{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T03:51:19Z","timestamp":1778989879754,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:00:00Z","timestamp":1740614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007709","name":"Michigan State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007709","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.jbc.2025.108370","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T11:09:33Z","timestamp":1740740973000},"page":"108370","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Upregulation of the interferon-inducible antiviral gene RSAD2 in neuroendocrine prostate cancer via PVT1 exon 9 dependent and independent pathways"],"prefix":"10.1016","volume":"301","author":[{"given":"Rachel E.","family":"Bonacci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meghan","family":"McGill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nu Thuy Anh","family":"Le","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murtaza","family":"Barkarar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin","family":"Finnegan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oluwabusola","family":"Ajagbe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chinedum C.","family":"Udekwu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6277-9691","authenticated-orcid":false,"given":"Kathryn","family":"Gorski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyothi","family":"Manohar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6915-3070","authenticated-orcid":false,"given":"Andrea","family":"Sboner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olorunseun O.","family":"Ogunwobi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2025.108370_bib1","first-page":"11384","article-title":"Increasing aggressive prostate cancer","volume":"29","author":"Shah","year":"2022","journal-title":"Can. J. Urol."},{"key":"10.1016\/j.jbc.2025.108370_bib2","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1158\/1078-0432.CCR-13-3309","article-title":"Aggressive variants of castration-resistant prostate cancer","volume":"20","author":"Beltran","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.jbc.2025.108370_bib3","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s11658-022-00385-x","article-title":"lncRNA PVT1: a novel oncogene in multiple cancers","volume":"27","author":"Li","year":"2022","journal-title":"Cell Mol. Biol. Lett."},{"key":"10.1016\/j.jbc.2025.108370_bib4","doi-asserted-by":"crossref","first-page":"5418","DOI":"10.12659\/MSM.917601","article-title":"PVT1 promotes angiogenesis by regulating miR-29c\/vascular endothelial growth factor (VEGF) signaling pathway in non-small-cell lung cancer (NSCLC)","volume":"25","author":"Mao","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.jbc.2025.108370_bib5","doi-asserted-by":"crossref","DOI":"10.1177\/1533033820971610","article-title":"PVT1 expression is a predictor for poor survival of prostate cancer patients","volume":"20","author":"Liu","year":"2021","journal-title":"Technol. Cancer Res. Treat"},{"key":"10.1016\/j.jbc.2025.108370_bib6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3389\/fonc.2020.00017","article-title":"Oncogenic role of PVT1 andTherapeutic Implications","volume":"10","author":"Onagoruwa","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.jbc.2025.108370_bib7","doi-asserted-by":"crossref","first-page":"964","DOI":"10.3390\/genes10120964","article-title":"Long noncoding RNA from PVT1 exon 9 is overexpressed in prostate cancer and induces malignant Transformation and castration resistance in prostate epithelial cells","volume":"10","author":"Pal","year":"2019","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.jbc.2025.108370_bib8","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.3390\/v14112587","article-title":"RSAD2 is an effective target for high-yield vaccine production in MDCK cells","volume":"14","author":"Qiao","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.jbc.2025.108370_bib9","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1039\/C7MT00341B","article-title":"A unifying view of the broad-spectrum antiviral activity of RSAD2 (viperin) based on its radical-SAM chemistry","volume":"10","author":"Honarmand Ebrahimi","year":"2018","journal-title":"Metallomics."},{"key":"10.1016\/j.jbc.2025.108370_bib10","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev-virology-011720-095930","article-title":"Viperin reveals its true function","volume":"7","author":"Rivera-Serrano","year":"2020","journal-title":"Annu. Rev. Virol."},{"key":"10.1016\/j.jbc.2025.108370_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003497","article-title":"Viperin regulates cellular lipid metabolism during human cytomegalovirus infection","volume":"9","author":"Seo","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2025.108370_bib12","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1172\/JCI63120","article-title":"Viperin restricts chikungunya virus replication and pathology","volume":"122","author":"Teng","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jbc.2025.108370_bib13","first-page":"115","article-title":"RSAD2 suppresses viral replication by interacting with the Senecavirus A 2 C protein","volume":"55","author":"Hou","year":"2024","journal-title":"VetRes"},{"key":"10.1016\/j.jbc.2025.108370_bib14","doi-asserted-by":"crossref","first-page":"15125","DOI":"10.1073\/pnas.011593298","article-title":"Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus","volume":"98","author":"Chin","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.jbc.2025.108370_bib15","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.3389\/fimmu.2019.02810","article-title":"The interaction mechanism between herpes simplex virus 1 glycoprotein D and host antiviral protein viperin","volume":"10","author":"Li","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jbc.2025.108370_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph13010012","article-title":"PVT1 exon 9: a potential biomarker of aggressive prostate cancer?","volume":"13","author":"Ilboudo","year":"2015","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.jbc.2025.108370_bib17","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3390\/cells8060618","article-title":"Fibronectin regulation of integrin B1 and SLUG in circulating tumor cells","volume":"8","author":"Huaman","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jbc.2025.108370_bib18","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.bbrc.2018.04.219","article-title":"Long noncoding RNA PVT1 inhibits interferon-\u03b1 mediated therapy for hepatocellular carcinoma cells by interacting with signal transducer and activator of transcription 1","volume":"500","author":"Ding","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jbc.2025.108370_bib19","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14566","article-title":"PVT1 promotes proliferation and macrophage immunosuppressive polarization through STAT1 and CX3CL1 regulation in glioblastoma multiforme","volume":"30","author":"Huang","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.jbc.2025.108370_bib20","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s40364-020-00228-x","article-title":"Roles of IFN-\u03b3 in tumor progression and regression: a review","volume":"8","author":"Jorgovanovic","year":"2020","journal-title":"Biomark Res."},{"key":"10.1016\/j.jbc.2025.108370_bib21","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/s41419-018-0889-y","article-title":"Rsad2 is necessary for mouse dendritic cell maturation via the IRF7-mediated signaling pathway","volume":"9","author":"Jang","year":"2018","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jbc.2025.108370_bib22","doi-asserted-by":"crossref","first-page":"38898","DOI":"10.1074\/jbc.C500324200","article-title":"Interaction between the androgen receptor and RNase L mediates a cross-talk between the interferon and androgen signaling pathways","volume":"280","author":"Bettoun","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.108370_bib23","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1038\/sj.onc.1209304","article-title":"Choubey D. Androgen receptor levels are increased by interferons in human prostate stromal and epithelial cells","volume":"25","author":"Basrawala","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.jbc.2025.108370_bib24","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12964-020-00691-x","article-title":"PVT1 signals an androgen-dependent transcriptional repression program in prostate cancer cells and a set of the repressed genes predicts high-risk tumors","volume":"19","author":"Videira","year":"2021","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.jbc.2025.108370_bib25","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1056\/NEJMoa1903835","article-title":"ENZAMET trial investigators and the Australian and New Zealand urogenital and prostate cancer trials group. Enzalutamide with standard first-line therapy in metastatic prostate cancer","volume":"381","author":"Davis","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jbc.2025.108370_bib26","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s40262-015-0271-5","article-title":"Clinical pharmacokinetic studies of enzalutamide","volume":"54","author":"Gibbons","year":"2015","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.jbc.2025.108370_bib27","first-page":"153","article-title":"A profile of enzalutamide for the treatment of advanced castration resistant prostate cancer","volume":"7","author":"Greasley","year":"2015","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.jbc.2025.108370_bib28","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.62347\/RGJO6884","article-title":"RSAD2, a pyroptosisrelated gene, predicts the prognosis and immunotherapy response for colorectal cancer","volume":"14","author":"Li","year":"2024","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.jbc.2025.108370_bib29","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.canlet.2022.01.028","article-title":"Racial disparities in prostate cancer: a complex interplay between socioeconomic inequities and genomics","volume":"531","author":"Lowder","year":"2022","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jbc.2025.108370_bib30","doi-asserted-by":"crossref","first-page":"217","DOI":"10.5534\/wjmh.210070","article-title":"Racial differences in prostate cancer characteristics and cancer-specific mortality: an overview","volume":"40","author":"Hinata","year":"2022","journal-title":"World J. Mens Health"},{"key":"10.1016\/j.jbc.2025.108370_bib31","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nm.4045","article-title":"Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer","volume":"22","author":"Beltran","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.jbc.2025.108370_bib32","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.celrep.2014.03.034","article-title":"Structure, mechanism, and specificity of a eukaryal tRNA restriction enzyme involved in self-nonself discrimination","volume":"7","author":"Chakravarty","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2025.108370_bib33","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1001\/jamaoncol.2015.1313","article-title":"Whole-exome sequencing of metastatic cancer and biomarkers of treatment response","volume":"1","author":"Beltran","year":"2015","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.jbc.2025.108370_bib34","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jbc.2025.108370_bib35","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"1000 genome project data processing subgroup. The sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jbc.2025.108370_bib36","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nprot.2012.016","article-title":"Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks","volume":"7","author":"Trapnell","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jbc.2025.108370_bib37","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1101\/gr.132159.111","article-title":"The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression","volume":"22","author":"Derrien","year":"2012","journal-title":"Genome Res."},{"key":"10.1016\/j.jbc.2025.108370_bib38","doi-asserted-by":"crossref","first-page":"11667","DOI":"10.1073\/pnas.0904715106","article-title":"Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression","volume":"106","author":"Khalil","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.jbc.2025.108370_bib39","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.cell.2007.05.022","article-title":"Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs","volume":"129","author":"Rinn","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.108370_bib40","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1038\/nprot.2006.339","article-title":"Clonogenic assay of cells in vitro","volume":"1","author":"Franken","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jbc.2025.108370_bib41","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1158\/1078-0432.CCR-21-4289","article-title":"Implications for intrinsic phenotype classification of metastatic castration-resistant prostate cancer","volume":"28","author":"Coleman","year":"2022","journal-title":"Clin. Cancer Res."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925825002194?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925825002194?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T16:53:12Z","timestamp":1762188792000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925825002194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S0021925825002194"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2025.108370","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Upregulation of the interferon-inducible antiviral gene RSAD2 in neuroendocrine prostate cancer via PVT1 exon 9 dependent and independent pathways","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2025.108370","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology\u00e9","name":"copyright","label":"Copyright"}],"article-number":"108370"}}