{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:37:29Z","timestamp":1790797049164,"version":"4.1.0"},"reference-count":101,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.jbc.2023.105356","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T11:24:42Z","timestamp":1697628282000},"page":"105356","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["The dimerized pentraxin-like domain of the adhesion G protein\u2013coupled receptor 112 (ADGRG4) suggests function in sensing mechanical forces"],"prefix":"10.1016","volume":"299","author":[{"given":"Bj\u00f6rn","family":"Kieslich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1736-8085","authenticated-orcid":false,"given":"Renato H.","family":"Wei\u00dfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Brendler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Ricken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5313-0237","authenticated-orcid":false,"given":"Torsten","family":"Sch\u00f6neberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Str\u00e4ter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2023.105356_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-28682-6","article-title":"Oligomerization of a G protein-coupled receptor in neurons controlled by its structural dynamics","volume":"8","author":"M\u00f8ller","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2023.105356_bib2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ceb.2018.10.007","article-title":"GPCR homo-oligomerization","volume":"57","author":"Milligan","year":"2019","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.jbc.2023.105356_bib3","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.bpj.2018.05.036","article-title":"Single Proteoliposome high-Content analysis reveals differences in the homo-oligomerization of GPCRs","volume":"115","author":"Walsh","year":"2018","journal-title":"Biophys. J."},{"key":"10.1016\/j.jbc.2023.105356_bib4","first-page":"5223","article-title":"Silencing of secretin receptor function by dimerization with a misspliced variant secretin receptor in ductal pancreatic adenocarcinoma","volume":"62","author":"Ding","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.jbc.2023.105356_bib5","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fendo.2015.00010","article-title":"Oligomerization of family B GPCRs: exploration in inter-family oligomer formation","volume":"6","author":"Ng","year":"2015","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jbc.2023.105356_bib6","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1124\/pr.114.009647","article-title":"International union of basic and clinical pharmacology. XCIV. Adhesion G protein-coupled receptors","volume":"67","author":"Hamann","year":"2015","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jbc.2023.105356_bib7","doi-asserted-by":"crossref","first-page":"19957","DOI":"10.1074\/jbc.274.28.19957","article-title":"Ig-hepta, a novel member of the G protein-coupled hepta-helical receptor (GPCR) family that has immunoglobulin-like repeats in a long N-terminal extracellular domain and defines a new subfamily of GPCRs","volume":"274","author":"Abe","year":"1999","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.105356_bib8","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.celrep.2012.06.015","article-title":"The GPS motif is a molecular switch for bimodal activities of adhesion class G protein-coupled receptors","volume":"2","author":"Pr\u00f6mel","year":"2012","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2023.105356_bib9","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2302047120","article-title":"Antiparallel dimer structure of CELSR cadherin in solution revealed by high-speed atomic force microscopy","volume":"120","author":"Nishiguchi","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2023.105356_bib10","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.cell.2012.04.021","article-title":"Planar cell polarity links axes of spatial dynamics in neural-tube closure","volume":"149","author":"Nishimura","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2023.105356_bib11","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/nn1933","article-title":"Opposing roles in neurite growth control by two seven-pass transmembrane cadherins","volume":"10","author":"Shima","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jbc.2023.105356_bib12","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1038\/onc.2012.301","article-title":"CD97 amplifies LPA receptor signaling and promotes thyroid cancer progression in a mouse model","volume":"32","author":"Ward","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.jbc.2023.105356_bib13","doi-asserted-by":"crossref","first-page":"7301","DOI":"10.1158\/0008-5472.CAN-11-2381","article-title":"LPA receptor heterodimerizes with CD97 to amplify LPA-initiated RHO-dependent signaling and invasion in prostate cancer cells","volume":"71","author":"Ward","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.jbc.2023.105356_bib14","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.1038\/sj.emboj.7600443","article-title":"Latrophilin fragments behave as independent proteins that associate and signal on binding of LTX(N4C)","volume":"23","author":"Volynski","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2023.105356_bib15","doi-asserted-by":"crossref","first-page":"27343","DOI":"10.1074\/jbc.M704096200","article-title":"The role of receptor oligomerization in modulating the expression and function of leukocyte adhesion-G protein-coupled receptors","volume":"282","author":"Davies","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.105356_bib16","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.1074\/jbc.M004814200","article-title":"ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. ETL is a member of the secretin family and belongs to the epidermal growth factor-seven-transmembrane subfamily","volume":"276","author":"Nechiporuk","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.105356_bib17","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1124\/pharmrev.120.000011","article-title":"Mutations in G protein-coupled receptors: mechanisms, pathophysiology and potential therapeutic approaches","volume":"73","author":"Sch\u00f6neberg","year":"2021","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.jbc.2023.105356_bib18","doi-asserted-by":"crossref","first-page":"10147","DOI":"10.1074\/jbc.M708535200","article-title":"Structural characterization of PTX3 disulfide bond network and its multimeric status in cumulus matrix organization","volume":"283","author":"Inforzato","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.105356_bib19","doi-asserted-by":"crossref","first-page":"17786","DOI":"10.1074\/jbc.M002254200","article-title":"Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2","volume":"275","author":"Kirkpatrick","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.105356_bib20","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.3389\/fimmu.2018.02382","article-title":"The pentraxins 1975-2018: serendipity, diagnostics and drugs","volume":"9","author":"Pepys","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jbc.2023.105356_bib21","first-page":"32","article-title":"Isolation of C-reactive protein by affinity chromatography","volume":"30","author":"Pepys","year":"1977","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jbc.2023.105356_bib22","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0968-0004(01)01832-1","article-title":"LG\/LNS domains: multiple functions \u2013 one business end?","volume":"26","author":"Rudenko","year":"2001","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jbc.2023.105356_bib23","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.sbi.2018.11.007","article-title":"Laminin G-like domains: dystroglycan-specific lectins","volume":"56","author":"Hohenester","year":"2019","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.jbc.2023.105356_bib24","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4161\/cam.21831","article-title":"Laminins in basement membrane assembly","volume":"7","author":"Hohenester","year":"2013","journal-title":"Cell Adh. Migr."},{"key":"10.1016\/j.jbc.2023.105356_bib25","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S1097-2765(00)80388-3","article-title":"The crystal structure of a laminin G\u2013like module reveals the molecular basis of \u03b1-dystroglycan binding to laminins, perlecan, and agrin","volume":"4","author":"Hohenester","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2023.105356_bib26","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.str.2004.02.001","article-title":"Modulation of agrin function by alternative splicing and Ca2+ binding","volume":"12","author":"Stetefeld","year":"2004","journal-title":"Structure"},{"key":"10.1016\/j.jbc.2023.105356_bib27","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jmb.2011.09.048","article-title":"Crystal structure of the LG3 domain of endorepellin, an angiogenesis inhibitor","volume":"414","author":"Le","year":"2011","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.jbc.2023.105356_bib28","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nsmb1350","article-title":"Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions","volume":"15","author":"Chen","year":"2008","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.jbc.2023.105356_bib29","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0022-2836(02)00169-9","article-title":"Resolution of a disordered region at the entrance of the human sex hormone-binding globulin steroid-binding site","volume":"318","author":"Grishkovskaya","year":"2002","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.jbc.2023.105356_bib30","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0168-9525(97)01324-3","article-title":"Neurexins: three genes and 1001 products","volume":"14","author":"Missler","year":"1998","journal-title":"Trends Genet."},{"key":"10.1016\/j.jbc.2023.105356_bib31","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/modpathol.2008.174","article-title":"Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas","volume":"22","author":"Leja","year":"2009","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.jbc.2023.105356_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111803","article-title":"The evolutionary history of vertebrate adhesion GPCRs and its Implication on their classification","volume":"22","author":"Wittlake","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbc.2023.105356_bib33","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/s41586-022-04590-8","article-title":"Tethered peptide activation mechanism of the adhesion GPCRs ADGRG2 and ADGRG4","volume":"604","author":"Xiao","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2023.105356_bib34","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/s41392-022-01083-y","article-title":"Stachel-mediated activation of adhesion G protein-coupled receptors: insights from cryo-EM studies","volume":"7","author":"Liebscher","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jbc.2023.105356_bib35","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1038\/emboj.2012.26","article-title":"A\u00a0novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis","volume":"31","author":"Ara\u00e7","year":"2012","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2023.105356_bib36","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41467-019-14040-1","article-title":"Structural basis for adhesion G protein-coupled receptor Gpr126 function","volume":"11","author":"Leon","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2023.105356_bib37","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.neuron.2016.08.022","article-title":"Structural basis for regulation of GPR56\/ADGRG1 by its alternatively spliced extracellular domains","volume":"91","author":"Salzman","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.jbc.2023.105356_bib38","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1006\/jmbi.1997.1271","article-title":"Pentameric and decameric structures in solution of serum amyloid P component by X-ray and neutron scattering and molecular modelling analyses","volume":"272","author":"Ashton","year":"1997","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.jbc.2023.105356_bib39","first-page":"310","article-title":"Prediction of glycosylation across the human proteome and the correlation to protein function","author":"Gupta","year":"2002","journal-title":"Pac. Symp. Biocomput."},{"key":"10.1016\/j.jbc.2023.105356_bib40","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1016\/j.jinorgbio.2008.05.006","article-title":"Data mining of metal ion environments present in protein structures","volume":"102","author":"Zheng","year":"2008","journal-title":"J.\u00a0Inorg. Biochem."},{"key":"10.1016\/j.jbc.2023.105356_bib41","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1107\/S0907444904026460","article-title":"Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions","volume":"60","author":"Krissinel","year":"2004","journal-title":"Acta Crystallogr. D, Biol. Crystallogr."},{"key":"10.1016\/j.jbc.2023.105356_bib42","doi-asserted-by":"crossref","DOI":"10.1126\/science.abb4853","article-title":"A\u00a0synthetic synaptic organizer protein restores glutamatergic neuronal circuits","volume":"369","author":"Suzuki","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jbc.2023.105356_bib43","doi-asserted-by":"crossref","first-page":"5656","DOI":"10.1021\/ja069124n","article-title":"Structural characterization of flexible proteins using small-angle X-ray scattering","volume":"129","author":"Bernad\u00f3","year":"2007","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.jbc.2023.105356_bib44","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1107\/S205225251500202X","article-title":"Advanced ensemble modelling of flexible macromolecules using X-ray solution scattering","volume":"2","author":"Tria","year":"2015","journal-title":"IUCrJ"},{"key":"10.1016\/j.jbc.2023.105356_bib45","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1107\/S0021889803012779","article-title":"Primus : a windows PC-based system for small-angle scattering data analysis","volume":"36","author":"Konarev","year":"2003","journal-title":"J.\u00a0Appl. Cryst."},{"key":"10.1016\/j.jbc.2023.105356_bib46","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2023.105356_bib47","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/S0021-9258(17)49880-2","article-title":"Molecular interactions between sex hormone-binding globulin and nonsteroidal ligands that enhance androgen activity","volume":"295","author":"Round","year":"2020","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.105356_bib48","doi-asserted-by":"crossref","first-page":"10622","DOI":"10.1021\/bi00201a008","article-title":"Steroid-binding and dimerization domains of human sex hormone-binding globulin partially overlap: steroids and Ca2+ stabilize dimer formation","volume":"33","author":"Bocchinfuso","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/j.jbc.2023.105356_bib49","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fmolb.2019.00018","article-title":"Analysis of \u03b1-dystroglycan\/LG domain binding modes: investigating protein motifs that regulate the affinity of isolated LG domains","volume":"6","author":"Dempsey","year":"2019","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.jbc.2023.105356_bib50","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1093\/emboj\/19.4.504","article-title":"Crystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domain","volume":"19","author":"Grishkovskaya","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2023.105356_bib51","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0092-8674(00)80046-X","article-title":"Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled","volume":"98","author":"Usui","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2023.105356_bib52","doi-asserted-by":"crossref","first-page":"28914","DOI":"10.1074\/jbc.M111.247973","article-title":"The N terminus of the adhesion G protein-coupled receptor GPR56 controls receptor signaling activity","volume":"286","author":"Paavola","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.105356_bib53","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0014-5793(02)03574-3","article-title":"Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser\/Thr-rich regions","volume":"531","author":"Fredriksson","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jbc.2023.105356_bib54","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1529\/biophysj.106.091561","article-title":"Contour length and refolding rate of a small protein controlled by engineered disulfide bonds","volume":"92","author":"Ainavarapu","year":"2007","journal-title":"Biophys. J."},{"key":"10.1016\/j.jbc.2023.105356_bib55","doi-asserted-by":"crossref","first-page":"5536","DOI":"10.1021\/bi00439a030","article-title":"Effects of glycosylation on the conformation and dynamics of O-linked glycoproteins: carbon-13 NMR studies of ovine submaxillary mucin","volume":"28","author":"Gerken","year":"1989","journal-title":"Biochemistry"},{"key":"10.1016\/j.jbc.2023.105356_bib56","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.1038\/s41467-022-31062-4","article-title":"Revealing the human mucinome","volume":"13","author":"Malaker","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2023.105356_bib57","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1038\/emboj.2013.79","article-title":"Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology","volume":"32","author":"Steentoft","year":"2013","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2023.105356_bib58","article-title":"ColabFold - Making protein folding accessible to all","author":"Mirdita","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.jbc.2023.105356_bib59","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1111\/febs.12144","article-title":"Unfolding dynamics of the mucin SEA domain probed by force spectroscopy suggest that it acts as a cell-protective device","volume":"280","author":"Pelaseyed","year":"2013","journal-title":"FEBS J."},{"key":"10.1016\/j.jbc.2023.105356_bib60","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1471-2407-10-40","article-title":"Orphan receptor GPR110, an oncogene overexpressed in lung and prostate cancer","volume":"10","author":"Lum","year":"2010","journal-title":"BMC cancer"},{"key":"10.1016\/j.jbc.2023.105356_bib61","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2112814118","article-title":"Single-cell sequencing of rotavirus-infected intestinal epithelium reveals cell-type specific epithelial repair and tuft cell infection","volume":"118","author":"Bomidi","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2023.105356_bib62","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/s41586-021-03852-1","article-title":"Cells of the human intestinal tract mapped across space and time","volume":"597","author":"Elmentaite","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2023.105356_bib63","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature24489","article-title":"A\u00a0single-cell survey of the small intestinal epithelium","volume":"551","author":"Haber","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2023.105356_bib64","doi-asserted-by":"crossref","DOI":"10.1093\/database\/baz046","article-title":"PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data","volume":"2019","author":"Franz\u00e9n","year":"2019","journal-title":"Database (Oxford)"},{"key":"10.1016\/j.jbc.2023.105356_bib65","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00441-009-0859-x","article-title":"Anatomical and histological profiling of orphan G-protein-coupled receptor expression in gastrointestinal tract of C57BL\/6J mice","volume":"338","author":"Ito","year":"2009","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.jbc.2023.105356_bib66","series-title":"Surgical Pathology of the GI Tract, Liver, Biliary Tract, and Pancreas","first-page":"653","article-title":"Neuroendocrine Tumors of the GI tract and Appendix","author":"Graeme-Cook","year":"2009"},{"key":"10.1016\/j.jbc.2023.105356_bib67","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/bs.pmbts.2020.08.012","article-title":"The microbiota-gut-brain axis: focus on the fundamental communication pathways","volume":"176","author":"Bistoletti","year":"2020","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.jbc.2023.105356_bib68","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.neuron.2014.12.057","article-title":"The adhesion GPCR GPR126 has distinct, domain-dependent functions in Schwann cell development mediated by interaction with laminin-211","volume":"85","author":"Petersen","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.jbc.2023.105356_bib69","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.28360","article-title":"Mechano-dependent signaling by Latrophilin\/CIRL quenches cAMP in proprioceptive neurons","volume":"6","author":"Scholz","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.jbc.2023.105356_bib70","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1096\/fj.15-276220","article-title":"The constitutive activity of the adhesion GPCR GPR114\/ADGRG5 is mediated by its tethered agonist","volume":"30","author":"Wilde","year":"2016","journal-title":"FASEB J."},{"key":"10.1016\/j.jbc.2023.105356_bib71","doi-asserted-by":"crossref","first-page":"28275","DOI":"10.1073\/pnas.2008921117","article-title":"GPR56\/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force","volume":"117","author":"Yeung","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2023.105356_bib72","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/978-3-319-41523-9_6","article-title":"Tethered agonism: a common activation mechanism of adhesion GPCRs","volume":"234","author":"Liebscher","year":"2016","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.jbc.2023.105356_bib73","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.phrs.2016.03.027","article-title":"What are they waiting for?-Tethered agonism in G protein-coupled receptors","volume":"108","author":"Sch\u00f6neberg","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jbc.2023.105356_bib74","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1093\/clinchem\/4.6.476","article-title":"An improved periodic acid fuchsin sulfite staining method for evaluation of glycoproteins","volume":"4","author":"McGuckin","year":"1958","journal-title":"Clin. Chem."},{"key":"10.1016\/j.jbc.2023.105356_bib75","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/0003-2697(69)90383-2","article-title":"Glycoprotein staining following electrophoresis on acrylamide gels","volume":"30","author":"Zacharius","year":"1969","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jbc.2023.105356_bib76","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1107\/S1600576716004416","article-title":"XDSAPP2.0","volume":"49","author":"Sparta","year":"2016","journal-title":"J.\u00a0Appl. Crystallogr."},{"key":"10.1016\/j.jbc.2023.105356_bib77","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1107\/S0021889807021206","article-title":"Phaser crystallographic software","volume":"40","author":"McCoy","year":"2007","journal-title":"J.\u00a0Appl. Crystallogr."},{"key":"10.1016\/j.jbc.2023.105356_bib78","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1107\/S2059798319011471","article-title":"Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix","volume":"75","author":"Liebschner","year":"2019","journal-title":"Acta Crystallogr. D, Struct. Biol."},{"key":"10.1016\/j.jbc.2023.105356_bib79","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","article-title":"Features and development of coot.","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr. D, Biol. Crystallogr."},{"key":"10.1016\/j.jbc.2023.105356_bib80","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1107\/S160057671500254X","article-title":"Versatile sample environments and automation for biological solution X-ray scattering experiments at the P12 beamline (PETRA III, DESY)","volume":"48","author":"Blanchet","year":"2015","journal-title":"J.\u00a0Appl. Crystallogr."},{"key":"10.1016\/j.jbc.2023.105356_bib81","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.nima.2012.06.008","article-title":"Automated acquisition and analysis of small angle X-ray scattering data","volume":"689","author":"Franke","year":"2012","journal-title":"Nucl. Instrum. Methods Phys. Res. Sect. A Accel. Spectrom. Detect. Assoc. Equip."},{"key":"10.1016\/j.jbc.2023.105356_bib82","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1107\/S1600576720013412","article-title":"Atsas 3.0: expanded functionality and new tools for small-angle scattering data analysis","volume":"54","author":"Manalastas-Cantos","year":"2021","journal-title":"J.\u00a0Appl. Crystallogr."},{"key":"10.1016\/j.jbc.2023.105356_bib83","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1006\/jmbi.1993.1626","article-title":"Comparative protein modelling by satisfaction of spatial restraints","volume":"234","author":"Sali","year":"1993","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.jbc.2023.105356_bib84","doi-asserted-by":"crossref","first-page":"4875","DOI":"10.1073\/pnas.1116274109","article-title":"Structure-based model of allostery predicts coupling between distant sites","volume":"109","author":"Weinkam","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2023.105356_bib85","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1107\/S0021889895007047","article-title":"Crysol \u2013 a program to Evaluate X-ray solution scattering of biological macromolecules from atomic coordinates","volume":"28","author":"Svergun","year":"1995","journal-title":"J.\u00a0Appl. Crystallogr."},{"key":"10.1016\/j.jbc.2023.105356_bib86","series-title":"Small-Angle Scattering of X-Rays. Structure of Matter Series","author":"Andr\u00e9 Guinier","year":"1955"},{"key":"10.1016\/j.jbc.2023.105356_bib87","doi-asserted-by":"crossref","first-page":"14632","DOI":"10.1021\/bi061746y","article-title":"SARS CoV main proteinase: the monomer-dimer equilibrium dissociation constant","volume":"45","author":"Graziano","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.jbc.2023.105356_bib88","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1093\/molbev\/msz312","article-title":"Molecular evolutionary Genetics analysis (MEGA) for macOS","volume":"37","author":"Stecher","year":"2020","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.jbc.2023.105356_bib89","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1093\/molbev\/msab120","article-title":"MEGA11: molecular evolutionary genetics analysis version 11","volume":"38","author":"Tamura","year":"2021","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.jbc.2023.105356_bib90","first-page":"275","article-title":"The rapid generation of mutation data matrices from protein sequences","volume":"8","author":"Jones","year":"1992","journal-title":"Comput. Appl. Biosci."},{"key":"10.1016\/j.jbc.2023.105356_bib91","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1558-5646.1985.tb00420.x","article-title":"Confidence limits on phylogenies: an approach using the bootstrap","volume":"39","author":"Felsenstein","year":"1985","journal-title":"Evolution"},{"key":"10.1016\/j.jbc.2023.105356_bib92","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/j.1538-7305.1948.tb01338.x","article-title":"A\u00a0mathematical theory of communication","volume":"27","author":"Shannon","year":"1948","journal-title":"Bell Syst. Tech. J."},{"key":"10.1016\/j.jbc.2023.105356_bib93","doi-asserted-by":"crossref","first-page":"W35","DOI":"10.1093\/nar\/gkn211","article-title":"PVS: a web server for protein sequence variability analysis tuned to facilitate conserved epitope discovery","volume":"36","author":"Garcia-Boronat","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2023.105356_bib94","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1107\/S2052252515005163","article-title":"A posteriori determination of the useful data range for small-angle scattering experiments on dilute monodisperse systems","volume":"2","author":"Konarev","year":"2015","journal-title":"IUCrJ"},{"key":"10.1016\/j.jbc.2023.105356_bib95","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/B978-0-12-381270-4.00019-6","article-title":"ROSETTA3: an object-oriented software suite for the simulation and design of macromolecules","volume":"487","author":"Leaver-Fay","year":"2011","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jbc.2023.105356_bib96","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nprot.2015.053","article-title":"The Phyre2 web portal for protein modeling, prediction and analysis","volume":"10","author":"Kelley","year":"2015","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jbc.2023.105356_bib97","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1107\/S0907444904026460","article-title":"Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions","volume":"60","author":"Krissinel","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.jbc.2023.105356_bib98","series-title":"Theoretical and Experimental Insights into Immunology","first-page":"485","author":"Perelson","year":"1992"},{"key":"10.1016\/j.jbc.2023.105356_bib99","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0969-2126(99)80023-9","article-title":"The physiological structure of human C-reactive protein and its complex with phosphocholine","volume":"7","author":"Thompson","year":"1999","journal-title":"Structure"},{"key":"10.1016\/j.jbc.2023.105356_bib100","doi-asserted-by":"crossref","first-page":"31999","DOI":"10.1074\/jbc.M504403200","article-title":"Ligand-assisted aggregation of proteins. Dimerization of serum amyloid P component by bivalent ligands","volume":"280","author":"Ho","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.105356_bib101","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1006\/jmbi.2000.4042","article-title":"T-Coffee: a novel method for fast and accurate multiple sequence alignment","volume":"302","author":"Notredame","year":"2000","journal-title":"J.\u00a0Mol. Biol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925823023840?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925823023840?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T16:43:44Z","timestamp":1762188224000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925823023840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":101,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S0021925823023840"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2023.105356","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.09.20.508530","asserted-by":"object"}]},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The dimerized pentraxin-like domain of the adhesion G protein\u2013coupled receptor 112 (ADGRG4) suggests function in sensing mechanical forces","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2023.105356","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"105356"}}