{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:42:58Z","timestamp":1780375378642,"version":"3.54.1"},"reference-count":75,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.jbc.2024.107684","type":"journal-article","created":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T06:12:09Z","timestamp":1723875129000},"page":"107684","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["The serine protease inhibitor HAMpin-1 produced by the ectoparasite Hyalomma anatolicum salivary gland modulates the host complement system"],"prefix":"10.1016","volume":"300","author":[{"given":"Rajitha","family":"Mood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnagaanth","family":"Mohankumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Macha","family":"Vijay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2031-4643","authenticated-orcid":false,"given":"Anand","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2024.107684_bib1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.pt.2012.07.003","article-title":"Ticks and tick-borne diseases: a One Health perspective","volume":"28","author":"Dantas-Torres","year":"2012","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.jbc.2024.107684_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e05675","article-title":"A\u00a0review on Hyalomma species infestations on human and animals and progress on management strategies","volume":"6","author":"Kumar","year":"2020","journal-title":"Heliyon"},{"key":"10.1016\/j.jbc.2024.107684_bib3","article-title":"Tick saliva and salivary glands: what do we know so far on their role in arthropod blood feeding and pathogen transmission","volume":"11","author":"Neelakanta","year":"2021","journal-title":"Front Cell Infect Microbiol."},{"key":"10.1016\/j.jbc.2024.107684_bib4","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0014-4894(87)90046-4","article-title":"Ixodes dammini: salivary anti-complement activity","volume":"64","author":"Ribeiro","year":"1987","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.jbc.2024.107684_bib5","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1186\/s13071-016-1726-8","article-title":"Saliva of Rhipicephalus (Boophilus) microplus (Acari: Ixodidae) inhibits classical and alternative complement pathways","volume":"9","author":"Silva","year":"2016","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.jbc.2024.107684_bib6","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41467-021-27920-2","article-title":"Structure and function of a family of tick-derived complement inhibitors targeting properdin","volume":"13","author":"Braunger","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2024.107684_bib7","series-title":"Immunobiology : The Immune System in Health and Disease","author":"Janeway","year":"2001"},{"key":"10.1016\/j.jbc.2024.107684_bib8","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/ni1113","article-title":"The complement system in regulation of adaptive immunity","volume":"5","author":"Carroll","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jbc.2024.107684_bib9","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/1756-3305-4-187","article-title":"Implication of haematophagous arthropod salivary proteins in host-vector interactions","volume":"4","author":"Fontaine","year":"2011","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.jbc.2024.107684_bib10","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.chom.2011.06.010","article-title":"A\u00a0tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent","volume":"10","author":"Schuijt","year":"2011","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jbc.2024.107684_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22179480","article-title":"Ixodes ricinus salivary serpin iripin-8 inhibits the intrinsic pathway of coagulation and complement","volume":"22","author":"Kotal","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbc.2024.107684_bib12","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.ijpara.2012.12.012","article-title":"Deorphanization and target validation of cross-tick species conserved novel Amblyomma americanum tick saliva protein","volume":"43","author":"Mulenga","year":"2013","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.jbc.2024.107684_bib13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.exppara.2016.03.002","article-title":"Inhibition of the classical pathway of the complement system by saliva of Amblyomma cajennense (Acari: Ixodidae)","volume":"164","author":"Franco","year":"2016","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.jbc.2024.107684_bib14","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1093\/molbev\/msab081","article-title":"A\u00a0comprehensive phylogenetic analysis of the serpin superfamily","volume":"38","author":"Spence","year":"2021","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.jbc.2024.107684_bib15","article-title":"Serpin inhibition mechanism: a delicate balance between native metastable state and polymerization","volume":"2011","author":"Khan","year":"2011","journal-title":"J.\u00a0Amino. Acids"},{"key":"10.1016\/j.jbc.2024.107684_bib16","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1128\/IAI.72.5.2858-2863.2004","article-title":"Cleavage of complement C3b to iC3b on the surface of Staphylococcus aureus is mediated by serum complement factor I","volume":"72","author":"Cunnion","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jbc.2024.107684_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.exppara.2022.108408","article-title":"Economic impact of predominant ticks and tick-borne diseases on Indian dairy production systems","volume":"243","author":"Singh","year":"2022","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.jbc.2024.107684_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph19105833","article-title":"One health approach to tick and tick-borne disease surveillance in the United Kingdom","volume":"19","author":"Johnson","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.jbc.2024.107684_bib19","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ijpara.2023.09.003","article-title":"Insight into Hyalomma anatolicum biology by comparative genomics analyses","volume":"54","author":"Wang","year":"2023","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.jbc.2024.107684_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ttbdis.2021.101791","article-title":"Ivermectin resistance in the multi-host tick Hyalomma anatolicum (Acari: Ixodidae) in India","volume":"12","author":"Shyma","year":"2021","journal-title":"Ticks Tick Borne Dis."},{"key":"10.1016\/j.jbc.2024.107684_bib21","doi-asserted-by":"crossref","DOI":"10.1111\/pim.12807","article-title":"Tick salivary gland transcriptomics and proteomics","volume":"43","author":"Martins","year":"2021","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.jbc.2024.107684_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.809052","article-title":"Host immune responses to salivary components - a critical facet of tick-host interactions","volume":"12","author":"Ali","year":"2022","journal-title":"Front Cell Infect Microbiol."},{"key":"10.1016\/j.jbc.2024.107684_bib23","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jprot.2015.07.005","article-title":"Modulation of host immunity by tick saliva","volume":"128","author":"Kotal","year":"2015","journal-title":"J.\u00a0Proteomics"},{"key":"10.1016\/j.jbc.2024.107684_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jprot.2020.103899","article-title":"Integrated analysis of sialotranscriptome and sialoproteome of the brown dog tick Rhipicephalus sanguineus (s.l.): insights into gene expression during blood feeding","volume":"229","author":"Tirloni","year":"2020","journal-title":"J.\u00a0Proteomics"},{"key":"10.1016\/j.jbc.2024.107684_bib25","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1186\/s13071-016-1655-6","article-title":"Host specificity in a diverse Neotropical tick community: an assessment using quantitative network analysis and host phylogeny","volume":"9","author":"Esser","year":"2016","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.jbc.2024.107684_bib26","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fcimb.2013.00057","article-title":"Host specialization in ticks and transmission of tick-borne diseases: a review","volume":"3","author":"McCoy","year":"2013","journal-title":"Front Cell Infect Microbiol."},{"key":"10.1016\/j.jbc.2024.107684_bib27","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1046\/j.1365-3024.2001.00366.x","article-title":"A\u00a0calreticulin-like molecule from the human hookworm Necator americanus interacts with C1q and the cytoplasmic signalling domains of some integrins","volume":"23","author":"Kasper","year":"2001","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.jbc.2024.107684_bib28","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.molbiopara.2009.02.007","article-title":"Mapping the complement C1q binding site in Haemonchus contortus calreticulin","volume":"166","author":"Naresha","year":"2009","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.jbc.2024.107684_bib29","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ttbdis.2014.10.002","article-title":"Amblyomma americanum tick calreticulin binds C1q but does not inhibit activation of the classical complement cascade","volume":"6","author":"Kim","year":"2015","journal-title":"Ticks Tick Borne Dis."},{"key":"10.1016\/j.jbc.2024.107684_bib30","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1093\/intimm\/13.8.983","article-title":"Contribution of heat shock proteins to cell protection from complement-mediated lysis","volume":"13","author":"Fishelson","year":"2001","journal-title":"Int. Immunol."},{"key":"10.1016\/j.jbc.2024.107684_bib31","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1379\/1466-1268(2002)007<0017:HSPIAP>2.0.CO;2","article-title":"Heat shock protein 70 is a potent activator of the human complement system","volume":"7","author":"Prohaszka","year":"2002","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.jbc.2024.107684_bib32","doi-asserted-by":"crossref","first-page":"4125","DOI":"10.4049\/jimmunol.1700779","article-title":"Extracellular histones inhibit complement activation through interacting with complement component 4","volume":"200","author":"Qaddoori","year":"2018","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jbc.2024.107684_bib33","doi-asserted-by":"crossref","first-page":"6445","DOI":"10.4049\/jimmunol.1002948","article-title":"Staphylococcus aureus metalloprotease aureolysin cleaves complement C3 to mediate immune evasion","volume":"186","author":"Laarman","year":"2011","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jbc.2024.107684_bib34","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3389\/fcimb.2017.00166","article-title":"Staphylococcus aureus manipulates innate immunity through own and host-expressed proteases","volume":"7","author":"Pietrocola","year":"2017","journal-title":"Front Cell Infect Microbiol."},{"key":"10.1016\/j.jbc.2024.107684_bib35","doi-asserted-by":"crossref","first-page":"11786","DOI":"10.1073\/pnas.1323557111","article-title":"Zinc transporter SLC39A10\/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength","volume":"111","author":"Hojyo","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2024.107684_bib36","doi-asserted-by":"crossref","first-page":"4751","DOI":"10.1021\/cr010170+","article-title":"Serpin structure, mechanism, and function","volume":"102","author":"Gettins","year":"2002","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jbc.2024.107684_bib37","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1111\/j.1742-4658.2009.07038.x","article-title":"Exosites mediate the anti-inflammatory effects of a multifunctional serpin from the saliva of the tick Ixodes ricinus","volume":"276","author":"Prevot","year":"2009","journal-title":"FEBS J."},{"key":"10.1016\/j.jbc.2024.107684_bib38","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.7224","article-title":"Serine protease inhibitors and human wellbeing interplay: new insights for old friends","volume":"7","author":"Mkaouar","year":"2019","journal-title":"PeerJ"},{"key":"10.1016\/j.jbc.2024.107684_bib39","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.semcdb.2016.09.001","article-title":"Serpins in arthropod biology","volume":"62","author":"Meekins","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.jbc.2024.107684_bib40","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ttbdis.2013.02.001","article-title":"Isolation and characterization of two novel serpins from the tick Rhipicephalus haemaphysaloides","volume":"4","author":"Yu","year":"2013","journal-title":"Ticks Tick Borne Dis."},{"key":"10.1016\/j.jbc.2024.107684_bib41","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1186\/s13071-019-3607-4","article-title":"Immunomodulatory effects of Rhipicephalus haemaphysaloides serpin RHS2 on host immune responses","volume":"12","author":"Xu","year":"2019","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.jbc.2024.107684_bib42","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1016\/j.vaccine.2005.10.055","article-title":"Two serine protease inhibitors (serpins) that induce a bovine protective immune response against Rhipicephalus appendiculatus ticks","volume":"24","author":"Imamura","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.jbc.2024.107684_bib43","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/imm.13130","article-title":"The immunosuppressive functions of two novel tick serpins, HlSerpin-a and HlSerpin-b, from Haemaphysalis longicornis","volume":"159","author":"Wang","year":"2020","journal-title":"Immunology"},{"key":"10.1016\/j.jbc.2024.107684_bib44","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.exppara.2013.12.001","article-title":"A\u00a0family of serine protease inhibitors (serpins) in the cattle tick Rhipicephalus (Boophilus) microplus","volume":"137","author":"Tirloni","year":"2014","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.jbc.2024.107684_bib45","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ttbdis.2015.09.006","article-title":"Identification and the preliminary in\u00a0vitro characterization of IRIS homologue from salivary glands of Ixodes persulcatus Schulze","volume":"7","author":"Toyomane","year":"2016","journal-title":"Ticks Tick Borne Dis."},{"key":"10.1016\/j.jbc.2024.107684_bib46","doi-asserted-by":"crossref","first-page":"10083","DOI":"10.1074\/jbc.M111391200","article-title":"Characterization of a novel salivary immunosuppressive protein from Ixodes ricinus ticks","volume":"277","author":"Leboulle","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2024.107684_bib47","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s12325-017-0648-y","article-title":"The role of trypsin:chymotrypsin in tissue repair","volume":"35","author":"Shah","year":"2018","journal-title":"Adv. Ther."},{"key":"10.1016\/j.jbc.2024.107684_bib48","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1002\/art.24300","article-title":"Triggering of proteinase-activated receptor 4 leads to joint pain and inflammation in mice","volume":"60","author":"McDougall","year":"2009","journal-title":"Arthritis. Rheum."},{"key":"10.1016\/j.jbc.2024.107684_bib49","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1042\/bj1550273","article-title":"Human cathepsin G. Catalytic and immunological properties","volume":"155","author":"Starkey","year":"1976","journal-title":"Biochem. J."},{"key":"10.1016\/j.jbc.2024.107684_bib50","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.2741\/3462","article-title":"Neutrophil-derived serine proteases modulate innate immune responses","volume":"14","author":"Meyer-Hoffert","year":"2009","journal-title":"Front Biosci."},{"key":"10.1016\/j.jbc.2024.107684_bib51","doi-asserted-by":"crossref","first-page":"4476","DOI":"10.4049\/jimmunol.1103346","article-title":"Cathepsin G and neutrophil elastase contribute to lung-protective immunity against mycobacterial infections in mice","volume":"188","author":"Steinwede","year":"2012","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jbc.2024.107684_bib52","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nri1841","article-title":"Neutrophil serine proteases: specific regulators of inflammation","volume":"6","author":"Pham","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jbc.2024.107684_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0040489","article-title":"Novel scabies mite serpins inhibit the three pathways of the human complement system","volume":"7","author":"Mika","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.jbc.2024.107684_bib54","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1107\/S2059798321007920","article-title":"Structural and biochemical characterization of the novel serpin Iripin-5 from Ixodes ricinus","volume":"77","author":"Kascakova","year":"2021","journal-title":"Acta Crystallogr. D Struct. Biol."},{"key":"10.1016\/j.jbc.2024.107684_bib55","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.pt.2016.01.004","article-title":"All for one and one for all on the tick-host Battlefield","volume":"32","author":"Chmelar","year":"2016","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.jbc.2024.107684_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetpar.2020.109064","article-title":"A\u00a0serpin from the tick Rhipicephalus haemaphysaloides: involvement in vitellogenesis","volume":"279","author":"Xu","year":"2020","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.jbc.2024.107684_bib57","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.blre.2006.11.001","article-title":"Thrombin generation and fibrin clot structure","volume":"21","author":"Wolberg","year":"2007","journal-title":"Blood Rev."},{"key":"10.1016\/j.jbc.2024.107684_bib58","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1080\/13510002.2016.1200289","article-title":"Prothrombin and fibrinogen carbonylation: how that can affect the blood clotting","volume":"22","author":"Harutyunyan","year":"2017","journal-title":"Redox Rep."},{"key":"10.1016\/j.jbc.2024.107684_bib59","article-title":"Longitudinal change of serum inter-alpha-trypsin inhibitor heavy chain H4, and its correlation with inflammation, multiorgan injury, and death risk in sepsis","volume":"37","author":"Zhao","year":"2023","journal-title":"J.\u00a0Clin. Lab. Anal."},{"key":"10.1016\/j.jbc.2024.107684_bib60","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0079787","article-title":"Different host complement systems and their interactions with saliva from Lutzomyia longipalpis (Diptera, Psychodidae) and Leishmania infantum promastigotes","volume":"8","author":"Mendes-Sousa","year":"2013","journal-title":"PloS one"},{"key":"10.1016\/j.jbc.2024.107684_bib61","doi-asserted-by":"crossref","first-page":"W362","DOI":"10.1093\/nar\/gkl124","article-title":"ScanProsite: detection of PROSITE signature matches and ProRule-associated functional and structural residues in proteins","volume":"34","author":"de Castro","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2024.107684_bib62","first-page":"310","article-title":"Prediction of glycosylation across the human proteome and the correlation to protein function","author":"Gupta","year":"2002","journal-title":"Pac. Symp. Biocomput."},{"key":"10.1016\/j.jbc.2024.107684_bib63","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1038\/emboj.2013.79","article-title":"Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology","volume":"32","author":"Steentoft","year":"2013","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2024.107684_bib64","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ttbdis.2014.08.002","article-title":"Bioinformatic analyses of male and female Amblyomma americanum tick expressed serine protease inhibitors (serpins)","volume":"6","author":"Porter","year":"2015","journal-title":"Ticks Tick Borne Dis."},{"key":"10.1016\/j.jbc.2024.107684_bib65","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1242\/jeb.006494","article-title":"Molecular and expression analysis of a family of the Amblyomma americanum tick Lospins","volume":"210","author":"Mulenga","year":"2007","journal-title":"J.\u00a0Exp. Biol."},{"key":"10.1016\/j.jbc.2024.107684_bib66","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.vaccine.2004.08.041","article-title":"A\u00a0serine protease inhibitor (serpin) from Haemaphysalis longicornis as an anti-tick vaccine","volume":"23","author":"Imamura","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.jbc.2024.107684_bib67","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.626200","article-title":"Iripin-3, a new salivary protein isolated from Ixodes ricinus ticks, Displays Immunomodulatory and Anti-Hemostatic Properties In\u00a0Vitro","volume":"12","author":"Chlastakova","year":"2021","journal-title":"Front Immunol."},{"key":"10.1016\/j.jbc.2024.107684_bib68","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1182\/blood-2010-06-293241","article-title":"A\u00a0tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation","volume":"117","author":"Chmelar","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jbc.2024.107684_bib69","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ijpara.2014.01.010","article-title":"A\u00a0blood meal-induced Ixodes scapularis tick saliva serpin inhibits trypsin and thrombin, and interferes with platelet aggregation and blood clotting","volume":"44","author":"Ibelli","year":"2014","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.jbc.2024.107684_bib70","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0965-1748(02)00240-0","article-title":"Four serine proteinase inhibitors (serpin) from the brown ear tick, Rhiphicephalus appendiculatus; cDNA cloning and preliminary characterization","volume":"33","author":"Mulenga","year":"2003","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.jbc.2024.107684_bib71","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.1021\/bi00316a003","article-title":"Complete sequence of the cDNA for human alpha 1-antitrypsin and the gene for the S variant","volume":"23","author":"Long","year":"1984","journal-title":"Biochemistry"},{"key":"10.1016\/j.jbc.2024.107684_bib72","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1116324","article-title":"Iripin-1, a new anti-inflammatory tick serpin, inhibits leukocyte recruitment in\u00a0vivo while altering the levels of chemokines and adhesion molecules","volume":"14","author":"Chlastakova","year":"2023","journal-title":"Front Immunol."},{"key":"10.1016\/j.jbc.2024.107684_bib73","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1107\/S2059798323002322","article-title":"Conformational transition of the Ixodes ricinus salivary serpin Iripin-4","volume":"79","author":"Kascakova","year":"2023","journal-title":"Acta Crystallogr. D Struct. Biol."},{"key":"10.1016\/j.jbc.2024.107684_bib74","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1107\/S1744309110032343","article-title":"Crystallization and diffraction analysis of the serpin IRS-2 from the hard tick Ixodes ricinus","volume":"66","author":"Kovarova","year":"2010","journal-title":"Acta Crystallogr. Sect F Struct. Biol. Cryst. Commun."},{"key":"10.1016\/j.jbc.2024.107684_bib75","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925824021859?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925824021859?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:39:54Z","timestamp":1734395994000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925824021859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":75,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S0021925824021859"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2024.107684","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The serine protease inhibitor HAMpin-1 produced by the ectoparasite Hyalomma anatolicum salivary gland modulates the host complement system","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2024.107684","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"107684"}}