5OB02517F","article-title":"Antimalarial activity of novel 4-cyano-3-methylisoquinoline inhibitors against Plasmodium falciparum: design, synthesis and biological evaluation","volume":"14","author":"Buskes","year":"2016","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.jbc.2022.102360_bib37","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02575-21","article-title":"Plasmodium falciparum calcium-dependent protein kinase 4 is critical for male gametogenesis and transmission to the mosquito vector","volume":"12","author":"Kumar","year":"2021","journal-title":"mBio"},{"key":"10.1016\/j.jbc.2022.102360_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-68717-5","article-title":"PfMAP-2 is essential for male gametogenesis in the malaria parasite Plasmodium falciparum","volume":"10","author":"Hitz","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2022.102360_bib39","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1146\/annurev-micro-090817-062712","article-title":"Regulation of sexual commitment and gametocytogenesis in malaria parasites","volume":"72","author":"Josling","year":"2018","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.jbc.2022.102360_bib40","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0035-9203(71)90036-8","article-title":"Evidence for cyclic development and short-lived maturity in the gametocytes of Plasmodium falciparum","volume":"65","author":"Hawking","year":"1971","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.jbc.2022.102360_bib41","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.cell.2005.03.027","article-title":"Proteome analysis of separated male and female gametocytes reveals novel sex-specific Plasmodium biology","volume":"121","author":"Khan","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2022.102360_bib42","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.pt.2010.06.016","article-title":"A\u00a0genotype and phenotype database of genetically modified malaria-parasites","volume":"27","author":"Janse","year":"2011","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.jbc.2022.102360_bib43","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.chom.2010.09.006","article-title":"The systematic functional analysis of Plasmodium protein kinases identifies essential regulators of mosquito transmission","volume":"8","author":"Tewari","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jbc.2022.102360_bib44","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.chom.2015.01.014","article-title":"A\u00a0genome-scale vector resource enables high-throughput reverse genetic screening in a malaria parasite","volume":"17","author":"Gomes","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jbc.2022.102360_bib45","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nmeth.4223","article-title":"A\u00a0genetic system to study Plasmodium falciparum protein function","volume":"14","author":"Birnbaum","year":"2017","journal-title":"Nat. Met."},{"key":"10.1016\/j.jbc.2022.102360_bib46","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1042\/BCJ20210829","article-title":"N-terminal phosphorylation regulates the activity of glycogen synthase kinase 3 from Plasmodium falciparum","volume":"479","author":"Pazicky","year":"2022","journal-title":"Biochem. J."},{"key":"10.1016\/j.jbc.2022.102360_bib47","doi-asserted-by":"crossref","first-page":"6087","DOI":"10.1093\/nar\/gkw536","article-title":"Integrated transcriptomic and proteomic analyses of P. Falciparum gametocytes: Molecular insight into sex-specific processes and translational repression","volume":"44","author":"Lasonder","year":"2016","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.jbc.2022.102360_bib48","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13073-015-0133-7","article-title":"Transcriptional profiling defines dynamics of parasite tissue sequestration during malaria infection","volume":"7","author":"Pelle","year":"2015","journal-title":"Genome Med."},{"key":"10.1016\/j.jbc.2022.102360_bib49","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.molbiopara.2005.05.007","article-title":"The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identification","volume":"143","author":"Young","year":"2005","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.jbc.2022.102360_bib50","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1126\/science.aan6042","article-title":"GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing","volume":"359","author":"Filarsky","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.jbc.2022.102360_bib51","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.1038\/s41467-021-24954-4","article-title":"CRISPR\/Cas9-engineered inducible gametocyte producer lines as a valuable tool for Plasmodium falciparum malaria transmission research","volume":"12","author":"Boltryk","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2022.102360_bib52","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.00623-22","article-title":"PMRT1, a plasmodium-specific parasite plasma membrane transporter, is essential for asexual and sexual blood stage development","volume":"13","author":"Wichers","year":"2022","journal-title":"mBio"},{"key":"10.1016\/j.jbc.2022.102360_bib53","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/bs.apcsb.2020.10.004","article-title":"Targeting malaria protein kinases","volume":"124","author":"Cassiano","year":"2021","journal-title":"Adv. Protein Chem. Struct. Biol."},{"key":"10.1016\/j.jbc.2022.102360_bib54","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01896-19","article-title":"Safety, tolerability, pharmacokinetics, and antimalarial activity of the novel Plasmodium phosphatidylinositol 4-kinase inhibitor MMV390048 in healthy volunteers","volume":"64","author":"Sinxadi","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jbc.2022.102360_bib55","doi-asserted-by":"crossref","first-page":"e657","DOI":"10.1093\/cid\/ciaa368","article-title":"A\u00a0phase 1, placebo-controlled, randomized, single ascending dose study and a volunteer infection study to characterize the safety, pharmacokinetics, and antimalarial activity of the Plasmodium phosphatidylinositol 4-kinase inhibitor MMV390048","volume":"71","author":"McCarthy","year":"2020","journal-title":"Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am."},{"key":"10.1016\/j.jbc.2022.102360_bib56","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02011-16","article-title":"Reduced activity of mutant calcium-dependent protein kinase 1 is compensated in Plasmodium falciparum through the action of protein kinase G","volume":"7","author":"Bansal","year":"2016","journal-title":"mBio"},{"key":"10.1016\/j.jbc.2022.102360_bib57","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nrd773","article-title":"Protein kinases\u2014the major drug targets of the twenty-first century?","volume":"1","author":"Cohen","year":"2002","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jbc.2022.102360_bib58","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1741-7007-10-5","article-title":"Involvement of Plasmodium falciparum protein kinase CK2 in the chromatin assembly pathway","volume":"10","author":"Dastidar","year":"2012","journal-title":"BMC Biol."},{"key":"10.1016\/j.jbc.2022.102360_bib59","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1128\/EC.00334-08","article-title":"Functional analysis of protein kinase CK2 of the human malaria parasite Plasmodium falciparum","volume":"8","author":"Holland","year":"2009","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.jbc.2022.102360_bib60","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1021\/pr400394g","article-title":"Global analysis of protein expression and phosphorylation of three stages of Plasmodium falciparum intraerythrocytic development","volume":"12","author":"Pease","year":"2013","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.jbc.2022.102360_bib61","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/nature01107","article-title":"A\u00a0proteomic view of the Plasmodium falciparum life cycle","volume":"419","author":"Florens","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2022.102360_bib62","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1126\/science.1087025","article-title":"Discovery of gene function by expression profiling of the malaria parasite life cycle","volume":"301","author":"Le Roch","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.jbc.2022.102360_bib63","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1126\/science.3299700","article-title":"Genetic analysis of the human malaria parasite Plasmodium falciparum","volume":"236","author":"Walliker","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.jbc.2022.102360_bib64","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.781840","article-title":"Human malaria parasites in continuous culture","volume":"193","author":"Trager","year":"1976","journal-title":"Science"},{"key":"10.1016\/j.jbc.2022.102360_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107817","article-title":"Structure-based identification and functional characterization of a lipocalin in the malaria parasite Plasmodium falciparum","volume":"31","author":"Burda","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2022.102360_bib66","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1073\/pnas.1216457110","article-title":"Adaptation of the genetically tractable malaria pathogen Plasmodium knowlesi to continuous culture in human erythrocytes","volume":"110","author":"Moon","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2022.102360_bib67","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0157873","article-title":"Development and application of a simple plaque assay for the human malaria parasite Plasmodium falciparum","volume":"11","author":"Thomas","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2022.102360_bib68","doi-asserted-by":"crossref","first-page":"5603","DOI":"10.1242\/jcs.02673","article-title":"Re-defining the Golgi complex in plasmodium falciparum using the novel Golgi marker PfGRASP","volume":"118","author":"Struck","year":"2005","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.jbc.2022.102360_bib69","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/srep00118","article-title":"A\u00a0rapid and robust tri-color flow cytometry assay for monitoring malaria parasite development","volume":"1","author":"Malleret","year":"2011","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2022.102360_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005538","article-title":"Mosquito passage dramatically changes var gene expression in controlled human Plasmodium falciparum infections","volume":"12","author":"Bachmann","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2022.102360_bib71","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00743-21","article-title":"Characterization of apicomplexan amino acid transporters (ApiATs) in the malaria parasite Plasmodium falciparum","volume":"6","author":"Wichers","year":"2021","journal-title":"mSphere"},{"key":"10.1016\/j.jbc.2022.102360_bib72","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.0020022","article-title":"Mutually exclusive expression of virulence genes by malaria parasites is regulated independently of antigen production","volume":"2","author":"Dzikowski","year":"2006","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2022.102360_bib73","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925822008031?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925822008031?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:27:13Z","timestamp":1758241633000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925822008031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":73,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S0021925822008031"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2022.102360","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional inactivation of Plasmodium falciparum glycogen synthase kinase GSK3 modulates erythrocyte invasion and blocks gametocyte maturation","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2022.102360","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"102360"}}