{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:24:05Z","timestamp":1789586645988,"version":"build-2803163510"},"reference-count":60,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI137403"],"award-info":[{"award-number":["R01 AI137403"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009776","name":"McMaster University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009776","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-166050"],"award-info":[{"award-number":["PJT-166050"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.jbc.2024.107455","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T12:51:31Z","timestamp":1717764691000},"page":"107455","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Discovery of an antivirulence compound that targets the Staphylococcus aureus SaeRS two-component system to inhibit toxic shock syndrome toxin-1 production"],"prefix":"10.1016","volume":"300","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9423-2037","authenticated-orcid":false,"given":"Karine","family":"Dufresne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2093-2345","authenticated-orcid":false,"suffix":"Jr.","given":"Dennis A.","family":"DiMaggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8916-3619","authenticated-orcid":false,"given":"Carla S.","family":"Maduta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5381-2817","authenticated-orcid":false,"given":"Shaun R.","family":"Brinsmade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John K.","family":"McCormick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2024.107455_bib1","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1056\/NEJM198012183032501","article-title":"Toxic-shock syndrome: epidemiologic features, recurrence, risk factors, and prevention","volume":"303","author":"Davis","year":"1980","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.jbc.2024.107455_bib2","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1093\/infdis\/143.4.509","article-title":"Identification and characterization of an exotoxin from Staphylococcus aureus associated with toxic-shock syndrome","volume":"143","author":"Schlievert","year":"1981","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.jbc.2024.107455_bib3","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0140-6736(81)92186-3","article-title":"A\u00a0new staphylococcal enterotoxin, enterotoxin F, associated with toxic-shock-syndrome Staphylococcus aureus isolates","volume":"1","author":"Bergdoll","year":"1981","journal-title":"Lancet"},{"key":"10.1016\/j.jbc.2024.107455_bib4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1146\/annurev.micro.55.1.77","article-title":"Toxic shock syndrome and bacterial superantigens: an update","volume":"55","author":"McCormick","year":"2001","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.jbc.2024.107455_bib5","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S1473-3099(05)70295-4","article-title":"The role of nasal carriage in Staphylococcus aureus infections","volume":"5","author":"Wertheim","year":"2005","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.jbc.2024.107455_bib6","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1128\/CMR.00134-14","article-title":"Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management","volume":"28","author":"Tong","year":"2015","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.jbc.2024.107455_bib7","doi-asserted-by":"crossref","first-page":"9942","DOI":"10.1038\/s41598-018-28116-3","article-title":"Complex ecological interactions of Staphylococcus aureus in tampons during menstruation","volume":"8","author":"Jacquemond","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2024.107455_bib8","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.01249-20","article-title":"Vaginal tampon colonization by Staphylococcus aureus in healthy women","volume":"86","author":"Chiaruzzi","year":"2020","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.jbc.2024.107455_bib9","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1128\/JB.183.4.1113-1123.2001","article-title":"Identification of a novel two-component regulatory system that acts in global regulation of virulence factors of Staphylococcus aureus","volume":"183","author":"Yarwood","year":"2001","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.jbc.2024.107455_bib10","doi-asserted-by":"crossref","first-page":"5093","DOI":"10.1128\/IAI.00724-08","article-title":"CcpA mediates the catabolite repression of tst in Staphylococcus aureus","volume":"76","author":"Seidl","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jbc.2024.107455_bib11","first-page":"447","article-title":"Rely and toxic shock syndrome: a technological health crisis","volume":"84","author":"Vostral","year":"2011","journal-title":"Yale J. Biol. Med."},{"key":"10.1016\/j.jbc.2024.107455_bib12","doi-asserted-by":"crossref","DOI":"10.1128\/jb.00269-22","article-title":"Glucose mediates niche-specific repression of Staphylococcus aureus toxic shock syndrome toxin-1 through the activity of CcpA in the vaginal environment","volume":"204","author":"Dufresne","year":"2022","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.jbc.2024.107455_bib13","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00032-19","article-title":"Device-associated menstrual toxic shock syndrome","volume":"33","author":"Schlievert","year":"2020","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.jbc.2024.107455_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2020.100308","article-title":"Association of characteristics of tampon use with menstrual toxic shock syndrome in France","volume":"21","author":"Billon","year":"2020","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.jbc.2024.107455_bib15","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1093\/infdis\/151.5.883","article-title":"Development of serum antibody to toxic shock toxin among individuals with toxic shock syndrome in Wisconsin","volume":"151","author":"Stolz","year":"1985","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.jbc.2024.107455_bib16","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1073\/pnas.1017431108","article-title":"Lactobacillus reuteri-produced cyclic dipeptides quench agr-mediated expression of toxic shock syndrome toxin-1 in staphylococci","volume":"108","author":"Li","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2024.107455_bib17","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1128\/AEM.02908-12","article-title":"Influence of the vaginal microbiota on toxic shock syndrome toxin-1 production by Staphylococcus aureus","volume":"79","author":"MacPhee","year":"2013","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.jbc.2024.107455_bib18","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.01735-23","article-title":"Inhibition of toxic shock syndrome-associated Staphylococcus aureus by probiotic lactobacilli","volume":"11","author":"Schlievert","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.jbc.2024.107455_bib19","doi-asserted-by":"crossref","DOI":"10.1128\/jb.00447-23","article-title":"Vaginal community state types (CSTs) alter environmental cues and production of the Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1)","volume":"206","author":"Maduta","year":"2024","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.jbc.2024.107455_bib20","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1128\/JCM.38.5.1797-1803.2000","article-title":"Oxygen and carbon dioxide regulation of toxic shock syndrome toxin 1 production by Staphylococcus aureus MN8","volume":"38","author":"Yarwood","year":"2000","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.jbc.2024.107455_bib21","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/infdis\/147.2.236","article-title":"Production of staphylococcal pyrogenic exotoxin type C: influence of physical and chemical factors","volume":"147","author":"Schlievert","year":"1983","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.jbc.2024.107455_bib22","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/s41564-022-01083-2","article-title":"Towards a deeper understanding of the vaginal microbiota","volume":"7","author":"France","year":"2022","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.jbc.2024.107455_bib23","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev.genet.42.110807.091640","article-title":"Quorum sensing in staphylococci","volume":"42","author":"Novick","year":"2008","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.jbc.2024.107455_bib24","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1111\/mmi.14353","article-title":"Regulation of toxic shock syndrome toxin-1 by the accessory gene regulator in Staphylococcus aureus is mediated by the repressor of toxins","volume":"112","author":"Tuffs","year":"2019","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jbc.2024.107455_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aat8329","article-title":"Quorum sensing between bacterial species on the skin protects against epidermal injury in atopic dermatitis","volume":"11","author":"Williams","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jbc.2024.107455_bib26","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.00930-22","article-title":"The ubiquitous human skin commensal Staphylococcus hominis protects against opportunistic pathogens","volume":"13","author":"Severn","year":"2022","journal-title":"mBio"},{"key":"10.1016\/j.jbc.2024.107455_bib27","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1086\/656047","article-title":"Staphylococcus aureus small-colony variants are adapted phenotypes for intracellular persistence","volume":"202","author":"Tuchscherr","year":"2010","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.jbc.2024.107455_bib28","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1128\/IAI.05669-11","article-title":"The Staphylococcus aureus two-component regulatory system, GraRS, senses and confers resistance to selected cationic antimicrobial peptides","volume":"80","author":"Yang","year":"2012","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jbc.2024.107455_bib29","doi-asserted-by":"crossref","DOI":"10.1128\/JB.00219-20","article-title":"Novel functions and signaling specificity for the GraS sensor kinase of Staphylococcus aureus in response to acidic pH","volume":"202","author":"Kuiack","year":"2020","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.jbc.2024.107455_bib30","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41589-019-0401-8","article-title":"Discovery of an antivirulence compound that reverses \u03b2-lactam resistance in MRSA","volume":"16","author":"El-Halfawy","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jbc.2024.107455_bib31","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/mmi.14404","article-title":"The Staphylococcus aureus ArlRS two-component system regulates virulence factor expression through MgrA","volume":"113","author":"Crosby","year":"2020","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jbc.2024.107455_bib32","doi-asserted-by":"crossref","DOI":"10.1128\/aac.00187-22","article-title":"Therapeutic inhibition of Staphylococcus aureus ArlRS two-component regulatory system blocks virulence","volume":"66","author":"Kwiecinski","year":"2022","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jbc.2024.107455_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1268044","article-title":"Identification of an antivirulence agent targeting the master regulator of virulence genes in Staphylococcus aureus","volume":"13","author":"Arya","year":"2023","journal-title":"Front Cell Infect. Microbiol."},{"key":"10.1016\/j.jbc.2024.107455_bib34","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1021\/acscentsci.3c00499","article-title":"Repurposed Fenoprofen targeting SaeR attenuates Staphylococcus aureus virulence in implant-associated infections","volume":"9","author":"Jiang","year":"2023","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.jbc.2024.107455_bib35","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1128\/JB.00425-16","article-title":"The SaeRS two-component system Is a direct and dominant transcriptional activator of toxic shock syndrome toxin 1 in Staphylococcus aureus","volume":"198","author":"Baroja","year":"2016","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.jbc.2024.107455_bib36","doi-asserted-by":"crossref","first-page":"4680","DOI":"10.1073\/pnas.1002611107","article-title":"Vaginal microbiome of reproductive-age women","volume":"108","author":"Ravel","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2024.107455_bib37","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.tim.2023.12.005","article-title":"Interplay between Staphylococcus aureus and the vaginal microbiota","volume":"32","author":"Maduta","year":"2024","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.jbc.2024.107455_bib38","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1177\/106002809603000727","article-title":"Phenazopyridine in urinary tract infections","volume":"30","author":"Zelenitsky","year":"1996","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.jbc.2024.107455_bib39","doi-asserted-by":"crossref","first-page":"10989","DOI":"10.1073\/pnas.1921307117","article-title":"The SrrAB two-component system regulates Staphylococcus aureus pathogenicity through redox sensitive cysteines","volume":"117","author":"Tiwari","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2024.107455_bib40","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3390\/genes7100081","article-title":"The SaeRS two-component system of Staphylococcus aureus","volume":"7","author":"Liu","year":"2016","journal-title":"Genes"},{"key":"10.1016\/j.jbc.2024.107455_bib41","doi-asserted-by":"crossref","first-page":"9439","DOI":"10.1073\/pnas.1707032114","article-title":"Immune evasion by a staphylococcal inhibitor of myeloperoxidase","volume":"114","author":"de Jong","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2024.107455_bib42","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1128\/JB.01524-09","article-title":"In the Staphylococcus aureus two-component system sae, the response regulator SaeR binds to a direct repeat sequence and DNA binding requires phosphorylation by the sensor kinase SaeS","volume":"192","author":"Sun","year":"2010","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.jbc.2024.107455_bib43","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1128\/JB.01927-07","article-title":"The virulence regulator Sae of Staphylococcus aureus: promoter activities and response to phagocytosis-related signals","volume":"190","author":"Geiger","year":"2008","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.jbc.2024.107455_bib44","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1128\/JB.00987-10","article-title":"Staphylococcus aureus ClpC divergently regulates capsule via sae and codY in strain Newman but activates capsule via codY in Strain UAMS-1 and in strain Newman with repaired saeS","volume":"193","author":"Luong","year":"2011","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.jbc.2024.107455_bib45","doi-asserted-by":"crossref","first-page":"e00828-16","DOI":"10.1128\/JB.00828-16","article-title":"VfrB is a fey activator of the Staphylococcus aureus SaeRS two-component system","volume":"199","author":"Krute","year":"2017","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.jbc.2024.107455_bib46","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.GPP3-0031-2018","article-title":"Regulation of Staphylococcus aureus virulence","volume":"7","author":"Jenul","year":"2019","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.jbc.2024.107455_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.664608","article-title":"Novel mechanism for an old drug: phenazopyridine is a kinase inhibitor affecting autophagy and cellular differentiation","volume":"12","author":"Preynat-Seauve","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jbc.2024.107455_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/frph.2023.1167868","article-title":"The safety assessment of tampons: illustration of a comprehensive approach for four different products","volume":"5","author":"Hochwalt","year":"2023","journal-title":"Front. Reprod. Health"},{"key":"10.1016\/j.jbc.2024.107455_bib49","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1146\/annurev.biochem.69.1.183","article-title":"Two-component signal transduction","volume":"69","author":"Stock","year":"2000","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.jbc.2024.107455_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0038407","article-title":"Staphylococcus aureus surface protein SdrE binds complement regulator Factor H as an immune evasion tactic","volume":"7","author":"Sharp","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2024.107455_bib51","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s002030050469","article-title":"The sae locus of Staphylococcus aureus controls exoprotein synthesis at the transcriptional level","volume":"168","author":"Giraudo","year":"1997","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.jbc.2024.107455_bib52","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.01472-22","article-title":"Regulation of the Sae two-component system by branched-chain fatty acids in Staphylococcus aureus","volume":"13","author":"Pendleton","year":"2022","journal-title":"mBio"},{"key":"10.1016\/j.jbc.2024.107455_bib53","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1111\/mmi.12629","article-title":"Impact of the functional status of saeRS on in\u00a0vivo phenotypes of Staphylococcus aureus sarA mutants","volume":"92","author":"Beenken","year":"2014","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.jbc.2024.107455_bib54","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1086\/598967","article-title":"The SaeR\/S gene regulatory system is essential for innate immune evasion by Staphylococcus aureus","volume":"199","author":"Voyich","year":"2009","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.jbc.2024.107455_bib55","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015177","article-title":"Importance of the global regulators Agr and SaeRS in the pathogenesis of CA-MRSA USA300 infection","volume":"5","author":"Montgomery","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2024.107455_bib56","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02321-19","article-title":"Identification of key determinants of Staphylococcus aureus vaginal colonization","volume":"10","author":"Deng","year":"2019","journal-title":"mBio"},{"key":"10.1016\/j.jbc.2024.107455_bib57","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1086\/592051","article-title":"Prevalence of agr dysfunction among colonizing Staphylococcus aureus strains","volume":"198","author":"Shopsin","year":"2008","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.jbc.2024.107455_bib58","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.mib.2016.06.001","article-title":"Considerations and caveats in anti-virulence drug development","volume":"33","author":"Maura","year":"2016","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.jbc.2024.107455_bib59","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1128\/jcm.30.5.1323-1326.1992","article-title":"Defined medium simulating genital tract secretions for growth of vaginal microflora","volume":"30","author":"Geshnizgani","year":"1992","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.jbc.2024.107455_bib60","doi-asserted-by":"crossref","first-page":"15783","DOI":"10.1016\/S0021-9258(18)66787-0","article-title":"The nucleotide and partial amino acid sequence of toxic shock syndrome toxin-1","volume":"261","author":"Blomster-Hautamaa","year":"1986","journal-title":"J.\u00a0Biol. Chem."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925824019562?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925824019562?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T19:26:10Z","timestamp":1721676370000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925824019562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":60,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S0021925824019562"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2024.107455","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of an antivirulence compound that targets the Staphylococcus aureus SaeRS two-component system to inhibit toxic shock syndrome toxin-1 production","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2024.107455","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"107455"}}