{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T10:31:23Z","timestamp":1761215483252,"version":"3.37.3"},"reference-count":61,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"publisher","award":["R43AI174328"],"award-info":[{"award-number":["R43AI174328"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.jbc.2024.107652","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T01:34:03Z","timestamp":1723080843000},"page":"107652","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Interchain disulfide engineering enables the efficient production of functional HLA-DQ-Fc fusion proteins"],"prefix":"10.1016","volume":"300","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0161-7224","authenticated-orcid":false,"given":"Xiamuxiya","family":"Aisihaer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8446-6788","authenticated-orcid":false,"given":"Hongjie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6624-1454","authenticated-orcid":false,"given":"Chang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2024.107652_bib1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-genom-091212-153455","article-title":"Major histocompatibility complex genomics and human disease","volume":"14","author":"Trowsdale","year":"2013","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"10.1016\/j.jbc.2024.107652_bib2","series-title":"Manual of Molecular and Clinical Laboratory Immunology","article-title":"Human leukocyte antigen Genotyping for allogeneic transplantations","author":"Duffy","year":"2024"},{"key":"10.1016\/j.jbc.2024.107652_bib3","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1056\/NEJM199209173271202","article-title":"Survival of nationally shared, HLA-matched kidney transplants from cadaveric donors. The UNOS Scientific Renal Transplant Registry","volume":"327","author":"Takemoto","year":"1992","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.jbc.2024.107652_bib4","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12882-018-0908-3","article-title":"What is the impact of human leukocyte antigen mismatching on graft survival and mortality in renal transplantation? A meta-analysis of 23 cohort studies involving 486,608 recipients","volume":"19","author":"Shi","year":"2018","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.jbc.2024.107652_bib5","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.humimm.2021.11.005","article-title":"Role of HLA molecular mismatch in clinical practice","volume":"83","author":"Wiebe","year":"2022","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.jbc.2024.107652_bib6","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.humimm.2017.09.004","article-title":"Accelerated humoral renal allograft rejection due to HLA-C14 mediated allosensitization to HLA-Bw6","volume":"78","author":"Persaud","year":"2017","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.jbc.2024.107652_bib7","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ajt.2022.11.013","article-title":"Clinical recommendations for posttransplant assessment of anti-HLA (Human Leukocyte Antigen) donor-specific antibodies: a Sensitization in Transplantation: Assessment of Risk consensus document","volume":"23","author":"Lefaucheur","year":"2023","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.jbc.2024.107652_bib8","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1056\/NEJMra1802677","article-title":"Antibody-mediated rejection of solid-organ Allografts","volume":"379","author":"Loupy","year":"2018","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.jbc.2024.107652_bib9","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/TP.0000000000000220","article-title":"Epitope analysis of HLA-DQ antigens: what does the antibody see?","volume":"98","author":"Tambur","year":"2014","journal-title":"Transplantation"},{"key":"10.1016\/j.jbc.2024.107652_bib10","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1111\/ajt.15177","article-title":"HLA-DR\/DQ molecular mismatch: a prognostic biomarker for primary alloimmunity","volume":"19","author":"Wiebe","year":"2019","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.jbc.2024.107652_bib11","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1097\/TP.0b013e3182543950","article-title":"De novo DQ donor-specific antibodies are associated with a significant risk of antibody-mediated rejection and transplant glomerulopathy","volume":"94","author":"Willicombe","year":"2012","journal-title":"Transplantation"},{"key":"10.1016\/j.jbc.2024.107652_bib12","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/ki.2012.190","article-title":"Donor-specific HLA-DQ antibodies may contribute to poor graft outcome after renal transplantation","volume":"82","author":"DeVos","year":"2012","journal-title":"Kidney Int."},{"key":"10.1016\/j.jbc.2024.107652_bib13","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.ajt.2023.04.004","article-title":"Specific human leucocyte antigen-DQ risk epitope mismatches are associated with chronic lung allograft dysfunction after lung transplantation","volume":"23","author":"Ennis","year":"2023","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.jbc.2024.107652_bib14","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1111\/ajt.14951","article-title":"Identification of risk epitope mismatches associated with de novo donor-specific HLA antibody development in cardiothoracic transplantation","volume":"18","author":"McCaughan","year":"2018","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.jbc.2024.107652_bib15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/ajt.14584","article-title":"Antibody-mediated rejection: new approaches in prevention and management","volume":"18","author":"Montgomery","year":"2018","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.jbc.2024.107652_bib16","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/TP.0000000000002049","article-title":"The treatment of antibody-mediated rejection in kidney transplantation: an updated systematic review and meta-analysis","volume":"102","author":"Wan","year":"2018","journal-title":"Transplantation"},{"key":"10.1016\/j.jbc.2024.107652_bib17","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s41581-023-00791-0","article-title":"Translating B cell immunology to the treatment of antibody-mediated allograft rejection","volume":"20","author":"Heeger","year":"2024","journal-title":"Nat. Rev. Nephrol"},{"key":"10.1016\/j.jbc.2024.107652_bib18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.trre.2017.01.002","article-title":"A\u00a0systematic review of the use of rituximab for the treatment of antibody-mediated renal transplant rejection","volume":"31","author":"Macklin","year":"2017","journal-title":"Transplant. Rev."},{"key":"10.1016\/j.jbc.2024.107652_bib19","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1111\/ajt.14001","article-title":"Eculizumab therapy for chronic antibody-mediated injury in kidney transplant recipients: a pilot randomized Controlled trial","volume":"17","author":"Kulkarni","year":"2017","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.jbc.2024.107652_bib20","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1681\/ASN.2017070818","article-title":"A\u00a0randomized trial of Bortezomib in late antibody-mediated kidney transplant rejection","volume":"29","author":"Eskandary","year":"2018","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.jbc.2024.107652_bib21","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1111\/ajt.15514","article-title":"Safety, pharmacokinetics, and pharmacodynamic activity of obinutuzumab, a type 2 anti-CD20 monoclonal antibody for the desensitization of candidates for renal transplant","volume":"19","author":"Redfield","year":"2019","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.jbc.2024.107652_bib22","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/ajt.16709","article-title":"Immune responses following tocilizumab therapy to desensitize HLA-sensitized kidney-transplant candidates","volume":"22","author":"Jouve","year":"2021","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.jbc.2024.107652_bib23","doi-asserted-by":"crossref","first-page":"e690","DOI":"10.1097\/TXD.0000000000001139","article-title":"Marginal impact of tocilizumab Monotherapy on anti-HLA Alloantibodies in highly sensitized kidney transplant candidates","volume":"7","author":"Daligault","year":"2021","journal-title":"Transplant. Direct."},{"key":"10.1016\/j.jbc.2024.107652_bib24","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1097\/TP.0000000000002895","article-title":"Impact of tocilizumab (Anti-IL-6R) treatment on immunoglobulins and anti-HLA antibodies in kidney transplant patients with chronic antibody-mediated rejection","volume":"104","author":"Shin","year":"2020","journal-title":"Transplantation"},{"key":"10.1016\/j.jbc.2024.107652_bib25","series-title":"The Washington Manual of Transplant Nephrology","first-page":"25","article-title":"The Science of histocompatibility testing","author":"Shen","year":"2023"},{"key":"10.1016\/j.jbc.2024.107652_bib26","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1182\/blood.2022016376","article-title":"Antigen-guided depletion of anti-HLA antibody-producing cells by HLA-Fc fusion proteins","volume":"140","author":"Webber","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.jbc.2024.107652_bib27","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.chembiol.2007.07.010","article-title":"Structural engineering of pMHC reagents for T cell vaccines and diagnostics","volume":"14","author":"Mitaksov","year":"2007","journal-title":"Chem. Biol."},{"key":"10.1016\/j.jbc.2024.107652_bib28","doi-asserted-by":"crossref","first-page":"7480","DOI":"10.1074\/jbc.M709935200","article-title":"Human major histocompatibility complex (MHC) class I molecules with disulfide traps secure disease-related antigenic peptides and exclude competitor peptides","volume":"283","author":"Truscott","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2024.107652_bib29","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nnano.2017.56","article-title":"Peptide\u2013MHC-based nanomedicines for autoimmunity function as T-cell receptor microclustering devices","volume":"12","author":"Singha","year":"2017","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.jbc.2024.107652_bib30","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1038\/s41467-019-09893-5","article-title":"Suppression of a broad spectrum of liver autoimmune pathologies by single peptide-MHC-based nanomedicines","volume":"10","author":"Umeshappa","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2024.107652_bib31","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.1038\/s41467-019-12902-2","article-title":"Increased yields and biological potency of knob-into-hole-based soluble MHC class II molecules","volume":"10","author":"Serra","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2024.107652_bib32","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1126\/science.1329208","article-title":"Role of transmembrane domain interactions in the assembly of class II MHC molecules","volume":"258","author":"Cosson","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.jbc.2024.107652_bib33","doi-asserted-by":"crossref","first-page":"4885","DOI":"10.4049\/jimmunol.157.11.4885","article-title":"Single-chain MHC class II molecules induce T cell activation and apoptosis","volume":"157","author":"Rhode","year":"1996","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jbc.2024.107652_bib34","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.1073\/pnas.0306885101","article-title":"Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease","volume":"101","author":"Kim","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2024.107652_bib35","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/88694","article-title":"Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes","volume":"2","author":"Lee","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jbc.2024.107652_bib36","doi-asserted-by":"crossref","first-page":"baac005","DOI":"10.1093\/database\/baac005","article-title":"DSDBASE 2.0: updated version of DiSulphide dataBASE, a database on disulphide bonds in proteins","volume":"2022","author":"Kalmankar","year":"2022","journal-title":"Database"},{"key":"10.1016\/j.jbc.2024.107652_bib37","doi-asserted-by":"crossref","first-page":"D1053","DOI":"10.1093\/nar\/gkac1011","article-title":"The IPD-IMGT\/HLA database","volume":"51","author":"Barker","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2024.107652_bib38","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.humimm.2019.06.009","article-title":"pHLA3D: an online database of predicted three-dimensional structures of HLA molecules","volume":"80","author":"Menezes Teles E Oliveira","year":"2019","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.jbc.2024.107652_bib39","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/iji.12017","article-title":"16th IHIW: a website for antibody-defined HLA epitope Registry","volume":"40","author":"Duquesnoy","year":"2013","journal-title":"Int. J. Immunogenet."},{"key":"10.1016\/j.jbc.2024.107652_bib40","doi-asserted-by":"crossref","first-page":"D339","DOI":"10.1093\/nar\/gky1006","article-title":"The immune epitope database (IEDB): 2018 update","volume":"47","author":"Vita","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2024.107652_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1009842","article-title":"Broadly directed SARS-CoV-2-specific CD4+ T cell response includes frequently detected peptide specificities within the membrane and nucleoprotein in patients with acute and resolved COVID-19","volume":"17","author":"Heide","year":"2021","journal-title":"Plos Pathog."},{"key":"10.1016\/j.jbc.2024.107652_bib42","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.febslet.2013.11.024","article-title":"Protein disulfide engineering","volume":"588","author":"Dombkowski","year":"2014","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jbc.2024.107652_bib43","doi-asserted-by":"crossref","first-page":"6562","DOI":"10.1073\/pnas.86.17.6562","article-title":"Stabilization of phage T4 lysozyme by engineered disulfide bonds","volume":"86","author":"Matsumura","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2024.107652_bib44","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1002\/prot.23249","article-title":"Geofold: Topology-based protein unfolding pathways capture the effects of engineered disulfides on kinetic stability","volume":"80","author":"Ramakrishnan","year":"2012","journal-title":"Proteins"},{"key":"10.1016\/j.jbc.2024.107652_bib45","doi-asserted-by":"crossref","first-page":"5987","DOI":"10.1021\/bi00368a023","article-title":"Computer-aided model-building strategies for protein design","volume":"25","author":"Pabo","year":"1986","journal-title":"Biochemistry"},{"key":"10.1016\/j.jbc.2024.107652_bib46","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/protein\/2.2.119","article-title":"Model building of disulfide bonds in proteins with known three-dimensional structure","volume":"2","author":"Hazes","year":"1988","journal-title":"Protein Eng. Des. Sel."},{"key":"10.1016\/j.jbc.2024.107652_bib47","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/proeng\/gzg024","article-title":"MODIP revisited: re-evaluation and refinement of an automated procedure for modeling of disulfide bonds in proteins","volume":"16","author":"Dani","year":"2003","journal-title":"Protein Eng. Des. Sel."},{"key":"10.1016\/j.jbc.2024.107652_bib48","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1093\/bioinformatics\/btg231","article-title":"Disulfide by DesignTM: a computational method for the rational design of disulfide bonds in proteins","volume":"19","author":"Dombkowski","year":"2003","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jbc.2024.107652_bib49","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1021\/bi00462a023","article-title":"Structure of a thermostable disulfide-bridge mutant of phage T4 lysozyme shows that an engineered cross-link in a flexible region does not increase the rigidity of the folded protein","volume":"29","author":"Pjura","year":"1990","journal-title":"Biochemistry"},{"key":"10.1016\/j.jbc.2024.107652_bib50","doi-asserted-by":"crossref","first-page":"23836","DOI":"10.1074\/jbc.M802168200","article-title":"Protein-protein docking and analysis reveal that two homologous bacterial adenylyl cyclase toxins interact with calmodulin differently","volume":"283","author":"Guo","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2024.107652_bib51","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1002\/cpz1.36","article-title":"Production of class II MHC proteins in Lentiviral vector-Transduced HEK-293T cells for tetramer staining reagents","volume":"1","author":"Willis","year":"2021","journal-title":"Curr. Protoc."},{"key":"10.1016\/j.jbc.2024.107652_bib52","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1365-2567.2007.02801.x","article-title":"Class II major histocompatibility complex tetramer staining: progress, problems, and prospects","volume":"123","author":"Vollers","year":"2008","journal-title":"Immunology"},{"key":"10.1016\/j.jbc.2024.107652_bib53","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.4049\/jimmunol.148.5.1547","article-title":"Formation of a bispecific antibody by the use of leucine zippers","volume":"148","author":"Kostelny","year":"1992","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jbc.2024.107652_bib54","first-page":"1933","article-title":"A\u00a0recombinant single-chain human class II MHC","volume":"27","author":"Bavari","year":"1997","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jbc.2024.107652_bib55","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1002\/eji.1830270817","article-title":"A\u00a0recombinant single-chain human class II MHC molecule (HLA-DR1) as a covalently linked heterotrimer of alpha chain, beta chain, and antigenic peptide, with immunogenicity in\u00a0vitro and reduced affinity for bacterial superantigens","volume":"27","author":"Zhu","year":"1997","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jbc.2024.107652_bib56","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.4049\/jimmunol.168.5.2554","article-title":"A\u00a0single-chain class II MHC-IgG3 fusion protein inhibits autoimmune arthritis by induction of antigen-specific hyporesponsiveness","volume":"168","author":"Zuo","year":"2002","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jbc.2024.107652_bib57","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/mi.2010.44","article-title":"Single-chain recombinant HLA-DQ2.5\/peptide molecules block \u03b12-gliadin-specific pathogenic CD4+ T-cell proliferation and attenuate production of inflammatory cytokines: a potential therapy for celiac disease","volume":"4","author":"Huan","year":"2011","journal-title":"Mucosal. Immunol."},{"key":"10.1016\/j.jbc.2024.107652_bib58","article-title":"Peptide-MHC-based nanomedicines for the treatment of autoimmunity: engineering, Mechanisms, and diseases","volume":"11","author":"Serra","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jbc.2024.107652_bib59","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2304055120","article-title":"Universal open MHC-I molecules for rapid peptide loading and enhanced complex stability across HLA allotypes","volume":"120","author":"Sun","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2024.107652_bib60","doi-asserted-by":"crossref","first-page":"W431","DOI":"10.1093\/nar\/gkab314","article-title":"Mol\u2217 Viewer: modern web app for 3D visualization and analysis of large biomolecular structures","volume":"49","author":"Sehnal","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2024.107652_bib61","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1101\/gr.849004","article-title":"WebLogo: a sequence logo generator","volume":"14","author":"Crooks","year":"2004","journal-title":"Genome Res."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925824021537?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925824021537?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:38:44Z","timestamp":1734395924000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925824021537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":61,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S0021925824021537"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2024.107652","relation":{},"ISSN":["0021-9258"],"issn-type":[{"type":"print","value":"0021-9258"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interchain disulfide engineering enables the efficient production of functional HLA-DQ-Fc fusion proteins","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2024.107652","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"107652"}}