{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T03:45:55Z","timestamp":1776138355897,"version":"3.50.1"},"reference-count":51,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.jbc.2024.107708","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T11:47:15Z","timestamp":1724413635000},"page":"107708","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Rhodoquinone-dependent electron transport chain is essential for Caenorhabditis elegans survival in hydrogen sulfide environments"],"prefix":"10.1016","volume":"300","author":[{"given":"Laura","family":"Romanelli-Cedrez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5160-2250","authenticated-orcid":false,"given":"Franco","family":"Vairoletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Salinas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2024.107708_bib1","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1139\/o82-076","article-title":"Sulphide as an inhibitor and electron donor for the cytochrome c oxidase system","volume":"60","author":"Nicholls","year":"1982","journal-title":"Can. J. Biochem."},{"key":"10.1016\/j.jbc.2024.107708_bib2","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1021\/acs.chemrev.7b00205","article-title":"Chemical biology of H2S signaling through persulfidation","volume":"118","author":"Filipovic","year":"2018","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jbc.2024.107708_bib3","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jinorgbio.2004.10.012","article-title":"The sulfide binding function of annelid hemoglobins: relic of an old biosystem?","volume":"99","author":"Bailly","year":"2005","journal-title":"J.\u00a0Inorg. Biochem."},{"key":"10.1016\/j.jbc.2024.107708_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-020-0822-7","article-title":"Uncovering diversity and metabolic spectrum of animals in dead zone sediments","volume":"3","author":"Broman","year":"2020","journal-title":"Commun. Biol."},{"key":"10.1016\/j.jbc.2024.107708_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.150054","article-title":"Adaption to hydrogen sulfide-rich environments: strategies for active detoxification in deep-sea symbiotic mussels, Gigantidas platifrons","volume":"804","author":"Sun","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jbc.2024.107708_bib6","article-title":"Rhodoquinone in bacteria and animals: two distinct pathways for biosynthesis of this key electron transporter used in anaerobic bioenergetics","volume":"1861","author":"Salinas","year":"2020","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbc.2024.107708_bib7","doi-asserted-by":"crossref","first-page":"30901","DOI":"10.1074\/jbc.M114.602664","article-title":"Organization of the human mitochondrial hydrogen sulfide oxidation pathway","volume":"289","author":"Libiad","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2024.107708_bib8","doi-asserted-by":"crossref","first-page":"6804","DOI":"10.1021\/bi300778t","article-title":"Human sulfide:Quinone oxidoreductase catalyzes the first step in hydrogen sulfide metabolism and produces a sulfane sulfur metabolite","volume":"51","author":"Jackson","year":"2012","journal-title":"Biochemistry"},{"key":"10.1016\/j.jbc.2024.107708_bib9","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1093\/molbev\/msg174","article-title":"Single eubacterial origin of eukaryotic sulfide:quinone oxidoreductase, a mitochondrial enzyme conserved from the early evolution of eukaryotes during anoxic and sulfidic times","volume":"20","author":"Theissen","year":"2003","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.jbc.2024.107708_bib10","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.1128\/JB.183.21.6207-6214.2001","article-title":"Pseudomonas aeruginosa PAO1 kills Caenorhabditis elegans by cyanide poisoning","volume":"183","author":"Gallagher","year":"2001","journal-title":"J.\u00a0Bact."},{"key":"10.1016\/j.jbc.2024.107708_bib11","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1534\/genetics.111.129841","article-title":"The response of caenorhabditis elegans to hydrogen sulfide and hydrogen cyanide","volume":"189","author":"Budde","year":"2011","journal-title":"Genetics"},{"key":"10.1016\/j.jbc.2024.107708_bib12","doi-asserted-by":"crossref","first-page":"15202","DOI":"10.1073\/pnas.96.26.15202","article-title":"Lethal paralysis of Caenorhabditis elegans by Pseudomonas aeruginosa","volume":"96","author":"Darby","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2024.107708_bib13","doi-asserted-by":"crossref","first-page":"4941","DOI":"10.1016\/j.cub.2022.09.041","article-title":"Co-opted genes of algal origin protect C. elegans against cyanogenic toxins","volume":"32","author":"Wang","year":"2022","journal-title":"Curr. Biol."},{"key":"10.1016\/j.jbc.2024.107708_bib14","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.neuron.2011.12.037","article-title":"CYSL-1 interacts with the O 2-sensing hydroxylase EGL-9 to promote H 2S-modulated hypoxia-induced behavioral plasticity in C. elegans","volume":"73","author":"Ma","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.jbc.2024.107708_bib15","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1016\/j.bbapap.2013.09.020","article-title":"Biochemical properties of nematode O-acetylserine(thiol)lyase paralogs imply their distinct roles in hydrogen sulfide homeostasis","volume":"1834","author":"Vozdek","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbc.2024.107708_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025476","article-title":"HIF-1 and SKN-1 coordinate the transcriptional response to hydrogen sulfide in Caenorhabditis elegans","volume":"6","author":"Miller","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2024.107708_bib17","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1091\/mbc.e09-03-0199","article-title":"Hydrogen Sulfide Increases Hypoxia-Inducible Factor-1 Activity Independently of von Hippel-Lindau Tumor Suppressor-1 in C. elegans","volume":"21","author":"Budde","year":"2010","journal-title":"Mol. Biol. Cell."},{"key":"10.1016\/j.jbc.2024.107708_bib18","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1534\/genetics.119.302326","article-title":"A\u00a0novel mechanism to prevent H2S toxicity in caenorhabditis elegans","volume":"213","author":"Horsman","year":"2019","journal-title":"Genetics"},{"key":"10.1016\/j.jbc.2024.107708_bib19","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1093\/oxfordjournals.jbchem.a129090","article-title":"Occurrence of ubiquinone and rhodoquinone in parasitic nematodes, metastrongylus elongatus and Ascaris lumbricoides va.suis","volume":"65","author":"Sato","year":"1969","journal-title":"J.\u00a0Biochem."},{"key":"10.1016\/j.jbc.2024.107708_bib20","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0014-4894(73)90080-5","article-title":"Helminths: Comparison of their rhodoquinone","volume":"34","author":"Allen","year":"1973","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.jbc.2024.107708_bib21","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0005-2728(98)00045-0","article-title":"The electron transport chain in anaerobically functioning eukaryotes","volume":"1365","author":"Tielens","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbc.2024.107708_bib22","doi-asserted-by":"crossref","first-page":"31065","DOI":"10.1074\/jbc.270.52.31065","article-title":"Rhodoquinone and complex II of the electron transport chain in anaerobically functioning eukaryotes","volume":"270","author":"Van Hellemond","year":"1995","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2024.107708_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.48165","article-title":"Rhodoquinone biosynthesis in 1 C.elegans requires precursors generated by the kynurenine pathway","volume":"8","author":"Del Borrello","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.jbc.2024.107708_bib24","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1093\/oxfordjournals.jbchem.a130968","article-title":"Polarographic studies on ubiquinone-10 and rhodoquinone bound with chromatophores from rhodospirillum rubrum","volume":"78","author":"Erabi","year":"1975","journal-title":"J. Biochem."},{"key":"10.1016\/j.jbc.2024.107708_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101435","article-title":"A redox cycle with complex II prioritizes sulfide quinone oxidoreductase dependent H2S oxidation","volume":"298","author":"Kumar","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2024.107708_bib26","doi-asserted-by":"crossref","first-page":"25072","DOI":"10.1074\/jbc.M115.682369","article-title":"Transient kinetic analysis of hydrogen sulfide oxidation catalyzed by human sulfide quinone oxidoreductase","volume":"290","author":"Mishanina","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2024.107708_bib27","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nchembio.1834","article-title":"Biogenesis of reactive sulfur species for signaling by hydrogen sulfide oxidation pathways","volume":"11","author":"Mishanina","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jbc.2024.107708_bib28","doi-asserted-by":"crossref","first-page":"11047","DOI":"10.1074\/jbc.AC119.009475","article-title":"The kynurenine pathway is essential for rhodoquinone biosynthesis in Caenorhabditis elegans","volume":"294","author":"Roberts Buceta","year":"2019","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2024.107708_bib29","article-title":"Alternative splicing of COQ-2 determines the choice between ubiquinone and rhodoquinone biosynthesis in helminths","author":"Tan","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.jbc.2024.107708_bib30","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1074\/jbc.M708597200","article-title":"Complex I is the major site of mitochondrial superoxide production by paraquat","volume":"283","author":"Cochem\u00e9","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2024.107708_bib31","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1016\/j.cmet.2019.10.007","article-title":"Selective persulfide detection reveals evolutionarily conserved antiaging effects of S-Sulfhydration","volume":"30","author":"Zivanovic","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbc.2024.107708_bib32","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aax8358","article-title":"Control of protein function through oxidation and reduction of persulfidated states","volume":"6","author":"D\u00f3ka","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jbc.2024.107708_bib33","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1126\/science.1196914","article-title":"Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project","volume":"330","author":"Gerstein","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.jbc.2024.107708_bib34","doi-asserted-by":"crossref","first-page":"6168","DOI":"10.1038\/s41467-022-33849-x","article-title":"The hypoxia response pathway promotes PEP carboxykinase and gluconeogenesis in C. elegans","volume":"13","author":"Vora","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2024.107708_bib35","series-title":"The Nematode Caenorhabditis elegans (Cold Spring Harbor Monograph Series 17)","first-page":"587","article-title":"Methods","author":"Sulston","year":"1997"},{"key":"10.1016\/j.jbc.2024.107708_bib36","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/0003-2697(65)90051-5","article-title":"A\u00a0direct microdetermination for sulfide","volume":"11","author":"Siegel","year":"1965","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jbc.2024.107708_bib37","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jneumeth.2006.11.015","article-title":"An automated tracking system for Caenorhabditis elegans locomotor behavior and circadian studies application","volume":"161","author":"Simonetta","year":"2007","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.jbc.2024.107708_bib38","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/pro.3943","article-title":"UCSF ChimeraX: structure visualization for researchers, educators, and developers","volume":"30","author":"Pettersen","year":"2021","journal-title":"Protein Sci."},{"key":"10.1016\/j.jbc.2024.107708_bib39","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nprot.2015.053","article-title":"Europe PMC Funders Group the Phyre2 web portal for protein modelling , prediction and analysis","volume":"10","author":"Kelley","year":"2015","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jbc.2024.107708_bib40","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/nar\/gkn750","article-title":"The SWISS-MODEL Repository and associated resources","volume":"37","author":"Kiefer","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2024.107708_bib41","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1038\/s41596-022-00728-0","article-title":"I-TASSER-MTD: a deep-learning-based platform for multi-domain protein structure and function prediction","volume":"17","author":"Xiaogen","year":"2022","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jbc.2024.107708_bib42","series-title":"Molecular Operating Environment (MOE), 2022.02","year":"2022"},{"key":"10.1016\/j.jbc.2024.107708_bib43","series-title":"The Amber Molecular Dynamics Package, Amber","author":"Case","year":"2014"},{"key":"10.1016\/j.jbc.2024.107708_bib44","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/prot.21715","article-title":"QMEAN: a comprehensive scoring function for model quality assessment","volume":"71","author":"Benkert","year":"2008","journal-title":"Proteins Struct. Funct. Genet."},{"key":"10.1016\/j.jbc.2024.107708_bib45","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.3390\/molecules27092659","article-title":"Structure-Based bioisosterism design, synthesis, biological evaluation and in silico studies of benzamide analogs as potential anthelmintics","volume":"27","author":"Vairoletti","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.jbc.2024.107708_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep26536","article-title":"QwikMD - integrative molecular dynamics toolkit for novices and experts","volume":"6","author":"Ribeiro","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2024.107708_bib47","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","article-title":"VMD: visual molecular dynamics","volume":"14","author":"Humphrey","year":"1996","journal-title":"J.\u00a0Mol. Graph."},{"key":"10.1016\/j.jbc.2024.107708_bib48","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/jcc.21367","article-title":"CHARMM General Force Field A Force Field for Drug-like Molecules Compatible with.Pdf","volume":"31","author":"Vanommeslaeghe","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.jbc.2024.107708_bib49","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.1021\/ci300363c","article-title":"Automation of the CHARMM general force field (CGenFF) I: bond perception and atom typing","volume":"52","author":"Vanommeslaeghe","year":"2012","journal-title":"J.\u00a0Chem. Inf. Model."},{"key":"10.1016\/j.jbc.2024.107708_bib50","doi-asserted-by":"crossref","DOI":"10.1063\/5.0014475","article-title":"Scalable molecular dynamics on CPU and GPU architectures with NAMD","volume":"153","author":"Phillips","year":"2020","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.jbc.2024.107708_bib51","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/0038-0717(87)90037-X","article-title":"Microbial cyanide production in the rhizosphere in relation to potato yield reduction and Pseudomonas SPP-mediated plant growth-stimulation","volume":"19","author":"Bakker","year":"1987","journal-title":"Soil Biol. Biochem."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925824022099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925824022099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:40:42Z","timestamp":1734396042000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925824022099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":51,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S0021925824022099"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2024.107708","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rhodoquinone-dependent electron transport chain is essential for Caenorhabditis elegans survival in hydrogen sulfide environments","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2024.107708","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"107708"}}