{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T08:26:35Z","timestamp":1784795195029,"version":"3.55.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22H02658"],"award-info":[{"award-number":["JP22H02658"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.jbc.2025.108375","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:25:36Z","timestamp":1741047936000},"page":"108375","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ovarian tachykinin signaling system induces the growth of secondary follicles during the gonadotropin-independent process"],"prefix":"10.1016","volume":"301","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1769-5226","authenticated-orcid":false,"given":"Tsuyoshi","family":"Kawada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Aoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7794-534X","authenticated-orcid":false,"given":"Shin","family":"Matsubara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6987-9576","authenticated-orcid":false,"given":"Tomohiro","family":"Osugi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsubasa","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9248-9442","authenticated-orcid":false,"given":"Shinji","family":"Kirimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satsuki","family":"Nakaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Sugiura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1165-3624","authenticated-orcid":false,"given":"Honoo","family":"Satake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2025.108375_bib1","first-page":"200","article-title":"Initial and cyclic recruitment of ovarian follicles","volume":"21","author":"McGee","year":"2000","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.jbc.2025.108375_bib2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1757-2215-2-9","article-title":"Oocyte-granulosa-theca cell interactions during preantral follicular development","volume":"2","author":"Orisaka","year":"2009","journal-title":"J.\u00a0Ovarian Res."},{"key":"10.1016\/j.jbc.2025.108375_bib3","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1210\/en.2018-00485","article-title":"Coordination of ovulation and oocyte maturation: a good egg at the right time","volume":"159","author":"Robker","year":"2018","journal-title":"Endocrinology"},{"key":"10.1016\/j.jbc.2025.108375_bib4","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1210\/er.2018-00075","article-title":"Ovulation: parallels with inflammatory processes","volume":"40","author":"Duffy","year":"2019","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.jbc.2025.108375_bib5","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/rmb2.12371","article-title":"The role of pituitary gonadotropins and intraovarian regulators in follicle development: a mini-review","volume":"20","author":"Orisaka","year":"2021","journal-title":"Reprod. Med. Biol."},{"key":"10.1016\/j.jbc.2025.108375_bib6","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1093\/humupd\/dmv059","article-title":"GnRH and GnRH receptors in the pathophysiology of the human female reproductive system","volume":"22","author":"Maggi","year":"2016","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.jbc.2025.108375_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.925206","article-title":"The role of kisspeptin in the control of the hypothalamic-pituitary-gonadal Axis and reproduction","volume":"13","author":"Xie","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.jbc.2025.108375_bib8","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1530\/rep.1.01074","article-title":"TGF-beta superfamily members and ovarian follicle development","volume":"132","author":"Knight","year":"2006","journal-title":"Reproduction"},{"key":"10.1016\/j.jbc.2025.108375_bib9","doi-asserted-by":"crossref","DOI":"10.1100\/2012\/938138","article-title":"Biology and biotechnology of follicle development","volume":"2012","author":"Palma","year":"2012","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.jbc.2025.108375_bib10","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1262\/jrd.2014-107","article-title":"Regulation of secondary follicle growth by theca cells and insulin-like growth factor 1","volume":"61","author":"Shiomi-Sugaya","year":"2015","journal-title":"J.\u00a0Reprod. Dev."},{"key":"10.1016\/j.jbc.2025.108375_bib11","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/bs.vh.2017.12.003","article-title":"Molecular aspects and clinical relevance of GDF9 and BMP15 in ovarian function","volume":"107","author":"Belli","year":"2018","journal-title":"Vitam Horm."},{"key":"10.1016\/j.jbc.2025.108375_bib12","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.2174\/0929867043364748","article-title":"Tachykinins and tachykinin receptors: structure and activity relationships","volume":"11","author":"Almeida","year":"2004","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.jbc.2025.108375_bib13","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1152\/physrev.00031.2013","article-title":"Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease","volume":"94","author":"Steinhoff","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jbc.2025.108375_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1056939","article-title":"Tachykinins, new players in the control of reproduction and food intake: a comparative review in mammals and teleosts","volume":"13","author":"Campo","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.jbc.2025.108375_bib15","doi-asserted-by":"crossref","first-page":"963","DOI":"10.2174\/138945006778019273","article-title":"Overview of the primary structure, tissue-distribution, and functions of tachykinins and their receptors","volume":"7","author":"Satake","year":"2006","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.jbc.2025.108375_bib16","doi-asserted-by":"crossref","first-page":"615","DOI":"10.2174\/0929866511320060002","article-title":"Insight into molecular and functional diversity of tachykinins and their receptors","volume":"20","author":"Satake","year":"2013","journal-title":"Protein Pept. Lett."},{"key":"10.1016\/j.jbc.2025.108375_bib17","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.3389\/fnins.2019.01262","article-title":"Tachykinins: neuropeptides that are ancient, diverse, widespread and functionally pleiotropic","volume":"13","author":"N\u00e4ssel","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.jbc.2025.108375_bib18","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1016\/j.peptides.2011.07.009","article-title":"Tachykinins and the hypothalamo-pituitary-gonadal axis: an update","volume":"32","author":"Lasaga","year":"2011","journal-title":"Peptides"},{"key":"10.1016\/j.jbc.2025.108375_bib19","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1210\/en.2014-2012","article-title":"Substance p regulates puberty onset and fertility in the female mouse","volume":"156","author":"Simavli","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.jbc.2025.108375_bib20","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.lfs.2004.10.004","article-title":"Tachykinins and tachykinin receptors: effects in the genitourinary tract","volume":"76","author":"Candenas","year":"2005","journal-title":"Life Sci."},{"key":"10.1016\/j.jbc.2025.108375_bib21","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1093\/humrep\/dem069","article-title":"A\u00a0role for tachykinins in the regulation of human sperm motility","volume":"22","author":"Ravina","year":"2007","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jbc.2025.108375_bib22","doi-asserted-by":"crossref","first-page":"53798","DOI":"10.1074\/jbc.M408161200","article-title":"Tachykinin and tachykinin receptor of an ascidian, Ciona intestinalis: evolutionary origin of the vertebrate tachykinin family","volume":"279","author":"Satake","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jbc.2025.108375_bib23","doi-asserted-by":"crossref","first-page":"4346","DOI":"10.1210\/en.2008-0323","article-title":"A\u00a0novel biological role of tachykinins as an up-regulator of oocyte growth: identification of an evolutionary origin of tachykininergic functions in the ovary of the ascidian, Ciona intestinalis","volume":"149","author":"Aoyama","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.jbc.2025.108375_bib24","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.peptides.2011.07.019","article-title":"Localization and enzymatic activity profiles of the proteases responsible for tachykinin-directed oocyte growth in the protochordate, Ciona intestinalis","volume":"34","author":"Aoyama","year":"2012","journal-title":"Peptides"},{"key":"10.1016\/j.jbc.2025.108375_bib25","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1095\/biolreprod.103.017111","article-title":"A\u00a0role for tachykinins in female mouse and rat reproductive function","volume":"69","author":"Pintado","year":"2003","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jbc.2025.108375_bib26","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1093\/humrep\/deu247","article-title":"Expression of neurokinin B\/NK3 receptor and kisspeptin\/KISS1 receptor in human granulosa cells","volume":"29","author":"Garc\u00eda-Ortega","year":"2014","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jbc.2025.108375_bib27","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1095\/biolreprod.116.139881","article-title":"Expression of tachykinins and tachykinin receptors and interaction with kisspeptin in human granulosa and cumulus cells","volume":"94","author":"Garc\u00eda-Ortega","year":"2016","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jbc.2025.108375_bib28","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1210\/en.2019-00195","article-title":"Characterization of the role of NKA in the control of puberty onset and gonadotropin release in the female mouse","volume":"160","author":"Le\u00f3n","year":"2019","journal-title":"Endocrinology"},{"key":"10.1016\/j.jbc.2025.108375_bib29","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1159\/000509222","article-title":"Tachykinin signaling is required for induction of the preovulatory luteinizing hormone surge and normal luteinizing hormone pulses","volume":"111","author":"Le\u00f3n","year":"2021","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.jbc.2025.108375_bib30","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1152\/physrev.1999.79.4.1193","article-title":"Prostanoid receptors: structures, properties, and functions","volume":"79","author":"Narumiya","year":"1999","journal-title":"Physiol. Rev."},{"issue":"Suppl 1","key":"10.1016\/j.jbc.2025.108375_bib31","first-page":"65","article-title":"A\u00a0postgenomic integrated view of prostaglandins in reproduction: implications for other body systems","volume":"59","author":"Fortier","year":"2008","journal-title":"J.\u00a0Physiol. Pharmacol."},{"key":"10.1016\/j.jbc.2025.108375_bib32","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0090-6980(02)00025-4","article-title":"The enzymology of prostaglandin endoperoxide H synthases-1 and -2","volume":"68-69","author":"Smith","year":"2002","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1016\/j.jbc.2025.108375_bib33","doi-asserted-by":"crossref","first-page":"6265","DOI":"10.4049\/jimmunol.1001739","article-title":"Substance P upregulates cyclooxygenase-2 and prostaglandin E metabolite by activating ERK1\/2 and NF-kappaB in a mouse model of burn-induced remote acute lung injury","volume":"185","author":"Sio","year":"2010","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jbc.2025.108375_bib34","doi-asserted-by":"crossref","first-page":"5050","DOI":"10.4049\/jimmunol.176.8.5050","article-title":"Substance P stimulates cyclooxygenase-2 and prostaglandin E2 expression through JAK-STAT activation in human colonic epithelial cells","volume":"176","author":"Koon","year":"2006","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jbc.2025.108375_bib35","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1477-7827-2-78","article-title":"The role of transforming growth factor-beta (TGF-beta) during ovarian follicular development in sheep","volume":"2","author":"Juengel","year":"2004","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.jbc.2025.108375_bib36","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1530\/REP-08-0538","article-title":"Temporal regulation of BMP2, BMP6, BMP15, GDF9, BMPR1A, BMPR1B, BMPR2 and TGFBR1 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig","volume":"138","author":"Paradis","year":"2009","journal-title":"Reproduction"},{"key":"10.1016\/j.jbc.2025.108375_bib37","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1477-7827-9-159","article-title":"Co-culturing of follicles with interstitial cells in collagen gel reproduce follicular development accompanied with theca cell layer formation","volume":"9","author":"Itami","year":"2011","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.jbc.2025.108375_bib38","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.peptides.2005.08.002","article-title":"Tachykinins and ovarian function in mammals","volume":"27","author":"Debeljuk","year":"2006","journal-title":"Peptides"},{"key":"10.1016\/j.jbc.2025.108375_bib39","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/jb\/mvu081","article-title":"Roles of prostaglandin receptors in female reproduction","volume":"157","author":"Sugimoto","year":"2015","journal-title":"J.\u00a0Biochem."},{"key":"10.1016\/j.jbc.2025.108375_bib40","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s12079-020-00585-0","article-title":"A\u00a0review of prostanoid receptors: expression, characterization, regulation, and mechanism of action","volume":"15","author":"Biringer","year":"2021","journal-title":"J.\u00a0Cell Commun. Signal."},{"key":"10.1016\/j.jbc.2025.108375_bib41","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12958-018-0359-5","article-title":"Prostaglandin E2 involvement in mammalian female fertility: ovulation, fertilization, embryo development and early implantation","volume":"16","author":"Niringiyumukiza","year":"2018","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.jbc.2025.108375_bib42","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0303-7207(02)00056-4","article-title":"Regulation of progesterone and prostaglandin F2alpha production in the CL","volume":"191","author":"Diaz","year":"2002","journal-title":"Mol. Cell Endocrinol."},{"key":"10.1016\/j.jbc.2025.108375_bib43","first-page":"6562","article-title":"Exogenous hydrogen sulfide promotes hepatocellular carcinoma cell growth by activating the STAT3-COX-2 signaling pathway","volume":"15","author":"Zhen","year":"2018","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.jbc.2025.108375_bib44","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.49062","article-title":"The regulation of oocyte maturation and ovulation in the closest sister group of vertebrates","volume":"8","author":"Matsubara","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.jbc.2025.108375_bib45","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-90295-3","article-title":"Cionin, a vertebrate cholecystokinin\/gastrin homolog, induces ovulation in the ascidian Ciona intestinalis type A","volume":"11","author":"Osugi","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2025.108375_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.668564","article-title":"Vasopressin promoter transgenic and vasopressin gene-edited ascidian","volume":"12","author":"Kawada","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.jbc.2025.108375_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.ygcen.2023.114262","article-title":"Kobayashi Award 2021: neuropeptides, receptors, and follicle development in the ascidian, Ciona intestinalis Type A: new clues to the evolution of chordate neuropeptidergic systems from biological niches","volume":"337","author":"Satake","year":"2023","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.jbc.2025.108375_bib48","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1051\/rnd:2005019","article-title":"Particularities of reproduction and oogenesis in teleost fish compared to mammals","volume":"45","author":"Jalabert","year":"2005","journal-title":"Reprod. Nutr. Dev."},{"key":"10.1016\/j.jbc.2025.108375_bib49","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ygcen.2005.12.007","article-title":"Role of cathepsins in ovarian follicle growth and maturation","volume":"146","author":"Carnevali","year":"2006","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.jbc.2025.108375_bib50","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3389\/fendo.2019.00553","article-title":"Identification of a new theca\/interstitial cell-specific gene and its biological role in growth of mouse ovarian follicles at the gonadotropin-independent stage","volume":"10","author":"Aoyama","year":"2019","journal-title":"Front. Endocrinol. (Lausanne)"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925825002248?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925825002248?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T03:17:15Z","timestamp":1747106235000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925825002248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S0021925825002248"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2025.108375","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ovarian tachykinin signaling system induces the growth of secondary follicles during the gonadotropin-independent process","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2025.108375","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology\u00e9","name":"copyright","label":"Copyright"}],"article-number":"108375"}}