{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:52:00Z","timestamp":1790985120308,"version":"4.1.0"},"reference-count":294,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01DA057204"],"award-info":[{"award-number":["R01DA057204"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI170228"],"award-info":[{"award-number":["R01AI170228"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54MD007586"],"award-info":[{"award-number":["U54MD007586"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R25AI164610"],"award-info":[{"award-number":["R25AI164610"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI162694"],"award-info":[{"award-number":["R01AI162694"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI136740"],"award-info":[{"award-number":["R01AI136740"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.jbc.2025.110440","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T12:14:26Z","timestamp":1751544866000},"page":"110440","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["The role of chromatin in retroviral preintegration complex function"],"prefix":"10.1016","volume":"301","author":[{"given":"Nicklas","family":"Sapp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prem","family":"Prakash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8704-9648","authenticated-orcid":false,"given":"Rajasree","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muthukumar","family":"Balasubramaniam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4466-8355","authenticated-orcid":false,"given":"Chandravanu","family":"Dash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2025.110440_bib1","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0042-6822(63)90282-4","article-title":"The effects of actinomycin D on growth of Rous sarcoma virus in vitro","volume":"20","author":"Temin","year":"1963","journal-title":"Virology"},{"key":"10.1016\/j.jbc.2025.110440_bib2","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/0042-6822(64)90232-6","article-title":"The participation of DNA in Rous sarcoma virus production","volume":"23","author":"Temin","year":"1964","journal-title":"Virology"},{"key":"10.1016\/j.jbc.2025.110440_bib3","series-title":"Retroviruses","year":"1997"},{"key":"10.1016\/j.jbc.2025.110440_bib4","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.virol.2017.12.035","article-title":"Spumaretroviruses: updated taxonomy and nomenclature","volume":"516","author":"Khan","year":"2018","journal-title":"Virology"},{"key":"10.1016\/j.jbc.2025.110440_bib5","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006882","article-title":"HIV-1 reverse transcription","volume":"2","author":"Hu","year":"2012","journal-title":"Cold Spring Harb Perspect. Med."},{"key":"10.1016\/j.jbc.2025.110440_bib6","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006890","article-title":"HIV DNA integration","volume":"2","author":"Craigie","year":"2012","journal-title":"Cold Spring Harb Perspect. Med."},{"key":"10.1016\/j.jbc.2025.110440_bib7","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006916","article-title":"Transcriptional and posttranscriptional regulation of HIV-1 gene expression","volume":"2","author":"Karn","year":"2012","journal-title":"Cold Spring Harb Perspect. Med."},{"key":"10.1016\/j.jbc.2025.110440_bib8","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006924","article-title":"HIV-1 assembly, budding, and maturation","volume":"2","author":"Sundquist","year":"2012","journal-title":"Cold Spring Harb Perspect. Med."},{"key":"10.1016\/j.jbc.2025.110440_bib9","series-title":"Fact Sheet 2024 Global HIV Statistics","year":"2024"},{"key":"10.1016\/j.jbc.2025.110440_bib10","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s40121-018-0201-6","article-title":"A review of long-term toxicity of antiretroviral treatment regimens and implications for an aging population","volume":"7","author":"Chawla","year":"2018","journal-title":"Infect. Dis. Ther."},{"key":"10.1016\/j.jbc.2025.110440_bib11","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1021\/cr500373h","article-title":"Nucleosome structure and function","volume":"115","author":"McGinty","year":"2015","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jbc.2025.110440_bib12","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/38444","article-title":"Crystal structure of the nucleosome core particle at 2.8 A resolution","volume":"389","author":"Luger","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.110440_bib13","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/288675a0","article-title":"The structure of histone H1 and its location in chromatin","volume":"288","author":"Allan","year":"1980","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.110440_bib14","doi-asserted-by":"crossref","first-page":"5524","DOI":"10.1021\/bi00618a030","article-title":"Structure of the chromatosome, a chromatin particle containing 160 base pairs of DNA and all the histones","volume":"17","author":"Simpson","year":"1978","journal-title":"Biochemistry"},{"key":"10.1016\/j.jbc.2025.110440_bib15","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nrg.2016.59","article-title":"The molecular hallmarks of epigenetic control","volume":"17","author":"Allis","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.jbc.2025.110440_bib16","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1021\/cr500350x","article-title":"Post-translational modifications of histones that influence nucleosome dynamics","volume":"115","author":"Bowman","year":"2015","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jbc.2025.110440_bib17","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1111\/j.1432-1033.2004.04162.x","article-title":"Chromatin dynamics at DNA replication, transcription and repair","volume":"271","author":"Ehrenhofer-Murray","year":"2004","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.jbc.2025.110440_bib18","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/cr.2011.22","article-title":"Regulation of chromatin by histone modifications","volume":"21","author":"Bannister","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.jbc.2025.110440_bib19","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.gde.2012.02.013","article-title":"Combinatorial complexity in chromatin structure and function: revisiting the histone code","volume":"22","author":"Rando","year":"2012","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.jbc.2025.110440_bib20","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1038\/nsmb.2436","article-title":"Perceiving the epigenetic landscape through histone readers","volume":"19","author":"Musselman","year":"2012","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.jbc.2025.110440_bib21","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1146\/annurev-cellbio-100617-062653","article-title":"Heterochromatin: guardian of the genome","volume":"34","author":"Janssen","year":"2018","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.jbc.2025.110440_bib22","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0065-3527(08)60307-3","article-title":"Substrate recognition by retroviral integrases","volume":"52","author":"Katzman","year":"1999","journal-title":"Adv. Virus. Res."},{"key":"10.1016\/j.jbc.2025.110440_bib23","doi-asserted-by":"crossref","first-page":"5319","DOI":"10.1128\/jvi.63.12.5319-5327.1989","article-title":"The avian retroviral integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration","volume":"63","author":"Katzman","year":"1989","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib24","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0092-8674(89)90401-7","article-title":"Structure of the termini of DNA intermediates in the integration of retroviral DNA: dependence on IN function and terminal DNA sequence","volume":"58","author":"Roth","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.110440_bib25","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/0092-8674(90)90126-Y","article-title":"The IN protein of Moloney murine leukemia virus processes the viral DNA ends and accomplishes their integration in vitro","volume":"62","author":"Craigie","year":"1990","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.110440_bib26","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/0042-6822(90)90161-J","article-title":"Two bases are deleted from the termini of HIV-1 linear DNA during integrative recombination","volume":"179","author":"Pauza","year":"1990","journal-title":"Virology"},{"key":"10.1016\/j.jbc.2025.110440_bib27","doi-asserted-by":"crossref","first-page":"5656","DOI":"10.1128\/jvi.64.11.5656-5659.1990","article-title":"Removal of 3'-OH-terminal nucleotides from blunt-ended long terminal repeat termini by the avian retrovirus integration protein","volume":"64","author":"Vora","year":"1990","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib28","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/0092-8674(88)90071-2","article-title":"Retroviral DNA integration: structure of an integration intermediate","volume":"54","author":"Fujiwara","year":"1988","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.110440_bib29","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1073\/pnas.86.8.2525","article-title":"Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN protein","volume":"86","author":"Brown","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110440_bib30","first-page":"1419","article-title":"Relationship of avian retrovirus DNA synthesis to integration in vitro","volume":"11","author":"Lee","year":"1991","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2025.110440_bib31","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1126\/science.284.5414.644","article-title":"A role for DNA-PK in retroviral DNA integration","volume":"284","author":"Daniel","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.jbc.2025.110440_bib32","doi-asserted-by":"crossref","first-page":"11191","DOI":"10.1128\/JVI.74.23.11191-11200.2000","article-title":"Repair of gaps in retroviral DNA integration intermediates","volume":"74","author":"Yoder","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib33","doi-asserted-by":"crossref","first-page":"8573","DOI":"10.1128\/JVI.78.16.8573-8581.2004","article-title":"Evidence that stable retroviral transduction and cell survival following DNA integration depend on components of the nonhomologous end joining repair pathway","volume":"78","author":"Daniel","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib34","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0092-8674(02)00864-4","article-title":"HIV-1 integration in the human genome favors active genes and local hotspots","volume":"110","author":"Schr\u00f6der","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.110440_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0020234","article-title":"Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences","volume":"2","author":"Mitchell","year":"2004","journal-title":"PLoS Biol."},{"key":"10.1016\/j.jbc.2025.110440_bib36","doi-asserted-by":"crossref","first-page":"7316","DOI":"10.1128\/JVI.00604-06","article-title":"Genomic sites of human immunodeficiency virus type 2 (HIV-2) integration: similarities to HIV-1 in vitro and possible differences in vivo","volume":"80","author":"MacNeil","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib37","doi-asserted-by":"crossref","first-page":"12035","DOI":"10.1128\/JVI.79.18.12035-12044.2005","article-title":"Integration targeting by avian sarcoma-leukosis virus and human immunodeficiency virus in the chicken genome","volume":"79","author":"Barr","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib38","doi-asserted-by":"crossref","first-page":"4504","DOI":"10.1128\/JVI.00011-14","article-title":"Enhancers are major targets for murine leukemia virus vector integration","volume":"88","author":"De Ravin","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib39","doi-asserted-by":"crossref","first-page":"4257","DOI":"10.1093\/nar\/gkt1399","article-title":"MLV integration site selection is driven by strong enhancers and active promoters","volume":"42","author":"LaFave","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2025.110440_bib40","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1099\/vir.0.81554-0","article-title":"Genome-wide mapping of foamy virus vector integrations into a human cell line","volume":"87","author":"Nowrouzi","year":"2006","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib41","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1073\/pnas.0510046103","article-title":"Foamy virus vector integration sites in normal human cells","volume":"103","author":"Trobridge","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110440_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003271","article-title":"Genome-wide determinants of proviral targeting, clonal abundance and expression in natural HTLV-1 infection","volume":"9","author":"Melamed","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2025.110440_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000027","article-title":"HTLV-1 integration into transcriptionally active genomic regions is associated with proviral expression and with HAM\/TSP","volume":"4","author":"Meekings","year":"2008","journal-title":"PLOS Pathog."},{"key":"10.1016\/j.jbc.2025.110440_bib44","doi-asserted-by":"crossref","first-page":"6731","DOI":"10.1128\/JVI.02752-06","article-title":"Human T-cell leukemia virus type 1 integration target sites in the human genome: comparison with those of other retroviruses","volume":"81","author":"Derse","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib45","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1128\/JVI.74.5.2305-2312.2000","article-title":"Host sequences flanking the human T-cell leukemia virus type 1 provirus in vivo","volume":"74","author":"Leclercq","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib46","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/j.1349-7006.2004.tb03207.x","article-title":"Integration of human T-cell leukemia virus type 1 in genes of leukemia cells of patients with adult T-cell leukemia","volume":"95","author":"Hanai","year":"2004","journal-title":"Cancer Sci."},{"key":"10.1016\/j.jbc.2025.110440_bib47","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s10038-004-0126-7","article-title":"Rapid isolation of viral integration site reveals frequent integration of HTLV-1 into expressed loci","volume":"49","author":"Ozawa","year":"2004","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.jbc.2025.110440_bib48","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1182\/blood-2004-11-4350","article-title":"Preferential selection of human T-cell leukemia virus type I provirus integration sites in leukemic versus carrier states","volume":"106","author":"Doi","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jbc.2025.110440_bib49","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1128\/JVI.02098-07","article-title":"Mouse mammary tumor virus integration site selection in human and mouse genomes","volume":"82","author":"Faschinger","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib50","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1742-4690-11-34","article-title":"Mouse mammary tumor virus-based vector transduces non-dividing cells, enters the nucleus via a TNPO3-independent pathway and integrates in a less biased fashion than other retroviruses","volume":"11","author":"Konstantoulas","year":"2014","journal-title":"Retrovirology"},{"key":"10.1016\/j.jbc.2025.110440_bib51","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/ni.1941","article-title":"The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1","volume":"11","author":"Yan","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jbc.2025.110440_bib52","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nature12769","article-title":"HIV-1 evades innate immune recognition through specific cofactor recruitment","volume":"503","author":"Rasaiyaah","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.110440_bib53","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nature19098","article-title":"HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis","volume":"536","author":"Jacques","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.110440_bib54","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1128\/jvi.68.1.510-516.1994","article-title":"Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus","volume":"68","author":"Lewis","year":"1994","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib55","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1002\/j.1460-2075.1993.tb05858.x","article-title":"Integration of murine leukemia virus DNA depends on mitosis","volume":"12","author":"Roe","year":"1993","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2025.110440_bib56","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.virol.2005.05.024","article-title":"A nuclear localization signal in the matrix of spleen necrosis virus (SNV) does not allow efficient gene transfer into quiescent cells with SNV-derived vectors","volume":"338","author":"Caron","year":"2005","journal-title":"Virology"},{"key":"10.1016\/j.jbc.2025.110440_bib57","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0092-8674(87)90287-X","article-title":"Correct integration of retroviral DNA in vitro","volume":"49","author":"Brown","year":"1987","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.110440_bib58","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1101\/gad.3.4.469","article-title":"A nucleoprotein complex mediates the integration of retroviral DNA","volume":"3","author":"Bowerman","year":"1989","journal-title":"Genes Dev."},{"key":"10.1016\/j.jbc.2025.110440_bib59","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1128\/jvi.64.6.2711-2715.1990","article-title":"Human immunodeficiency virus integration in a cell-free system","volume":"64","author":"Ellison","year":"1990","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib60","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1089\/aid.1993.9.817","article-title":"Characterization of HIV replication complexes early after cell-to-cell infection","volume":"9","author":"Karageorgos","year":"1993","journal-title":"AIDS Res. Hum. Retrovir."},{"key":"10.1016\/j.jbc.2025.110440_bib61","doi-asserted-by":"crossref","first-page":"5382","DOI":"10.1128\/jvi.71.7.5382-5390.1997","article-title":"Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition","volume":"71","author":"Miller","year":"1997","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib62","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0092-8674(00)81888-7","article-title":"HIV-1 cDNA integration: requirement of HMG I(Y) protein for function of preintegration complexes in vitro","volume":"88","author":"Farnet","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.110440_bib63","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1128\/jvi.65.4.1910-1915.1991","article-title":"Determination of viral proteins present in the human immunodeficiency virus type 1 preintegration complex","volume":"65","author":"Farnet","year":"1991","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib64","doi-asserted-by":"crossref","first-page":"6125","DOI":"10.1073\/pnas.90.13.6125","article-title":"Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infection","volume":"90","author":"Bukrinsky","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110440_bib65","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1742-4690-3-4","article-title":"Intracytoplasmic maturation of the human immunodeficiency virus type 1 reverse transcription complexes determines their capacity to integrate into chromatin","volume":"3","author":"Iordanskiy","year":"2006","journal-title":"Retrovirology"},{"key":"10.1016\/j.jbc.2025.110440_bib66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1001183","article-title":"The gag cleavage product, p12, is a functional constituent of the murine leukemia virus pre-integration complex","volume":"6","author":"Prizan-Ravid","year":"2010","journal-title":"PLOS Pathog."},{"key":"10.1016\/j.jbc.2025.110440_bib67","doi-asserted-by":"crossref","first-page":"8919","DOI":"10.1128\/JVI.73.11.8919-8925.1999","article-title":"Characterization of intracellular reverse transcription complexes of Moloney murine leukemia virus","volume":"73","author":"Fassati","year":"1999","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib68","doi-asserted-by":"crossref","first-page":"9823","DOI":"10.1073\/pnas.91.21.9823","article-title":"Protection of retroviral DNA from autointegration: involvement of a cellular factor","volume":"91","author":"Lee","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110440_bib69","doi-asserted-by":"crossref","first-page":"15270","DOI":"10.1073\/pnas.95.26.15270","article-title":"The barrier-to-autointegration protein is a host factor for HIV type 1 integration","volume":"95","author":"Chen","year":"1998","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jbc.2025.110440_bib70","doi-asserted-by":"crossref","first-page":"5030","DOI":"10.1128\/JVI.77.8.5030-5036.2003","article-title":"The barrier-to-autointegration factor is a component of functional human immunodeficiency virus type 1 preintegration complexes","volume":"77","author":"Lin","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib71","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1073\/pnas.95.4.1528","article-title":"A previously unidentified host protein protects retroviral DNA from autointegration","volume":"95","author":"Lee","year":"1998","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.jbc.2025.110440_bib72","doi-asserted-by":"crossref","first-page":"10965","DOI":"10.1128\/JVI.74.23.10965-10974.2000","article-title":"Retroviral cDNA integration: stimulation by HMG I family proteins","volume":"74","author":"Li","year":"2000","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib73","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1093\/emboj\/20.12.3272","article-title":"Role of the non-homologous DNA end joining pathway in the early steps of retroviral infection","volume":"20","author":"Li","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2025.110440_bib74","doi-asserted-by":"crossref","first-page":"5649","DOI":"10.1038\/s41598-017-05659-5","article-title":"Characterization of HIV-1 integrase interaction with human Ku70 protein and initial implications for drug targeting","volume":"7","author":"Anisenko","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2025.110440_bib75","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12977-019-0492-z","article-title":"NHEJ pathway is involved in post-integrational DNA repair due to Ku70 binding to HIV-1 integrase","volume":"16","author":"Knyazhanskaya","year":"2019","journal-title":"Retrovirology"},{"key":"10.1016\/j.jbc.2025.110440_bib76","doi-asserted-by":"crossref","first-page":"12507","DOI":"10.1128\/JVI.77.23.12507-12522.2003","article-title":"The human polycomb group EED protein interacts with the integrase of human immunodeficiency virus type 1","volume":"77","author":"Violot","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib77","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.1038\/sj.emboj.7600770","article-title":"Acetylation of HIV-1 integrase by p300 regulates viral integration","volume":"24","author":"Cereseto","year":"2005","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2025.110440_bib78","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1128\/JVI.02257-06","article-title":"Posttranslational acetylation of the human immunodeficiency virus type 1 integrase carboxyl-terminal domain is dispensable for viral replication","volume":"81","author":"Topper","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib79","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1126\/science.7801128","article-title":"Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5","volume":"266","author":"Kalpana","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.jbc.2025.110440_bib80","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1074\/jbc.M209278200","article-title":"HIV-1 integrase forms stable tetramers and associates with LEDGF\/p75 protein in human cells","volume":"278","author":"Cherepanov","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110440_bib81","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1038\/nm1329","article-title":"A role for LEDGF\/p75 in targeting HIV DNA integration","volume":"11","author":"Ciuffi","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.jbc.2025.110440_bib82","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.virol.2005.11.022","article-title":"Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)\/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication","volume":"346","author":"Vandegraaff","year":"2006","journal-title":"Virology"},{"key":"10.1016\/j.jbc.2025.110440_bib83","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/nar\/gkl885","article-title":"LEDGF\/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro","volume":"35","author":"Cherepanov","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2025.110440_bib84","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1101\/gad.1565107","article-title":"LEDGF\/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration","volume":"21","author":"Shun","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.jbc.2025.110440_bib85","doi-asserted-by":"crossref","first-page":"23735","DOI":"10.1073\/pnas.1912638116","article-title":"Unintegrated HIV-1 DNAs are loaded with core and linker histones and transcriptionally silenced","volume":"116","author":"Geis","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110440_bib86","doi-asserted-by":"crossref","first-page":"12376","DOI":"10.1128\/JVI.76.23.12376-12380.2002","article-title":"Regulatory mechanisms by which barrier-to-autointegration factor blocks autointegration and stimulates intermolecular integration of Moloney murine leukemia virus preintegration complexes","volume":"76","author":"Suzuki","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib87","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.chom.2016.10.009","article-title":"Histones are rapidly loaded onto unintegrated retroviral DNAs soon after nuclear entry","volume":"20","author":"Wang","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jbc.2025.110440_bib88","doi-asserted-by":"crossref","first-page":"4670","DOI":"10.1038\/sj.emboj.7600452","article-title":"LAP2\u03b1 and BAF collaborate to organize the Moloney murine leukemia virus preintegration complex","volume":"23","author":"Suzuki","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2025.110440_bib89","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1128\/JVI.01953-06","article-title":"Wild-type levels of human immunodeficiency virus type 1 infectivity in the absence of cellular emerin protein","volume":"81","author":"Shun","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib90","doi-asserted-by":"crossref","first-page":"5860","DOI":"10.1128\/JVI.00076-08","article-title":"The LEM domain proteins emerin and LAP2alpha are dispensable for human immunodeficiency virus type 1 and murine leukemia virus infections","volume":"82","author":"Mulky","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib91","doi-asserted-by":"crossref","first-page":"7511","DOI":"10.1093\/emboj\/16.24.7511","article-title":"A large nucleoprotein assembly at the ends of the viral DNA mediates retroviral DNA integration","volume":"16","author":"Wei","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2025.110440_bib92","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1126\/science.1132319","article-title":"An essential role for LEDGF\/p75 in HIV integration","volume":"314","author":"Llano","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.jbc.2025.110440_bib93","doi-asserted-by":"crossref","first-page":"E1054","DOI":"10.1073\/pnas.1524213113","article-title":"A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin","volume":"113","author":"Sowd","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110440_bib94","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.chom.2018.08.002","article-title":"Capsid-CPSF6 interaction licenses nuclear HIV-1 trafficking to sites of viral DNA integration","volume":"24","author":"Achuthan","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jbc.2025.110440_bib95","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02254-20","article-title":"CPSF6-Dependent targeting of speckle-associated domains distinguishes primate from nonprimate lentiviral integration","volume":"11","author":"Li","year":"2020","journal-title":"mBio"},{"key":"10.1016\/j.jbc.2025.110440_bib96","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003103","article-title":"p12 tethers the murine leukemia virus pre-integration complex to mitotic chromosomes","volume":"8","author":"Elis","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2025.110440_bib97","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1742-4690-5-48","article-title":"Host proteins interacting with the Moloney murine leukemia virus integrase: multiple transcriptional regulators and chromatin binding factors","volume":"5","author":"Studamire","year":"2008","journal-title":"Retrovirology"},{"key":"10.1016\/j.jbc.2025.110440_bib98","doi-asserted-by":"crossref","first-page":"9526","DOI":"10.1128\/JVI.75.19.9526-9531.2001","article-title":"Infection of nondividing cells by Rous sarcoma virus","volume":"75","author":"Hatziioannou","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib99","doi-asserted-by":"crossref","first-page":"5422","DOI":"10.1128\/JVI.76.11.5422-5434.2002","article-title":"Transduction of interphase cells by avian sarcoma virus","volume":"76","author":"Katz","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib100","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/jcb.20358","article-title":"Effects of cell cycle status on early events in retroviral replication","volume":"94","author":"Katz","year":"2005","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.jbc.2025.110440_bib101","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1742-4690-5-73","article-title":"Nuclear import of Avian Sarcoma Virus integrase is facilitated by host cell factors","volume":"5","author":"Andrake","year":"2008","journal-title":"Retrovirology"},{"key":"10.1016\/j.jbc.2025.110440_bib102","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1099\/0022-1317-83-10-2523","article-title":"Characterization of a human immunodeficiency virus type 1 pre-integration complex in which the majority of the cDNA is resistant to DNase I digestion","volume":"83","author":"Khiytani","year":"2002","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib103","doi-asserted-by":"crossref","first-page":"9524","DOI":"10.1128\/JVI.78.17.9524-9537.2004","article-title":"LEDGF\/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes","volume":"78","author":"Llano","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib104","doi-asserted-by":"crossref","first-page":"17841","DOI":"10.1074\/jbc.M411681200","article-title":"The interaction of LEDGF\/p75 with integrase is lentivirus-specific and promotes DNA binding","volume":"280","author":"Busschots","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110440_bib105","doi-asserted-by":"crossref","first-page":"48883","DOI":"10.1074\/jbc.M406307200","article-title":"Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor\/transcriptional co-activator p75 (LEDGF\/p75) that binds HIV-1 integrase","volume":"279","author":"Cherepanov","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110440_bib106","doi-asserted-by":"crossref","first-page":"17308","DOI":"10.1073\/pnas.0506924102","article-title":"Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75","volume":"102","author":"Cherepanov","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110440_bib107","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/nsmb937","article-title":"Solution structure of the HIV-1 integrase-binding domain in LEDGF\/p75","volume":"12","author":"Cherepanov","year":"2005","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.jbc.2025.110440_bib108","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.jmb.2006.04.073","article-title":"Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF\/p75","volume":"360","author":"Llano","year":"2006","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jbc.2025.110440_bib109","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.bbagrm.2009.10.001","article-title":"Chromatin tethering and retroviral integration: recent discoveries and parallels with DNA viruses","volume":"1799","author":"Meehan","year":"2010","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1016\/j.jbc.2025.110440_bib110","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.1093\/nar\/gkt074","article-title":"Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes","volume":"41","author":"Eidahl","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2025.110440_bib111","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1756-8935-6-12","article-title":"Nucleosomal DNA binding drives the recognition of H3K36-methylated nucleosomes by the PSIP1-PWWP domain","volume":"6","author":"van Nuland","year":"2013","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.jbc.2025.110440_bib112","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aay3068","article-title":"LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells","volume":"5","author":"LeRoy","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jbc.2025.110440_bib113","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41594-019-0345-4","article-title":"Structure of H3K36-methylated nucleosome-PWWP complex reveals multivalent cross-gyre binding","volume":"27","author":"Wang","year":"2020","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.jbc.2025.110440_bib114","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.virol.2006.08.011","article-title":"Structure-based mutagenesis of the integrase-LEDGF\/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness","volume":"357","author":"Rahman","year":"2007","journal-title":"Virology"},{"key":"10.1016\/j.jbc.2025.110440_bib115","doi-asserted-by":"crossref","first-page":"11555","DOI":"10.1128\/JVI.01561-08","article-title":"Identification and characterization of PWWP domain residues critical for LEDGF\/p75 chromatin binding and human immunodeficiency virus type 1 infectivity","volume":"82","author":"Shun","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib116","doi-asserted-by":"crossref","first-page":"33528","DOI":"10.1074\/jbc.M303594200","article-title":"LEDGF\/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells","volume":"278","author":"Maertens","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110440_bib117","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001340","article-title":"Role of PSIP1\/LEDGF\/p75 in lentiviral infectivity and integration targeting","volume":"2","author":"Marshall","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2025.110440_bib118","doi-asserted-by":"crossref","first-page":"11518","DOI":"10.1093\/nar\/gks913","article-title":"HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF\/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF\/p75-binding site integrase inhibitor","volume":"40","author":"Wang","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2025.110440_bib119","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1101\/gad.267609.115","article-title":"LEDGF\/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes","volume":"29","author":"Singh","year":"2015","journal-title":"Genes Dev."},{"key":"10.1016\/j.jbc.2025.110440_bib120","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ebiom.2016.04.039","article-title":"LEDGIN-Mediated inhibition of integrase-LEDGF\/p75 interaction reduces reactivation of residual latent HIV","volume":"8","author":"Vranckx","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jbc.2025.110440_bib121","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1128\/JVI.80.4.1886-1896.2006","article-title":"Transient and stable knockdown of the integrase cofactor LEDGF\/p75 reveals its role in the replication cycle of human immunodeficiency virus","volume":"80","author":"Vandekerckhove","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib122","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nchembio.370","article-title":"Rational design of small-molecule inhibitors of the LEDGF\/p75-integrase interaction and HIV replication","volume":"6","author":"Christ","year":"2010","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jbc.2025.110440_bib123","doi-asserted-by":"crossref","first-page":"4318","DOI":"10.1128\/AAC.02690-14","article-title":"Zinc finger endonuclease targeting PSIP1 inhibits HIV-1 integration","volume":"58","author":"Badia","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jbc.2025.110440_bib124","doi-asserted-by":"crossref","first-page":"9704","DOI":"10.1128\/JVI.01397-14","article-title":"TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism","volume":"88","author":"Fadel","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000522","article-title":"LEDGF\/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors","volume":"5","author":"Meehan","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2025.110440_bib126","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1073\/pnas.0914142107","article-title":"Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration","volume":"107","author":"Ferris","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110440_bib127","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12977-019-0472-3","article-title":"Impact of LEDGIN treatment during virus production on residual HIV-1 transcription","volume":"16","author":"Vansant","year":"2019","journal-title":"Retrovirology"},{"key":"10.1016\/j.jbc.2025.110440_bib128","doi-asserted-by":"crossref","first-page":"7801","DOI":"10.1093\/nar\/gkaa536","article-title":"The chromatin landscape at the HIV-1 provirus integration site determines viral expression","volume":"48","author":"Vansant","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2025.110440_bib129","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.3390\/v14091883","article-title":"Allosteric integrase inhibitor influences on HIV-1 integration and roles of LEDGF\/p75 and HDGFL2 host factors","volume":"14","author":"Singh","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.jbc.2025.110440_bib130","doi-asserted-by":"crossref","first-page":"7330","DOI":"10.1093\/nar\/gkab514","article-title":"rigrag: high-resolution mapping of genic targeting preferences during HIV-1 integration in vitro and in vivo","volume":"49","author":"Bedwell","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2025.110440_bib131","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.chom.2010.02.007","article-title":"Flexible use of nuclear import pathways by HIV-1","volume":"7","author":"Lee","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jbc.2025.110440_bib132","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002896","article-title":"CPSF6 defines a conserved capsid interface that modulates HIV-1 replication","volume":"8","author":"Price","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2025.110440_bib133","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/j.celrep.2015.10.036","article-title":"Direct visualization of HIV-1 replication intermediates shows that capsid and CPSF6 modulate HIV-1 intra-nuclear invasion and integration","volume":"13","author":"Chin","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2025.110440_bib134","doi-asserted-by":"crossref","first-page":"11809","DOI":"10.1074\/jbc.M116.721647","article-title":"The cleavage and polyadenylation specificity factor 6 (CPSF6) subunit of the capsid-recruited pre-messenger RNA cleavage factor I (CFIm) complex mediates HIV-1 integration into genes","volume":"291","author":"Rasheedi","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110440_bib135","doi-asserted-by":"crossref","first-page":"35788","DOI":"10.1074\/jbc.M403927200","article-title":"Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization","volume":"279","author":"Dettwiler","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110440_bib136","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108201","article-title":"Nuclear import of the HIV-1 core precedes reverse transcription and uncoating","volume":"32","author":"Selyutina","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2025.110440_bib137","first-page":"39","article-title":"Capsid-CPSF6 interaction: master regulator of nuclear HIV-1 positioning and integration","volume":"1","author":"Achuthan","year":"2019","journal-title":"J. Life Sci. (Westlake Village)"},{"key":"10.1016\/j.jbc.2025.110440_bib138","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.41800","article-title":"HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complex","volume":"8","author":"Bejarano","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.jbc.2025.110440_bib139","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02501-19","article-title":"Analysis of CA content and CPSF6 dependence of early HIV-1 replication complexes in SupT1-R5 cells","volume":"10","author":"Zila","year":"2019","journal-title":"mBio"},{"key":"10.1016\/j.jbc.2025.110440_bib140","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1038\/s41467-020-17256-8","article-title":"HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains","volume":"11","author":"Francis","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.110440_bib141","doi-asserted-by":"crossref","DOI":"10.1093\/jmcb\/mjac060","article-title":"HIV-induced membraneless organelles orchestrate post-nuclear entry steps","volume":"14","author":"Scoca","year":"2023","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2025.110440_bib142","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1128\/jvi.49.3.909-917.1984","article-title":"Mutations in gag proteins P12 and P15 of Moloney murine leukemia virus block early stages of infection","volume":"49","author":"Crawford","year":"1984","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib143","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/1742-4690-9-83","article-title":"The Gammaretroviral p12 protein has multiple domains that function during the early stages of replication","volume":"9","author":"Wight","year":"2012","journal-title":"Retrovirology"},{"key":"10.1016\/j.jbc.2025.110440_bib144","doi-asserted-by":"crossref","first-page":"11197","DOI":"10.1128\/JVI.01084-16","article-title":"Repression of the chromatin-tethering domain of murine leukemia virus p12","volume":"90","author":"Brzezinski","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib145","doi-asserted-by":"crossref","first-page":"11208","DOI":"10.1128\/JVI.01178-16","article-title":"Phosphorylation requirement of murine leukemia virus p12","volume":"90","author":"Brzezinski","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib146","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007117","article-title":"Murine leukemia virus p12 tethers the capsid-containing pre-integration complex to chromatin by binding directly to host nucleosomes in mitosis","volume":"14","author":"Wanaguru","year":"2018","journal-title":"PLOS Pathog."},{"key":"10.1016\/j.jbc.2025.110440_bib147","doi-asserted-by":"crossref","first-page":"9487","DOI":"10.1073\/pnas.1221736110","article-title":"Viral DNA tethering domains complement replication-defective mutations in the p12 protein of MuLV Gag","volume":"110","author":"Schneider","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110440_bib148","doi-asserted-by":"crossref","first-page":"385","DOI":"10.15698\/mic2018.08.643","article-title":"Gammaretroviruses tether to mitotic chromatin by directly binding nucleosomal histone proteins","volume":"5","author":"Wanaguru","year":"2018","journal-title":"Microb. Cell"},{"key":"10.1016\/j.jbc.2025.110440_bib149","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00495-21","article-title":"Moloney murine leukemia virus p12 is required for histone loading onto retroviral DNAs","volume":"95","author":"Wang","year":"2021","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib150","first-page":"D1008","article-title":"You bet-cha: a novel family of transcriptional regulators","volume":"6","author":"Florence","year":"2001","journal-title":"Front. Biosci."},{"key":"10.1016\/j.jbc.2025.110440_bib151","doi-asserted-by":"crossref","first-page":"8758","DOI":"10.1073\/pnas.1433065100","article-title":"The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis","volume":"100","author":"Dey","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110440_bib152","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/s41392-023-01647-6","article-title":"Bromodomain and extraterminal (BET) proteins: biological functions, diseases and targeted therapy","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.jbc.2025.110440_bib153","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1042\/BJ20060907","article-title":"Selective recognition of acetylated histones by bromodomains in transcriptional co-activators","volume":"402","author":"Hassan","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.jbc.2025.110440_bib154","doi-asserted-by":"crossref","first-page":"6403","DOI":"10.1021\/bi8001659","article-title":"Structural basis and binding properties of the second bromodomain of Brd4 with acetylated histone tails","volume":"47","author":"Liu","year":"2008","journal-title":"Biochemistry"},{"key":"10.1016\/j.jbc.2025.110440_bib155","doi-asserted-by":"crossref","first-page":"12721","DOI":"10.1128\/JVI.01942-13","article-title":"Bromo- and extraterminal domain chromatin regulators serve as cofactors for murine leukemia virus integration","volume":"87","author":"Gupta","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib156","doi-asserted-by":"crossref","first-page":"12036","DOI":"10.1073\/pnas.1307157110","article-title":"BET proteins promote efficient murine leukemia virus integration at transcription start sites","volume":"110","author":"Sharma","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110440_bib157","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1073\/pnas.1516813113","article-title":"Structure of the Brd4 ET domain bound to a C-terminal motif from \u03b3-retroviral integrases reveals a conserved mechanism of interaction","volume":"113","author":"Crowe","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110440_bib158","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.celrep.2013.09.040","article-title":"The BET family of proteins targets moloney murine leukemia virus integration near transcription start sites","volume":"5","author":"De Rijck","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2025.110440_bib159","doi-asserted-by":"crossref","first-page":"5917","DOI":"10.1093\/nar\/gku175","article-title":"Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction","volume":"42","author":"Aiyer","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2025.110440_bib160","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.3390\/v15091853","article-title":"BET inhibitor JQ1 attenuates feline leukemia virus DNA, provirus, and antigen production in domestic cat cell lines","volume":"15","author":"Moll","year":"2023","journal-title":"Viruses"},{"key":"10.1016\/j.jbc.2025.110440_bib161","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008154","article-title":"Disrupting MLV integrase: BET protein interaction biases integration into quiescent chromatin and delays but does not eliminate tumor activation in a MYC\/Runx2 mouse model","volume":"15","author":"Loyola","year":"2019","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2025.110440_bib162","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.01478-22","article-title":"BET-independent murine leukemia virus integration is retargeted in vivo and selects distinct genomic elements for lymphomagenesis","volume":"10","author":"Nombela","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.jbc.2025.110440_bib163","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00082-17","article-title":"The FACT complex promotes avian leukosis virus DNA integration","volume":"91","author":"Winans","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib164","doi-asserted-by":"crossref","first-page":"18369","DOI":"10.1074\/jbc.R110.180778","article-title":"The histone chaperone FACT: structural insights and mechanisms for nucleosome reorganization","volume":"286","author":"Winkler","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110440_bib165","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/22350","article-title":"The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins","volume":"400","author":"Orphanides","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.110440_bib166","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0092-8674(00)80903-4","article-title":"FACT, a factor that facilitates transcript elongation through nucleosomes","volume":"92","author":"Orphanides","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.110440_bib167","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1093\/genetics\/162.4.1557","article-title":"Defects in SPT16 or POB3 (yFACT) in saccharomyces cerevisiae cause dependence on the Hir\/Hpc pathway: polymerase passage may degrade chromatin structure","volume":"162","author":"Formosa","year":"2002","journal-title":"Genetics"},{"key":"10.1016\/j.jbc.2025.110440_bib168","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1126\/science.1085703","article-title":"FACT facilitates transcription-dependent nucleosome alteration","volume":"301","author":"Belotserkovskaya","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.jbc.2025.110440_bib169","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/emboj.2009.33","article-title":"FACT facilitates chromatin transcription by RNA polymerases I and III","volume":"28","author":"Birch","year":"2009","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2025.110440_bib170","doi-asserted-by":"crossref","first-page":"7654","DOI":"10.1073\/pnas.1222198110","article-title":"Histone chaperone FACT action during transcription through chromatin by RNA polymerase II","volume":"110","author":"Hsieh","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110440_bib171","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.bbagrm.2013.11.003","article-title":"Chromatin and DNA sequences in defining promoters for transcription initiation","volume":"1839","author":"M\u00fcller","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbc.2025.110440_bib172","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nature12819","article-title":"Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification","volume":"505","author":"Tessarz","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.110440_bib173","doi-asserted-by":"crossref","first-page":"3975","DOI":"10.1038\/sj.emboj.7601271","article-title":"Functional cooperation between FACT and MCM helicase facilitates initiation of chromatin DNA replication","volume":"25","author":"Tan","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2025.110440_bib174","doi-asserted-by":"crossref","first-page":"30504","DOI":"10.1074\/jbc.M111.264721","article-title":"The histone chaperone facilitates chromatin transcription (FACT) protein maintains normal replication fork rates","volume":"286","author":"Abe","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110440_bib175","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.molcel.2016.11.016","article-title":"Chromatin controls DNA replication origin selection, lagging-strand synthesis, and replication fork rates","volume":"65","author":"Kurat","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2025.110440_bib176","doi-asserted-by":"crossref","first-page":"5858","DOI":"10.1074\/jbc.273.10.5858","article-title":"DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139","volume":"273","author":"Rogakou","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110440_bib177","doi-asserted-by":"crossref","first-page":"50206","DOI":"10.1074\/jbc.M209820200","article-title":"p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex","volume":"277","author":"Keller","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110440_bib178","doi-asserted-by":"crossref","first-page":"12710","DOI":"10.1074\/jbc.M300250200","article-title":"Protein kinase CK2 phosphorylates the high mobility group domain protein SSRP1, inducing the recognition of UV-damaged DNA","volume":"278","author":"Krohn","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110440_bib179","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.molcel.2008.02.029","article-title":"FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16","volume":"30","author":"Heo","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2025.110440_bib180","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.molcel.2013.08.007","article-title":"Enhanced chromatin dynamics by FACT promotes transcriptional restart after UV-induced DNA damage","volume":"51","author":"Dinant","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2025.110440_bib181","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006221","article-title":"FACT assists base excision repair by boosting the remodeling activity of RSC","volume":"12","author":"Charles Richard","year":"2016","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jbc.2025.110440_bib182","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.bbagrm.2018.07.008","article-title":"Structure and function of the histone chaperone FACT - resolving FACTual issues","volume":"1861","author":"Gurova","year":"2018","journal-title":"Biochim. Biophys. Acta Gene Regul. Mech."},{"key":"10.1016\/j.jbc.2025.110440_bib183","doi-asserted-by":"crossref","first-page":"41883","DOI":"10.1074\/jbc.M111.301465","article-title":"Histone chaperone FACT coordinates nucleosome interaction through multiple synergistic binding events","volume":"286","author":"Winkler","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110440_bib184","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.201800107","article-title":"The histone chaperone FACT modulates nucleosome structure by tethering its components","volume":"1","author":"Wang","year":"2018","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.jbc.2025.110440_bib185","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.sbi.2020.05.019","article-title":"Histone chaperone FACT FAcilitates Chromatin Transcription: mechanistic and structural insights","volume":"65","author":"Zhou","year":"2020","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.jbc.2025.110440_bib186","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/nar\/gkv1347","article-title":"B'-protein phosphatase 2A is a functional binding partner of delta-retroviral integrase","volume":"44","author":"Maertens","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2025.110440_bib187","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3109\/10409238.2016.1143913","article-title":"PP2A as a master regulator of the cell cycle","volume":"51","author":"Wlodarchak","year":"2016","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.jbc.2025.110440_bib188","doi-asserted-by":"crossref","first-page":"5043","DOI":"10.1038\/s41467-020-18874-y","article-title":"Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56\u03b3","volume":"11","author":"Barski","year":"2020","journal-title":"Nat Commun."},{"key":"10.1016\/j.jbc.2025.110440_bib189","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1038\/s41467-020-16963-6","article-title":"Structural basis of host protein hijacking in human T-cell leukemia virus integration","volume":"11","author":"Bhatt","year":"2020","journal-title":"Nat Commun."},{"key":"10.1016\/j.jbc.2025.110440_bib190","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.1182\/blood-2014-02-553602","article-title":"The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia\/lymphoma","volume":"123","author":"Cook","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.jbc.2025.110440_bib191","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abm6210","article-title":"Selective clonal persistence of human retroviruses in vivo: radial chromatin organization, integration site, and host transcription","volume":"8","author":"Melamed","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jbc.2025.110440_bib192","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1128\/JVI.02435-09","article-title":"The foamy virus genome remains unintegrated in the nuclei of G1\/S phase-arrested cells, and integrase is critical for preintegration complex transport into the nucleus","volume":"84","author":"Lo","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib193","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1111\/j.1600-0854.2008.00792.x","article-title":"Chromatin tethering of incoming foamy virus by the structural Gag protein","volume":"9","author":"Tobaly-Tapiero","year":"2008","journal-title":"Traffic"},{"key":"10.1016\/j.jbc.2025.110440_bib194","doi-asserted-by":"crossref","first-page":"9276","DOI":"10.1128\/JVI.00663-11","article-title":"Prototype foamy virus gag nuclear localization: a novel pathway among retroviruses","volume":"85","author":"M\u00fcllers","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib195","doi-asserted-by":"crossref","first-page":"5509","DOI":"10.1073\/pnas.1621159114","article-title":"Structural basis for spumavirus GAG tethering to chromatin","volume":"114","author":"Lesbats","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110440_bib196","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.virol.2018.08.007","article-title":"The chromatin binding domain, including the QPQRYG motif, of feline foamy virus Gag is required for viral DNA integration and nuclear accumulation of Gag and the viral genome","volume":"524","author":"Wei","year":"2018","journal-title":"Virology"},{"key":"10.1016\/j.jbc.2025.110440_bib197","doi-asserted-by":"crossref","first-page":"13193","DOI":"10.1073\/pnas.94.24.13193","article-title":"Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy","volume":"94","author":"Chun","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110440_bib198","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.cell.2013.09.020","article-title":"Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure","volume":"155","author":"Ho","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.110440_bib199","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.cell.2015.01.020","article-title":"HIV-1 integration landscape during latent and active infection","volume":"160","author":"Cohn","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.110440_bib200","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34655","article-title":"Distinct chromatin functional states correlate with HIV latency reactivation in infected primary CD4(+) T cells","volume":"7","author":"Battivelli","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.jbc.2025.110440_bib201","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.3390\/v13091858","article-title":"The clonal expansion dynamics of the HIV-1 reservoir: mechanisms of integration site-dependent proliferation and HIV-1 persistence","volume":"13","author":"Yeh","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.jbc.2025.110440_bib202","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2202003121","article-title":"Structural rearrangements in the nucleus localize latent HIV proviruses to a perinucleolar compartment supportive of reactivation","volume":"121","author":"Kizito","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110440_bib203","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3390\/v15010032","article-title":"Determinants of retroviral integration and implications for gene therapeutic MLV-based vectors and for a cure for HIV-1 infection","volume":"15","author":"Pellaers","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.jbc.2025.110440_bib204","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/251249a0","article-title":"Subunit structure of chromatin","volume":"251","author":"Noll","year":"1974","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.110440_bib205","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1126\/science.184.4139.868","article-title":"Chromatin structure: a repeating unit of histones and DNA","volume":"184","author":"Kornberg","year":"1974","journal-title":"Science"},{"key":"10.1016\/j.jbc.2025.110440_bib206","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/j.1460-2075.1992.tb05052.x","article-title":"Retroviral integration into minichromosomes in vitro","volume":"11","author":"Pryciak","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2025.110440_bib207","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/0092-8674(92)90289-O","article-title":"Nucleosomes, DNA-binding proteins, and DNA sequence modulate retroviral integration target site selection","volume":"69","author":"Pryciak","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.110440_bib208","doi-asserted-by":"crossref","first-page":"4704","DOI":"10.1002\/j.1460-2075.1994.tb06794.x","article-title":"DNA bending creates favored sites for retroviral integration: an explanation for preferred insertion sites in nucleosomes","volume":"13","author":"M\u00fcller","year":"1994","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2025.110440_bib209","doi-asserted-by":"crossref","first-page":"5913","DOI":"10.1073\/pnas.91.13.5913","article-title":"Human immunodeficiency virus integrase directs integration to sites of severe DNA distortion within the nucleosome core","volume":"91","author":"Pruss","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110440_bib210","doi-asserted-by":"crossref","first-page":"25031","DOI":"10.1016\/S0021-9258(17)31494-1","article-title":"The influence of DNA and nucleosome structure on integration events directed by HIV integrase","volume":"269","author":"Pruss","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110440_bib211","doi-asserted-by":"crossref","first-page":"9237","DOI":"10.1073\/pnas.89.19.9237","article-title":"Simian virus 40 minichromosomes as targets for retroviral integration in vivo","volume":"89","author":"Pryciak","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110440_bib212","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/nature14495","article-title":"Structural basis for retroviral integration into nucleosomes","volume":"523","author":"Maskell","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.110440_bib213","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12977-017-0378-x","article-title":"Modulation of the functional association between the HIV-1 intasome and the nucleosome by histone amino-terminal tails","volume":"14","author":"Benleulmi","year":"2017","journal-title":"Retrovirology"},{"key":"10.1016\/j.jbc.2025.110440_bib214","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature08784","article-title":"Retroviral intasome assembly and inhibition of DNA strand transfer","volume":"464","author":"Hare","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.110440_bib215","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.1038\/s41467-019-12007-w","article-title":"Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer","volume":"10","author":"Wilson","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.110440_bib216","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1101\/gr.6286907","article-title":"HIV integration site selection: analysis by massively parallel pyrosequencing reveals association with epigenetic modifications","volume":"17","author":"Wang","year":"2007","journal-title":"Genome Res."},{"key":"10.1016\/j.jbc.2025.110440_bib217","doi-asserted-by":"crossref","first-page":"7393","DOI":"10.1128\/JVI.00635-11","article-title":"Gammaretroviral integration into nucleosomal target DNA in vivo","volume":"85","author":"Roth","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib218","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41467-019-08333-8","article-title":"Physical principles of retroviral integration in the human genome","volume":"10","author":"Michieletto","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.110440_bib219","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1093\/nar\/gkm1127","article-title":"Chromatinized templates reveal the requirement for the LEDGF\/p75 PWWP domain during HIV-1 integration in vitro","volume":"36","author":"Botbol","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2025.110440_bib220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0129427","article-title":"DNA physical properties and nucleosome positions are major determinants of HIV-1 integrase selectivity","volume":"10","author":"Naughtin","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2025.110440_bib221","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1001280","article-title":"Functional coupling between HIV-1 integrase and the SWI\/SNF chromatin remodeling complex for efficient in vitro integration into stable nucleosomes","volume":"7","author":"Lesbats","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2025.110440_bib222","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12977-015-0145-9","article-title":"Intasome architecture and chromatin density modulate retroviral integration into nucleosome","volume":"12","author":"Benleulmi","year":"2015","journal-title":"Retrovirology"},{"key":"10.1016\/j.jbc.2025.110440_bib223","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12977-017-0363-4","article-title":"Modulation of chromatin structure by the FACT histone chaperone complex regulates HIV-1 integration","volume":"14","author":"Matysiak","year":"2017","journal-title":"Retrovirology"},{"key":"10.1016\/j.jbc.2025.110440_bib224","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00648-18","article-title":"Nup153 unlocks the nuclear pore complex for HIV-1 nuclear translocation in nondividing cells","volume":"92","author":"Buffone","year":"2018","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib225","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.molcel.2018.06.020","article-title":"Functions of FACT in breaking the nucleosome and maintaining its integrity at the single-nucleosome level","volume":"71","author":"Chen","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2025.110440_bib226","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41586-019-1820-0","article-title":"FACT caught in the act of manipulating the nucleosome","volume":"577","author":"Liu","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.110440_bib227","doi-asserted-by":"crossref","first-page":"10596","DOI":"10.1073\/pnas.88.23.10596","article-title":"Nucleosome positioning is determined by the (H3-H4)2 tetramer","volume":"88","author":"Dong","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110440_bib228","doi-asserted-by":"crossref","first-page":"22736","DOI":"10.1074\/jbc.M604849200","article-title":"Inhibition of early steps of HIV-1 replication by SNF5\/ini1\u2217","volume":"281","author":"Maroun","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110440_bib229","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1742-4690-10-66","article-title":"INI1\/hSNF5-interaction defective HIV-1 IN mutants exhibit impaired particle morphology, reverse transcription and integration in vivo","volume":"10","author":"Mathew","year":"2013","journal-title":"Retrovirology"},{"key":"10.1016\/j.jbc.2025.110440_bib230","doi-asserted-by":"crossref","first-page":"5848","DOI":"10.1128\/JVI.78.11.5848-5855.2004","article-title":"Integrase-specific enhancement and suppression of retroviral DNA integration by compacted chromatin structure in vitro","volume":"78","author":"Taganov","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib231","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01011-22","article-title":"HIV-1 preintegration complex preferentially integrates the viral DNA into nucleosomes containing trimethylated histone 3-lysine 36 modification and flanking linker DNA","volume":"96","author":"Sapp","year":"2022","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib232","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1006\/jmbi.1997.1494","article-title":"New DNA sequence rules for high affinity binding to histone octamer and sequence-directed nucleosome positioning","volume":"276","author":"Lowary","year":"1998","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jbc.2025.110440_bib233","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1006\/jmbi.1999.2686","article-title":"Sequence motifs and free energies of selected natural and non-natural nucleosome positioning DNA sequences","volume":"288","author":"Th\u00e5str\u00f6m","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jbc.2025.110440_bib234","doi-asserted-by":"crossref","first-page":"7830","DOI":"10.1093\/nar\/gkw651","article-title":"DNA minicircles clarify the specific role of DNA structure on retroviral integration","volume":"44","author":"Pasi","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2025.110440_bib235","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.1093\/nar\/gkz091","article-title":"Human H4 tail stimulates HIV-1 integration through binding to the carboxy-terminal domain of integrase","volume":"47","author":"Mauro","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2025.110440_bib236","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01741-18","article-title":"PF74 inhibits HIV-1 integration by altering the composition of the preintegration complex","volume":"93","author":"Balasubramaniam","year":"2019","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib237","doi-asserted-by":"crossref","DOI":"10.1126\/science.abc8420","article-title":"Reconstitution and visualization of HIV-1 capsid-dependent replication and integration in vitro","volume":"370","author":"Christensen","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jbc.2025.110440_bib238","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00555-21","article-title":"Human three prime repair exonuclease 1 promotes HIV-1 integration by preferentially degrading unprocessed viral DNA","volume":"95","author":"Davids","year":"2021","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib239","doi-asserted-by":"crossref","DOI":"10.1093\/pnasnexus\/pgac064","article-title":"HIV-1 mutants that escape the cytotoxic T-lymphocytes are defective in viral DNA integration","volume":"1","author":"Balasubramaniam","year":"2022","journal-title":"PNAS Nexus"},{"key":"10.1016\/j.jbc.2025.110440_bib240","doi-asserted-by":"crossref","first-page":"6483","DOI":"10.1038\/ncomms7483","article-title":"Chromatin organization at the nuclear pore favours HIV replication","volume":"6","author":"Lelek","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.110440_bib241","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nature14226","article-title":"Nuclear architecture dictates HIV-1 integration site selection","volume":"521","author":"Marini","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.110440_bib242","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0002413","article-title":"HIV-1 pre-integration complexes selectively target decondensed chromatin in the nuclear periphery","volume":"3","author":"Albanese","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2025.110440_bib243","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.139783","article-title":"Assessment of HIV-1 integration in tissues and subsets across infection stages","volume":"5","author":"Wu","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.jbc.2025.110440_bib244","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1038\/s41467-019-12046-3","article-title":"Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration","volume":"10","author":"Lucic","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.110440_bib245","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1128\/JVI.72.5.4005-4014.1998","article-title":"Chromosome structure and human immunodeficiency virus type 1 cDNA integration: centromeric alphoid repeats are a disfavored target","volume":"72","author":"Carteau","year":"1998","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib246","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1097\/QAD.0b013e32832caf28","article-title":"HIV integration site distributions in resting and activated CD4+ T cells infected in culture","volume":"23","author":"Brady","year":"2009","journal-title":"AIDS"},{"key":"10.1016\/j.jbc.2025.110440_bib247","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/mt.2009.16","article-title":"Analysis of lentiviral vector integration in HIV+ study subjects receiving autologous infusions of gene modified CD4+ T cells","volume":"17","author":"Wang","year":"2009","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jbc.2025.110440_bib248","doi-asserted-by":"crossref","first-page":"11241","DOI":"10.1093\/nar\/gkab886","article-title":"Modulation of the intrinsic chromatin binding property of HIV-1 integrase by LEDGF\/p75","volume":"49","author":"Lapaillerie","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2025.110440_bib249","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/nature06561","article-title":"Cell cycle control of centromeric repeat transcription and heterochromatin assembly","volume":"451","author":"Chen","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.110440_bib250","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nature09906","article-title":"Mapping and analysis of chromatin state dynamics in nine human cell types","volume":"473","author":"Ernst","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.110440_bib251","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2017.19","article-title":"Modulation of gene expression dynamics by co-transcriptional histone methylations","volume":"49","author":"Woo","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.jbc.2025.110440_bib252","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nrm3274","article-title":"Understanding the language of Lys36 methylation at histone H3","volume":"13","author":"Wagner","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2025.110440_bib253","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.cell.2013.03.025","article-title":"The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutS\u03b1","volume":"153","author":"Li","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.110440_bib254","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/nature21373","article-title":"Intragenic DNA methylation prevents spurious transcription initiation","volume":"543","author":"Neri","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.110440_bib255","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41467-023-44544-w","article-title":"PSIP1\/LEDGF reduces R-loops at transcription sites to maintain genome integrity","volume":"15","author":"Jayakumar","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.110440_bib256","doi-asserted-by":"crossref","first-page":"83","DOI":"10.12688\/wellcomeopenres.11589.4","article-title":"H3K36me3 and PSIP1\/LEDGF associate with several DNA repair proteins, suggesting their role in efficient DNA repair at actively transcribing loci","volume":"2","author":"Sundarraj","year":"2017","journal-title":"Wellcome Open Res."},{"key":"10.1016\/j.jbc.2025.110440_bib257","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.tibs.2014.09.001","article-title":"Structure and function of the nucleosome-binding PWWP domain","volume":"39","author":"Qin","year":"2014","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jbc.2025.110440_bib258","doi-asserted-by":"crossref","first-page":"4868","DOI":"10.1093\/nar\/gku135","article-title":"Bimodal high-affinity association of Brd4 with murine leukemia virus integrase and mononucleosomes","volume":"42","author":"Larue","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2025.110440_bib259","doi-asserted-by":"crossref","DOI":"10.1038\/srep43613","article-title":"Chromatin states shape insertion profiles of the piggyBac, Tol2 and sleeping beauty transposons and murine leukemia virus","volume":"7","author":"Yoshida","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2025.110440_bib260","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/nature07730","article-title":"ChIP-seq accurately predicts tissue-specific activity of enhancers","volume":"457","author":"Visel","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.110440_bib261","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.gene.2017.06.056","article-title":"Histone H3 lysine 4 methyltransferase KMT2D","volume":"627","author":"Froimchuk","year":"2017","journal-title":"Gene"},{"key":"10.1016\/j.jbc.2025.110440_bib262","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1038\/s41467-017-02403-5","article-title":"Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis","volume":"8","author":"Lee","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.110440_bib263","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.cell.2013.03.036","article-title":"Selective inhibition of tumor oncogenes by disruption of super-enhancers","volume":"153","author":"Lov\u00e9n","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.110440_bib264","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.molcel.2015.04.011","article-title":"BET bromodomain inhibition suppresses the function of hematopoietic transcription factors in acute myeloid leukemia","volume":"58","author":"Roe","year":"2015","journal-title":"Mol. Cell."},{"key":"10.1016\/j.jbc.2025.110440_bib265","doi-asserted-by":"crossref","first-page":"6537","DOI":"10.1128\/.20.17.6537-6549.2000","article-title":"A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition","volume":"20","author":"Dey","year":"2000","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.jbc.2025.110440_bib266","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nature12147","article-title":"The bromodomain protein Brd4 insulates chromatin from DNA damage signalling","volume":"498","author":"Floyd","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.110440_bib267","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3410\/B1-98","article-title":"Brd4 engagement from chromatin targeting to transcriptional regulation: selective contact with acetylated histone H3 and H4","volume":"1","author":"Chiang","year":"2009","journal-title":"F1000 Biol Rep."},{"key":"10.1016\/j.jbc.2025.110440_bib268","doi-asserted-by":"crossref","first-page":"6927","DOI":"10.1073\/pnas.1120422109","article-title":"BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain","volume":"109","author":"Devaiah","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110440_bib269","doi-asserted-by":"crossref","first-page":"38755","DOI":"10.1074\/jbc.M112.412015","article-title":"Cross-talk among RNA polymerase II kinases modulates C-terminal domain phosphorylation","volume":"287","author":"Devaiah","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110440_bib270","doi-asserted-by":"crossref","first-page":"10209","DOI":"10.1093\/nar\/gku769","article-title":"Molecular mechanisms of retroviral integration site selection","volume":"42","author":"Kvaratskhelia","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2025.110440_bib271","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1002\/bies.201500051","article-title":"Retroviral integration: site matters: mechanisms and consequences of retroviral integration site selection","volume":"37","author":"Demeulemeester","year":"2015","journal-title":"Bioessays"},{"key":"10.1016\/j.jbc.2025.110440_bib272","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/s41467-019-08810-0","article-title":"Cellular TRIM33 restrains HIV-1 infection by targeting viral integrase for proteasomal degradation","volume":"10","author":"Ali","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.110440_bib273","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020105247","article-title":"Clustering and reverse transcription of HIV-1 genomes in nuclear niches of macrophages","volume":"40","author":"Rensen","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2025.110440_bib274","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a000646","article-title":"Nuclear speckles","volume":"3","author":"Spector","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.jbc.2025.110440_bib275","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1083\/jcb.200803174","article-title":"Association between active genes occurs at nuclear speckles and is modulated by chromatin environment","volume":"182","author":"Brown","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jbc.2025.110440_bib276","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-37364-x","article-title":"Formation of nuclear CPSF6\/CPSF5 biomolecular condensates upon HIV-1 entry into the nucleus is important for productive infection","volume":"13","author":"Luchsinger","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2025.110440_bib277","doi-asserted-by":"crossref","first-page":"670","DOI":"10.3390\/v16050670","article-title":"HIV-1 capsid rapidly induces long-lived CPSF6 puncta in non-dividing cells, but similar puncta already exist in uninfected T-cells","volume":"16","author":"Gued\u00e1n","year":"2024","journal-title":"Viruses"},{"key":"10.1016\/j.jbc.2025.110440_bib278","doi-asserted-by":"crossref","first-page":"11060","DOI":"10.1093\/nar\/gkae769","article-title":"HIV-1 usurps mixed-charge domain-dependent CPSF6 phase separation for higher-order capsid binding, nuclear entry and viral DNA integration","volume":"52","author":"Jang","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2025.110440_bib279","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107374","article-title":"Integrase-LEDGF\/p75 complex triggers the formation of biomolecular condensates that modulate HIV-1 integration efficiency in vitro","volume":"300","author":"Batisse","year":"2024","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110440_bib280","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.gde.2015.11.006","article-title":"Liquid-like behavior of chromatin","volume":"37","author":"Maeshima","year":"2016","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.jbc.2025.110440_bib281","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.cell.2019.08.037","article-title":"Organization of chromatin by intrinsic and regulated phase separation","volume":"179","author":"Gibson","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.110440_bib282","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ceb.2020.02.016","article-title":"Fluid-like chromatin: toward understanding the real chromatin organization present in the cell","volume":"64","author":"Maeshima","year":"2020","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.jbc.2025.110440_bib283","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1038\/s41467-021-23090-3","article-title":"Nucleosome plasticity is a critical element of chromatin liquid-liquid phase separation and multivalent nucleosome interactions","volume":"12","author":"Farr","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.110440_bib284","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1093\/cid\/ciw382","article-title":"Transmitted HIV drug resistance is high and longstanding in metropolitan Washington, DC","volume":"63","author":"Kassaye","year":"2016","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jbc.2025.110440_bib285","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.00361-23","article-title":"HIV-1 3'-Polypurine tract mutations confer dolutegravir resistance by switching to an integration-independent replication mechanism via 1-LTR circles","volume":"97","author":"Dekker","year":"2023","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110440_bib286","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adn0042","article-title":"Epistatic pathways can drive HIV-1 escape from integrase strand transfer inhibitors","volume":"10","author":"Hikichi","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jbc.2025.110440_bib287","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.cell.2016.07.044","article-title":"HIV-1 integrase binds the viral RNA genome and is essential during virion morphogenesis","volume":"166","author":"Kessl","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.110440_bib288","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.00465-24","article-title":"The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir","volume":"15","author":"Dinh","year":"2024","journal-title":"mBio"},{"key":"10.1016\/j.jbc.2025.110440_bib289","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11409","article-title":"Retroviral intasomes search for a target DNA by 1D diffusion which rarely results in integration","volume":"7","author":"Jones","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.110440_bib290","doi-asserted-by":"crossref","first-page":"770","DOI":"10.3390\/v11090770","article-title":"Structural insights on retroviral DNA integration: learning from foamy viruses","volume":"11","author":"Lee","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.jbc.2025.110440_bib291","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0212764","article-title":"Nucleosome DNA unwrapping does not affect prototype foamy virus integration efficiency or site selection","volume":"14","author":"Mackler","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2025.110440_bib292","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100550","article-title":"Retroviral prototype foamy virus intasome binding to a nucleosome target does not determine integration efficiency","volume":"296","author":"Kotlar","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110440_bib293","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.3390\/biom11121910","article-title":"Prototype foamy virus integrase displays unique biochemical activities among retroviral integrases","volume":"11","author":"Rabe","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.jbc.2025.110440_bib294","article-title":"Modulation of the functional interfaces between retroviral intasomes and the human nucleosome","volume":"14","author":"Mauro","year":"2023","journal-title":"mBio"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925825022902?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925825022902?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T16:56:15Z","timestamp":1762188975000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925825022902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":294,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S0021925825022902"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2025.110440","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of chromatin in retroviral preintegration complex function","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2025.110440","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology\u00e9","name":"copyright","label":"Copyright"}],"article-number":"110440"}}