{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:19:30Z","timestamp":1793038770738,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22H00442"],"award-info":[{"award-number":["22H00442"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K18375"],"award-info":[{"award-number":["22K18375"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22KJ2383"],"award-info":[{"award-number":["22KJ2383"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004096","name":"Kyushu University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004096","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23am121031"],"award-info":[{"award-number":["JP23am121031"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.jbc.2024.107890","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T20:45:58Z","timestamp":1729025158000},"page":"107890","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Oncogenic accumulation of cysteine promotes cancer cell\u00a0proliferation by regulating the translation of D-type cyclins"],"prefix":"10.1016","volume":"300","author":[{"given":"Yumi","family":"Okano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2598-4566","authenticated-orcid":false,"given":"Tomoaki","family":"Yamauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runa","family":"Fukuzaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0588-0302","authenticated-orcid":false,"given":"Akito","family":"Tsuruta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2394-9748","authenticated-orcid":false,"given":"Yuya","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6454-9778","authenticated-orcid":false,"given":"Yuya","family":"Tsurudome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2637-3916","authenticated-orcid":false,"given":"Kentaro","family":"Ushijima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0004-4535","authenticated-orcid":false,"given":"Naoya","family":"Matsunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4849-2377","authenticated-orcid":false,"given":"Satoru","family":"Koyanagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigehiro","family":"Ohdo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2024.107890_bib1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4161\/cbt.22958","article-title":"Altered energy metabolism in cancer","volume":"14","author":"Zhang","year":"2013","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.jbc.2024.107890_bib2","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/nature22314","article-title":"Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia","volume":"545","author":"Hattori","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2024.107890_bib3","doi-asserted-by":"crossref","first-page":"907","DOI":"10.3390\/ijms19030907","article-title":"Amino acid transporters and glutamine metabolism in breast cancer","volume":"19","author":"Cha","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbc.2024.107890_bib4","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1158\/0008-5472.CAN-14-3745","article-title":"Amino acid transporters in cancer and their relevance to \u201cglutamine addiction\u201d: novel targets for the design of a new class of anticancer drugs","volume":"75","author":"Bhutia","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.jbc.2024.107890_bib5","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nchembio.2070","article-title":"A\u00a0PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate","volume":"12","author":"Pacold","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jbc.2024.107890_bib6","doi-asserted-by":"crossref","first-page":"678","DOI":"10.3390\/cancers11050678","article-title":"The non-essential amino acid cysteine becomes essential for tumor proliferation and survival","volume":"11","author":"Combs","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jbc.2024.107890_bib7","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrd2803","article-title":"Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?","volume":"8","author":"Trachootham","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jbc.2024.107890_bib8","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Patel","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2024.107890_bib9","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1126\/science.aaw9872","article-title":"Cysteine depletion induces pancreatic tumor ferroptosis in mice","volume":"368","author":"Badgley","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jbc.2024.107890_bib10","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1038\/s41467-021-21841-w","article-title":"mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2024.107890_bib11","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"10.1016\/j.jbc.2024.107890_bib12","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1038\/s41418-020-00685-9","article-title":"Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer\u2019s disease","volume":"28","author":"Bao","year":"2021","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jbc.2024.107890_bib13","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41568-022-00459-0","article-title":"Targeting ferroptosis as a vulnerability in cancer","volume":"22","author":"Lei","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jbc.2024.107890_bib14","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/s43018-022-00355-4","article-title":"MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis","volume":"3","author":"Alborzinia","year":"2022","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.jbc.2024.107890_bib15","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1016\/j.molcel.2023.08.004","article-title":"Lysosomal cystine governs ferroptosis sensitivity in cancer via cysteine stress response","volume":"83","author":"Swanda","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2024.107890_bib16","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1038\/s41467-023-36630-w","article-title":"Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism","volume":"14","author":"Upadhyayula","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2024.107890_bib17","doi-asserted-by":"crossref","first-page":"569","DOI":"10.15252\/embr.201643068","article-title":"MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer","volume":"18","author":"Anderton","year":"2017","journal-title":"EMBO Rep."},{"key":"10.1016\/j.jbc.2024.107890_bib18","article-title":"Cystathionine \u03b2 -synthase in physiology and cancer","author":"Zhu","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.jbc.2024.107890_bib19","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/s41568-019-0187-8","article-title":"Methionine metabolism in health and cancer: a nexus of diet and precision medicine","volume":"19","author":"Sanderson","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jbc.2024.107890_bib20","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/s41416-020-01156-1","article-title":"Cysteine metabolic circuitries: druggable targets in cancer","volume":"124","author":"Bonif\u00e1cio","year":"2021","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.jbc.2024.107890_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.00947","article-title":"Cysteine as a carbon source, a hot spot in cancer cells survival","volume":"10","author":"Serpa","year":"2020","journal-title":"Front Oncol."},{"key":"10.1016\/j.jbc.2024.107890_bib22","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1248\/bpb.b19-00546","article-title":"Dosing time-dependent changes in the anti-tumor effect of xCT inhibitor erastin in human breast cancer xenograft mice","volume":"42","author":"Shiromizu","year":"2019","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.jbc.2024.107890_bib23","doi-asserted-by":"crossref","first-page":"261","DOI":"10.5487\/TR.2014.30.4.261","article-title":"Transformation of mouse liver cells by methylcholanthrene leads to phenotypic changes associated with epithelial-mesenchymal transition","volume":"30","author":"Oh","year":"2014","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.jbc.2024.107890_bib24","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2024.107890_bib25","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/s41419-023-06045-y","article-title":"The diversified role of mitochondria in ferroptosis in cancer","volume":"14","author":"Liu","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jbc.2024.107890_bib26","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S1357-2725(96)00178-1","article-title":"Regulation of CDK\/cyclin complexes during the cell cycle","volume":"29","author":"Arellano","year":"1997","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.jbc.2024.107890_bib27","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/s41392-021-00581-9","article-title":"Cyst(e)ine in nutrition formulation promotes colon cancer growth and chemoresistance by activating mTORC1 and scavenging ROS","volume":"6","author":"Wu","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jbc.2024.107890_bib28","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.cmet.2008.01.008","article-title":"ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress","volume":"7","author":"Yamaguchi","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbc.2024.107890_bib29","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.molcel.2016.09.020","article-title":"The structures of eIF4E-eIF4G complexes reveal an extended interface to regulate translation initiation","volume":"64","author":"Gr\u00fcner","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2024.107890_bib30","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1146\/annurev.biochem.68.1.913","article-title":"eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation","volume":"68","author":"Gingras","year":"1999","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.jbc.2024.107890_bib31","first-page":"7358","article-title":"Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E","volume":"13","author":"Rosenwald","year":"1993","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2024.107890_bib32","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1023\/A:1022943419011","article-title":"Translational control and metastatic progression: enhanced activity of the mRNA cap-binding protein eIF-4E selectively enhances translation of metastasis-related mRNAs","volume":"20","author":"Graff","year":"2003","journal-title":"Clin. Exp. Metastasis"},{"key":"10.1016\/j.jbc.2024.107890_bib33","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","article-title":"Cystine transporter SLC7A11\/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy","volume":"12","author":"Koppula","year":"2021","journal-title":"Protein Cell"},{"key":"10.1016\/j.jbc.2024.107890_bib34","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1158\/1541-7786.MCR-16-0028","article-title":"Increased expression of system xc\u2212 in glioblastoma confers an altered metabolic state and temozolomide resistance","volume":"14","author":"Polewski","year":"2016","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.jbc.2024.107890_bib35","doi-asserted-by":"crossref","first-page":"5007","DOI":"10.1038\/s41388-018-0307-z","article-title":"xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression","volume":"37","author":"Ji","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.jbc.2024.107890_bib36","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40170-024-00352-4","article-title":"Epigenetic repression of de novo cysteine synthetases induces intra-cellular accumulation of cysteine in hepatocarcinoma by up-regulating the cystine uptake transporter xCT","volume":"12","author":"Yamauchi","year":"2024","journal-title":"Cancer Metab."},{"key":"10.1016\/j.jbc.2024.107890_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101328","article-title":"Insight into the mechanism of ferroptosis inhibition by ferrostatin-1","volume":"28","author":"Miotto","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.jbc.2024.107890_bib38","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/nrc3090","article-title":"Cyclin D as a therapeutic target in cancer","volume":"11","author":"Musgrove","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jbc.2024.107890_bib39","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1074\/jbc.275.5.3479","article-title":"Cyclin D3 compensates for loss of cyclin D2 in mouse B-lymphocytes activated via the antigen receptor and CD40","volume":"275","author":"Lam","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2024.107890_bib40","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S1535-6108(03)00301-5","article-title":"Requirement for cyclin D3 in lymphocyte development and T cell leukemias","volume":"4","author":"Sicinska","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jbc.2024.107890_bib41","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1182\/blood-2005-01-0034","article-title":"Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma","volume":"106","author":"Bergsagel","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jbc.2024.107890_bib42","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1101\/gad.1023602","article-title":"Development of mice expressing a single D-type cyclin","volume":"16","author":"Ciemerych","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.jbc.2024.107890_bib43","doi-asserted-by":"crossref","first-page":"11264","DOI":"10.1073\/pnas.92.24.11264","article-title":"Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site","volume":"92","author":"Schulze","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2024.107890_bib44","doi-asserted-by":"crossref","first-page":"12146","DOI":"10.1073\/pnas.92.26.12146","article-title":"Regulation of the cyclin E gene by transcription factor E2F1","volume":"92","author":"Ohtani","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2024.107890_bib45","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/bjc.2012.579","article-title":"Y-box binding protein-1 regulates cell proliferation and is associated with clinical outcomes of osteosarcoma","volume":"108","author":"Fujiwara-Okada","year":"2013","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.jbc.2024.107890_bib46","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/gtc.12150","article-title":"YB-1 promotes transcription of cyclin D1 in human non-small-cell lung cancers","volume":"19","author":"Harada","year":"2014","journal-title":"Genes Cells"},{"key":"10.1016\/j.jbc.2024.107890_bib47","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nrm2838","article-title":"The mechanism of eukaryotic translation initiation and principles of its regulation","volume":"11","author":"Jackson","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2024.107890_bib48","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1038\/sj.onc.1207545","article-title":"eIF-4E expression and its role in malignancies and metastases","volume":"23","author":"De Benedetti","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.jbc.2024.107890_bib49","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1083\/jcb.200501019","article-title":"eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3\u2032UTR","volume":"169","author":"Culjkovic","year":"2005","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.jbc.2024.107890_bib50","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1038\/sj.emboj.7600193","article-title":"Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases","volume":"23","author":"Raught","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2024.107890_bib51","doi-asserted-by":"crossref","first-page":"6869","DOI":"10.1007\/s00018-021-03938-z","article-title":"Control of the eIF4E activity: structural insights and pharmacological implications","volume":"78","author":"Romagnoli","year":"2021","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.jbc.2024.107890_bib52","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/nature05859","article-title":"RAS\u2013RAF\u2013MEK-dependent oxidative cell death involving voltage-dependent anion channels","volume":"447","author":"Yagoda","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2024.107890_bib53","first-page":"2363","article-title":"Upregulation and activation of p53 by erastin-induced reactive oxygen species contribute to cytotoxic and cytostatic effects in A549 lung cancer cells","volume":"40","author":"Huang","year":"2018","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.jbc.2024.107890_bib54","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S1535-6108(03)00050-3","article-title":"Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells","volume":"3","author":"Dolma","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jbc.2024.107890_bib55","doi-asserted-by":"crossref","first-page":"4787","DOI":"10.1016\/j.bmcl.2015.07.018","article-title":"Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility","volume":"25","author":"Larraufie","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.jbc.2024.107890_bib56","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.chembiol.2019.01.008","article-title":"Imidazole ketone erastin induces ferroptosis and slows tumor growth in a mouse lymphoma model","volume":"26","author":"Zhang","year":"2019","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.jbc.2024.107890_bib57","doi-asserted-by":"crossref","first-page":"7101","DOI":"10.1523\/JNEUROSCI.5258-04.2005","article-title":"Inhibition of cystine uptake disrupts the growth of primary brain tumors","volume":"25","author":"Chung","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.jbc.2024.107890_bib58","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s40170-021-00249-6","article-title":"Sulfasalazine modifies metabolic profiles and enhances cisplatin chemosensitivity on cholangiocarcinoma cells in in\u00a0vitro and in\u00a0vivo models","volume":"9","author":"Thanee","year":"2021","journal-title":"Cancer Metab."},{"key":"10.1016\/j.jbc.2024.107890_bib59","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/nm.4232","article-title":"Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth","volume":"23","author":"Cramer","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.jbc.2024.107890_bib60","first-page":"809","article-title":"Rat hepatocyte primary cell cultures. III. Improved dissociation and attachment techniques and the enhancement of survival by culture medium","volume":"13","author":"Williams","year":"1977","journal-title":"In\u00a0Vitro"},{"key":"10.1016\/j.jbc.2024.107890_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2020.100086","article-title":"Protocol for primary mouse hepatocyte isolation","volume":"1","author":"Charni-Natan","year":"2020","journal-title":"STAR Protoc."},{"key":"10.1016\/j.jbc.2024.107890_bib62","doi-asserted-by":"crossref","first-page":"32886","DOI":"10.1038\/srep32886","article-title":"Integrated stress response of vertebrates is regulated by four eIF2\u03b1 kinases","volume":"6","author":"Taniuchi","year":"2016","journal-title":"Sci. Rep."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925824023925?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925824023925?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:08:11Z","timestamp":1778645291000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925824023925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":62,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S0021925824023925"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2024.107890","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oncogenic accumulation of cysteine promotes cancer cell\u00a0proliferation by regulating the translation of D-type cyclins","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2024.107890","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"107890"}}