{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T20:15:31Z","timestamp":1781381731085,"version":"3.54.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA270608"],"award-info":[{"award-number":["CA270608"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002590","name":"American Lung Association","doi-asserted-by":"publisher","award":["R01HL135648"],"award-info":[{"award-number":["R01HL135648"]}],"id":[{"id":"10.13039\/100002590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002590","name":"American Lung Association","doi-asserted-by":"publisher","award":["GRT00060635"],"award-info":[{"award-number":["GRT00060635"]}],"id":[{"id":"10.13039\/100002590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002590","name":"American Lung Association","doi-asserted-by":"publisher","award":["R01HL131941"],"award-info":[{"award-number":["R01HL131941"]}],"id":[{"id":"10.13039\/100002590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.jbc.2024.107626","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T23:58:08Z","timestamp":1722643088000},"page":"107626","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Nicotine inhalation and metabolism triggers AOX-mediated superoxide generation with oxidative lung injury"],"prefix":"10.1016","volume":"300","author":[{"given":"Jay L.","family":"Zweier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapan","family":"Kundu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud S.","family":"Eid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Hemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Leimk\u00fchler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"El-Mahdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2024.107626_bib1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1146\/annurev-publhealth-040617-013757","article-title":"E-cigarettes: use, effects on smoking, risks, and policy implications","volume":"39","author":"Glantz","year":"2018","journal-title":"Annu. Rev. Public Health"},{"key":"10.1016\/j.jbc.2024.107626_bib2","doi-asserted-by":"crossref","first-page":"267","DOI":"10.5694\/mja2.51890","article-title":"Electronic cigarettes and health outcomes: umbrella and systematic review of the global evidence","volume":"218","author":"Banks","year":"2023","journal-title":"Med. J. Aust."},{"key":"10.1016\/j.jbc.2024.107626_bib3","doi-asserted-by":"crossref","first-page":"328","DOI":"10.4187\/respcare.06300","article-title":"Impact of electronic cigarettes on various organ systems","volume":"64","author":"Eltorai","year":"2019","journal-title":"Respir. Care"},{"key":"10.1016\/j.jbc.2024.107626_bib4","article-title":"The potential health effects associated with electronic-cigarette","volume":"245","author":"Tao","year":"2023","journal-title":"Environ. Res."},{"key":"10.1016\/j.jbc.2024.107626_bib5","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1136\/thoraxjnl-2015-208039","article-title":"Chronic electronic cigarette exposure in mice induces features of COPD in a nicotine-dependent manner","volume":"71","author":"Garcia-Arcos","year":"2016","journal-title":"Thorax"},{"key":"10.1016\/j.jbc.2024.107626_bib6","doi-asserted-by":"crossref","first-page":"H2112","DOI":"10.1152\/ajpheart.00997.2020","article-title":"Long-term electronic cigarette exposure induces cardiovascular dysfunction similar to tobacco cigarettes: role of nicotine and exposure duration","volume":"320","author":"El-Mahdy","year":"2021","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.jbc.2024.107626_bib7","doi-asserted-by":"crossref","first-page":"L149","DOI":"10.1152\/ajplung.00396.2012","article-title":"Nicotine alters mucin rheological properties","volume":"307","author":"Chen","year":"2014","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.jbc.2024.107626_bib8","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1038\/bjp.2008.47","article-title":"Cardiovascular effects of activation of central alpha7 and alpha4beta2 nAChRs: a role for vasopressin in anaesthetized rats","volume":"153","author":"Moore","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jbc.2024.107626_bib9","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1523\/JNEUROSCI.3837-07.2008","article-title":"Nicotine self-administration differentially regulates hypothalamic corticotropin-releasing factor and arginine vasopressin mRNAs and facilitates stress-induced neuronal activation","volume":"28","author":"Yu","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.jbc.2024.107626_bib10","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/0006-291X(79)91977-6","article-title":"Enzyme aldehyde oxidase is an iminium oxidase - reaction with nicotine delta-1'(5')Iminium ion","volume":"91","author":"Brandange","year":"1979","journal-title":"Biochem. Bioph Res. Commun."},{"key":"10.1016\/j.jbc.2024.107626_bib11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/978-3-540-69248-5_2","article-title":"Nicotine chemistry, metabolism, kinetics and biomarkers","author":"Benowitz","year":"2009","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.jbc.2024.107626_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100722","article-title":"Biochemistry of nicotine metabolism and its relevance to lung cancer","volume":"296","author":"Murphy","year":"2021","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2024.107626_bib13","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1007\/s00018-007-7398-y","article-title":"Mammalian aldehyde oxidases: genetics, evolution and biochemistry","volume":"65","author":"Garattini","year":"2008","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.jbc.2024.107626_bib14","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1021\/cr400443z","article-title":"The mononuclear molybdenum enzymes","volume":"114","author":"Hille","year":"2014","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jbc.2024.107626_bib15","doi-asserted-by":"crossref","first-page":"5377","DOI":"10.1074\/jbc.REV119.007741","article-title":"Evolution, expression, and substrate specificities of aldehyde oxidase enzymes in eukaryotes","volume":"295","author":"Terao","year":"2020","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2024.107626_bib16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1177\/0091270003260336","article-title":"Human liver aldehyde oxidase: inhibition by 239 drugs","volume":"44","author":"Obach","year":"2004","journal-title":"J.\u00a0Clin. Pharmacol."},{"key":"10.1016\/j.jbc.2024.107626_bib17","first-page":"508","article-title":"Radioimmunoassay of nicotine-delta 1'(5')-iminium ion, an intermediate formed during the metabolism of nicotine to cotinine","volume":"18","author":"Obach","year":"1990","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jbc.2024.107626_bib18","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.abb.2006.12.032","article-title":"Characterization of superoxide production from aldehyde oxidase: an important source of oxidants in biological tissues","volume":"460","author":"Kundu","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.jbc.2024.107626_bib19","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.1021\/bi3000879","article-title":"Aldehyde oxidase functions as a superoxide generating NADH oxidase: an important redox regulated pathway of cellular oxygen radical formation","volume":"51","author":"Kundu","year":"2012","journal-title":"Biochemistry"},{"key":"10.1016\/j.jbc.2024.107626_bib20","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1124\/dmd.111.043828","article-title":"The impact of single nucleotide polymorphisms on human aldehyde oxidase","volume":"40","author":"Hartmann","year":"2012","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.jbc.2024.107626_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0182061","article-title":"A\u00a0single nucleotide polymorphism causes enhanced radical oxygen species production by human aldehyde oxidase","volume":"12","author":"Foti","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2024.107626_bib22","doi-asserted-by":"crossref","first-page":"5063","DOI":"10.1113\/JP278388","article-title":"E-cigarettes, nicotine, the lung and the brain: multi-level cascading pathophysiology","volume":"598","author":"Herman","year":"2020","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.jbc.2024.107626_bib23","doi-asserted-by":"crossref","first-page":"H549","DOI":"10.1152\/ajpheart.00460.2021","article-title":"Electronic cigarette exposure causes vascular endothelial dysfunction due to NADPH oxidase activation and eNOS uncoupling","volume":"322","author":"El-Mahdy","year":"2022","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.jbc.2024.107626_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0191819","article-title":"Direct comparison of the four aldehyde oxidase enzymes present in mouse gives insight into their substrate specificities","volume":"13","author":"Kucukgoze","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2024.107626_bib25","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/jlb.47.5.440","article-title":"Flow cytometric analysis of respiratory burst activity in phagocytes with hydroethidine and 2',7'-dichlorofluorescin","volume":"47","author":"Rothe","year":"1990","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.jbc.2024.107626_bib26","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/jlb.55.2.253","article-title":"Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells","volume":"55","author":"Carter","year":"1994","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.jbc.2024.107626_bib27","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0006-3002(59)90259-8","article-title":"The microestimation of succinate and the extinction coefficient of cytochrome c","volume":"34","author":"Massey","year":"1959","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbc.2024.107626_bib28","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2105053118","article-title":"Cytoglobin has potent superoxide dismutase function","volume":"118","author":"Zweier","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2024.107626_bib29","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1006\/jmrb.1994.1062","article-title":"Simulation of multiple isotropic spin-trap EPR spectra","volume":"104","author":"Duling","year":"1994","journal-title":"J.\u00a0Magn. Reson. B"},{"key":"10.1016\/j.jbc.2024.107626_bib30","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0969-8043(93)90249-A","article-title":"Identification and quantitation of free radicals and paramagnetic centers from complex multi-component EPR spectra","volume":"44","author":"Kuppusamy","year":"1993","journal-title":"Appl. Radiat. Isot."},{"key":"10.1016\/j.jbc.2024.107626_bib31","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1080\/08958378.2020.1850935","article-title":"Whole body electronic cigarette exposure system for efficient evaluation of diverse inhalation conditions and products","volume":"32","author":"Zweier","year":"2020","journal-title":"Inhal Toxicol."},{"key":"10.1016\/j.jbc.2024.107626_bib32","doi-asserted-by":"crossref","first-page":"H51","DOI":"10.1152\/ajpheart.00657.2019","article-title":"Chronic cigarette smoke exposure triggers a vicious cycle of leukocyte and endothelial-mediated oxidant stress that results in vascular dysfunction","volume":"319","author":"El-Mahdy","year":"2020","journal-title":"Am. J. Physiol. Heart Circ. Physiol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925824021276?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925824021276?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:37:28Z","timestamp":1734395848000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925824021276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S0021925824021276"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2024.107626","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nicotine inhalation and metabolism triggers AOX-mediated superoxide generation with oxidative lung injury","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2024.107626","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"107626"}}