{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:40:24Z","timestamp":1791906024313,"version":"4.3.4"},"reference-count":46,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG3K2221"],"award-info":[{"award-number":["CMRPG3K2221"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["OMRPG3C0048"],"award-info":[{"award-number":["OMRPG3C0048"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG3M0951"],"award-info":[{"award-number":["CMRPG3M0951"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG3K0311"],"award-info":[{"award-number":["CMRPG3K0311"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001869","name":"Academia Sinica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001869","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 112 to 2314 B-182A-047"],"award-info":[{"award-number":["NSTC 112 to 2314 B-182A-047"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 112-2314-B-182A-047"],"award-info":[{"award-number":["NSTC 112-2314-B-182A-047"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.jbc.2025.108368","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T16:09:47Z","timestamp":1740758987000},"page":"108368","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["ST3GAL1 regulates cancer cell migration through crosstalk between EGFR and neuropilin-1 signaling"],"prefix":"10.1016","volume":"301","author":[{"given":"Tan-chi","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2105-0555","authenticated-orcid":false,"given":"Hui Ling","family":"Yeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsai-Hsien","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nai-Chuan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Hsin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Hsiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice L.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2025.108368_bib1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s12253-015-0033-6","article-title":"Sialylation: an avenue to target cancer cells","volume":"22","author":"Vajaria","year":"2016","journal-title":"Pathol. Oncol. Res."},{"key":"10.1016\/j.jbc.2025.108368_bib2","doi-asserted-by":"crossref","first-page":"32830","DOI":"10.1074\/jbc.M202493200","article-title":"Hyposialylation of integrins stimulates the activity of myeloid fibronectin receptors","volume":"277","author":"Semel","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2025.108368_bib3","doi-asserted-by":"crossref","first-page":"37610","DOI":"10.1074\/jbc.M508476200","article-title":"A\u00a0protein kinase C\/Ras\/ERK signaling pathway activates myeloid fibronectin receptors by altering beta1 integrin sialylation","volume":"280","author":"Seales","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2025.108368_bib4","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0300-9084(01)01301-3","article-title":"The human sialyltransferase family","volume":"83","author":"Harduin-Lepers","year":"2001","journal-title":"Biochimie"},{"key":"10.1016\/j.jbc.2025.108368_bib5","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1093\/glycob\/9.12.1307","article-title":"An alpha2,3 sialyltransferase (ST3Gal I) is elevated in primary breast carcinomas","volume":"9","author":"Burchell","year":"1999","journal-title":"Glycobiology"},{"key":"10.1016\/j.jbc.2025.108368_bib6","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.canlet.2018.07.026","article-title":"Reciprocal feedback regulation of ST3GAL1 and GFRA1 signaling in breast cancer cells","volume":"434","author":"Fan","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jbc.2025.108368_bib7","doi-asserted-by":"crossref","first-page":"29120","DOI":"10.1074\/jbc.R115.687327","article-title":"Neuropilin functions as an essential cell surface receptor","volume":"290","author":"Guo","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2025.108368_bib8","doi-asserted-by":"crossref","first-page":"921","DOI":"10.18632\/oncotarget.626","article-title":"Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity","volume":"3","author":"Prud'homme","year":"2012","journal-title":"Oncotarget"},{"key":"10.1016\/j.jbc.2025.108368_bib9","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.bbrc.2012.07.151","article-title":"Neuropilin-1 is expressed by breast cancer stem-like cells and is linked to NF-kappaB activation and tumor sphere formation","volume":"425","author":"Glinka","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jbc.2025.108368_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2016.01.010","article-title":"VEGF\/NRP-1axis promotes progression of breast cancer via enhancement of epithelial-mesenchymal transition and activation of NF-kappaB and beta-catenin","volume":"373","author":"Luo","year":"2016","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jbc.2025.108368_bib11","first-page":"537","article-title":"Anti-neuropilin-1 monoclonal antibody suppresses the migration and invasion of human gastric cancer cells via Akt dephosphorylation","volume":"16","author":"Ding","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.jbc.2025.108368_bib12","first-page":"3301","article-title":"Neuropilin-1 associated molecules in the blood distinguish poor prognosis breast cancer: a cross-sectional","volume":"7","author":"Naik","year":"2017","journal-title":"Study Sci. Rep."},{"key":"10.1016\/j.jbc.2025.108368_bib13","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/01913120290076784","article-title":"Type 1 protein tyrosine kinases in breast carcinoma: a review","volume":"26","author":"Suo","year":"2002","journal-title":"Ultrastruct Pathol."},{"key":"10.1016\/j.jbc.2025.108368_bib14","first-page":"120","article-title":"The complexity of targeting EGFR signalling in cancer: from expression to turnover","volume":"1766","author":"Sebastian","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbc.2025.108368_bib15","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.gene.2005.10.018","article-title":"Epidermal growth factor receptor (EGFR) signaling in cancer","volume":"366","author":"Normanno","year":"2006","journal-title":"Gene"},{"key":"10.1016\/j.jbc.2025.108368_bib16","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1023\/A:1013397232011","article-title":"Prognostic value of epidermal growth factor receptor (EGFR) and its relationship to the estrogen receptor status in 1029 patients with breast cancer","volume":"71","author":"Tsutsui","year":"2002","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.jbc.2025.108368_bib17","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.2174\/1871520621666201222143213","article-title":"Recent advances on epidermal growth factor receptor as a molecular target for breast cancer therapeutics","volume":"21","author":"Shetty","year":"2021","journal-title":"Anticancer Agents Med. Chem."},{"key":"10.1016\/j.jbc.2025.108368_bib18","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.bcp.2012.01.007","article-title":"Sialylation of epidermal growth factor receptor regulates receptor activity and chemosensitivity to gefitinib in colon cancer cells","volume":"83","author":"Park","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jbc.2025.108368_bib19","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.abb.2009.02.005","article-title":"EGF-mediated migration signaling activated by N-acetylglucosaminyltransferase-V via receptor protein tyrosine phosphatase kappa","volume":"486","author":"Wang","year":"2009","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.jbc.2025.108368_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105217","article-title":"Sialylation of EGFR by ST6GAL1 induces receptor activation and modulates trafficking dynamics","volume":"299","author":"Ankenbauer","year":"2023","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2025.108368_bib21","doi-asserted-by":"crossref","first-page":"11332","DOI":"10.1073\/pnas.1107385108","article-title":"Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells","volume":"108","author":"Liu","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1016\/j.jbc.2025.108368_bib22","doi-asserted-by":"crossref","first-page":"5801","DOI":"10.1158\/0008-5472.CAN-12-0995","article-title":"Neuropilin-1-dependent regulation of EGF-receptor signaling","volume":"72","author":"Rizzolio","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.jbc.2025.108368_bib23","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s41419-023-05696-1","article-title":"NRP1 promotes prostate cancer progression via modulating EGFR-dependent AKT pathway activation","volume":"14","author":"Zhang","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jbc.2025.108368_bib24","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1042\/BJ20071639","article-title":"Neuropilins: structure, function and role in disease","volume":"411","author":"Pellet-Many","year":"2008","journal-title":"Biochem. J."},{"key":"10.1016\/j.jbc.2025.108368_bib25","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s10719-015-9602-x","article-title":"Detailed characterization of the O-linked glycosylation of the neuropilin-1 c\/MAM-domain","volume":"33","author":"Windwarder","year":"2016","journal-title":"Glycoconj. J."},{"key":"10.1016\/j.jbc.2025.108368_bib26","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0008-6215(00)84040-9","article-title":"Immunochemical studies on the specificity of the peanut (Arachis hypogaea) agglutinin","volume":"51","author":"Pereira","year":"1976","journal-title":"Carbohydr. Res."},{"key":"10.1016\/j.jbc.2025.108368_bib27","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1002\/ijc.31891","article-title":"Sialylation of vasorin by ST3Gal1 facilitates TGF-beta1-mediated tumor angiogenesis and progression","volume":"144","author":"Yeo","year":"2019","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.jbc.2025.108368_bib28","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1158\/2326-6066.CIR-20-0203","article-title":"Sialylation of CD55 by ST3GAL1 facilitates immune evasion in cancer","volume":"9","author":"Lin","year":"2021","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.jbc.2025.108368_bib29","doi-asserted-by":"crossref","first-page":"5865","DOI":"10.1038\/s41467-020-19575-2","article-title":"ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL","volume":"11","author":"Pietrobono","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.108368_bib30","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/s41419-018-1101-0","article-title":"Sialyltransferase ST3GAL1 promotes cell migration, invasion, and TGF-beta1-induced EMT and confers paclitaxel resistance in ovarian cancer","volume":"9","author":"Wu","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jbc.2025.108368_bib31","first-page":"3950","article-title":"Icaritin enhances the efficacy of cetuximab against triple-negative breast cancer cells","volume":"19","author":"Yin","year":"2020","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.jbc.2025.108368_bib32","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1002\/cncr.24816","article-title":"Epidermal growth factor receptor expression in breast cancer association with biologic phenotype and clinical outcomes","volume":"116","author":"Rimawi","year":"2010","journal-title":"Cancer"},{"key":"10.1016\/j.jbc.2025.108368_bib33","doi-asserted-by":"crossref","first-page":"4852","DOI":"10.1073\/pnas.85.13.4852","article-title":"Biological activity of human-mouse IgG1, IgG2, IgG3, and IgG4 chimeric monoclonal antibodies with antitumor specificity","volume":"85","author":"Steplewski","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"10.1016\/j.jbc.2025.108368_bib34","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3390\/cells10020263","article-title":"Sialic acids and their influence on human NK cell function","volume":"10","author":"Rosenstock","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jbc.2025.108368_bib35","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/s41467-021-21550-4","article-title":"Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9","volume":"12","author":"Rodriguez","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.108368_bib36","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13058-015-0662-4","article-title":"Antitumor activity of Cetuximab in combination with Ixabepilone on triple negative breast cancer stem cells","volume":"18","author":"Tanei","year":"2016","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.jbc.2025.108368_bib37","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s001099900019","article-title":"Molecular and biological properties of vascular endothelial growth factor","volume":"77","author":"Ferrara","year":"1999","journal-title":"J.\u00a0Mol. Med."},{"key":"10.1016\/j.jbc.2025.108368_bib38","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.2147\/CMAR.S169533","article-title":"Neuropilin-1 expression is associated with lymph node metastasis in breast cancer tissues","volume":"10","author":"Seifi-Alan","year":"2018","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.jbc.2025.108368_bib39","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1007\/s00432-021-03635-1","article-title":"Soluble Neuropilin-1 is an independent marker of poor prognosis in early breast cancer","volume":"147","author":"Rachner","year":"2021","journal-title":"J.\u00a0Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.jbc.2025.108368_bib40","article-title":"The miR-124-3p\/neuropilin-1 Axis contributes to the proliferation and metastasis of triple-negative breast cancer cells and Co-activates the TGF-beta pathway","volume":"11","author":"Zhang","year":"2021","journal-title":"Front Oncol."},{"key":"10.1016\/j.jbc.2025.108368_bib41","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/embor.2008.151","article-title":"Chondroitin sulphate-modified neuropilin 1 is expressed in human tumour cells and modulates 3D invasion in the U87MG human glioblastoma cell line through a p130Cas-mediated pathway","volume":"9","author":"Frankel","year":"2008","journal-title":"EMBO Rep."},{"key":"10.1016\/j.jbc.2025.108368_bib42","doi-asserted-by":"crossref","first-page":"6277","DOI":"10.1158\/1078-0432.CCR-08-0482","article-title":"A\u00a0phase I-II study of combined blockade of the ErbB receptor network with trastuzumab and gefitinib in patients with HER2 (ErbB2)-overexpressing metastatic breast cancer","volume":"14","author":"Arteaga","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jbc.2025.108368_bib43","doi-asserted-by":"crossref","first-page":"4394","DOI":"10.1002\/smll.201500878","article-title":"Tracking and finding slow-proliferating\/quiescent cancer stem cells with fluorescent nanodiamonds","volume":"11","author":"Lin","year":"2015","journal-title":"Small"},{"key":"10.1016\/j.jbc.2025.108368_bib44","first-page":"13.20.1","article-title":"Byonic: advanced peptide and protein identification software","volume":"13","author":"Bern","year":"2012","journal-title":"Curr. Protoc. Bioinformatics"},{"key":"10.1016\/j.jbc.2025.108368_bib45","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/BF01049915","article-title":"A\u00a0systematic nomenclature for carbohydrate fragmentations in FAB-MS\/MS spectra of glycoconjugates","volume":"5","author":"Domon","year":"1988","journal-title":"Glycoconjugate J."},{"key":"10.1016\/j.jbc.2025.108368_bib46","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.2527\/2001.7961502x","article-title":"Effect of postmortem storage on mu-calpain and m-calpain in ovine skeletal muscle","volume":"79","author":"Veiseth","year":"2001","journal-title":"J.\u00a0Anim. Sci."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925825002170?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925825002170?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T03:16:59Z","timestamp":1747106219000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925825002170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S0021925825002170"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2025.108368","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ST3GAL1 regulates cancer cell migration through crosstalk between EGFR and neuropilin-1 signaling","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2025.108368","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology\u00e9","name":"copyright","label":"Copyright"}],"article-number":"108368"}}