{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:45:06Z","timestamp":1789749906460,"version":"4.0.1"},"reference-count":45,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100022960","name":"Guangdong Provincial Special Fund for Modern Agriculture Industry Technology Innovation Teams","doi-asserted-by":"publisher","award":["2019KJ141"],"award-info":[{"award-number":["2019KJ141"]}],"id":[{"id":"10.13039\/100022960","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007421","name":"Li Ka Shing Foundation","doi-asserted-by":"publisher","award":["2020LKSFG01E"],"award-info":[{"award-number":["2020LKSFG01E"]}],"id":[{"id":"10.13039\/100007421","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42076125"],"award-info":[{"award-number":["42076125"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41876152"],"award-info":[{"award-number":["41876152"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.jbc.2023.105463","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T18:44:30Z","timestamp":1700073870000},"page":"105463","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Exosomes drive ferroptosis by stimulating iron accumulation to inhibit bacterial infection in crustaceans"],"prefix":"10.1016","volume":"299","author":[{"given":"Qian","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngoc Tuan","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kok-Gan","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengkang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2023.105463_bib1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death Nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2023.105463_bib2","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2023.105463_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101365","article-title":"Tumor suppressor p53 promotes ferroptosis in oxidative stress conditions independent of modulation of ferroptosis by p21, CDKs, RB, and E2F","volume":"297","author":"Kuganesan","year":"2021","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.105463_bib4","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1074\/jbc.RA119.009548","article-title":"Ferroptosis is controlled by the coordinated transcriptional regulation of glutathione and labile iron metabolism by the transcription factor BACH1","volume":"295","author":"Nishizawa","year":"2020","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.105463_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.101824","article-title":"Mitochondrial glutathione peroxidase 4 is indispensable for photoreceptor development and survival in mice","volume":"298","author":"Azuma","year":"2022","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.105463_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.101703","article-title":"Expression of gamma-glutamyltransferase 1 in glioblastoma cells confers resistance to cystine deprivation-induced ferroptosis","volume":"298","author":"Hayashima","year":"2022","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.105463_bib7","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2023.105463_bib8","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1021\/acscentsci.7b00589","article-title":"Resolving the role of lipoxygenases in the initiation and execution of ferroptosis","volume":"4","author":"Shah","year":"2018","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.jbc.2023.105463_bib9","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2023.105463_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.161183","article-title":"Cadmium chloride exposure impairs the growth and behavior of Drosophila via ferroptosis","volume":"865","author":"Hu","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jbc.2023.105463_bib11","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41419-020-2458-4","article-title":"SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in Caenorhabditis elegans","volume":"11","author":"Krabbendam","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jbc.2023.105463_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111381","article-title":"Early-life vitamin B12 orchestrates lipid peroxidation to ensure reproductive success via SBP-1\/SREBP1 in Caenorhabditis elegans","volume":"40","author":"Qin","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2023.105463_bib13","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.tim.2022.11.006","article-title":"When ferroptosis meets pathogenic infections","volume":"31","author":"Gao","year":"2023","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.jbc.2023.105463_bib14","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1084\/jem.20181776","article-title":"A\u00a0major role for ferroptosis in Mycobacterium tuberculosis-induced cell death and tissue necrosis","volume":"216","author":"Amaral","year":"2019","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.jbc.2023.105463_bib15","doi-asserted-by":"crossref","first-page":"590","DOI":"10.33594\/000000437","article-title":"P.\u00a0aeruginosa induced lipid peroxidation causes ferroptotic cell death in airways","volume":"55","author":"Ousingsawat","year":"2021","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.jbc.2023.105463_bib16","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.fsi.2020.09.036","article-title":"Escherichia coli induced ferroptosis in red blood cells of grass carp (Ctenopharyngodon idella)","volume":"112","author":"Yang","year":"2021","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.jbc.2023.105463_bib17","doi-asserted-by":"crossref","DOI":"10.1093\/mtomcs\/mfab072","article-title":"Gut microbiota-mediated ferroptosis contributes to mercury exposure-induced brain injury in common carp","volume":"14","author":"Zhang","year":"2022","journal-title":"Metallomics"},{"key":"10.1016\/j.jbc.2023.105463_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.825824","article-title":"Dysregulation of cytosolic c-di-GMP in Edwardsiella piscicida promotes cellular non-canonical ferroptosis","volume":"12","author":"Wen","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jbc.2023.105463_bib19","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.13317","article-title":"Intracellular Staphylococcus aureus and host cell death pathways","volume":"23","author":"Soe","year":"2021","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.jbc.2023.105463_bib20","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/cac2.12275","article-title":"Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma","volume":"42","author":"Zhang","year":"2022","journal-title":"Cancer Commun."},{"key":"10.1016\/j.jbc.2023.105463_bib21","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12943-020-01168-8","article-title":"CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer","volume":"19","author":"Zhang","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jbc.2023.105463_bib22","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.devcel.2019.10.007","article-title":"Prominin2 drives ferroptosis resistance by stimulating iron export","volume":"51","author":"Brown","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.jbc.2023.105463_bib23","doi-asserted-by":"crossref","first-page":"710","DOI":"10.4049\/jimmunol.2200094","article-title":"SpRab11a-regulated exosomes inhibit bacterial infection through the activation of antilipopolysaccharide factors in crustaceans","volume":"209","author":"Sun","year":"2022","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jbc.2023.105463_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008366","article-title":"Exosome-mediated apoptosis pathway during WSSV infection in crustacean mud crab","volume":"16","author":"Gong","year":"2020","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2023.105463_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009837","article-title":"Exosomal miR-224 contributes to hemolymph microbiota homeostasis during bacterial infection in crustacean","volume":"17","author":"Gong","year":"2021","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2023.105463_bib26","doi-asserted-by":"crossref","first-page":"34176","DOI":"10.1074\/jbc.M203436200","article-title":"Constitutive activation of peroxisome proliferator-activated receptor-gamma suppresses pro-inflammatory adhesion molecules in human vascular endothelial cells","volume":"277","author":"Wang","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.105463_bib27","doi-asserted-by":"crossref","first-page":"8328","DOI":"10.1074\/jbc.274.12.8328","article-title":"Peroxisome proliferators enhance cyclooxygenase-2 expression in epithelial cells","volume":"274","author":"Meade","year":"1999","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.105463_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102868","article-title":"Exosomes are involved in iron transport from human blood-brain barrier endothelial cells and are modified by endothelial cell iron status","volume":"299","author":"Palsa","year":"2023","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2023.105463_bib29","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1080\/15548627.2022.2146894","article-title":"Defensosomes: a new role for autophagy proteins in innate immune defense","volume":"19","author":"Ching","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.jbc.2023.105463_bib30","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/s41586-020-2066-6","article-title":"Decoy exosomes provide protection against bacterial toxins","volume":"579","author":"Keller","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2023.105463_bib31","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41419-022-04708-w","article-title":"Mesenchymal stem cells protect against ferroptosis via exosome-mediated stabilization of SLC7A11 in acute liver injury","volume":"13","author":"Lin","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jbc.2023.105463_bib32","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/s41392-023-01336-4","article-title":"Exosomes secreted from cardiomyocytes suppress the sensitivity of tumor ferroptosis in ischemic heart failure","volume":"8","author":"Yuan","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jbc.2023.105463_bib33","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2023.105463_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101402","article-title":"miR-30-5p-mediated ferroptosis of trophoblasts is implicated in the pathogenesis of preeclampsia","volume":"29","author":"Zhang","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.jbc.2023.105463_bib35","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41580-019-0195-2","article-title":"Iron expulsion by exosomes drives ferroptosis resistance","volume":"21","author":"Strzyz","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2023.105463_bib36","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1038\/s41467-018-06817-7","article-title":"Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction","volume":"9","author":"Oosterheert","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2023.105463_bib37","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s12951-022-01407-8","article-title":"miR-124-3p delivered by exosomes from heme oxygenase-1 modified bone marrow mesenchymal stem cells inhibits ferroptosis to attenuate ischemia-reperfusion injury in steatotic grafts","volume":"20","author":"Wu","year":"2022","journal-title":"J.\u00a0Nanobiotechnology"},{"key":"10.1016\/j.jbc.2023.105463_bib38","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/j.molcel.2022.03.022","article-title":"Ferroptosis at the intersection of lipid metabolism and cellular signaling","volume":"82","author":"Liang","year":"2022","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2023.105463_bib39","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1021\/acscentsci.3c00052","article-title":"Dihydroxy-metabolites of dihomo-\u03b3-linolenic acid drive ferroptosis-mediated neurodegeneration","volume":"9","author":"Sarparast","year":"2023","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.jbc.2023.105463_bib40","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1152\/physrev.00021.2001","article-title":"P-450 metabolites of arachidonic acid in the control of cardiovascular function","volume":"82","author":"Roman","year":"2002","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jbc.2023.105463_bib41","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1097-2765(01)00164-2","article-title":"A\u00a0PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis","volume":"7","author":"Chawla","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2023.105463_bib42","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/s41419-022-05115-x","article-title":"The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages","volume":"13","author":"Wu","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jbc.2023.105463_bib43","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1101\/gad.334219.119","article-title":"MDM2 and MDMX promote ferroptosis by PPAR\u03b1-mediated lipid remodeling","volume":"34","author":"Venkatesh","year":"2020","journal-title":"Genes Dev."},{"key":"10.1016\/j.jbc.2023.105463_bib44","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.cmet.2021.02.015","article-title":"CD36-mediated ferroptosis dampens intratumoral CD8(+) T cell effector function and impairs their antitumor ability","volume":"33","author":"Ma","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbc.2023.105463_bib45","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/978-1-4939-6960-9_6","article-title":"Ferroptosis and cell death analysis by flow cytometry","volume":"1601","author":"Chen","year":"2017","journal-title":"Methods Mol. Biol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925823024912?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925823024912?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:38:41Z","timestamp":1777415921000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925823024912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":45,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S0021925823024912"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2023.105463","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exosomes drive ferroptosis by stimulating iron accumulation to inhibit bacterial infection in crustaceans","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2023.105463","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"105463"}}