{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:27:12Z","timestamp":1788827232284,"version":"build-2803163510"},"reference-count":64,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["EY027349"],"award-info":[{"award-number":["EY027349"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jbc.2025.110330","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T11:09:22Z","timestamp":1748948962000},"page":"110330","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Biosynthesis of fatty aldehydes and alcohols in the eye and their role in meibogenesis"],"prefix":"10.1016","volume":"301","author":[{"given":"Seher","family":"Yuksel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor A.","family":"Butovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2025.110330_bib1","first-page":"522","article-title":"Meibomian gland studies: comparison of steer and human lipids","volume":"20","author":"Nicolaides","year":"1981","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jbc.2025.110330_bib2","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1194\/jlr.M700237-JLR200","article-title":"Lipids of human meibum: mass-spectrometric analysis and structural elucidation","volume":"48","author":"Butovich","year":"2007","journal-title":"J. Lipid. Res."},{"key":"10.1016\/j.jbc.2025.110330_bib3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.exer.2017.06.020","article-title":"Meibomian glands, meibum, and meibogenesis","volume":"163","author":"Butovich","year":"2017","journal-title":"Exp. Eye. Res."},{"key":"10.1016\/j.jbc.2025.110330_bib4","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/BF02532567","article-title":"The monoene and other Wax alcohols of human skin surface lipid and their relation to the fatty acids of this lipid","volume":"2","author":"Nicolaides","year":"1967","journal-title":"Lipids"},{"key":"10.1016\/j.jbc.2025.110330_bib5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/BF02531461","article-title":"Diester waxes in surface lipids of animal skin","volume":"5","author":"Nicolaides","year":"1970","journal-title":"Lipids"},{"key":"10.1016\/j.jbc.2025.110330_bib6","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1002\/jimd.12275","article-title":"Disturbed brain ether lipid metabolism and histology in Sjogren-Larsson syndrome","volume":"43","author":"Staps","year":"2020","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.jbc.2025.110330_bib7","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.bbalip.2013.09.001","article-title":"Fatty aldehyde and fatty alcohol metabolism: review and importance for epidermal structure and function","volume":"1841","author":"Rizzo","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbc.2025.110330_bib8","doi-asserted-by":"crossref","first-page":"23532","DOI":"10.1074\/jbc.272.38.23532","article-title":"Isolation of animal cell mutants defective in long-chain fatty aldehyde dehydrogenase. Sensitivity to fatty aldehydes and Schiff's base modification of phospholipids: implications for Sj-ogren-Larsson syndrome","volume":"272","author":"James","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110330_bib9","article-title":"Sjogren-Larsson syndrome: a biochemical rationale for using aldehyde-reactive therapeutic agents","volume":"30","author":"Rizzo","year":"2022","journal-title":"Mol. Genet. Metab. Rep."},{"key":"10.1016\/j.jbc.2025.110330_bib10","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1182\/blood.2019004316","article-title":"Genotoxic aldehydes in the hematopoietic system","volume":"139","author":"Wang","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.jbc.2025.110330_bib11","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s10038-007-0180-z","article-title":"Novel and recurrent ALDH3A2 mutations in Italian patients with Sjogren-Larsson syndrome","volume":"52","author":"Didona","year":"2007","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.jbc.2025.110330_bib12","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1080\/00207454.2020.1716750","article-title":"Compound heterozygous mutations in the ALDH3A2 gene cause Sjogren-Larsson syndrome: a case report","volume":"130","author":"Liu","year":"2020","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.jbc.2025.110330_bib13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2147\/TACG.S193969","article-title":"Sjogren-larsson syndrome: mechanisms and management","volume":"13","author":"Bindu","year":"2020","journal-title":"Appl. Clin. Genet."},{"key":"10.1016\/j.jbc.2025.110330_bib14","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ymgme.2020.08.002","article-title":"1-O-Alkylglycerol accumulation reveals abnormal ether glycerolipid metabolism in Sjogren-Larsson syndrome","volume":"131","author":"S'Aulis","year":"2020","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.jbc.2025.110330_bib15","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1007\/BF02534741","article-title":"The occurrence of long chain alpha, omega-diols in the lipids of steer and human meibomian glands","volume":"19","author":"Nicolaides","year":"1984","journal-title":"Lipids"},{"key":"10.1016\/j.jbc.2025.110330_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2022.109101","article-title":"Biochemistry of human tear film: a review","volume":"220","author":"Masoudi","year":"2022","journal-title":"Exp. Eye. Res."},{"key":"10.1016\/j.jbc.2025.110330_bib17","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1167\/iovs.10-6997d","article-title":"The international workshop on meibomian gland dysfunction: report of the subcommittee on tear film lipids and lipid-protein interactions in health and disease","volume":"52","author":"Green-Church","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jbc.2025.110330_bib18","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1167\/iovs.10-6997c","article-title":"The international workshop on meibomian gland dysfunction: report of the subcommittee on anatomy, physiology, and pathophysiology of the meibomian gland","volume":"52","author":"Knop","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jbc.2025.110330_bib19","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cbi.2008.10.040","article-title":"The SDR (short-chain dehydrogenase\/reductase and related enzymes) nomenclature initiative","volume":"178","author":"Persson","year":"2009","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jbc.2025.110330_bib20","doi-asserted-by":"crossref","first-page":"17060","DOI":"10.1074\/jbc.RA119.010835","article-title":"Mice lacking the epidermal retinol dehydrogenases SDR16C5 and SDR16C6 display accelerated hair growth and enlarged meibomian glands","volume":"294","author":"Wu","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110330_bib21","doi-asserted-by":"crossref","first-page":"7884","DOI":"10.3390\/ijms23147884","article-title":"Dynamic changes in the gene expression patterns and lipid profiles in the developing and maturing meibomian glands","volume":"23","author":"Butovich","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbc.2025.110330_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.104725","article-title":"Sdr16c5 and Sdr16c6 control a dormant pathway at a bifurcation point between meibogenesis and sebogenesis","volume":"299","author":"Butovich","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110330_bib23","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.3390\/ijms25063109","article-title":"Comparative characterization of human meibomian glands, free sebaceous glands, and hair-associated sebaceous glands based on biomarkers, analysis of secretion composition, and gland morphology","volume":"25","author":"Liu","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbc.2025.110330_bib24","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.aca.2014.08.027","article-title":"N-alkylpyridinium quaternization combined with liquid chromatography-electrospray ionization-tandem mass spectrometry: a highly sensitive method to quantify fatty alcohols in thyroid tissues","volume":"849","author":"Cao","year":"2014","journal-title":"Anal. Chim. Acta."},{"key":"10.1016\/j.jbc.2025.110330_bib25","doi-asserted-by":"crossref","first-page":"3766","DOI":"10.1167\/iovs.11-9333","article-title":"Evaluation and quantitation of intact wax esters of human meibum by gas-liquid chromatography-ion trap mass spectrometry","volume":"53","author":"Butovich","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jbc.2025.110330_bib26","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.bbalip.2016.03.024","article-title":"Dissecting lipid metabolism in meibomian glands of humans and mice: an integrative study reveals a network of metabolic reactions not duplicated in other tissues","volume":"1861","author":"Butovich","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbc.2025.110330_bib27","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jtos.2021.11.012","article-title":"Human meibomian gland epithelial cell culture models: current progress, challenges, and future directions","volume":"23","author":"Phan","year":"2022","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.jbc.2025.110330_bib28","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1167\/iovs.17-23266","article-title":"Differentiation patterns of immortalized human meibomian gland epithelial cells in three-dimensional culture","volume":"59","author":"Asano","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jbc.2025.110330_bib29","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cbi.2016.10.019","article-title":"Characterization of human short chain dehydrogenase\/reductase SDR16C family members related to retinol dehydrogenase 10","volume":"276","author":"Adams","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jbc.2025.110330_bib30","doi-asserted-by":"crossref","first-page":"9061","DOI":"10.1074\/jbc.M111.336727","article-title":"Short chain dehydrogenase\/reductase rdhe2 is a novel retinol dehydrogenase essential for frog embryonic development","volume":"287","author":"Belyaeva","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110330_bib31","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/1044-0305(91)80051-8","article-title":"Pyridine-Containing schiff base derivatives for the struxtural determination of long-chain aldehydes by gas chromatography combined with mass spectrometry","volume":"2","author":"Harvey","year":"1991","journal-title":"J. Am. Soc. Mass. Spectrom."},{"key":"10.1016\/j.jbc.2025.110330_bib32","doi-asserted-by":"crossref","first-page":"37798","DOI":"10.1074\/jbc.M406226200","article-title":"Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family","volume":"279","author":"Cheng","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110330_bib33","first-page":"2632","article-title":"Inactivation of Awat2 in mice causes loss of wax ester lipids from meibum","volume":"61","author":"McMahon","year":"2020","journal-title":"Invest .Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jbc.2025.110330_bib34","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jtos.2021.11.010","article-title":"Expression of Acyl-CoA wax-alcohol acyltransferase 2 (AWAT2) by human and rabbit meibomian glands and meibocytes","volume":"23","author":"Rho","year":"2022","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.jbc.2025.110330_bib35","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.jtos.2024.10.003","article-title":"Meibomian gland lipid alterations and ocular surface sequela in Awat2 knockout murine model of meibomian gland dysfunction and evaporative dry eye disease","volume":"34","author":"Hisey","year":"2024","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.jbc.2025.110330_bib36","doi-asserted-by":"crossref","first-page":"37789","DOI":"10.1074\/jbc.M406225200","article-title":"Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions","volume":"279","author":"Cheng","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110330_bib37","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1096\/fj.201700947R","article-title":"Very long-chain tear film lipids produced by fatty acid elongase ELOVL1 prevent dry eye disease in mice","volume":"32","author":"Sassa","year":"2018","journal-title":"FASEB J."},{"key":"10.1016\/j.jbc.2025.110330_bib38","doi-asserted-by":"crossref","first-page":"10034","DOI":"10.1096\/fj.201900725R","article-title":"On the pivotal role of Elovl3\/ELOVL3 in meibogenesis and ocular physiology of mice","volume":"33","author":"Butovich","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.jbc.2025.110330_bib39","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1167\/iovs.13-13335","article-title":"A role for ELOVL4 in the mouse meibomian gland and sebocyte cell biology","volume":"55","author":"McMahon","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jbc.2025.110330_bib40","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.jtos.2019.03.002","article-title":"Effects of sex (or lack thereof) on meibogenesis in mice (Mus musculus): comparative evaluation of lipidomes and transcriptomes of male and female tarsal plates","volume":"17","author":"Butovich","year":"2019","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.jbc.2025.110330_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0198323","article-title":"Genome wide analysis of TLR1\/2- and TLR4-activated SZ95 sebocytes reveals a complex immune-competence and identifies serum amyloid A as a marker for activated sebaceous glands","volume":"13","author":"Torocsik","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2025.110330_bib42","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.peptides.2005.05.030","article-title":"Melanocortin-5 receptor: a marker of human sebocyte differentiation","volume":"27","author":"Zhang","year":"2006","journal-title":"Peptides"},{"key":"10.1016\/j.jbc.2025.110330_bib43","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ajo.2024.10.001","article-title":"Single-cell RNA profiling of ocular adnexal sebaceous carcinoma reveals a complex tumor microenvironment and identifies new biomarkers","volume":"270","author":"Zhang","year":"2025","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.jbc.2025.110330_bib44","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12864-024-10008-8","article-title":"Skin single-cell transcriptomics reveals a core of sebaceous gland-relevant genes shared by mice and humans","volume":"25","author":"Thalheim","year":"2024","journal-title":"BMC. Genomics."},{"key":"10.1016\/j.jbc.2025.110330_bib45","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1469-8749.2007.00152.x","article-title":"Sjogren-Larsson syndrome","volume":"49","author":"Gordon","year":"2007","journal-title":"Dev. Med. Child. Neurol."},{"key":"10.1016\/j.jbc.2025.110330_bib46","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2165\/00128071-200304020-00002","article-title":"Ichthyosis: etiology, diagnosis, and management","volume":"4","author":"DiGiovanna","year":"2003","journal-title":"Am. J. Clin. Dermatol."},{"key":"10.1016\/j.jbc.2025.110330_bib47","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00403-009-1022-y","article-title":"Ichthyosis in Sjogren-Larsson syndrome reflects defective barrier function due to abnormal lamellar body structure and secretion","volume":"302","author":"Rizzo","year":"2010","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.jbc.2025.110330_bib48","doi-asserted-by":"crossref","first-page":"611","DOI":"10.2147\/OPTH.S8407","article-title":"Spontaneous corneal perforation in a patient with lamellar ichthyosis and dry eye","volume":"3","author":"Turgut","year":"2009","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.jbc.2025.110330_bib49","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.jogc.2019.06.005","article-title":"Antenatal findings of keratitis-ichthyosis-deafness syndrome","volume":"42","author":"Okmen","year":"2020","journal-title":"J. Obstet. Gynaecol. Can"},{"key":"10.1016\/j.jbc.2025.110330_bib50","doi-asserted-by":"crossref","first-page":"365","DOI":"10.4103\/0301-4738.116486","article-title":"Meibomian gland dysfunction in a case of ichthyosis follicularis with alopecia and photophobia syndrome","volume":"62","author":"Fatima","year":"2014","journal-title":"Indian. J. Ophthalmol."},{"key":"10.1016\/j.jbc.2025.110330_bib51","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.clae.2017.06.001","article-title":"Dry eye and Meibomian gland dysfunction with meibography in patients with lamellar ichthyosis","volume":"41","author":"Palamar","year":"2018","journal-title":"Cont Lens Anterior Eye."},{"key":"10.1016\/j.jbc.2025.110330_bib52","doi-asserted-by":"crossref","first-page":"6006","DOI":"10.3390\/jcm12186006","article-title":"Advanced anterior eye segment imaging for ichthyosis","volume":"12","author":"Micinska","year":"2023","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.jbc.2025.110330_bib53","doi-asserted-by":"crossref","first-page":"45537","DOI":"10.1074\/jbc.M208882200","article-title":"Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina","volume":"277","author":"Haeseleer","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110330_bib54","doi-asserted-by":"crossref","first-page":"6996","DOI":"10.1074\/jbc.RA117.001646","article-title":"Retinol dehydrogenase 11 is essential for the maintenance of retinol homeostasis in liver and testis in mice","volume":"293","author":"Belyaeva","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110330_bib55","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.cbi.2008.09.019","article-title":"Biochemical characterization of human epidermal retinol dehydrogenase 2","volume":"178","author":"Lee","year":"2009","journal-title":"Chem. Biol. Interact"},{"key":"10.1016\/j.jbc.2025.110330_bib56","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.bmc.2013.11.025","article-title":"Retinoic acid signaling pathways in development and diseases","volume":"22","author":"Das","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.jbc.2025.110330_bib57","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3390\/nu3010063","article-title":"Vitamin A metabolism: an update","volume":"3","author":"D'Ambrosio","year":"2011","journal-title":"Nutrients"},{"key":"10.1016\/j.jbc.2025.110330_bib58","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/neu.20239","article-title":"Retinoids, eye development, and maturation of visual function","volume":"66","author":"Luo","year":"2006","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.jbc.2025.110330_bib59","doi-asserted-by":"crossref","first-page":"871","DOI":"10.3390\/cells13100871","article-title":"Retinoid synthesis regulation by retinal cells in health and disease","volume":"13","author":"Andreazzoli","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.jbc.2025.110330_bib60","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1167\/iovs.61.6.8","article-title":"All-trans-Retinaldehyde contributes to retinal vascular permeability in ischemia reperfusion","volume":"61","author":"Dreffs","year":"2020","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.jbc.2025.110330_bib61","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1097\/ICO.0000000000003345","article-title":"Effects on the human tear film of applying skin lipids to the ocular surface","volume":"42","author":"Kokkinakis","year":"2023","journal-title":"Cornea"},{"key":"10.1016\/j.jbc.2025.110330_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108189","article-title":"Delineating a novel metabolic high triglycerides-low waxes syndrome that affects lipid homeostasis in meibomian and sebaceous glands","volume":"199","author":"Butovich","year":"2020","journal-title":"Exp. Eye. Res."},{"key":"10.1016\/j.jbc.2025.110330_bib63","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/s42003-023-04870-7","article-title":"Forward genetic screening using fundus spot scale identifies an essential role for Lipe in murine retinal homeostasis","volume":"6","author":"Yuksel","year":"2023","journal-title":"Commun. Biol."},{"key":"10.1016\/j.jbc.2025.110330_bib64","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1093\/biomet\/93.3.491","article-title":"Adaptive linear step-up procedures that control the false discovery rate","volume":"93","author":"Benjamini","year":"2006","journal-title":"Biometrika"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925825021805?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925825021805?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T15:43:16Z","timestamp":1761147796000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925825021805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":64,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S0021925825021805"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2025.110330","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biosynthesis of fatty aldehydes and alcohols in the eye and their role in meibogenesis","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2025.110330","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology\u00e9","name":"copyright","label":"Copyright"}],"article-number":"110330"}}