{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:12:21Z","timestamp":1793229141271,"version":"4.5.0"},"reference-count":118,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32HL007227"],"award-info":[{"award-number":["T32HL007227"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL139640"],"award-info":[{"award-number":["R01HL139640"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01CA230978"],"award-info":[{"award-number":["U01CA230978"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["R01HL134821"],"award-info":[{"award-number":["R01HL134821"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["HL141952"],"award-info":[{"award-number":["HL141952"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["935823"],"award-info":[{"award-number":["935823"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["R01HL134821"],"award-info":[{"award-number":["R01HL134821"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["18TPA34170575"],"award-info":[{"award-number":["18TPA34170575"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004326","name":"Simon Fraser University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.jbc.2023.102907","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T03:13:13Z","timestamp":1673579593000},"page":"102907","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Inhibiting O-GlcNAcylation impacts p38 and Erk1\/2 signaling and perturbs cardiomyocyte hypertrophy"],"prefix":"10.1016","volume":"299","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3088-7119","authenticated-orcid":false,"given":"Kyriakos N.","family":"Papanicolaou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0252-4716","authenticated-orcid":false,"given":"Deepthi","family":"Ashok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Modaressanavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddie","family":"Avila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9290-9590","authenticated-orcid":false,"given":"D. Brian","family":"Foster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7250-8282","authenticated-orcid":false,"given":"Natasha E.","family":"Zachara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5548-4853","authenticated-orcid":false,"given":"Brian","family":"O'Rourke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2023.102907_bib1","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/nature05815","article-title":"Cycling of O-linked \u03b2-N-acetylglucosamine on nucleocytoplasmic proteins","volume":"446","author":"Hart","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2023.102907_bib2","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1083\/jcb.201501101","article-title":"A\u00a0little sugar goes a long way: the cell biology of O-GlcNAc","volume":"208","author":"Bond","year":"2015","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.jbc.2023.102907_bib3","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1146\/annurev-biochem-060713-035344","article-title":"The biochemistry of O-GlcNAc transferase: which functions make it essential in mammalian cells?","volume":"85","author":"Levine","year":"2016","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.jbc.2023.102907_bib4","doi-asserted-by":"crossref","first-page":"53665","DOI":"10.1074\/jbc.M410406200","article-title":"Characterization of the histone acetyltransferase (HAT) domain of a bifunctional protein with activable O-GlcNAcase and HAT activities","volume":"279","author":"Toleman","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.102907_bib5","doi-asserted-by":"crossref","first-page":"9838","DOI":"10.1074\/jbc.M010420200","article-title":"Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic \u03b2-N-acetylglucosaminidase from human brain","volume":"276","author":"Gao","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.102907_bib6","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/SHK.0b013e3181598bad","article-title":"Hexosamine biosynthesis and protein O-glycosylation: the first line of defense against stress, ischemia, and trauma","volume":"29","author":"Chatham","year":"2008","journal-title":"Shock"},{"key":"10.1016\/j.jbc.2023.102907_bib7","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s12192-013-0426-y","article-title":"Dynamic O-GlcNAcylation and its roles in the cellular stress response and homeostasis","volume":"18","author":"Groves","year":"2013","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.jbc.2023.102907_bib8","doi-asserted-by":"crossref","first-page":"5735","DOI":"10.1073\/pnas.100471497","article-title":"The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny","volume":"97","author":"Shafi","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2023.102907_bib9","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1474-9726.2012.00801.x","article-title":"O-GlcNAcase is essential for embryonic development and maintenance of genomic stability","volume":"11","author":"Yang","year":"2012","journal-title":"Aging Cell"},{"key":"10.1016\/j.jbc.2023.102907_bib10","doi-asserted-by":"crossref","first-page":"7097","DOI":"10.1074\/jbc.M114.617779","article-title":"Conditional knock-out reveals a requirement for O-linked N-acetylglucosaminase (O-GlcNAcase) in metabolic homeostasis","volume":"290","author":"Keembiyehetty","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.102907_bib11","doi-asserted-by":"crossref","first-page":"H2227","DOI":"10.1152\/ajpheart.01091.2006","article-title":"Glucosamine cardioprotection in perfused rat heart associated with increased O-Linked N-acetylglucosamine protein modification and altered p38 activation","volume":"292","author":"F\u00fcl\u00f6p","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.jbc.2023.102907_bib12","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1161\/CIRCULATIONAHA.107.730515","article-title":"Cardioprotection by N-acetylglucosamine linkage to cellular proteins","volume":"117","author":"Jones","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jbc.2023.102907_bib13","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1152\/physiolgenomics.00016.2011","article-title":"Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failure","volume":"44","author":"Lunde","year":"2011","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.jbc.2023.102907_bib14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00395-017-0612-7","article-title":"Cardiomyocyte Ogt limits ventricular dysfunction in mice following pressure overload without affecting hypertrophy","volume":"112","author":"Dassanayaka","year":"2017","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.jbc.2023.102907_bib15","article-title":"O-GlcNAc transferase promotes compensated cardiac function and protein kinase AO-GlcNAcylation during early and established pathological hypertrophy from pressure overload","volume":"8","author":"Zhu","year":"2019","journal-title":"J.\u00a0Am. Heart Assoc."},{"key":"10.1016\/j.jbc.2023.102907_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0242250","article-title":"Cardiomyocyte Oga haploinsufficiency increases O-GlcNAcylation but hastens ventricular dysfunction following myocardial infarction","volume":"15","author":"Dassanayaka","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2023.102907_bib17","first-page":"R689","article-title":"Excess protein O-GlcNAcylation and the progression of diabetic cardiomyopathy","volume":"303","author":"Fricovsky","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.jbc.2023.102907_bib18","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1093\/cvr\/cvab043","article-title":"Fine-tuning the cardiac O-GlcNAcylation regulatory enzymes governs the functional and structural phenotype of the diabetic heart","volume":"118","author":"Prakoso","year":"2022","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jbc.2023.102907_bib19","doi-asserted-by":"crossref","DOI":"10.1172\/JCI95747","article-title":"Oxidized CaMKII and O-GlcNAcylation cause increased atrial fibrillation in diabetic mice by distinct mechanisms","volume":"131","author":"Mesubi","year":"2021","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.jbc.2023.102907_bib20","doi-asserted-by":"crossref","first-page":"17797","DOI":"10.1073\/pnas.1001907107","article-title":"O-linked \u03b2-N-acetylglucosamine transferase is indispensable in the failing heart","volume":"107","author":"Watson","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2023.102907_bib21","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1161\/CIRCULATIONAHA.120.051911","article-title":"Excessive O-GlcNAcylation causes heart failure and sudden death","volume":"143","author":"Umapathi","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.jbc.2023.102907_bib22","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.pharmthera.2013.11.005","article-title":"O-GlcNAc and the cardiovascular system","volume":"142","author":"Dassanayaka","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jbc.2023.102907_bib23","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1016\/j.bbadis.2016.08.012","article-title":"O-GlcNAcylation, enemy or ally during cardiac hypertrophy development?","volume":"1862","author":"Mailleux","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbc.2023.102907_bib24","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1042\/BST20160164","article-title":"O-GlcNAcylation and cardiovascular disease","volume":"45","author":"Wright","year":"2017","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.jbc.2023.102907_bib25","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3389\/fendo.2018.00642","article-title":"Chronic O-GlcNAcylation and diabetic cardiomyopathy: the bitterness of glucose","volume":"9","author":"Ducheix","year":"2018","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jbc.2023.102907_bib26","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1146\/annurev-biochem-060608-102511","article-title":"Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease","volume":"80","author":"Hart","year":"2011","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.jbc.2023.102907_bib27","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nature12537","article-title":"Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation","volume":"502","author":"Erickson","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2023.102907_bib28","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41467-017-02795-4","article-title":"AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation","volume":"9","author":"G\u00e9linas","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2023.102907_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-020-15640-y","article-title":"Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling","volume":"11","author":"Tran","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2023.102907_bib30","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nrm1983","article-title":"Regulation of cardiac hypertrophy by intracellular signalling pathways","volume":"7","author":"Heineke","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2023.102907_bib31","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1161\/CIRCULATIONAHA.106.679589","article-title":"Mitogen-activated protein kinases in heart development and diseases","volume":"116","author":"Wang","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.jbc.2023.102907_bib32","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1161\/01.CIR.0000127126.73759.23","article-title":"MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in\u00a0vivo","volume":"109","author":"Lips","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jbc.2023.102907_bib33","doi-asserted-by":"crossref","first-page":"31246","DOI":"10.1074\/jbc.M806085200","article-title":"DUSP6 (MKP3) null mice show enhanced ERK1\/2 phosphorylation at baseline and increased myocyte proliferation in the heart affecting disease susceptibility","volume":"283","author":"Maillet","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.102907_bib34","doi-asserted-by":"crossref","first-page":"14074","DOI":"10.1073\/pnas.0610906104","article-title":"Genetic inhibition of cardiac ERK1\/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in\u00a0vivo","volume":"104","author":"Purcell","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2023.102907_bib35","doi-asserted-by":"crossref","first-page":"6341","DOI":"10.1093\/emboj\/19.23.6341","article-title":"The MEK1-ERK1\/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice","volume":"19","author":"Bueno","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2023.102907_bib36","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1083\/jcb.200108062","article-title":"PKC alpha regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1\/2 (ERK1\/2)","volume":"156","author":"Braz","year":"2002","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.jbc.2023.102907_bib37","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3389\/fphar.2015.00149","article-title":"Extracellular signal-regulated kinases 1\/2 as regulators of cardiac hypertrophy","volume":"6","author":"Mutlak","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jbc.2023.102907_bib38","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1161\/CIRCRESAHA.115.308238","article-title":"DUSP8 regulates cardiac ventricular remodeling by altering ERK1\/2 signaling","volume":"119","author":"Liu","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.jbc.2023.102907_bib39","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1146\/annurev.physiol.63.1.391","article-title":"Cytoplasmic signaling pathways that regulate cardiac hypertrophy","volume":"63","author":"Molkentin","year":"2001","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.jbc.2023.102907_bib40","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1128\/MMBR.00031-10","article-title":"Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases","volume":"75","author":"Cargnello","year":"2011","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.jbc.2023.102907_bib41","doi-asserted-by":"crossref","first-page":"13721","DOI":"10.1074\/jbc.275.18.13721","article-title":"Phosphorylation of GATA-4 is involved in alpha 1-adrenergic agonist-responsive transcription of the endothelin-1 gene in cardiac myocytes","volume":"275","author":"Morimoto","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.102907_bib42","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1006\/jmcc.2000.1185","article-title":"Phosphorylation of elk-1 by MEK\/ERK pathway is necessary for c-fos gene activation during cardiac myocyte hypertrophy","volume":"32","author":"Babu","year":"2000","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.jbc.2023.102907_bib43","doi-asserted-by":"crossref","first-page":"6584","DOI":"10.1073\/pnas.0802785105","article-title":"Activation of PI3K\/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1","volume":"105","author":"Zhu","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2023.102907_bib44","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.273.5277.959","article-title":"Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase","volume":"273","author":"Xing","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.jbc.2023.102907_bib45","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1128\/MCB.22.8.2871-2881.2002","article-title":"MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts","volume":"22","author":"Wiggin","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jbc.2023.102907_bib46","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1161\/01.CIR.0000165117.71483.0C","article-title":"p38 MAP kinase mediates inflammatory cytokine induction in cardiomyocytes and extracellular matrix remodeling in heart","volume":"111","author":"Li","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jbc.2023.102907_bib47","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1161\/CIRCRESAHA.112.272963","article-title":"Unrestrained p38 MAPK activation in Dusp1\/4 double-null mice induces cardiomyopathy","volume":"112","author":"Auger-Messier","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.jbc.2023.102907_bib48","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1172\/JCI200317295","article-title":"Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling","volume":"111","author":"Braz","year":"2003","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.jbc.2023.102907_bib49","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0006-2952(98)00059-8","article-title":"Signaling from G-protein-coupled receptors to mitogen-activated protein (MAP)-kinase cascades","volume":"56","author":"Lopez-Ilasaca","year":"1998","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jbc.2023.102907_bib50","doi-asserted-by":"crossref","first-page":"23362","DOI":"10.1074\/jbc.M011752200","article-title":"Parallel regulation of mitogen-activated protein kinase kinase 3 (MKK3) and MKK6 in Gq-signaling cascade","volume":"276","author":"Yamauchi","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.102907_bib51","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1161\/01.RES.0000216039.75913.9e","article-title":"The Rac and Rho hall of fame: a decade of hypertrophic signaling hits","volume":"98","author":"Brown","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.jbc.2023.102907_bib52","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1042\/BJ20100323","article-title":"Mechanisms and functions of p38 MAPK signalling","volume":"429","author":"Cuadrado","year":"2010","journal-title":"Biochem. J."},{"key":"10.1016\/j.jbc.2023.102907_bib53","doi-asserted-by":"crossref","first-page":"19229","DOI":"10.1074\/jbc.M201729200","article-title":"Dynamic interplay between O-glycosylation and O-phosphorylation of nucleocytoplasmic proteins: alternative glycosylation\/phosphorylation of Thr-58, a known mutational hot spot of c-Myc in lymphomas, is regulated by mitogens","volume":"277","author":"Kamemura","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.102907_bib54","doi-asserted-by":"crossref","first-page":"19248","DOI":"10.1074\/jbc.M109.005678","article-title":"O-linked N-acetylglucosamine modification on CCAAT enhancer-binding protein \u03b2. Role during adipocyte differentiation","volume":"284","author":"Li","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.102907_bib55","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nchembio.770","article-title":"Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation","volume":"8","author":"Rexach","year":"2012","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jbc.2023.102907_bib56","doi-asserted-by":"crossref","first-page":"494","DOI":"10.3892\/or.2012.1844","article-title":"Translocation of HSP27 into liver cancer cell nucleus may be associated with phosphorylation and O-GlcNAc glycosylation","volume":"28","author":"Guo","year":"2012","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.jbc.2023.102907_bib57","first-page":"2193","article-title":"Decreasing O-GlcNAcylation affects the malignant transformation of MCF-7 cells via Hsp27 expression and its O-GlcNAc modification","volume":"40","author":"Netsirisawan","year":"2018","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.jbc.2023.102907_bib58","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/s41557-021-00648-8","article-title":"O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity","volume":"13","author":"Balana","year":"2021","journal-title":"Nat. Chem."},{"key":"10.1016\/j.jbc.2023.102907_bib59","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1158\/2159-8290.CD-13-0070","article-title":"Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors","volume":"3","author":"Morris","year":"2013","journal-title":"Cancer Discov."},{"key":"10.1016\/j.jbc.2023.102907_bib60","doi-asserted-by":"crossref","first-page":"12116","DOI":"10.1074\/jbc.272.18.12116","article-title":"Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site","volume":"272","author":"Young","year":"1997","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.102907_bib61","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1042\/bj3510095","article-title":"Specificity and mechanism of action of some commonly used protein kinase inhibitors","volume":"351","author":"Davies","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.jbc.2023.102907_bib62","doi-asserted-by":"crossref","first-page":"5793","DOI":"10.1093\/emboj\/cdg552","article-title":"Feedback control of the protein kinase TAK1 by SAPK2a\/p38\u03b1","volume":"22","author":"Cheung","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2023.102907_bib63","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1006\/bbrc.1999.1454","article-title":"Pyridinylimidazole compound SB 203580 inhibits the activity but not the activation of p38 mitogen-activated protein kinase","volume":"263","author":"Kumar","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jbc.2023.102907_bib64","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.cardiores.2004.03.025","article-title":"GATA transcription factors in the developing and adult heart","volume":"63","author":"Pikkarainen","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jbc.2023.102907_bib65","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1002\/cbic.201700020","article-title":"Metabolic chemical reporters of glycans exhibit cell-type selective metabolism and glycoprotein labeling","volume":"18","author":"Batt","year":"2017","journal-title":"Chembiochem"},{"key":"10.1016\/j.jbc.2023.102907_bib66","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/bs.mie.2019.02.017","article-title":"Identifying potentially O-GlcNAcylated proteins using metabolic labeling, bioorthogonal enrichment, and western blotting","volume":"622","author":"Darabedian","year":"2019","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jbc.2023.102907_bib67","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1021\/acschembio.1c00034","article-title":"Optimization of metabolic oligosaccharide engineering with Ac4GalNAlk and Ac4GlcNAlk by an engineered pyrophosphorylase","volume":"16","author":"Cioce","year":"2021","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.jbc.2023.102907_bib68","doi-asserted-by":"crossref","first-page":"7145","DOI":"10.1021\/jacs.5b02383","article-title":"CalFluors: a universal motif for fluorogenic azide probes across the visible spectrum","volume":"137","author":"Shieh","year":"2015","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.jbc.2023.102907_bib69","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1021\/acschembio.5b00004","article-title":"A\u00a0small molecule that inhibits OGT activity in cells","volume":"10","author":"Ortiz-Meoz","year":"2015","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.jbc.2023.102907_bib70","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nchembio.96","article-title":"A\u00a0potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in\u00a0vivo","volume":"4","author":"Yuzwa","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jbc.2023.102907_bib71","doi-asserted-by":"crossref","first-page":"13542","DOI":"10.1021\/jacs.8b07328","article-title":"Structure-based evolution of low nanomolar O-GlcNAc transferase inhibitors","volume":"140","author":"Martin","year":"2018","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.jbc.2023.102907_bib72","doi-asserted-by":"crossref","first-page":"7770","DOI":"10.1002\/ange.201803254","article-title":"Metabolic inhibitors of O-GlcNAc transferase that act in\u00a0vivo implicate decreased O-GlcNAc levels in leptin-mediated nutrient sensing","volume":"130","author":"Liu","year":"2018","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.jbc.2023.102907_bib73","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41569-019-0260-8","article-title":"NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets","volume":"17","author":"Zhang","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.jbc.2023.102907_bib74","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1161\/CIRCRESAHA.109.213769","article-title":"Specific regulation of noncanonical p38\u03b1 activation by Hsp90-Cdc37 chaperone complex in cardiomyocyte","volume":"106","author":"Ota","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.jbc.2023.102907_bib75","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1126\/science.1067289","article-title":"MAPKK-independent activation of p38\u03b1 mediated by TAB1-dependent autophosphorylation of p38\u03b1","volume":"295","author":"Ge","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.jbc.2023.102907_bib76","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1038\/emboj.2012.8","article-title":"O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release","volume":"31","author":"Pathak","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2023.102907_bib77","doi-asserted-by":"crossref","first-page":"13793","DOI":"10.1073\/pnas.0806216105","article-title":"Cross-talk between GlcNAcylation and phosphorylation: site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc","volume":"105","author":"Wang","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2023.102907_bib78","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00726-013-1504-2","article-title":"O-GlcNAcylation involvement in high glucose-induced cardiac hypertrophy via ERK1\/2 and cyclin D2","volume":"45","author":"Ding","year":"2013","journal-title":"Amino Acids"},{"key":"10.1016\/j.jbc.2023.102907_bib79","doi-asserted-by":"crossref","first-page":"61390","DOI":"10.18632\/oncotarget.11359","article-title":"Elevated O-GlcNAcylation promotes gastric cancer cells proliferation by modulating cell cycle related proteins and ERK 1\/2 signaling","volume":"7","author":"Jiang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.jbc.2023.102907_bib80","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1074\/jbc.M807431200","article-title":"In\u00a0vivo modulation of O-GlcNAc levels regulates hippocampal synaptic plasticity through interplay with phosphorylation","volume":"284","author":"Tallent","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.102907_bib81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41597-021-00810-4","article-title":"The human O-GlcNAcome database and meta-analysis","volume":"8","author":"Wulff-Fuentes","year":"2021","journal-title":"Sci. Data"},{"key":"10.1016\/j.jbc.2023.102907_bib82","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s00726-010-0645-9","article-title":"Human Alzheimer\u2019s disease synaptic O-GlcNAc site mapping and iTRAQ expression proteomics with ion trap mass spectrometry","volume":"40","author":"Skorobogatko","year":"2011","journal-title":"Amino Acids"},{"key":"10.1016\/j.jbc.2023.102907_bib83","doi-asserted-by":"crossref","first-page":"E713","DOI":"10.1152\/ajpendo.00108.2011","article-title":"O-linked \u03b2-N-acetylglucosamine supports p38 MAPK activation by high glucose in glomerular mesangial cells","volume":"301","author":"Goldberg","year":"2011","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.jbc.2023.102907_bib84","doi-asserted-by":"crossref","first-page":"14579","DOI":"10.1074\/jbc.M414066200","article-title":"Protein O-GlcNAc modulates motility-associated signaling intermediates in neutrophils","volume":"280","author":"Kneass","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.102907_bib85","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1161\/HYPERTENSIONAHA.119.14556","article-title":"Redox regulation of cardiac ASK1 (apoptosis signal-regulating kinase 1) controls p38-MAPK (mitogen-activated protein kinase) and orchestrates cardiac remodeling to hypertension","volume":"76","author":"Meijles","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.jbc.2023.102907_bib86","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.3390\/antiox10091363","article-title":"p47phox-dependent oxidant signalling through ASK1, MKK3\/6 and MAPKs in angiotensin II-induced cardiac hypertrophy and apoptosis","volume":"10","author":"Liu","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jbc.2023.102907_bib87","doi-asserted-by":"crossref","first-page":"e80","DOI":"10.1161\/CIRCRESAHA.119.316288","article-title":"Hyperglycemia acutely increases cytosolic reactive oxygen species via O-linked GlcNAcylation and CaMKII activation in mouse ventricular myocytes","volume":"126","author":"Lu","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.jbc.2023.102907_bib88","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00395-020-00834-8","article-title":"Hyperglycemia regulates cardiac K+ channels via O-GlcNAc-CaMKII and NOX2-ROS-PKC pathways","volume":"115","author":"Hegyi","year":"2020","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.jbc.2023.102907_bib89","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1139\/cjpp-2017-0225","article-title":"Glycosylation with O-linked \u03b2-N-acetylglucosamine induces vascular dysfunction via production of superoxide anion\/reactive oxygen species","volume":"96","author":"Souza-Silva","year":"2018","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.jbc.2023.102907_bib90","doi-asserted-by":"crossref","first-page":"6087","DOI":"10.1074\/jbc.M507610200","article-title":"TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling","volume":"281","author":"Lu","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.102907_bib91","doi-asserted-by":"crossref","first-page":"6508","DOI":"10.1038\/s41467-021-26796-6","article-title":"Cryo-EM structure provides insights into the dimer arrangement of the O-linked \u03b2-N-acetylglucosamine transferase OGT","volume":"12","author":"Meek","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2023.102907_bib92","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1038\/nsmb.2668","article-title":"Mechanism and consequence of the autoactivation of p38\u03b1 mitogen-activated protein kinase promoted by TAB1","volume":"20","author":"De Nicola","year":"2013","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.jbc.2023.102907_bib93","doi-asserted-by":"crossref","first-page":"128","DOI":"10.12688\/wellcomeopenres.15394.1","article-title":"A\u00a0mouse model for functional dissection of TAB1 O-GlcNAcylation","volume":"4","author":"Authier","year":"2019","journal-title":"Wellcome Open Res."},{"key":"10.1016\/j.jbc.2023.102907_bib94","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.bbrc.2012.04.124","article-title":"O-GlcNAcylation of kinases","volume":"422","author":"Dias","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jbc.2023.102907_bib95","doi-asserted-by":"crossref","first-page":"e00409","DOI":"10.1128\/MCB.00409-17","article-title":"TAB1-induced autoactivation of p38\u03b1 mitogen-activated protein kinase is crucially dependent on threonine 185","volume":"38","author":"Thapa","year":"2018","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jbc.2023.102907_bib96","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1152\/physrev.00054.2009","article-title":"Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale","volume":"90","author":"Rose","year":"2010","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jbc.2023.102907_bib97","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1161\/01.RES.0000041029.97988.E9","article-title":"Ras\/Erk signaling is essential for activation of protein synthesis by Gq protein-coupled receptor agonists in adult cardiomyocytes","volume":"91","author":"Wang","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.jbc.2023.102907_bib98","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1161\/01.CIR.0000138190.50127.6A","article-title":"Raf-1 kinase is required for cardiac hypertrophy and cardiomyocyte survival in response to pressure overload","volume":"110","author":"Harris","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.jbc.2023.102907_bib99","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1083\/jcb.142.2.523","article-title":"Stimulation of the p38 mitogen-activated protein kinase pathway in neonatal rat ventricular myocytes by the G protein\u2013coupled receptor agonists, endothelin-1 and phenylephrine: a role in cardiac myocyte hypertrophy?","volume":"142","author":"Clerk","year":"1998","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.jbc.2023.102907_bib100","doi-asserted-by":"crossref","first-page":"12283","DOI":"10.1073\/pnas.211086598","article-title":"The in\u00a0vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy","volume":"98","author":"Liao","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2023.102907_bib101","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.1074\/jbc.M205616200","article-title":"Endothelin-1-specific activation of B-type natriuretic peptide gene via p38 mitogen-activated protein kinase and nuclear ETS factors","volume":"278","author":"Pikkarainen","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.102907_bib102","doi-asserted-by":"crossref","first-page":"H142","DOI":"10.1152\/ajpheart.00438.2013","article-title":"Cardiomyocyte Ogt is essential for postnatal viability","volume":"306","author":"Watson","year":"2014","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.jbc.2023.102907_bib103","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008730","article-title":"O-linked \u03b2-N-acetylglucosamine transferase plays an essential role in heart development through regulating angiopoietin-1","volume":"16","author":"Mu","year":"2020","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jbc.2023.102907_bib104","doi-asserted-by":"crossref","first-page":"H2122","DOI":"10.1152\/ajpheart.00775.2011","article-title":"O-GlcNAc signaling is essential for NFAT-mediated transcriptional reprogramming during cardiomyocyte hypertrophy","volume":"302","author":"Facundo","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.jbc.2023.102907_bib105","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.14965","article-title":"Temporal regulation of protein O-GlcNAc levels during pressure-overload cardiac hypertrophy","volume":"9","author":"Zhu","year":"2021","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.jbc.2023.102907_bib106","doi-asserted-by":"crossref","first-page":"7460","DOI":"10.1128\/MCB.21.21.7460-7469.2001","article-title":"The transcription factor GATA4 is activated by extracellular signal-regulated kinase 1- and 2-mediated phosphorylation of serine 105 in cardiomyocytes","volume":"21","author":"Liang","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jbc.2023.102907_bib107","doi-asserted-by":"crossref","first-page":"12331","DOI":"10.1073\/pnas.1104499108","article-title":"Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in\u00a0vivo","volume":"108","author":"Van Berlo","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2023.102907_bib108","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.15252\/emmm.201404669","article-title":"Cardiac LXR \u03b1 protects against pathological cardiac hypertrophy and dysfunction by enhancing glucose uptake and utilization","volume":"7","author":"Cannon","year":"2015","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.jbc.2023.102907_bib109","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1021\/cb500886n","article-title":"Unexpected off-targets and paradoxical pathway activation by kinase inhibitors","volume":"10","author":"Hantschel","year":"2015","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.jbc.2023.102907_bib110","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nbt1068","article-title":"A\u00a0small molecule-kinase interaction map for clinical kinase inhibitors","volume":"23","author":"Fabian","year":"2005","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jbc.2023.102907_bib111","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/nchembio.1629","article-title":"A\u00a0unique inhibitor binding site in ERK1\/2 is associated with slow binding kinetics","volume":"10","author":"Chaikuad","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jbc.2023.102907_bib112","doi-asserted-by":"crossref","first-page":"4485","DOI":"10.1172\/JCI99768","article-title":"ASK1 contributes to fibrosis and dysfunction in models of kidney disease","volume":"128","author":"Liles","year":"2018","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.jbc.2023.102907_bib113","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.chembiol.2017.07.011","article-title":"Takinib, a selective TAK1 inhibitor, broadens the therapeutic efficacy of TNF-\u03b1 inhibition for cancer and autoimmune disease","volume":"24","author":"Totzke","year":"2017","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.jbc.2023.102907_bib114","doi-asserted-by":"crossref","first-page":"8032","DOI":"10.1021\/jm401094t","article-title":"Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3","volume":"56","author":"Goodfellow","year":"2013","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.jbc.2023.102907_bib115","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M111.016675","article-title":"Systematic identification of the HSP90 candidate regulated proteome","volume":"11","author":"Wu","year":"2012","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.jbc.2023.102907_bib116","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.yjmcc.2009.11.015","article-title":"Cyclic GMP\/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation: novel mechanism of cardiac stress modulation by PDE5 inhibition","volume":"48","author":"Koitabashi","year":"2010","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.jbc.2023.102907_bib117","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nm1175","article-title":"Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy","volume":"11","author":"Takimoto","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.jbc.2023.102907_bib118","doi-asserted-by":"crossref","first-page":"3966","DOI":"10.1021\/pr5002862","article-title":"Direct detection of biotinylated proteins by mass spectrometry","volume":"13","author":"Schiapparelli","year":"2014","journal-title":"J.\u00a0Proteome Res."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582300039X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582300039X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T21:44:49Z","timestamp":1777412689000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002192582300039X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":118,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S002192582300039X"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2023.102907","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibiting O-GlcNAcylation impacts p38 and Erk1\/2 signaling and perturbs cardiomyocyte hypertrophy","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2023.102907","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 THE AUTHORS. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"102907"}}