{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:26:11Z","timestamp":1793406371134,"version":"4.5.0"},"reference-count":88,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"NIAMS","doi-asserted-by":"publisher","award":["R01 AR049069"],"award-info":[{"award-number":["R01 AR049069"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010941","name":"University of Vermont","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010941","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002848","name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["11190998"],"award-info":[{"award-number":["11190998"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.jbc.2023.105155","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T21:22:17Z","timestamp":1691702537000},"page":"105155","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Inhibition of Ezh2 redistributes bivalent domains within transcriptional regulators associated with WNT and Hedgehog pathways in osteoblasts"],"prefix":"10.1016","volume":"299","author":[{"given":"Margarita E.","family":"Carrasco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Thaler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2342-6480","authenticated-orcid":false,"given":"Gino","family":"Nardocci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amel","family":"Dudakovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4458-0946","authenticated-orcid":false,"given":"Andre J.","family":"van Wijnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2023.105155_bib1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/5584_2020_489","article-title":"The importance of stem cell senescence in regenerative medicine","volume":"1288","author":"Khademi-Shirvan","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.jbc.2023.105155_bib2","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1002\/jor.24305","article-title":"Epigenetics as a new frontier in orthopedic regenerative medicine and oncology","volume":"37","author":"van Wijnen","year":"2019","journal-title":"J.\u00a0Orthop. Res."},{"key":"10.1016\/j.jbc.2023.105155_bib3","article-title":"Epigenetic control of osteogenic lineage commitment","volume":"8","author":"Montecino","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jbc.2023.105155_bib4","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.bone.2015.03.011","article-title":"Chromatin modifiers and histone modifications in bone formation, regeneration, and therapeutic intervention for bone-related disease","volume":"81","author":"Gordon","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.jbc.2023.105155_bib5","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.bone.2015.03.013","article-title":"Multiple levels of epigenetic control for bone biology and pathology","volume":"81","author":"Montecino","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.jbc.2023.105155_bib6","doi-asserted-by":"crossref","first-page":"5883","DOI":"10.1038\/s41467-022-32915-8","article-title":"Vitamin C epigenetically controls osteogenesis and bone mineralization","volume":"13","author":"Thaler","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2023.105155_bib7","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1101\/gad.219626.113","article-title":"A\u00a0double take on bivalent promoters","volume":"27","author":"Voigt","year":"2013","journal-title":"Genes Dev."},{"key":"10.1016\/j.jbc.2023.105155_bib8","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/aps.2017.7","article-title":"Structure of the PRC2 complex and application to drug discovery","volume":"38","author":"Shi","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.jbc.2023.105155_bib9","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s40610-017-0064-8","article-title":"Epigenetic control of osteoblast differentiation by enhancer of zeste homolog 2 (EZH2)","volume":"3","author":"Dudakovic","year":"2017","journal-title":"Curr. Mol. Biol. Rep."},{"key":"10.1016\/j.jbc.2023.105155_bib10","first-page":"349","article-title":"Expression levels of the EZH2 polycomb transcriptional repressor correlate with aggressiveness and invasive potential of bladder carcinomas","volume":"16","author":"Weikert","year":"2005","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jbc.2023.105155_bib11","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S1535-6108(02)00187-3","article-title":"The EZH2 polycomb transcriptional repressor--a marker or mover of metastatic prostate cancer?","volume":"2","author":"Sellers","year":"2002","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jbc.2023.105155_bib12","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/ajmg.c.31754","article-title":"PRC2-complex related dysfunction in overgrowth syndromes: a review of EZH2, EED, and SUZ12 and their syndromic phenotypes","volume":"181","author":"Cyrus","year":"2019","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"key":"10.1016\/j.jbc.2023.105155_bib13","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/ajmg.a.61066","article-title":"EED and EZH2 constitutive variants: a study to expand the Cohen-Gibson syndrome phenotype and contrast it with Weaver syndrome","volume":"179","author":"Griffiths","year":"2019","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.jbc.2023.105155_bib14","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/ajmg.c.31748","article-title":"Rare SUZ12 variants commonly cause an overgrowth phenotype","volume":"181","author":"Cyrus","year":"2019","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"key":"10.1016\/j.jbc.2023.105155_bib15","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.stem.2019.03.005","article-title":"Polycomb\/trithorax antagonism: cellular memory in stem cell fate and function","volume":"24","author":"Brand","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jbc.2023.105155_bib16","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/nm.4036","article-title":"Targeting EZH2 in cancer","volume":"22","author":"Kim","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.jbc.2023.105155_bib17","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1158\/0008-5472.CAN-21-4311","article-title":"EZH2 inhibitors: the unpacking revolution","volume":"82","author":"Adema","year":"2022","journal-title":"Cancer Res."},{"key":"10.1016\/j.jbc.2023.105155_bib18","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/mt.2015.152","article-title":"Suppression of EZH2 prevents the shift of osteoporotic MSC fate to adipocyte and enhances bone formation during osteoporosis","volume":"24","author":"Jing","year":"2016","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jbc.2023.105155_bib19","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1186\/s13287-021-02670-6","article-title":"DZNep promotes mouse bone defect healing via enhancing both osteogenesis and osteoclastogenesis","volume":"12","author":"Cao","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.jbc.2023.105155_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115605","article-title":"Clinical efficiency of epigenetic drugs therapy in bone malignancies","volume":"143","author":"de Nigris","year":"2021","journal-title":"Bone"},{"key":"10.1016\/j.jbc.2023.105155_bib21","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature11606","article-title":"EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations","volume":"492","author":"McCabe","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2023.105155_bib22","doi-asserted-by":"crossref","first-page":"24594","DOI":"10.1074\/jbc.M116.740571","article-title":"Enhancer of zeste homolog 2 inhibition stimulates bone formation and mitigates bone loss caused by ovariectomy in skeletally mature mice","volume":"291","author":"Dudakovic","year":"2016","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.105155_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2021.115993","article-title":"Multiple pharmacological inhibitors targeting the epigenetic suppressor enhancer of zeste homolog 2 (Ezh2) accelerate osteoblast differentiation","volume":"150","author":"Galvan","year":"2021","journal-title":"Bone"},{"key":"10.1016\/j.jbc.2023.105155_bib24","doi-asserted-by":"crossref","first-page":"27604","DOI":"10.1074\/jbc.M115.672345","article-title":"Epigenetic control of skeletal development by the histone methyltransferase Ezh2","volume":"290","author":"Dudakovic","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.105155_bib25","doi-asserted-by":"crossref","first-page":"7877","DOI":"10.1074\/jbc.RA119.011685","article-title":"Inhibition of the epigenetic suppressor EZH2 primes osteogenic differentiation mediated by BMP2","volume":"295","author":"Dudakovic","year":"2020","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.105155_bib26","doi-asserted-by":"crossref","first-page":"19001","DOI":"10.1074\/jbc.RA118.003909","article-title":"Loss of histone methyltransferase Ezh2 stimulates an osteogenic transcriptional program in chondrocytes but does not affect cartilage development","volume":"293","author":"Camilleri","year":"2018","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.105155_bib27","doi-asserted-by":"crossref","first-page":"12894","DOI":"10.1074\/jbc.RA118.002983","article-title":"Enhancer of zeste homolog 2 (Ezh2) controls bone formation and cell cycle progression during osteogenesis in mice","volume":"293","author":"Dudakovic","year":"2018","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.105155_bib28","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1242\/dev.063180","article-title":"Ezh2 regulates anteroposterior axis specification and proximodistal axis elongation in the developing limb","volume":"138","author":"Wyngaarden","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.jbc.2023.105155_bib29","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1242\/dev.094342","article-title":"Ezh2 is required for neural crest-derived cartilage and bone formation","volume":"141","author":"Schwarz","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.jbc.2023.105155_bib30","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1096\/fj.201600748R","article-title":"EZH2 deletion in early mesenchyme compromises postnatal bone microarchitecture and structural integrity and accelerates remodeling","volume":"31","author":"Hemming","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.jbc.2023.105155_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13685","article-title":"EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy","volume":"7","author":"Lui","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2023.105155_bib32","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/ncb2139","article-title":"CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells","volume":"13","author":"Wei","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jbc.2023.105155_bib33","article-title":"MiR-101 targets the EZH2\/Wnt\/beta-catenin the pathway to promote the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2023.105155_bib34","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/stem.1573","article-title":"EZH2 and KDM6A act as an epigenetic switch to regulate mesenchymal stem cell lineage specification","volume":"32","author":"Hemming","year":"2014","journal-title":"Stem Cells"},{"key":"10.1016\/j.jbc.2023.105155_bib35","doi-asserted-by":"crossref","first-page":"63561","DOI":"10.18632\/oncotarget.11538","article-title":"Long non-coding RNA HoxA-AS3 interacts with EZH2 to regulate lineage commitment of mesenchymal stem cells","volume":"7","author":"Zhu","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.jbc.2023.105155_bib36","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1002\/stem.2400","article-title":"Enhancer of zeste homolog 2 and histone deacetylase 9c regulate age-dependent mesenchymal stem cell differentiation into osteoblasts and adipocytes","volume":"34","author":"Chen","year":"2016","journal-title":"Stem Cells"},{"key":"10.1016\/j.jbc.2023.105155_bib37","doi-asserted-by":"crossref","first-page":"4452","DOI":"10.4049\/jimmunol.1501466","article-title":"Cutting edge: EZH2 promotes osteoclastogenesis by epigenetic silencing of the negative regulator IRF8","volume":"196","author":"Fang","year":"2016","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jbc.2023.105155_bib38","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1089\/scd.2020.0209","article-title":"Ezh2 is essential for patterning of multiple musculoskeletal tissues but dispensable for tendon differentiation","volume":"30","author":"Pal","year":"2021","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.jbc.2023.105155_bib39","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1089\/ten.tea.2020.0218","article-title":"Combination of BMP2 and EZH2 inhibition to stimulate osteogenesis in a 3D bone reconstruction model","volume":"27","author":"Lui","year":"2021","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.jbc.2023.105155_bib40","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.bbrc.2021.06.003","article-title":"Ezh2 knockout in mesenchymal cells causes enamel hyper-mineralization","volume":"567","author":"Kobayashi","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jbc.2023.105155_bib41","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-17579-0","article-title":"MicroRNA-101a enhances trabecular bone accrual in male mice","volume":"12","author":"Dudakovic","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2023.105155_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11154-006-9001-5","article-title":"Networks and hubs for the transcriptional control of osteoblastogenesis","volume":"7","author":"Lian","year":"2006","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.jbc.2023.105155_bib43","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.tig.2019.11.004","article-title":"The bivalent genome: characterization, structure, and regulation","volume":"36","author":"Blanco","year":"2020","journal-title":"Trends Genet."},{"key":"10.1016\/j.jbc.2023.105155_bib44","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang da","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jbc.2023.105155_bib45","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nature10730","article-title":"Differential oestrogen receptor binding is associated with clinical outcome in breast cancer","volume":"481","author":"Ross-Innes","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2023.105155_bib46","doi-asserted-by":"crossref","first-page":"W160","DOI":"10.1093\/nar\/gkw257","article-title":"deepTools2: a next generation web server for deep-sequencing data analysis","volume":"44","author":"Ramirez","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2023.105155_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115491","article-title":"Wnt modulation in bone healing","volume":"138","author":"Schupbach","year":"2020","journal-title":"Bone"},{"key":"10.1016\/j.jbc.2023.105155_bib48","article-title":"cAMP\/PKA regulates osteogenesis, adipogenesis and ratio of RANKL\/OPG mRNA expression in mesenchymal stem cells by suppressing leptin","volume":"3","author":"Yang","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2023.105155_bib49","doi-asserted-by":"crossref","first-page":"47145","DOI":"10.18632\/oncotarget.9975","article-title":"FH535, a beta-catenin pathway inhibitor, represses pancreatic cancer xenograft growth and angiogenesis","volume":"7","author":"Liu","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.jbc.2023.105155_bib50","doi-asserted-by":"crossref","first-page":"5946","DOI":"10.1073\/pnas.1601918113","article-title":"Enhancement of beta-catenin activity by BIG1 plus BIG2 via Arf activation and cAMP signals","volume":"113","author":"Li","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2023.105155_bib51","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3109\/07357907.2010.494318","article-title":"CRH and SRIF have opposite effects on the Wnt\/beta-catenin signalling pathway through PKA\/GSK-3beta in corticotroph pituitary cells","volume":"28","author":"Khattak","year":"2010","journal-title":"Cancer Invest."},{"key":"10.1016\/j.jbc.2023.105155_bib52","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nrrheum.2015.84","article-title":"The role of Hedgehog signalling in skeletal health and disease","volume":"11","author":"Alman","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jbc.2023.105155_bib53","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.cell.2006.02.041","article-title":"A\u00a0bivalent chromatin structure marks key developmental genes in embryonic stem cells","volume":"125","author":"Bernstein","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2023.105155_bib54","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.bbagrm.2016.05.009","article-title":"Polycomb PRC2 complex mediates epigenetic silencing of a critical osteogenic master regulator in the hippocampus","volume":"1859","author":"Aguilar","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbc.2023.105155_bib55","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.cell.2016.04.031","article-title":"Acquired tissue-specific promoter bivalency is a basis for PRC2 necessity in adult cells","volume":"165","author":"Jadhav","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2023.105155_bib56","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ceb.2020.12.014","article-title":"Epigenetic memory of cell fate commitment","volume":"69","author":"Elsherbiny","year":"2021","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.jbc.2023.105155_bib57","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1002\/jbmr.3975","article-title":"Beta-catenin preserves the stem state of murine bone marrow stromal cells through activation of EZH2","volume":"35","author":"Sen","year":"2020","journal-title":"J.\u00a0Bone Miner. Res."},{"key":"10.1016\/j.jbc.2023.105155_bib58","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/nrg.2017.57","article-title":"The interplay of epigenetic marks during stem cell differentiation and development","volume":"18","author":"Atlasi","year":"2017","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.jbc.2023.105155_bib59","doi-asserted-by":"crossref","first-page":"5293","DOI":"10.1002\/jcp.29415","article-title":"The epigenetic reader Brd4 is required for osteoblast differentiation","volume":"235","author":"Paradise","year":"2020","journal-title":"J.\u00a0Cell Physiol."},{"key":"10.1016\/j.jbc.2023.105155_bib60","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1038\/s41467-019-09624-w","article-title":"Dissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity","volume":"10","author":"Lavarone","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2023.105155_bib61","doi-asserted-by":"crossref","first-page":"3769","DOI":"10.1128\/MCB.01432-06","article-title":"The polycomb group protein Suz12 is required for embryonic stem cell differentiation","volume":"27","author":"Pasini","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jbc.2023.105155_bib62","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.1021\/acs.jmedchem.1c02148","article-title":"Discovery of the clinical candidate MAK683: an EED-directed, allosteric, and selective PRC2 inhibitor for the treatment of advanced malignancies","volume":"65","author":"Huang","year":"2022","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.jbc.2023.105155_bib63","article-title":"Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2","volume":"763S","author":"Galea","year":"2020","journal-title":"Gene"},{"key":"10.1016\/j.jbc.2023.105155_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2021.116234","article-title":"Brd4 is required for chondrocyte differentiation and endochondral ossification","volume":"154","author":"Paradise","year":"2022","journal-title":"Bone"},{"key":"10.1016\/j.jbc.2023.105155_bib65","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/ncb1403","article-title":"Chromatin signatures of pluripotent cell lines","volume":"8","author":"Azuara","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jbc.2023.105155_bib66","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nature04733","article-title":"Polycomb complexes repress developmental regulators in murine embryonic stem cells","volume":"441","author":"Boyer","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2023.105155_bib67","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1634\/stemcells.2008-0102","article-title":"Polycomb repressive complex 2 is dispensable for maintenance of embryonic stem cell pluripotency","volume":"26","author":"Chamberlain","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.jbc.2023.105155_bib68","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.molcel.2008.10.016","article-title":"EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency","volume":"32","author":"Shen","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2023.105155_bib69","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.gpb.2012.05.007","article-title":"Comparative analyses of H3K4 and H3K27 trimethylations between the mouse cerebrum and testis","volume":"10","author":"Cui","year":"2012","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"10.1016\/j.jbc.2023.105155_bib70","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1128\/MCB.00877-15","article-title":"Genome-wide studies reveal that H3K4me3 modification in bivalent genes is dynamically regulated during the pluripotent cell cycle and stabilized upon differentiation","volume":"36","author":"Grandy","year":"2016","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.jbc.2023.105155_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101646","article-title":"Cell signaling coordinates global PRC2 recruitment and developmental gene expression in murine embryonic stem cells","volume":"23","author":"Aljazi","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.jbc.2023.105155_bib72","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.molcel.2014.12.020","article-title":"Jarid2 methylation via the PRC2 complex regulates H3K27me3 deposition during cell differentiation","volume":"57","author":"Sanulli","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2023.105155_bib73","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/bs.apcsb.2019.01.002","article-title":"Molecular signaling in bone cells: regulation of cell differentiation and survival","volume":"116","author":"Plotkin","year":"2019","journal-title":"Adv. Protein Chem. Struct. Biol."},{"key":"10.1016\/j.jbc.2023.105155_bib74","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3389\/fphar.2017.00285","article-title":"FH535 suppresses osteosarcoma growth in\u00a0vitro and inhibits Wnt signaling through tankyrases","volume":"8","author":"Gustafson","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jbc.2023.105155_bib75","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.3074","article-title":"WNT signaling in bone homeostasis and disease: from human mutations to treatments","volume":"19","author":"Baron","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.jbc.2023.105155_bib76","doi-asserted-by":"crossref","first-page":"3875","DOI":"10.1007\/s00018-019-03099-0","article-title":"Regulation of WNT5A and WNT11 during MSC in\u00a0vitro chondrogenesis: WNT inhibition lowers BMP and hedgehog activity, and reduces hypertrophy","volume":"76","author":"Diederichs","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.jbc.2023.105155_bib77","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/jbmr.2377","article-title":"Planar cell polarity aligns osteoblast division in response to substrate strain","volume":"30","author":"Galea","year":"2015","journal-title":"J.\u00a0Bone Miner. Res."},{"key":"10.1016\/j.jbc.2023.105155_bib78","doi-asserted-by":"crossref","first-page":"6665","DOI":"10.3390\/ijms21186665","article-title":"Hedgehog signaling in skeletal development: roles of Indian hedgehog and the mode of its action","volume":"21","author":"Ohba","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbc.2023.105155_bib79","doi-asserted-by":"crossref","first-page":"5425","DOI":"10.1038\/ncomms6425","article-title":"An epigenetic switch induced by Shh signalling regulates gene activation during development and medulloblastoma growth","volume":"5","author":"Shi","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2023.105155_bib80","doi-asserted-by":"crossref","first-page":"5840","DOI":"10.3390\/ijms20235840","article-title":"Recent insights into long bone development: central role of hedgehog signaling pathway in regulating growth plate","volume":"20","author":"Haraguchi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbc.2023.105155_bib81","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/ijos.2015.14","article-title":"The Hedgehog signalling pathway in bone formation","volume":"7","author":"Yang","year":"2015","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.jbc.2023.105155_bib82","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1158\/1535-7163.MCT-13-0773","article-title":"Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma","volume":"13","author":"Knutson","year":"2014","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.jbc.2023.105155_bib83","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1161\/CIRCRESAHA.111.252205","article-title":"Polycomb repressive complex 2 regulates normal development of the mouse heart","volume":"110","author":"He","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.jbc.2023.105155_bib84","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2008-9-9-r137","article-title":"Model-based analysis of ChIP-seq (MACS)","volume":"9","author":"Zhang","year":"2008","journal-title":"Genome Biol."},{"key":"10.1016\/j.jbc.2023.105155_bib85","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2023.105155_bib86","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq--a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jbc.2023.105155_bib87","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.jbc.2023.105155_bib88","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0157022","article-title":"SARTools: a DESeq2- and EdgeR-based R pipeline for comprehensive differential analysis of RNA-seq data","volume":"11","author":"Varet","year":"2016","journal-title":"PLoS One"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582302183X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582302183X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T16:44:42Z","timestamp":1762188282000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002192582302183X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":88,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S002192582302183X"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2023.105155","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of Ezh2 redistributes bivalent domains within transcriptional regulators associated with WNT and Hedgehog pathways in osteoblasts","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2023.105155","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"105155"}}