{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:34:04Z","timestamp":1770834844573,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T00:00:00Z","timestamp":1745020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jbc.2025.108528","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:16:07Z","timestamp":1745435767000},"page":"108528","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["WWP1 mediates the ubiquitination and degradation of HIPK3 in bladder cancer cells"],"prefix":"10.1016","volume":"301","author":[{"given":"Haichao","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Na","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengcheng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2025.108528_bib1","first-page":"17","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer. J. Clin."},{"key":"10.1016\/j.jbc.2025.108528_bib2","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1001\/jama.2020.17598","article-title":"Bladder cancer: a review","volume":"324","author":"Lenis","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.jbc.2025.108528_bib3","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1007\/s00345-019-02984-4","article-title":"The global burden of urinary bladder cancer: an update","volume":"38","author":"Richters","year":"2020","journal-title":"World. J. Urol."},{"key":"10.1016\/j.jbc.2025.108528_bib4","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1091\/mbc.e15-09-0629","article-title":"HIPK family kinases bind and regulate the function of the CCR4-NOT complex","volume":"27","author":"Rodriguez-Gil","year":"2016","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.jbc.2025.108528_bib5","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.cub.2012.06.074","article-title":"Homeodomain-interacting protein kinase regulates Yorkie activity to promote tissue growth","volume":"22","author":"Chen","year":"2012","journal-title":"Curr. Biol."},{"key":"10.1016\/j.jbc.2025.108528_bib6","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1084\/jem.192.8.1165","article-title":"FIST\/HIPK3: a Fas\/FADD-interacting serine\/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation","volume":"192","author":"Rochat-Steiner","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jbc.2025.108528_bib7","doi-asserted-by":"crossref","first-page":"3536","DOI":"10.18632\/aging.202294","article-title":"Identification of HIPK3 as a potential biomarker and an inhibitor of clear cell renal cell carcinoma","volume":"13","author":"Xiao","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.jbc.2025.108528_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216643","article-title":"HIPK3 maintains sensitivity to platinum drugs and prevents disease progression in gastric cancer","volume":"584","author":"Wu","year":"2024","journal-title":"Cancer. Lett."},{"key":"10.1016\/j.jbc.2025.108528_bib9","doi-asserted-by":"crossref","first-page":"7459","DOI":"10.2147\/OTT.S166878","article-title":"The expression level and prognostic value of HIPK3 among non-small-cell lung cancer patients in China","volume":"11","author":"Liu","year":"2018","journal-title":"Onco. Targets. Ther."},{"key":"10.1016\/j.jbc.2025.108528_bib10","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41392-022-00966-4","article-title":"Targeted protein degradation: mechanisms, strategies and application","volume":"7","author":"Zhao","year":"2022","journal-title":"Signal Transduct Target Ther."},{"key":"10.1016\/j.jbc.2025.108528_bib11","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.biocel.2018.06.001","article-title":"Ubiquitination: friend and foe in cancer","volume":"101","author":"Mansour","year":"2018","journal-title":"Int. J. Biochem. Cell. Biol"},{"key":"10.1016\/j.jbc.2025.108528_bib12","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/nsmb.2780","article-title":"New insights into ubiquitin E3 ligase mechanism","volume":"21","author":"Berndsen","year":"2014","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.jbc.2025.108528_bib13","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.semcancer.2021.06.012","article-title":"The HECT family of E3 ubiquitin ligases and PTEN","volume":"85","author":"Song","year":"2022","journal-title":"Semin. Cancer. Biol."},{"key":"10.1016\/j.jbc.2025.108528_bib14","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/s41419-023-06380-0","article-title":"WWP1 E3 ligase at the crossroads of health and disease","volume":"14","author":"Behera","year":"2023","journal-title":"Cell. Death. Dis."},{"key":"10.1016\/j.jbc.2025.108528_bib15","first-page":"256","article-title":"High expression of WWP1 predicts poor prognosis and associates with tumor progression in human colorectal cancer","volume":"8","author":"Chen","year":"2018","journal-title":"Am. J. Cancer. Res."},{"key":"10.1016\/j.jbc.2025.108528_bib16","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1038\/onc.2009.162","article-title":"WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer","volume":"28","author":"Li","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.jbc.2025.108528_bib17","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2174\/157489209788452812","article-title":"Ras-MAPK pathway as a therapeutic target in cancer--emphasis on bladder cancer","volume":"4","author":"Dangle","year":"2009","journal-title":"Recent. Pat. Anticancer. Drug. Discov."},{"key":"10.1016\/j.jbc.2025.108528_bib18","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau0159","article-title":"Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway","volume":"364","author":"Lee","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.jbc.2025.108528_bib19","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.neuron.2018.10.008","article-title":"Polarity acquisition in cortical neurons is driven by synergistic action of Sox9-regulated Wwp1 and Wwp2 E3 ubiquitin ligases and intronic miR-140","volume":"100","author":"Ambrozkiewicz","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.jbc.2025.108528_bib20","article-title":"Exosomal miR-3174 induced by hypoxia promotes angiogenesis and metastasis of hepatocellular carcinoma by inhibiting HIPK3","volume":"27","author":"Yang","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.jbc.2025.108528_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-49694-x","article-title":"Overexpression of microRNA-205-5p promotes cholangiocarcinoma growth by reducing expression of homeodomain-interacting protein kinase 3","volume":"13","author":"Mon","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2025.108528_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2023.110635","article-title":"Exosomal miR-146b-5p derived from cancer-associated fibroblasts promotes progression of oral squamous cell carcinoma by downregulating HIPK3","volume":"106","author":"He","year":"2023","journal-title":"Cell Signal"},{"key":"10.1016\/j.jbc.2025.108528_bib23","doi-asserted-by":"crossref","first-page":"17090","DOI":"10.1074\/jbc.M307629200","article-title":"JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate carcinoma cells","volume":"279","author":"Curtin","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.108528_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1204","article-title":"The roles of E3 ubiquitin ligases in cancer progression and targeted therapy","volume":"13","author":"Sampson","year":"2023","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.jbc.2025.108528_bib25","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41418-024-01256-y","article-title":"ABLIM1, a novel ubiquitin E3 ligase, promotes growth and metastasis of colorectal cancer through targeting IkBalpha ubiquitination and activating NF-kB signaling","volume":"31","author":"He","year":"2024","journal-title":"Cell. Death. Differ."},{"key":"10.1016\/j.jbc.2025.108528_bib26","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41419-021-03521-1","article-title":"E3 ubiquitin ligase RNF126 affects bladder cancer progression through regulation of PTEN stability","volume":"12","author":"Xu","year":"2021","journal-title":"Cell. Death. Dis."},{"key":"10.1016\/j.jbc.2025.108528_bib27","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41420-021-00532-x","article-title":"The emerging role of WWP1 in cancer development and progression","volume":"7","author":"Hu","year":"2021","journal-title":"Cell. Death. Discov."},{"key":"10.1016\/j.jbc.2025.108528_bib28","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.bone.2011.12.022","article-title":"The ubiquitin E3 ligase WWP1 decreases CXCL12-mediated MDA231 breast cancer cell migration and bone metastasis","volume":"50","author":"Subik","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.jbc.2025.108528_bib29","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.biocel.2019.04.003","article-title":"A positive feedback loop of miR-30a-5p-WWP1-NF-kappaB in the regulation of glioma development","volume":"112","author":"Zhao","year":"2019","journal-title":"Int. J. Biochem. Cell Biol"},{"key":"10.1016\/j.jbc.2025.108528_bib30","doi-asserted-by":"crossref","first-page":"6845","DOI":"10.1038\/onc.2008.288","article-title":"The WW domain containing E3 ubiquitin protein ligase 1 upregulates ErbB2 and EGFR through RING finger protein 11","volume":"27","author":"Chen","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.jbc.2025.108528_bib31","doi-asserted-by":"crossref","first-page":"33447","DOI":"10.1074\/jbc.M111.225565","article-title":"WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) delays cellular senescence by promoting p27(Kip1) degradation in human diploid fibroblasts","volume":"286","author":"Cao","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.108528_bib32","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1007\/s00018-011-0871-7","article-title":"WWP1: a versatile ubiquitin E3 ligase in signaling and diseases","volume":"69","author":"Zhi","year":"2012","journal-title":"Cell. Mol. Life. Sci."},{"key":"10.1016\/j.jbc.2025.108528_bib33","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1038\/sj.onc.1209924","article-title":"Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1","volume":"26","author":"Laine","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.jbc.2025.108528_bib34","doi-asserted-by":"crossref","first-page":"4728","DOI":"10.1158\/0008-5472.CAN-10-0040","article-title":"The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation","volume":"70","author":"Zhao","year":"2010","journal-title":"Cancer. Res."},{"key":"10.1016\/j.jbc.2025.108528_bib35","doi-asserted-by":"crossref","first-page":"963","DOI":"10.2147\/OTT.S374908","article-title":"Role of the JNK pathway in bladder cancer","volume":"15","author":"Lee","year":"2022","journal-title":"Onco. Targets. Ther."},{"key":"10.1016\/j.jbc.2025.108528_bib36","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1038\/s41467-021-22638-7","article-title":"DUSP16 promotes cancer chemoresistance through regulation of mitochondria-mediated cell death","volume":"12","author":"Low","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.108528_bib37","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/s10753-020-01200-5","article-title":"HIPK3 mediates Inflammatory cytokines and oxidative stress markers in monocytes in a rat model of sepsis through the JNK\/c-Jun signaling pathway","volume":"43","author":"Liu","year":"2020","journal-title":"Inflammation"},{"key":"10.1016\/j.jbc.2025.108528_bib38","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s12672-024-01173-z","article-title":"The roles of FGFR3 and c-MYC in urothelial bladder cancer","volume":"15","author":"Bogale","year":"2024","journal-title":"Discov. Oncol."},{"key":"10.1016\/j.jbc.2025.108528_bib39","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13046-016-0312-4","article-title":"Anti-tumor effects of Atractylenolide I on bladder cancer cells","volume":"35","author":"Yu","year":"2016","journal-title":"J. Exp. Clin. Cancer. Res."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925825003771?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925825003771?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T16:54:31Z","timestamp":1762188871000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925825003771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S0021925825003771"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2025.108528","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"WWP1 mediates the ubiquitination and degradation of HIPK3 in bladder cancer cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2025.108528","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology\u00e9","name":"copyright","label":"Copyright"}],"article-number":"108528"}}