{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:46:37Z","timestamp":1791243997425,"version":"4.1.0"},"reference-count":88,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.jbc.2024.107686","type":"journal-article","created":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T15:24:15Z","timestamp":1723908255000},"page":"107686","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["ISGylation enhances dsRNA-induced interferon response and NF\u03baB signaling in fallopian tube epithelial cells"],"prefix":"10.1016","volume":"300","author":[{"given":"Vidushi","family":"Madaan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6786-9582","authenticated-orcid":false,"given":"Alexandra","family":"Kollara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Spaner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore J.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2024.107686_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1158\/2767-9764.CRC-22-0410","article-title":"Trends of ovarian cancer incidence by histotype and race\/ethnicity in the United States 1992-2019","volume":"3","author":"Phung","year":"2023","journal-title":"Cancer Res. Commun."},{"key":"10.1016\/j.jbc.2024.107686_bib2","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3322\/caac.21456","article-title":"Ovarian cancer statistics, 2018","volume":"68","author":"Torre","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.jbc.2024.107686_bib3","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/nrc4019","article-title":"Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer","volume":"15","author":"Bowtell","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jbc.2024.107686_bib4","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/s41467-017-00962-1","article-title":"High grade serous ovarian carcinomas originate in the fallopian tube","volume":"8","author":"Labidi-Galy","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2024.107686_bib5","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1001\/jama.2017.7112","article-title":"Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers","volume":"317","author":"Kuchenbaecker","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.jbc.2024.107686_bib6","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1200\/JCO.2006.09.1066","article-title":"Meta-analysis of BRCA1 and BRCA2 penetrance","volume":"25","author":"Chen","year":"2007","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.jbc.2024.107686_bib7","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1086\/375033","article-title":"Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies","volume":"72","author":"Antoniou","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jbc.2024.107686_bib8","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1001\/jama.283.17.2260","article-title":"Clinicopathologic features of BRCA-linked and sporadic ovarian cancer","volume":"283","author":"Boyd","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.jbc.2024.107686_bib9","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1200\/OP.21.00382","article-title":"Risk-Reducing bilateral salpingo-oophorectomy for ovarian cancer: a review and clinical guide for hereditary predisposition genes","volume":"18","author":"Liu","year":"2022","journal-title":"JCO Oncol. Pract."},{"key":"10.1016\/j.jbc.2024.107686_bib10","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1093\/jnci\/djad011","article-title":"Lifetime ovulatory years and risk of epithelial ovarian cancer: a multinational pooled analysis","volume":"115","author":"Fu","year":"2023","journal-title":"J.\u00a0Natl. Cancer Inst."},{"key":"10.1016\/j.jbc.2024.107686_bib11","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.ygyno.2022.04.001","article-title":"Lifetime ovulations and epithelial ovarian cancer risk and survival: a systematic review and meta-analysis","volume":"165","author":"Fu","year":"2022","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.jbc.2024.107686_bib12","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.ygyno.2013.12.015","article-title":"Exposure of fallopian tube epithelium to follicular fluid mimics carcinogenic changes in precursor lesions of serous papillary carcinoma","volume":"132","author":"Bahar-Shany","year":"2014","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.jbc.2024.107686_bib13","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.neo.2018.05.005","article-title":"BRCA1 mutation status and follicular fluid exposure alters NFkappaB signaling and ISGylation in human fallopian tube epithelial cells","volume":"20","author":"Hollingsworth","year":"2018","journal-title":"Neoplasia"},{"key":"10.1016\/j.jbc.2024.107686_bib14","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.1158\/1078-0432.CCR-07-4959","article-title":"Gene expression profiles of luteal phase fallopian tube epithelium from BRCA mutation carriers resemble high-grade serous carcinoma","volume":"14","author":"Tone","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jbc.2024.107686_bib15","doi-asserted-by":"crossref","first-page":"4334","DOI":"10.1158\/1078-0432.CCR-12-0199","article-title":"Prolonged postovulatory proinflammatory signaling in the fallopian tube epithelium may be mediated through a BRCA1\/DAB2 axis","volume":"18","author":"Tone","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jbc.2024.107686_bib16","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/s41579-018-0020-5","article-title":"ISG15 in antiviral immunity and beyond","volume":"16","author":"Perng","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.jbc.2024.107686_bib17","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1038\/sj.emboj.7601149","article-title":"UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity","volume":"25","author":"Malakhova","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2024.107686_bib18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nature13801","article-title":"Human intracellular ISG15 prevents interferon-alpha\/beta over-amplification and auto-inflammation","volume":"517","author":"Zhang","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2024.107686_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109412","article-title":"Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING","volume":"36","author":"Bruand","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2024.107686_bib20","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.trecan.2021.12.003","article-title":"When breaks get hot: inflammatory signaling in BRCA1\/2-mutant cancers","volume":"8","author":"van Vugt","year":"2022","journal-title":"Trends Cancer"},{"key":"10.1016\/j.jbc.2024.107686_bib21","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/1754-9485.13413","article-title":"Impact of DNA damage response defects in cancer cells on response to immunotherapy and radiotherapy","volume":"66","author":"Czajkowski","year":"2022","journal-title":"J.\u00a0Med. Imaging Radiat. Oncol."},{"key":"10.1016\/j.jbc.2024.107686_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006720","article-title":"MAVS activates TBK1 and IKKepsilon through TRAFs in NEMO dependent and independent manner","volume":"13","author":"Fang","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2024.107686_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.03.056","article-title":"TBK1 and IKKepsilon act redundantly to mediate STING-induced NF-kappaB responses in myeloid cells","volume":"31","author":"Balka","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2024.107686_bib24","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41564-021-00884-1","article-title":"ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity","volume":"6","author":"Liu","year":"2021","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.jbc.2024.107686_bib25","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1128\/JVI.01650-07","article-title":"Negative feedback regulation of RIG-I-mediated antiviral signaling by interferon-induced ISG15 conjugation","volume":"82","author":"Kim","year":"2008","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.jbc.2024.107686_bib26","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1128\/MCB.01466-09","article-title":"Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification","volume":"30","author":"Shi","year":"2010","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2024.107686_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113277","article-title":"Regulation of STING activity in DNA sensing by ISG15 modification","volume":"42","author":"Lin","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2024.107686_bib28","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.immuni.2019.06.025","article-title":"Inflammation and cancer: triggers, mechanisms, and consequences","volume":"51","author":"Greten","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.jbc.2024.107686_bib29","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1038\/s41590-022-01290-3","article-title":"Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B","volume":"23","author":"Musella","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jbc.2024.107686_bib30","doi-asserted-by":"crossref","first-page":"4883","DOI":"10.1074\/jbc.M111.255570","article-title":"Two independent mechanisms promote expression of an N-terminal truncated USP18 isoform with higher DeISGylation activity in the nucleus","volume":"287","author":"Burkart","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2024.107686_bib31","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1365-2249.2012.04638.x","article-title":"Type I interferon induces CX3CL1 (fractalkine) and CCL5 (RANTES) production in human pulmonary vascular endothelial cells","volume":"170","author":"Nakano","year":"2012","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jbc.2024.107686_bib32","doi-asserted-by":"crossref","first-page":"5352","DOI":"10.4049\/jimmunol.164.10.5352","article-title":"Regulation of RANTES chemokine gene expression requires cooperativity between NF-kappa B and IFN-regulatory factor transcription factors","volume":"164","author":"Genin","year":"2000","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jbc.2024.107686_bib33","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/s41577-021-00577-0","article-title":"Regulation of the nucleic acid-sensing Toll-like receptors","volume":"22","author":"Lind","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jbc.2024.107686_bib34","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/s41419-022-05101-3","article-title":"PKR and TLR3 trigger distinct signals that coordinate the induction of antiviral apoptosis","volume":"13","author":"Zuo","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jbc.2024.107686_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1087620","article-title":"The role of interferons in ovarian cancer progression: hinderer or promoter?","volume":"13","author":"Liu","year":"2022","journal-title":"Front Immunol."},{"key":"10.1016\/j.jbc.2024.107686_bib36","doi-asserted-by":"crossref","first-page":"18969","DOI":"10.1074\/jbc.RA119.009783","article-title":"Cytoplasmic dsRNA induces the expression of OCT3\/4 and NANOG mRNAs in differentiated human cells","volume":"294","author":"Wang","year":"2019","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2024.107686_bib37","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1038\/onc.2015.288","article-title":"YAP induces high-grade serous carcinoma in fallopian tube secretory epithelial cells","volume":"35","author":"Hua","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.jbc.2024.107686_bib38","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a000141","article-title":"NF-kappaB as a critical link between inflammation and cancer","volume":"1","author":"Karin","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.jbc.2024.107686_bib39","doi-asserted-by":"crossref","first-page":"7500","DOI":"10.1073\/pnas.0611551104","article-title":"Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125","volume":"104","author":"Arimoto","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2024.107686_bib40","doi-asserted-by":"crossref","first-page":"351","DOI":"10.15252\/embj.201796781","article-title":"LRRC25 inhibits type I IFN signaling by targeting ISG15-associated RIG-I for autophagic degradation","volume":"37","author":"Du","year":"2018","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2024.107686_bib41","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.molimm.2007.07.021","article-title":"UbcH8 regulates ubiquitin and ISG15 conjugation to RIG-I","volume":"45","author":"Arimoto","year":"2008","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.jbc.2024.107686_bib42","article-title":"Cellular targets and lysine selectivity of the HERC5 ISG15 ligase","volume":"27","author":"Zhao","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.jbc.2024.107686_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.720765","article-title":"Proteomics mapping of the ISGylation landscape in innate immunity","volume":"12","author":"Thery","year":"2021","journal-title":"Front Immunol."},{"key":"10.1016\/j.jbc.2024.107686_bib44","doi-asserted-by":"crossref","first-page":"10200","DOI":"10.1073\/pnas.0504754102","article-title":"Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways","volume":"102","author":"Zhao","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2024.107686_bib45","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.bbrc.2005.08.132","article-title":"Proteomic identification of proteins conjugated to ISG15 in mouse and human cells","volume":"336","author":"Giannakopoulos","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jbc.2024.107686_bib46","doi-asserted-by":"crossref","first-page":"R58","DOI":"10.1186\/bcr2117","article-title":"The ubiquitin-like molecule interferon-stimulated gene 15 (ISG15) is a potential prognostic marker in human breast cancer","volume":"10","author":"Bektas","year":"2008","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.jbc.2024.107686_bib47","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1158\/0008-5472.CAN-05-1123","article-title":"Elevated expression of ISG15 in tumor cells interferes with the ubiquitin\/26S proteasome pathway","volume":"66","author":"Desai","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.jbc.2024.107686_bib48","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1038\/sj.bjc.6603099","article-title":"Stage-associated overexpression of the ubiquitin-like protein, ISG15, in bladder cancer","volume":"94","author":"Andersen","year":"2006","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.jbc.2024.107686_bib49","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1038\/onc.2009.115","article-title":"Expression, regulation and function of the ISGylation system in prostate cancer","volume":"28","author":"Kiessling","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.jbc.2024.107686_bib50","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/PGP.0b013e31827b25a2","article-title":"Interferon-stimulated gene, 15 kDa (ISG15) in ovarian high-grade serous carcinoma: prognostic impact and link to NF-kappaB pathway","volume":"33","author":"Darb-Esfahani","year":"2014","journal-title":"Int. J. Gynecol. Pathol."},{"key":"10.1016\/j.jbc.2024.107686_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024291","article-title":"Interferon-beta signaling contributes to Ras transformation","volume":"6","author":"Tsai","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2024.107686_bib52","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/onc.2012.633","article-title":"ISGylation governs the oncogenic function of Ki-Ras in breast cancer","volume":"33","author":"Burks","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.jbc.2024.107686_bib53","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1258\/ebm.2011.011236","article-title":"ISG15 disrupts cytoskeletal architecture and promotes motility in human breast cancer cells","volume":"237","author":"Desai","year":"2012","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.jbc.2024.107686_bib54","doi-asserted-by":"crossref","first-page":"14313","DOI":"10.1073\/pnas.1505690112","article-title":"Type I IFN induces protein ISGylation to enhance cytokine expression and augments colonic inflammation","volume":"112","author":"Fan","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2024.107686_bib55","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1038\/emm.2013.36","article-title":"ISG15: leading a double life as a secreted molecule","volume":"45","author":"Bogunovic","year":"2013","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.jbc.2024.107686_bib56","doi-asserted-by":"crossref","first-page":"7221","DOI":"10.18632\/oncotarget.3372","article-title":"Free ISG15 triggers an antitumor immune response against breast cancer: a new perspective","volume":"6","author":"Burks","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.jbc.2024.107686_bib57","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11496","article-title":"ISG15 deficiency and increased viral resistance in humans but not mice","volume":"7","author":"Speer","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2024.107686_bib58","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1093\/carcin\/bgu237","article-title":"Comparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance","volume":"36","author":"Dabydeen","year":"2015","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.jbc.2024.107686_bib59","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0100068","article-title":"BRCA1 haploinsufficiency leads to altered expression of genes involved in cellular proliferation and development","volume":"9","author":"Feilotter","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2024.107686_bib60","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s10495-012-0707-4","article-title":"Synthetic lethality of PARP inhibition in BRCA-network disrupted tumor cells is associated with interferon pathway activation and enhanced by interferon-gamma","volume":"17","author":"Warrener","year":"2012","journal-title":"Apoptosis"},{"key":"10.1016\/j.jbc.2024.107686_bib61","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/path.4404","article-title":"Up-regulation of the interferon-related genes in BRCA2 knockout epithelial cells","volume":"234","author":"Xu","year":"2014","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.jbc.2024.107686_bib62","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1158\/1541-7786.MCR-06-0234","article-title":"Functional characterization of a novel BRCA1-null ovarian cancer cell line in response to ionizing radiation","volume":"5","author":"DelloRusso","year":"2007","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.jbc.2024.107686_bib63","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.jmb.2009.02.008","article-title":"Inhibition of RNA polymerase III transcription by BRCA1","volume":"387","author":"Veras","year":"2009","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.jbc.2024.107686_bib64","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1038\/ni.1779","article-title":"RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate","volume":"10","author":"Ablasser","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jbc.2024.107686_bib65","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/s41586-022-05545-9","article-title":"R-loop-derived cytoplasmic RNA-DNA hybrids activate an immune response","volume":"613","author":"Crossley","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2024.107686_bib66","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1158\/1541-7786.MCR-18-0504","article-title":"Ovarian cancer cells commonly exhibit defective STING signaling which affects sensitivity to viral oncolysis","volume":"17","author":"de Queiroz","year":"2019","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.jbc.2024.107686_bib67","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.cell.2012.09.034","article-title":"Activation of innate immunity is required for efficient nuclear reprogramming","volume":"151","author":"Lee","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2024.107686_bib68","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1016\/j.celrep.2017.02.037","article-title":"CD95\/Fas increases stemness in cancer cells by inducing a STAT1-dependent type I interferon response","volume":"18","author":"Qadir","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2024.107686_bib69","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1038\/s41598-020-58211-3","article-title":"The mechanism of how CD95\/Fas activates the Type I IFN\/STAT1 axis, driving cancer stemness in breast cancer","volume":"10","author":"Qadir","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2024.107686_bib70","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1038\/s41467-020-16395-2","article-title":"ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity","volume":"11","author":"Alcala","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2024.107686_bib71","doi-asserted-by":"crossref","first-page":"16910","DOI":"10.18632\/oncotarget.7626","article-title":"ISG15 predicts poor prognosis and promotes cancer stem cell phenotype in nasopharyngeal carcinoma","volume":"7","author":"Chen","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.jbc.2024.107686_bib72","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s13046-023-02751-9","article-title":"ISG15 and ISGylation modulates cancer stem cell-like characteristics in promoting tumor growth of anaplastic thyroid carcinoma","volume":"42","author":"Xu","year":"2023","journal-title":"J.\u00a0Exp. Clin. Cancer Res."},{"key":"10.1016\/j.jbc.2024.107686_bib73","doi-asserted-by":"crossref","first-page":"13792","DOI":"10.1073\/pnas.1713728114","article-title":"Interferon-beta represses cancer stem cell properties in triple-negative breast cancer","volume":"114","author":"Doherty","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2024.107686_bib74","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3892\/ol.2022.13355","article-title":"Interferon-alpha and its effects on cancer cell apoptosis","volume":"24","author":"Shi","year":"2022","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.jbc.2024.107686_bib75","doi-asserted-by":"crossref","first-page":"24152","DOI":"10.1074\/jbc.M312219200","article-title":"Interferon alpha-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase\/mammalian target of rapamycin signaling pathway","volume":"279","author":"Thyrell","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2024.107686_bib76","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/ncb1680","article-title":"Nanog maintains pluripotency of mouse embryonic stem cells by inhibiting NFkappaB and cooperating with Stat3","volume":"10","author":"Torres","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jbc.2024.107686_bib77","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1172\/JCI65859","article-title":"Reciprocal regulation by TLR4 and TGF-beta in tumor-initiating stem-like cells","volume":"123","author":"Chen","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.jbc.2024.107686_bib78","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.cmet.2015.12.004","article-title":"NANOG Metabolically reprograms tumor-initiating stem-like cells through tumorigenic changes in oxidative phosphorylation and fatty acid metabolism","volume":"23","author":"Chen","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbc.2024.107686_bib79","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s13046-018-0730-6","article-title":"Inflammatory interferon activates HIF-1alpha-mediated epithelial-to-mesenchymal transition via PI3K\/AKT\/mTOR pathway","volume":"37","author":"Yeh","year":"2018","journal-title":"J.\u00a0Exp. Clin. Cancer Res."},{"key":"10.1016\/j.jbc.2024.107686_bib80","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01216-21","article-title":"Retinoic acid-inducible gene I-like receptors activate snail to limit RNA viral infections","volume":"95","author":"Vedagiri","year":"2021","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.jbc.2024.107686_bib81","doi-asserted-by":"crossref","first-page":"4480","DOI":"10.1038\/s41388-019-0731-8","article-title":"Interferon-stimulated gene 15 modulates cell migration by interacting with Rac1 and contributes to lymph node metastasis of oral squamous cell carcinoma cells","volume":"38","author":"Chen","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.jbc.2024.107686_bib82","doi-asserted-by":"crossref","first-page":"5328","DOI":"10.1128\/JVI.00037-14","article-title":"Cytosolic-DNA-mediated, STING-dependent proinflammatory gene induction necessitates canonical NF-kappaB activation through TBK1","volume":"88","author":"Abe","year":"2014","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.jbc.2024.107686_bib83","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/nprot.2013.143","article-title":"Genome engineering using the CRISPR-Cas9 system","volume":"8","author":"Ran","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jbc.2024.107686_bib84","article-title":"Generation of two human ISG15 knockout iPSC clones using CRISPR\/Cas9 editing","volume":"50","author":"Merkert","year":"2020","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.jbc.2024.107686_bib85","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41586-019-1711-4","article-title":"Search-and-replace genome editing without double-strand breaks or donor DNA","volume":"576","author":"Anzalone","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2024.107686_bib86","doi-asserted-by":"crossref","first-page":"261","DOI":"10.4049\/jimmunol.1901472","article-title":"Direct antiviral activity of IFN-stimulated genes is responsible for resistance to paramyxoviruses in ISG15-deficient cells","volume":"205","author":"Holthaus","year":"2020","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jbc.2024.107686_bib87","doi-asserted-by":"crossref","first-page":"R19","DOI":"10.1186\/gb-2007-8-2-r19","article-title":"qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data","volume":"8","author":"Hellemans","year":"2007","journal-title":"Genome Biol."},{"key":"10.1016\/j.jbc.2024.107686_bib88","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925824021872?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925824021872?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:40:00Z","timestamp":1734396000000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925824021872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":88,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S0021925824021872"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2024.107686","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ISGylation enhances dsRNA-induced interferon response and NF\u03baB signaling in fallopian tube epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2024.107686","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"107686"}}