{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T06:46:49Z","timestamp":1769755609324,"version":"3.49.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Scientific Research Program of Higher Education Institutions in Anhui Province","award":["2024AH051248"],"award-info":[{"award-number":["2024AH051248"]}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jbc.2025.110321","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T15:51:13Z","timestamp":1748620273000},"page":"110321","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Molecular insights into chemotherapy resistance mediated by MLL-AF9 fusion gene in pediatric B-cell acute lymphoblastic leukemia"],"prefix":"10.1016","volume":"301","author":[{"given":"Xu","family":"Sang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanchun","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengying","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wansheng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2025.110321_bib1","article-title":"Evolving horizons in pediatric leukemia: novel insights, challenges, and the journey ahead","volume":"16","author":"Tito Rodriguez","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/j.jbc.2025.110321_bib2","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.3390\/biomedicines12081766","article-title":"Genetic and epigenetic biomarkers associated with early relapse in pediatric acute lymphoblastic leukemia: a focused bioinformatics study on DNA-repair genes","volume":"12","author":"Albaqami","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.jbc.2025.110321_bib3","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.3390\/ijms21093233","article-title":"Mechanisms of multidrug resistance in cancer chemotherapy","volume":"21","author":"Bukowski","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbc.2025.110321_bib4","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.3390\/biomedicines12081915","article-title":"The role of epithelial-to-mesenchymal transition transcription factors (EMT-TFs) in acute myeloid leukemia progression","volume":"12","author":"Cuevas","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.jbc.2025.110321_bib5","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/leu.2017.213","article-title":"The MLL recombinome of acute leukemias in 2017","volume":"32","author":"Meyer","year":"2018","journal-title":"Leukemia"},{"key":"10.1016\/j.jbc.2025.110321_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagrm.2020.194584","article-title":"Novel therapeutic strategies for MLL-rearranged leukemias","volume":"1863","author":"Wong","year":"2020","journal-title":"Biochim. Biophys. Acta Gene Regul. Mech."},{"key":"10.1016\/j.jbc.2025.110321_bib7","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.ccr.2008.04.020","article-title":"Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia","volume":"13","author":"Wei","year":"2008","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jbc.2025.110321_bib8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1476-4598-13-27","article-title":"RNAi-mediated silencing of MLL-AF9 reveals leukemia-associated downstream targets and processes","volume":"13","author":"Fleischmann","year":"2014","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jbc.2025.110321_bib9","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1158\/2159-8290.CD-19-1469","article-title":"Leukemia cell of origin influences apoptotic priming and sensitivity to LSD1 inhibition","volume":"10","author":"Cai","year":"2020","journal-title":"Cancer Discov."},{"key":"10.1016\/j.jbc.2025.110321_bib10","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1038\/s41418-018-0209-1","article-title":"Impact of elevated anti-apoptotic MCL-1 and BCL-2 on the development and treatment of MLL-AF9 AML in mice","volume":"26","author":"Anstee","year":"2019","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jbc.2025.110321_bib11","first-page":"685","article-title":"Pharmacogenetics of ATP-binding cassette transporters in cancer and chemotherapy","volume":"2","author":"Lockhart","year":"2003","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.jbc.2025.110321_bib12","doi-asserted-by":"crossref","first-page":"253","DOI":"10.20892\/j.issn.2095-3941.2019.0284","article-title":"ABC transporters and the hallmarks of cancer: roles in cancer aggressiveness beyond multidrug resistance","volume":"17","author":"Muriithi","year":"2020","journal-title":"Cancer Biol. Med."},{"key":"10.1016\/j.jbc.2025.110321_bib13","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1159\/000493815","article-title":"KU70 inhibition impairs both non-homologous end joining and homologous recombination DNA damage repair through SHP-1 induced dephosphorylation of SIRT1 in T-cell acute lymphoblastic leukemia (T-ALL) [corrected]","volume":"49","author":"Yu","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"10.1016\/j.jbc.2025.110321_bib14","first-page":"2152","article-title":"Checkpoint kinase-1 inhibition and etoposide exhibit a strong synergistic anticancer effect on chronic myeloid leukemia cell line K562 by impairing homologous recombination DNA damage repair","volume":"44","author":"Fan","year":"2020","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.jbc.2025.110321_bib15","doi-asserted-by":"crossref","first-page":"6368","DOI":"10.1182\/bloodadvances.2020002812","article-title":"IGFBP7 activates retinoid acid-induced responses in acute myeloid leukemia stem and progenitor cells","volume":"4","author":"van Gils","year":"2020","journal-title":"Blood Adv."},{"key":"10.1016\/j.jbc.2025.110321_bib16","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.bbrc.2018.02.013","article-title":"The pathogenic role of MEF2D-SS18 fusion gene in B-cell acute lymphoblastic leukemia","volume":"496","author":"Zhang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jbc.2025.110321_bib17","doi-asserted-by":"crossref","DOI":"10.1093\/narcan\/zcac041","article-title":"A convergent malignant phenotype in B-cell acute lymphoblastic leukemia involving the splicing factor SRRM1","volume":"4","author":"Closa","year":"2022","journal-title":"NAR Cancer"},{"key":"10.1016\/j.jbc.2025.110321_bib18","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1186\/s12885-017-3368-4","article-title":"First case of B ALL with KMT2A-MAML2 rearrangement: a case report","volume":"17","author":"Menu","year":"2017","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jbc.2025.110321_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.gde.2022.101920","article-title":"Polycomb complexes in MLL-AF9-related leukemias","volume":"75","author":"Sparavier","year":"2022","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.jbc.2025.110321_bib20","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1101\/gad.327593.119","article-title":"Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia","volume":"33","author":"Hurtz","year":"2019","journal-title":"Genes Dev."},{"key":"10.1016\/j.jbc.2025.110321_bib21","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1186\/s12885-017-3345-y","article-title":"XLF-mediated NHEJ activity in hepatocellular carcinoma therapy resistance","volume":"17","author":"Yang","year":"2017","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jbc.2025.110321_bib22","doi-asserted-by":"crossref","first-page":"13848","DOI":"10.3390\/molecules190913848","article-title":"Tyrosine kinase inhibitors as reversal agents for ABC transporter mediated drug resistance","volume":"19","author":"Anreddy","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.jbc.2025.110321_bib23","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1182\/bloodadvances.2017006247","article-title":"MLL-AF9 leukemias are sensitive to PARP1 inhibitors combined with cytotoxic drugs","volume":"1","author":"Maifrede","year":"2017","journal-title":"Blood Adv."},{"key":"10.1016\/j.jbc.2025.110321_bib24","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1182\/blood.V114.22.10.10","article-title":"Role of Survivin in drug resistant B-cell acute lymphoblastic leukemia","volume":"114","author":"Park","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.jbc.2025.110321_bib25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF01757343","article-title":"High expression of bcl-2 is the rule in acute lymphoblastic leukemia, except in Burkitt subtype at presentation, and is not correlated with the prognosis","volume":"69","author":"Gala","year":"1994","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.jbc.2025.110321_bib26","first-page":"6","article-title":"FLT3 gene involvement in B-cell acute lymphoblastic leukemia (B-ALL)","volume":"47","author":"Okabe","year":"2021","journal-title":"J. Assoc. Genet. Technol."},{"key":"10.1016\/j.jbc.2025.110321_bib27","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/pbc.24273","article-title":"Doxorubicin or daunorubicin given upfront in a therapeutic window are equally effective in children with newly diagnosed acute lymphoblastic leukemia. A randomized comparison in trial CoALL 07-03","volume":"60","author":"Escherich","year":"2013","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.jbc.2025.110321_bib28","article-title":"Cyclophosphamide for the treatment of acute lymphoblastic leukemia: a protocol for systematic review","volume":"98","author":"Zhao","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jbc.2025.110321_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112140","article-title":"Metformin dampens cisplatin cytotoxicity on leukemia cells after incorporation into cubosomal nanoformulation","volume":"143","author":"Saber","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jbc.2025.110321_bib30","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/s12967-018-1620-6","article-title":"Effect of metformin on the survival of patients with ALL who express high levels of the ABCB1 drug resistance gene","volume":"16","author":"Ramos-Penafiel","year":"2018","journal-title":"J. Transl Med."},{"key":"10.1016\/j.jbc.2025.110321_bib31","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1038\/s41467-019-10495-4","article-title":"ABCB1 protects bat cells from DNA damage induced by genotoxic compounds","volume":"10","author":"Koh","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.110321_bib32","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.biopha.2017.08.022","article-title":"Inhibition of DNA-PK enhances chemosensitivity of B-cell precursor acute lymphoblastic leukemia cells to doxorubicin","volume":"94","author":"Alikarami","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jbc.2025.110321_bib33","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.abb.2009.09.012","article-title":"P-glycoprotein (ABCB1) modulates collateral sensitivity of a multidrug resistant cell line to verapamil","volume":"491","author":"Laberge","year":"2009","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.jbc.2025.110321_bib34","first-page":"912","article-title":"Inactivation of DNA-PK by knockdown DNA-PKcs or NU7441 impairs non-homologous end-joining of radiation-induced double strand break repair","volume":"39","author":"Dong","year":"2018","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.jbc.2025.110321_bib35","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1182\/bloodadvances.2021006393","article-title":"Real-world use of tisagenlecleucel in infant acute lymphoblastic leukemia","volume":"6","author":"Moskop","year":"2022","journal-title":"Blood Adv."},{"key":"10.1016\/j.jbc.2025.110321_bib36","doi-asserted-by":"crossref","first-page":"448","DOI":"10.3892\/ol.2020.11583","article-title":"Pathogenesis of pediatric B-cell acute lymphoblastic leukemia: molecular pathways and disease treatments","volume":"20","author":"Huang","year":"2020","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.jbc.2025.110321_bib37","article-title":"Identification of hub genes and molecular mechanisms in infant acute lymphoblastic leukemia with MLL gene rearrangement","volume":"7","author":"Zhang","year":"2019","journal-title":"PeerJ"},{"key":"10.1016\/j.jbc.2025.110321_bib38","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.3324\/haematol.2018.206375","article-title":"Unraveling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis","volume":"104","author":"Agraz-Doblas","year":"2019","journal-title":"Haematologica"},{"key":"10.1016\/j.jbc.2025.110321_bib39","doi-asserted-by":"crossref","first-page":"9519","DOI":"10.7150\/thno.65398","article-title":"Glycoproteome remodeling in MLL-rearranged B-cell precursor acute lymphoblastic leukemia","volume":"11","author":"Oliveira","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.jbc.2025.110321_bib40","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1186\/s12935-021-02335-7","article-title":"Characterization of a novel glucocorticoid-resistant human B-cell acute lymphoblastic leukemia cell line, with AMPK, mTOR and fatty acid synthesis pathway inhibition","volume":"21","author":"Li","year":"2021","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.jbc.2025.110321_bib41","doi-asserted-by":"crossref","first-page":"7630","DOI":"10.1038\/s41467-022-34910-5","article-title":"SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-beta signaling","volume":"13","author":"Biering","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.110321_bib42","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1126\/science.1139851","article-title":"Modeling the initiation and progression of human acute leukemia in mice","volume":"316","author":"Barabe","year":"2007","journal-title":"Science"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925825021714?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925825021714?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T15:40:47Z","timestamp":1761147647000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925825021714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S0021925825021714"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2025.110321","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular insights into chemotherapy resistance mediated by MLL-AF9 fusion gene in pediatric B-cell acute lymphoblastic leukemia","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2025.110321","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology\u00e9","name":"copyright","label":"Copyright"}],"article-number":"110321"}}