{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T16:17:27Z","timestamp":1780330647056,"version":"3.54.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31730044"],"award-info":[{"award-number":["31730044"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31900581"],"award-info":[{"award-number":["31900581"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32022022"],"award-info":[{"award-number":["32022022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32192403"],"award-info":[{"award-number":["32192403"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["20DZ2261200"],"award-info":[{"award-number":["20DZ2261200"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1003500"],"award-info":[{"award-number":["2018YFC1003500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.jbc.2022.102490","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T11:46:46Z","timestamp":1663156006000},"page":"102490","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Chromatin remodeler Znhit1 controls bone morphogenetic protein signaling in embryonic lung tissue branching"],"prefix":"10.1016","volume":"298","author":[{"given":"Wei","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenfei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuyue","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdi","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaocai","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanlin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanmin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2022.102490_bib1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1146\/annurev.ph.46.030184.003153","article-title":"Fetal and postnatal development of the lung","volume":"46","author":"Burri","year":"1984","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.jbc.2022.102490_bib2","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1146\/annurev.cellbio.15.1.393","article-title":"Vertebrate endoderm development","volume":"15","author":"Wells","year":"1999","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.jbc.2022.102490_bib3","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1242\/dev.127.12.2695","article-title":"Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis","volume":"127","author":"Weaver","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.jbc.2022.102490_bib4","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0959-437X(98)80121-4","article-title":"Epithelial\/mesenchymal interactions and branching morphogenesis of the lung","volume":"8","author":"Hogan","year":"1998","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.jbc.2022.102490_bib5","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.devcel.2013.01.012","article-title":"Development and regeneration of Sox2+ endoderm progenitors are regulated by a HDAC1\/2-Bmp4\/Rb1 regulatory pathway","volume":"24","author":"Wang","year":"2013","journal-title":"Dev. Cell"},{"key":"10.1016\/j.jbc.2022.102490_bib6","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1242\/dev.149708","article-title":"Sin3a regulates epithelial progenitor cell fate during lung development","volume":"144","author":"Yao","year":"2017","journal-title":"Development"},{"key":"10.1016\/j.jbc.2022.102490_bib7","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1101\/gad.238873.114","article-title":"Histone variants: Dynamic punctuation in transcription","volume":"28","author":"Weber","year":"2014","journal-title":"Genes Dev."},{"key":"10.1016\/j.jbc.2022.102490_bib8","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.cell.2008.09.056","article-title":"H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment","volume":"135","author":"Creyghton","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2022.102490_bib9","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.stem.2012.11.003","article-title":"H2A.Z facilitates access of active and repressive complexes to chromatin in embryonic stem cell self-renewal and differentiation","volume":"12","author":"Hu","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jbc.2022.102490_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pgen.1003725","article-title":"H2A.Z acidic patch couples chromatin dynamics to regulation of gene expression programs during ESC differentiation","volume":"9","author":"Subramanian","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jbc.2022.102490_bib11","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1038\/emboj.2010.85","article-title":"Essential role of p18Hamlet\/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation","volume":"29","author":"Cuadrado","year":"2010","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2022.102490_bib12","first-page":"1","article-title":"Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation","volume":"10","author":"Zhao","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2022.102490_bib13","doi-asserted-by":"crossref","first-page":"3348","DOI":"10.1038\/s41375-020-0988-5","article-title":"Chromatin remodeler Znhit1 preserves hematopoietic stem cell quiescence by determining the accessibility of distal enhancers","volume":"34","author":"Sun","year":"2020","journal-title":"Leukemia"},{"key":"10.1016\/j.jbc.2022.102490_bib14","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.devcel.2022.03.006","article-title":"Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression","volume":"57","author":"Sun","year":"2022","journal-title":"Dev. Cell"},{"key":"10.1016\/j.jbc.2022.102490_bib15","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.cell.2004.07.024","article-title":"Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities","volume":"118","author":"Harfe","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2022.102490_bib16","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1242\/dev.034629","article-title":"Multiple roles for Sox2 in the developing and adult mouse trachea","volume":"136","author":"Que","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.jbc.2022.102490_bib17","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1242\/dev.003855","article-title":"Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm","volume":"134","author":"Que","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.jbc.2022.102490_bib18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/gene.20093","article-title":"Normal lung development and function after Sox9 inactivation in the respiratory epithelium","volume":"41","author":"Perl","year":"2005","journal-title":"Genesis"},{"key":"10.1016\/j.jbc.2022.102490_bib19","doi-asserted-by":"crossref","first-page":"E4456","DOI":"10.1073\/pnas.1311847110","article-title":"Sox9 plays multiple roles in the lung epithelium during branching morphogenesis","volume":"110","author":"Rockich","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2022.102490_bib20","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.stem.2014.07.012","article-title":"Repair and regeneration of the respiratory system: Complexity, plasticity, and mechanisms of lung stem cell function","volume":"15","author":"Hogan","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jbc.2022.102490_bib21","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.4161\/cc.6.19.4741","article-title":"p18(Hamlet) mediates different p53-dependent responses to DNA-damage inducing agents","volume":"6","author":"Lafarga","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jbc.2022.102490_bib22","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.bbrc.2009.05.139","article-title":"Znhit1 causes cell cycle arrest and down-regulates CDK6 expression","volume":"386","author":"Yang","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jbc.2022.102490_bib23","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1038\/sj.onc.1204326","article-title":"Histone H3 phosphorylation and cell division","volume":"20","author":"Hans","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.jbc.2022.102490_bib24","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.4049\/jimmunol.133.4.1710","article-title":"Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67","volume":"133","author":"Gerdes","year":"1984","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jbc.2022.102490_bib25","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1365-2559.1993.tb00135.x","article-title":"Detection of the Ki-67 antigen in fixed and wax-embedded sections with the monoclonal antibody MIB1","volume":"22","author":"McCormick","year":"1993","journal-title":"Histopathology"},{"key":"10.1016\/j.jbc.2022.102490_bib26","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1242\/dev.126.18.4005","article-title":"Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development","volume":"126","author":"Weaver","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.jbc.2022.102490_bib27","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1242\/dev.030338","article-title":"The regulation of TGFbeta signal transduction","volume":"136","author":"Moustakas","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.jbc.2022.102490_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/jcs.217406","article-title":"Histone arginine methylation by Prmt5 is required for lung branching morphogenesis through repression of BMP signaling","volume":"131","author":"Li","year":"2018","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.jbc.2022.102490_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/dev.199026","article-title":"The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development","volume":"148","author":"Xu","year":"2021","journal-title":"Development"},{"key":"10.1016\/j.jbc.2022.102490_bib30","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1242\/dev.098186","article-title":"Lung development: Orchestrating the generation and regeneration of a complex organ","volume":"141","author":"Herriges","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.jbc.2022.102490_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1183\/13993003.02553-2017","article-title":"Exaggerated BMP4 signalling alters human airway basal progenitor cell differentiation to cigarette smoking-related phenotypes","volume":"53","author":"Zuo","year":"2019","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jbc.2022.102490_bib32","doi-asserted-by":"crossref","first-page":"ITC17","DOI":"10.7326\/AITC202008040","article-title":"Chronic obstructive pulmonary disease","volume":"173","author":"Labaki","year":"2020","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.jbc.2022.102490_bib33","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","article-title":"TopHat: Discovering splice junctions with RNA-seq","volume":"25","author":"Trapnell","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jbc.2022.102490_bib34","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nprot.2012.016","article-title":"Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks","volume":"7","author":"Trapnell","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jbc.2022.102490_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pgen.1006992","article-title":"Epithelial heparan sulfate regulates Sonic Hedgehog signaling in lung development","volume":"13","author":"He","year":"2017","journal-title":"PLoS Genet."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925822009334?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925822009334?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:26:47Z","timestamp":1758241607000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925822009334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["S0021925822009334"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2022.102490","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chromatin remodeler Znhit1 controls bone morphogenetic protein signaling in embryonic lung tissue branching","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2022.102490","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"102490"}}