{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:00:20Z","timestamp":1787727620798,"version":"build-2784847793"},"reference-count":54,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["020814380161"],"award-info":[{"award-number":["020814380161"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2193005"],"award-info":[{"award-number":["2193005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81722047"],"award-info":[{"award-number":["81722047"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874317"],"award-info":[{"award-number":["81874317"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.jbc.2023.104909","type":"journal-article","created":{"date-parts":[[2023,6,10]],"date-time":"2023-06-10T12:38:51Z","timestamp":1686400731000},"page":"104909","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Mitochondrial folate metabolism\u2013mediated \u03b1-linolenic acid exhaustion masks liver fibrosis resolution"],"prefix":"10.1016","volume":"299","author":[{"given":"Yanjie","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingfeng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaiqi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibo","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3246-9415","authenticated-orcid":false,"given":"Wanyue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manman","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0834-4601","authenticated-orcid":false,"given":"Xingxin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2023.104909_bib1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1053\/j.gastro.2015.04.043","article-title":"Liver fibrosis, but no other histologic features, is associated with long-term outcomes of patients with nonalcoholic fatty liver disease","volume":"149","author":"Angulo","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jbc.2023.104909_bib2","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1056\/NEJMra1503519","article-title":"Cause, pathogenesis, and treatment of nonalcoholic Steatohepatitis","volume":"377","author":"Diehl","year":"2017","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.jbc.2023.104909_bib3","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1053\/j.gastro.2018.04.034","article-title":"Fibrosis severity as a determinant of cause-specific mortality in patients with advanced nonalcoholic fatty liver disease: a multi-national cohort study","volume":"155","author":"Vilar-Gomez","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jbc.2023.104909_bib4","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jbc.2023.104909_bib5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.addr.2017.05.007","article-title":"Hepatic stellate cells as key target in liver fibrosis","volume":"121","author":"Higashi","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jbc.2023.104909_bib6","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022293","article-title":"TGF-\u03b21 signaling and tissue fibrosis","volume":"10","author":"Kim","year":"2018","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.jbc.2023.104909_bib7","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1053\/j.gastro.2012.06.036","article-title":"Deactivation of hepatic stellate cells during liver fibrosis resolution in mice","volume":"143","author":"Troeger","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jbc.2023.104909_bib8","doi-asserted-by":"crossref","first-page":"9448","DOI":"10.1073\/pnas.1201840109","article-title":"Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis","volume":"109","author":"Kisseleva","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2023.104909_bib9","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/nrc.2016.81","article-title":"Serine and one-carbon metabolism in cancer","volume":"16","author":"Yang","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jbc.2023.104909_bib10","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/nrc3557","article-title":"Serine, glycine and one-carbon units: cancer metabolism in full circle","volume":"13","author":"Locasale","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jbc.2023.104909_bib11","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3945\/an.111.000596","article-title":"Trafficking of intracellular folates","volume":"2","author":"Stover","year":"2011","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.jbc.2023.104909_bib12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1146\/annurev.nutr.012809.104810","article-title":"Compartmentalization of Mammalian folate-mediated one-carbon metabolism","volume":"30","author":"Tibbetts","year":"2010","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.jbc.2023.104909_bib13","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/bdra.20553","article-title":"Insights into metabolic mechanisms underlying folate-responsive neural tube defects: a minireview","volume":"85","author":"Beaudin","year":"2009","journal-title":"Birth Defects Res. A. Clin. Mol. Teratol"},{"key":"10.1016\/j.jbc.2023.104909_bib14","doi-asserted-by":"crossref","first-page":"1213S","DOI":"10.1093\/ajcn\/81.5.1213","article-title":"Folic acid supplementation and the occurrence of congenital heart defects, orofacial clefts, multiple births, and miscarriage","volume":"81","author":"Bailey","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.jbc.2023.104909_bib15","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/biof.1154","article-title":"Novel insights on interactions between folate and lipid metabolism","volume":"40","author":"da Silva","year":"2014","journal-title":"Biofactors"},{"key":"10.1016\/j.jbc.2023.104909_bib16","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.3945\/jn.110.124917","article-title":"Steatosis in mice is associated with gender, folate intake, and expression of genes of one-carbon metabolism","volume":"140","author":"Christensen","year":"2010","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.jbc.2023.104909_bib17","doi-asserted-by":"crossref","first-page":"R1215","DOI":"10.1152\/ajpregu.00260.2015","article-title":"Folic acid supplementation during high-fat diet feeding restores AMPK activation via an AMP-LKB1-dependent mechanism","volume":"309","author":"Sid","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.jbc.2023.104909_bib18","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1139\/cjpp-2016-0681","article-title":"Role of folate in nonalcoholic fatty liver disease","volume":"95","author":"Sid","year":"2017","journal-title":"Can J. Physiol. Pharmacol."},{"key":"10.1016\/j.jbc.2023.104909_bib19","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1478-3231.2006.01404.x","article-title":"Open-label pilot study of folic acid in patients with nonalcoholic steatohepatitis","volume":"27","author":"Charatcharoenwitthaya","year":"2007","journal-title":"Liver Int."},{"key":"10.1016\/j.jbc.2023.104909_bib20","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jhep.2018.03.011","article-title":"A\u00a0simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer","volume":"69","author":"Tsuchida","year":"2018","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.jbc.2023.104909_bib21","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1002\/hep.31848","article-title":"Perivenous stellate cells are the main source of myofibroblasts and cancer-associated fibroblasts formed after chronic liver injuries","volume":"74","author":"Wang","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jbc.2023.104909_bib22","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1053\/j.gastro.2019.11.311","article-title":"Mechanisms of fibrosis development in nonalcoholic Steatohepatitis","volume":"158","author":"Schwabe","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jbc.2023.104909_bib23","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1053\/j.gastro.2020.01.027","article-title":"Identification of lineage-specific transcription factors that prevent activation of hepatic stellate cells and promote fibrosis resolution","volume":"158","author":"Liu","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jbc.2023.104909_bib24","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.jhep.2015.03.039","article-title":"Mechanisms of liver fibrosis resolution","volume":"63","author":"Tacke","year":"2015","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.jbc.2023.104909_bib25","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nature02006","article-title":"Smad-dependent and Smad-independent pathways in TGF-beta family signalling","volume":"425","author":"Derynck","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2023.104909_bib26","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0092-8674(03)00432-X","article-title":"Mechanisms of TGF-beta signaling from cell membrane to the nucleus","volume":"113","author":"Shi","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2023.104909_bib27","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrneph.2016.48","article-title":"TGF-\u03b2: the master regulator of fibrosis","volume":"12","author":"Meng","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.jbc.2023.104909_bib28","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.cmet.2020.12.002","article-title":"Tumor reliance on cytosolic versus mitochondrial one-carbon flux depends on folate availability","volume":"33","author":"Lee","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbc.2023.104909_bib29","doi-asserted-by":"crossref","first-page":"31480","DOI":"10.1074\/jbc.M111.272187","article-title":"Tetrahydrofolate recognition by the mitochondrial folate transporter","volume":"286","author":"Lawrence","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.104909_bib30","doi-asserted-by":"crossref","first-page":"36811","DOI":"10.1074\/jbc.M005163200","article-title":"Retrovirally mediated complementation of the glyB phenotype. Cloning of a human gene encoding the carrier for entry of folates into mitochondria","volume":"275","author":"Titus","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.104909_bib31","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.1038\/ncomms4128","article-title":"Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer","volume":"5","author":"Nilsson","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2023.104909_bib32","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1158\/0008-5472.CAN-13-2683","article-title":"Comparative oncogenomics identifies PSMB4 and SHMT2 as potential cancer driver genes","volume":"74","author":"Lee","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.jbc.2023.104909_bib33","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1126\/science.1218595","article-title":"Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation","volume":"336","author":"Jain","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.jbc.2023.104909_bib34","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.cmet.2016.04.016","article-title":"Reversal of cytosolic one-carbon flux compensates for loss of the mitochondrial folate pathway","volume":"23","author":"Ducker","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbc.2023.104909_bib35","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cell.2014.12.019","article-title":"Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration","volume":"160","author":"Liu","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2023.104909_bib36","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/s41418-020-0601-5","article-title":"Pyrroline-5-carboxylate synthase senses cellular stress and modulates metabolism by regulating mitochondrial respiration","volume":"28","author":"Yang","year":"2021","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jbc.2023.104909_bib37","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev-genom-082509-141720","article-title":"The mitochondrial proteome and human disease","volume":"11","author":"Calvo","year":"2010","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"10.1016\/j.jbc.2023.104909_bib38","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1002\/humu.23985","article-title":"Mutations in FASTKD2 are associated with mitochondrial disease with multi-OXPHOS deficiency","volume":"41","author":"Wei","year":"2020","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.jbc.2023.104909_bib39","first-page":"127","article-title":"Efficiency of conversion of alpha-linolenic acid to long chain n-3 fatty acids in man","volume":"5","author":"Brenna","year":"2002","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.jbc.2023.104909_bib40","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3945\/jn.108.094268","article-title":"Dietary stearidonic acid is a long chain (n-3) polyunsaturated fatty acid with potential health benefits","volume":"139","author":"Whelan","year":"2009","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.jbc.2023.104909_bib41","doi-asserted-by":"crossref","first-page":"965","DOI":"10.3390\/nu2090965","article-title":"Long-chain polyunsaturated fatty acids in inborn errors of metabolism","volume":"2","author":"Fekete","year":"2010","journal-title":"Nutrients"},{"key":"10.1016\/j.jbc.2023.104909_bib42","doi-asserted-by":"crossref","DOI":"10.1301\/nr.2004.jun.S3-S12","article-title":"Physiology of folate and vitamin B12 in health and disease","volume":"62","author":"Stover","year":"2004","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.jbc.2023.104909_bib43","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1056\/NEJMoa067103","article-title":"Reduction in neural-tube defects after folic acid fortification in Canada","volume":"357","author":"De Wals","year":"2007","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.jbc.2023.104909_bib44","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ajhg.2011.01.007","article-title":"Dihydrofolate reductase deficiency due to a homozygous DHFR mutation causes megaloblastic anemia and cerebral folate deficiency leading to severe neurologic disease","volume":"88","author":"Cario","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jbc.2023.104909_bib45","doi-asserted-by":"crossref","first-page":"440","DOI":"10.3390\/nu10040440","article-title":"Folate and B12 levels correlate with histological severity in NASH patients","volume":"10","author":"Mahamid","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.jbc.2023.104909_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110711","article-title":"Folate and macrophage folate receptor-\u03b2 in idiopathic pulmonary fibrosis disease: the potential therapeutic target?","volume":"131","author":"Qu","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jbc.2023.104909_bib47","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1093\/jn\/nxaa032","article-title":"One-carbon metabolism in fatty liver disease and fibrosis: one-carbon to rule them all","volume":"150","author":"Da Silva","year":"2020","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.jbc.2023.104909_bib48","doi-asserted-by":"crossref","first-page":"S116","DOI":"10.1080\/10408398.2018.1544542","article-title":"n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: a critical review","volume":"59","author":"Wang","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.jbc.2023.104909_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118399","article-title":"Endogenous tryptophan metabolite 5-Methoxytryptophan inhibits pulmonary fibrosis by downregulating the TGF-\u03b2\/SMAD3 and PI3K\/AKT signaling pathway","volume":"260","author":"Fang","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.jbc.2023.104909_bib50","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.cmet.2021.03.009","article-title":"Creatine promotes cancer metastasis through activation of Smad2\/3","volume":"33","author":"Zhang","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbc.2023.104909_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2020.108452","article-title":"n-3 PUFAs inhibit TGFbeta1-induced profibrogenic gene expression by ameliorating the repression of PPARgamma in hepatic stellate cells","volume":"85","author":"Hu","year":"2020","journal-title":"J.\u00a0Nutr. Biochem."},{"key":"10.1016\/j.jbc.2023.104909_bib52","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41419-018-1243-0","article-title":"The cirrhotic liver is depleted of docosahexaenoic acid (DHA), a key modulator of NF-\u03baB and TGF\u03b2 pathways in hepatic stellate cells","volume":"10","author":"Enguita","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jbc.2023.104909_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110509","article-title":"Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake","volume":"38","author":"Hu","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2023.104909_bib54","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13498","article-title":"CUG-binding protein 1 regulates HSC activation and liver fibrogenesis","volume":"7","author":"Wu","year":"2016","journal-title":"Nat. Commun."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925823019373?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925823019373?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:42:22Z","timestamp":1758242542000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925823019373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":54,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S0021925823019373"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2023.104909","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial folate metabolism\u2013mediated \u03b1-linolenic acid exhaustion masks liver fibrosis resolution","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2023.104909","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"104909"}}