{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:41:00Z","timestamp":1792449660605,"version":"4.5.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019470","name":"Lazio Innova","doi-asserted-by":"publisher","award":["A0375-2020-36575"],"award-info":[{"award-number":["A0375-2020-36575"]}],"id":[{"id":"10.13039\/100019470","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004462","name":"Consiglio Nazionale delle Ricerche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004462","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["20154JRJPP"],"award-info":[{"award-number":["20154JRJPP"]}],"id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.jbc.2022.102375","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T21:16:55Z","timestamp":1660339015000},"page":"102375","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Crystal structures of Schistosoma mansoni histone deacetylase 8 reveal a novel binding site for allosteric inhibitors"],"prefix":"10.1016","volume":"298","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3527-6694","authenticated-orcid":false,"given":"Fulvio","family":"Saccoccia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Pozzetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Gimmelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Butini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Guidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2251-8794","authenticated-orcid":false,"given":"Giuliana","family":"Papoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marialaura","family":"Giannaccari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9375-6242","authenticated-orcid":false,"given":"Simone","family":"Brogi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Scognamiglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Gemma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2367-9709","authenticated-orcid":false,"given":"Giovina","family":"Ruberti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Campiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2022.102375_bib1","first-page":"1","article-title":"Schistosomiasis","volume":"4","author":"McManus","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.jbc.2022.102375_bib2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.molbiopara.2014.06.002","article-title":"Schistosomiasis control: praziquantel forever?","volume":"195","author":"Cioli","year":"2014","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.jbc.2022.102375_bib3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1017\/S0031182016001190","article-title":"Hybridizations within the genus schistosoma: implications for evolution, epidemiology and control","volume":"144","author":"Leger","year":"2017","journal-title":"Parasitology"},{"key":"10.1016\/j.jbc.2022.102375_bib4","doi-asserted-by":"crossref","first-page":"4780","DOI":"10.1021\/acs.jmedchem.6b01595","article-title":"Lysine deacetylase inhibitors in parasites: past, present, and future perspectives","volume":"60","author":"Hailu","year":"2017","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.jbc.2022.102375_bib5","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.bbrc.2008.10.090","article-title":"The class I histone deacetylases of the platyhelminth parasite Schistosoma mansoni","volume":"377","author":"Oger","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jbc.2022.102375_bib6","first-page":"769","article-title":"Expression profile of class I histone deacetylases in human cancer tissues","volume":"18","author":"Nakagawa","year":"2007","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.jbc.2022.102375_bib7","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.tips.2016.12.006","article-title":"Targeting class I histone deacetylases in a \u201ccomplex\u201d environment","volume":"38","author":"Millard","year":"2017","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.jbc.2022.102375_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsb.2020.107681","article-title":"Structural analysis of histone deacetylase 8 mutants associated with Cornelia de Lange Syndrome spectrum disorders","volume":"213","author":"Osko","year":"2021","journal-title":"J.\u00a0Struct. Biol."},{"key":"10.1016\/j.jbc.2022.102375_bib9","doi-asserted-by":"crossref","first-page":"3841","DOI":"10.1038\/s41467-020-17610-w","article-title":"A\u00a0distal regulatory region of a class I human histone deacetylase","volume":"11","author":"Werbeck","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2022.102375_bib10","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3390\/ph15010080","article-title":"Histone deacetylase (HDAC) inhibitors for the treatment of schistosomiasis","volume":"15","author":"Ghazy","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jbc.2022.102375_bib11","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1021\/acsinfecdis.9b00224","article-title":"Screening and phenotypical characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) inhibitors as multistage antischistosomal agents","volume":"6","author":"Saccoccia","year":"2020","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.jbc.2022.102375_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0003484","article-title":"Development and validation of a luminescence-based, medium-throughput assay for drug screening in Schistosoma mansoni","volume":"9","author":"Lalli","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.jbc.2022.102375_bib13","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/978-1-0716-0635-3_18","article-title":"Luminescence-based, low- and medium-throughput assays for drug screening in Schistosoma mansoni larval stage","volume":"2151","author":"Guidi","year":"2020","journal-title":"Met. Mol. Biol."},{"key":"10.1016\/j.jbc.2022.102375_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005994","article-title":"Discovery by organism based high-throughput screening of new multi-stage compounds affecting Schistosoma mansoni viability, egg formation and production","volume":"11","author":"Guidi","year":"2017","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.jbc.2022.102375_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003645","article-title":"Structural basis for the inhibition of Histone Deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni","volume":"9","author":"Marek","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2022.102375_bib16","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1002\/cmdc.201800238","article-title":"Synthesis, crystallization studies, and in\u00a0vitro characterization of cinnamic acid derivatives as SmHDAC8 inhibitors for the treatment of Schistosomiasis","volume":"13","author":"Bayer","year":"2018","journal-title":"ChemMedChem"},{"key":"10.1016\/j.jbc.2022.102375_bib17","doi-asserted-by":"crossref","first-page":"10000","DOI":"10.1021\/acs.jmedchem.8b01087","article-title":"Characterization of Histone Deacetylase 8 (HDAC8) selective inhibition reveals specific active site structural and functional determinants","volume":"61","author":"Marek","year":"2018","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.jbc.2022.102375_bib18","doi-asserted-by":"crossref","first-page":"566","DOI":"10.3390\/molecules23030566","article-title":"A\u00a0novel class of Schistosoma mansoni histone deacetylase 8 (HDAC8) inhibitors identified by structure-based virtual screening and in\u00a0vitro testing","volume":"23","author":"Simoben","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.jbc.2022.102375_bib19","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.1016\/j.jmb.2014.03.007","article-title":"Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits Histone Deacetylase 8 (HDAC8) from the human pathogen","volume":"426","author":"Stolfa","year":"2014","journal-title":"Schistosoma Mansoni. J. Mol. Biol."},{"key":"10.1016\/j.jbc.2022.102375_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113745","article-title":"Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis","volume":"225","author":"Ghazy","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.jbc.2022.102375_bib21","series-title":"Understanding Enzymes","author":"Palmer","year":"1985"},{"key":"10.1016\/j.jbc.2022.102375_bib22","series-title":"Molecular Enzymology","author":"Wharton","year":"1981"},{"key":"10.1016\/j.jbc.2022.102375_bib23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.molbiopara.2009.06.001","article-title":"Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni","volume":"168","author":"Dubois","year":"2009","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.jbc.2022.102375_bib24","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1590\/S0074-02762011000700003","article-title":"Chromatin regulation in schistosomes and histone modifying enzymes as drug targets","volume":"106","author":"Pierce","year":"2011","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.jbc.2022.102375_bib25","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1158\/1535-7163.MCT-07-2289","article-title":"Competitive or noncompetitive, that\u2019s the question: research toward histone deacetylase inhibitors","volume":"7","author":"Su","year":"2008","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.jbc.2022.102375_bib26","series-title":"Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists","author":"Copeland","year":"2013"},{"key":"10.1016\/j.jbc.2022.102375_bib27","series-title":"Reversible Ligand Binding","author":"Bellelli","year":"2018"},{"key":"10.1016\/j.jbc.2022.102375_bib28","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1177\/2472555219829898","article-title":"Enzyme-inhibitor interactions and a Simple, rapid method for determining inhibition modality","volume":"24","author":"Buker","year":"2019","journal-title":"SLAS Discov."},{"key":"10.1016\/j.jbc.2022.102375_bib29","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1021\/acs.jcim.7b00251","article-title":"Intrinsic dynamics of the binding rail and its allosteric effect in the class I histone deacetylases","volume":"57","author":"Zhou","year":"2017","journal-title":"J.\u00a0Chem. Inf. Model."},{"key":"10.1016\/j.jbc.2022.102375_bib30","doi-asserted-by":"crossref","first-page":"9318","DOI":"10.1039\/D1SC01929E","article-title":"Aromatic side-chain flips orchestrate the conformational sampling of functional loops in human histone deacetylase 8","volume":"12","author":"Shukla","year":"2021","journal-title":"Chem. Sci."},{"key":"10.1016\/j.jbc.2022.102375_bib31","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/prot.340170408","article-title":"Essential dynamics of proteins","volume":"17","author":"Amadei","year":"1993","journal-title":"Proteins"},{"key":"10.1016\/j.jbc.2022.102375_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1002004","article-title":"Conformational sampling and nucleotide-dependent transitions of the GroEL subunit probed by unbiased molecular dynamics simulations","volume":"7","author":"Skjaerven","year":"2011","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.jbc.2022.102375_bib33","doi-asserted-by":"crossref","first-page":"L08","DOI":"10.1016\/j.bpj.2013.06.006","article-title":"Domain-opening and dynamic coupling in the \u03b1-subunit of heterotrimeric G proteins","volume":"105","author":"Yao","year":"2013","journal-title":"Biophys. J."},{"key":"10.1016\/j.jbc.2022.102375_bib34","doi-asserted-by":"crossref","DOI":"10.1063\/1.5092803","article-title":"Structural and dynamical description of the enzymatic reaction of a phosphohexomutase","volume":"6","author":"Stiers","year":"2019","journal-title":"Struct. Dyn."},{"key":"10.1016\/j.jbc.2022.102375_bib35","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1093\/bioinformatics\/btl461","article-title":"Bio3d: an R package for the comparative analysis of protein structures","volume":"22","author":"Grant","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jbc.2022.102375_bib36","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1186\/s13071-018-3268-8","article-title":"Identification of novel multi-stage histone deacetylase (HDAC) inhibitors that impair Schistosoma mansoni viability and egg production","volume":"11","author":"Guidi","year":"2018","journal-title":"Parasit Vectors"},{"key":"10.1016\/j.jbc.2022.102375_bib37","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1107\/S0907444909047374","article-title":"Integration, scaling, space-group assignment and post-refinement","volume":"66","author":"Kabsch","year":"2010","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr."},{"key":"10.1016\/j.jbc.2022.102375_bib38","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1107\/S0907444910045749","article-title":"Overview of the CCP4 suite and current developments","volume":"67","author":"Winn","year":"2011","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr."},{"key":"10.1016\/j.jbc.2022.102375_bib39","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1107\/S0021889807021206","article-title":"Phaser crystallographic software","volume":"40","author":"McCoy","year":"2007","journal-title":"J.\u00a0Appl. Crystallogr."},{"key":"10.1016\/j.jbc.2022.102375_bib40","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","article-title":"Features and development of Coot","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr."},{"key":"10.1016\/j.jbc.2022.102375_bib41","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1107\/S0907444996012255","article-title":"Refinement of macromolecular structures by the maximum-likelihood method","volume":"53","author":"Murshudov","year":"1997","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr."},{"key":"10.1016\/j.jbc.2022.102375_bib42","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1107\/S2059798319011471","article-title":"Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix","volume":"75","author":"Liebschner","year":"2019","journal-title":"Acta Crystallogr. Sect. D Struct. Biol."},{"key":"10.1016\/j.jbc.2022.102375_bib43","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1107\/S2059798316018210","article-title":"Polder maps: Improving OMIT maps by excluding bulk solvent","volume":"73","author":"Sobolev","year":"2017","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr."},{"key":"10.1016\/j.jbc.2022.102375_bib44","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","article-title":"PROCHECK: a program to check the stereochemical quality of protein structures","volume":"26","author":"Laskowski","year":"1993","journal-title":"J.\u00a0Appl. Crystallogr."},{"key":"10.1016\/j.jbc.2022.102375_bib45","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1107\/S0907444905036693","article-title":"Scaling and assessment of data quality","volume":"62","author":"Evans","year":"2006","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr."},{"key":"10.1016\/j.jbc.2022.102375_bib46","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/pro.3330","article-title":"MolProbity: more and better reference data for improved all-atom structure validation","volume":"27","author":"Williams","year":"2018","journal-title":"Protein Sci."},{"key":"10.1016\/j.jbc.2022.102375_bib47","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1107\/S1399004714014795","article-title":"Space-group and origin ambiguity in macromolecular structures with pseudo-symmetry and its treatment with the program Zanuda","volume":"70","author":"Lebedev","year":"2014","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr."},{"key":"10.1016\/j.jbc.2022.102375_bib48","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/1471-2105-5-113","article-title":"MUSCLE: a multiple sequence alignment method with reduced time and space complexity","volume":"5","author":"Edgar","year":"2004","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jbc.2022.102375_bib49","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1107\/S0567739478001680","article-title":"A\u00a0discussion of the solution for the best rotation to relate two sets of vectors","volume":"34","author":"Kabsch","year":"1978","journal-title":"Acta Crystallogr. Sect. A."},{"key":"10.1016\/j.jbc.2022.102375_bib50","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.molstruc.2011.05.023","article-title":"Fluorescence quenching and ligand binding: a critical discussion of a popular methodology","volume":"998","author":"van de Weert","year":"2011","journal-title":"J.\u00a0Mol. Struct."},{"key":"10.1016\/j.jbc.2022.102375_bib51","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1002\/pro.2813","article-title":"KDAC8 substrate specificity quantified by a biologically relevant, label-free deacetylation assay","volume":"24","author":"Toro","year":"2015","journal-title":"Protein Sci."},{"key":"10.1016\/j.jbc.2022.102375_bib52","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1093\/nar\/gkf436","article-title":"Mafft: a novel method for rapid multiple sequence alignment based on fast fourier transform","volume":"30","author":"Katoh","year":"2002","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.jbc.2022.102375_bib53","doi-asserted-by":"crossref","first-page":"10557","DOI":"10.1073\/pnas.0409137102","article-title":"An algorithm for progressive multiple alignment of sequences with insertions","volume":"102","author":"L\u00f6ytynoja","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2022.102375_bib54","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/molbev\/msu300","article-title":"IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies","volume":"32","author":"Nguyen","year":"2015","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.jbc.2022.102375_bib55","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1021\/acs.jmedchem.5b01478","article-title":"Structure-based design and synthesis of novel inhibitors targeting HDAC8 from Schistosoma mansoni for the treatment of schistosomiasis","volume":"59","author":"Heimburg","year":"2016","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.jbc.2022.102375_bib56","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1107\/S0907444912006737","article-title":"Tetartohedral twinning could happen to you too","volume":"68","author":"Roversi","year":"2012","journal-title":"Acta Crystallogr. D: Biol. Crystallogr."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925822008183?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925822008183?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T16:36:08Z","timestamp":1762187768000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925822008183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":56,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S0021925822008183"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2022.102375","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Crystal structures of Schistosoma mansoni histone deacetylase 8 reveal a novel binding site for allosteric inhibitors","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2022.102375","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"102375"}}