{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:27:20Z","timestamp":1790749640943,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MID-406688"],"award-info":[{"award-number":["MID-406688"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.jbc.2022.102473","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T02:05:55Z","timestamp":1662689155000},"page":"102473","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["A defect in cell wall recycling confers antibiotic resistance and sensitivity in Staphylococcus aureus"],"prefix":"10.1016","volume":"298","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7829-2064","authenticated-orcid":false,"given":"Stephanie","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin R.","family":"Nodwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2022.102473_bib1","doi-asserted-by":"crossref","first-page":"16187","DOI":"10.1038\/nmicrobiol.2016.187","article-title":"Combatting antimicrobial resistance globally","volume":"1","author":"Sugden","year":"2016","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.jbc.2022.102473_bib2","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1179\/2047773215Y.0000000030","article-title":"Antimicrobial resistance: a global multifaceted phenomenon antimicrobial resistance","volume":"109","author":"Prestinaci","year":"2015","journal-title":"Pathog. Glob. Health"},{"key":"10.1016\/j.jbc.2022.102473_bib3","first-page":"1330","article-title":"Clinical management of Staphylococcus aureus bacteremia","volume":"312","author":"Holland","year":"2014","journal-title":"Clin. Rev. Educ."},{"key":"10.1016\/j.jbc.2022.102473_bib4","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3201\/eid0702.010237","article-title":"Increasing resistance to vancomycin and other glycopeptides in Staphylococcus aureus","volume":"7","author":"Tenover","year":"2001","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.jbc.2022.102473_bib5","doi-asserted-by":"crossref","first-page":"12689","DOI":"10.1038\/s41598-020-69058-z","article-title":"Global prevalence and distribution of vancomycin resistant, vancomycin intermediate and heterogeneously vancomycin intermediate Staphylococcus aureus clinical isolates: a systematic review and meta-analysis","volume":"10","author":"ShariatiShariati","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2022.102473_bib6","series-title":"Global Antimicrobial Resistance and Use Surveillance System (GLASS) Report","author":"World Health Organization","year":"2021"},{"key":"10.1016\/j.jbc.2022.102473_bib7","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.3389\/fmicb.2016.02163","article-title":"Novel mutation sites in the development of vancomycin-intermediate resistance in Staphylococcus aureus","volume":"7","author":"Wang","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jbc.2022.102473_bib8","doi-asserted-by":"crossref","first-page":"429.e1","DOI":"10.1016\/j.cmi.2017.07.028","article-title":"Emergence of dalbavancin non-susceptible, vancomycin-intermediate Staphylococcus aureus (VISA) after treatment of MRSA central line-associated bloodstream infection with a dalbavancin- and vancomycin-containing regimen","volume":"24","author":"Werth","year":"2018","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.jbc.2022.102473_bib9","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nature13445","article-title":"AMA overcomes antibiotic resistance by NDM and VIM metallo-\u03b2- lactamases","volume":"510","author":"King","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2022.102473_bib10","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1093\/jac\/dkl460","article-title":"Bacterial efflux pump inhibitors from natural sources","volume":"59","author":"Stavri","year":"2007","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.jbc.2022.102473_bib11","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/s41570-021-00313-1","article-title":"Towards the sustainable discovery and development of new antibiotics","volume":"5","author":"Miethke","year":"2021","journal-title":"Nat. Rev. Chem."},{"key":"10.1016\/j.jbc.2022.102473_bib12","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nchembio.1205","article-title":"Systems-level antimicrobial drug and drug synergy discovery","volume":"9","author":"Roemer","year":"2013","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jbc.2022.102473_bib13","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2147\/IDR.S148335","article-title":"Novel single-nucleotide variations associated with vancomycin resistance in vancomycin- intermediate Staphylococcus aureus","volume":"11","author":"Lin","year":"2018","journal-title":"Infect. Drug Resist."},{"key":"10.1016\/j.jbc.2022.102473_bib14","doi-asserted-by":"crossref","first-page":"5845","DOI":"10.1128\/AAC.01139-12","article-title":"Contribution of selected gene mutations to resistance in clinical isolates of vancomycin-intermediate Staphylococcus aureus","volume":"56","author":"Hafer","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jbc.2022.102473_bib15","doi-asserted-by":"crossref","first-page":"3730","DOI":"10.1128\/AAC.00420-16","article-title":"Complete reconstitution of the vancomycin-intermediate Staphylococcus aureus phenotype of strain Mu50 in vancomycin-susceptible","volume":"60","author":"Katayama","year":"2016","journal-title":"S. Aureus. Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jbc.2022.102473_bib16","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1038\/s41467-020-15257-1","article-title":"Ca2+-Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids","volume":"11","author":"Grein","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2022.102473_bib17","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1128\/AAC.44.9.2276-2285.2000","article-title":"Contribution of a thickened cell wall and its glutamine nonamidated component to the vancomycin resistance expressed by Staphylococcus aureus Mu50","volume":"44","author":"Cui","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jbc.2022.102473_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002359","article-title":"Evolution of multidrug resistance during Staphylococcus aureus infection involves mutation of the essential two component regulator WalKR","volume":"7","author":"Howden","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2022.102473_bib19","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1021\/acschembio.9b00157","article-title":"The lasso peptide siamycin-I targets lipid II at the gram-positive cell surface","volume":"14","author":"Tan","year":"2019","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.jbc.2022.102473_bib20","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/mmi.13837","article-title":"Actinorhodin is a redox-active antibiotic with a complex mode of action against Gram-positive cells","volume":"106","author":"Mak","year":"2017","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jbc.2022.102473_bib21","doi-asserted-by":"crossref","first-page":"30823","DOI":"10.1038\/srep30823","article-title":"Vancomycin susceptibility in methicillin-resistant Staphylococcus aureus is mediated by YycHI activation of the WalRK essential two-component regulatory system","volume":"6","author":"Cameron","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2022.102473_bib22","doi-asserted-by":"crossref","first-page":"870","DOI":"10.3390\/microorganisms8060870","article-title":"YycH and YycI regulate expression of Staphylococcus aureus autolysins by activation of WalRK phosphorylation","volume":"8","author":"Gajdiss","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.jbc.2022.102473_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0151449","article-title":"Transcriptional analysis and subcellular protein localization reveal specific features of the essential WalKR system in Staphylococcus aureus","volume":"11","author":"Poupel","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2022.102473_bib24","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1128\/JB.01682-07","article-title":"Bypass, and targeting of the YycFG (VicRK) two-component regulatory system in gram-positive bacteria","volume":"190","author":"Winkler","year":"2008","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jbc.2022.102473_bib25","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.tim.2006.08.005","article-title":"MtrAB\u2013LpqB: a conserved three-component system in actinobacteria","volume":"14","author":"Hoskisson","year":"2006","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.jbc.2022.102473_bib26","doi-asserted-by":"crossref","first-page":"6121","DOI":"10.1128\/IAI.70.11.6121-6128.2002","article-title":"Genetic analysis and functional characterization of the Streptococcus pneumoniae vic operon","volume":"70","author":"Wagner","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jbc.2022.102473_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijmm.2016.12.001","article-title":"The cell wall precursor lipid II acts as a molecular signal for the Ser\/Thr kinase PknB of Staphylococcus aureus","volume":"307","author":"Hardt","year":"2017","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.jbc.2022.102473_bib28","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1038\/s41467-019-10932-4","article-title":"Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus","volume":"10","author":"Monk","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jbc.2022.102473_bib29","doi-asserted-by":"crossref","first-page":"8257","DOI":"10.1128\/JB.00645-07","article-title":"New insights into the WalK\/WalR (YycG\/YycF) essential signal tTransduction pathway reveal a major role in controlling cell wall metabolism and biofilm formation in Staphylococcus aureus","volume":"189","author":"Dubrac","year":"2007","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jbc.2022.102473_bib30","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.1128\/JB.01880-07","article-title":"Late-stage polyribitol phosphate wall teichoic acid biosynthesis in Staphylococcus aureus","volume":"190","author":"Meredith","year":"2008","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jbc.2022.102473_bib31","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1128\/AAC.22.1.172","article-title":"Penicillin-binding proteins in a Staphylococcus aureus strain resistant to specific B-lactam antibiotics","volume":"22","author":"Georgopapadakou","year":"1982","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jbc.2022.102473_bib32","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1046\/j.1365-2958.1999.01357.x","article-title":"New insights into the ATP-dependent clp protease: escherichia coli and beyond","volume":"32","author":"Porankiewicz","year":"1999","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jbc.2022.102473_bib33","article-title":"Preparation and analysis of Crude autolytic enzyme extracts from Staphylococcus aureus","volume":"5","author":"Vaz","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.jbc.2022.102473_bib34","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1574-6976.2007.00099.x","article-title":"Bacterial peptidoglycan (murein) hydrolases","volume":"32","author":"Vollmer","year":"2008","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.jbc.2022.102473_bib35","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/mmi.13552","article-title":"Utilization of glycerophosphodiesters by Staphylococcus aureus","volume":"103","author":"Jorge","year":"2017","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jbc.2022.102473_bib36","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.3389\/fmicb.2018.02725","article-title":"Recovery of the peptidoglycan turnover product released by the autolysin Atl in Staphylococcus aureus involves the phosphotransferase system transporter MurP and the novel 6-phospho-N-acetylmuramidase MupG","volume":"9","author":"Kluj","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jbc.2022.102473_bib37","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00923-16","article-title":"Peptidoglycan recycling in gram-positive bacteria is crucial for survival in stationary phase","volume":"7","author":"Borisova","year":"2016","journal-title":"mBio"},{"key":"10.1016\/j.jbc.2022.102473_bib38","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.plasmid.2008.10.001","article-title":"An improved tetracycline-inducible expression vector for Staphylococcus aureus","volume":"61","author":"Corrigan","year":"2009","journal-title":"Plasmid"},{"key":"10.1016\/j.jbc.2022.102473_bib39","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1128\/AAC.01040-08","article-title":"The lipopeptide antibiotic friulimicin B inhibits cell wall biosynthesis through complex formation with bactoprenol phosphate","volume":"53","author":"Schneider","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jbc.2022.102473_bib40","doi-asserted-by":"crossref","first-page":"151326","DOI":"10.1016\/j.ijmm.2019.06.006","article-title":"Bacteria\u2019s different ways to recycle their own cell wall","volume":"309","author":"Mayer","year":"2019","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.jbc.2022.102473_bib41","doi-asserted-by":"crossref","first-page":"6598","DOI":"10.1128\/JB.00642-08","article-title":"The transcriptional factors MurR and catabolite activator protein regulate N-acetylmuramic acid catabolism in Escherichia coli","volume":"190","author":"Jaeger","year":"2008","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jbc.2022.102473_bib42","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.1128\/JB.00117-09","article-title":"Transcriptome and functional analysis of the eukaryotic-type serine\/threonine kinase PknB in Staphylococcus aureus","volume":"191","author":"Donat","year":"2009","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.jbc.2022.102473_bib43","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/7651_2014_192","article-title":"RNA-sequencing of Staphylococcus aureus messenger RNA","volume":"1373","author":"Carroll","year":"2015","journal-title":"Met. Mol. Biol."},{"key":"10.1016\/j.jbc.2022.102473_bib44","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925822009164?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925822009164?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:37:34Z","timestamp":1778647054000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925822009164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S0021925822009164"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2022.102473","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A defect in cell wall recycling confers antibiotic resistance and sensitivity in Staphylococcus aureus","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2022.102473","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"102473"}}