{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:35:30Z","timestamp":1791945330626,"version":"4.3.4"},"reference-count":64,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000052","name":"National Institutes of Health Office of the Director","doi-asserted-by":"publisher","award":["S10OD027034"],"award-info":[{"award-number":["S10OD027034"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI158220"],"award-info":[{"award-number":["R01AI158220"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jbc.2025.110489","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:31:38Z","timestamp":1752712298000},"page":"110489","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Variants of the Ebola virus matrix protein VP40 have differential effects on oligomerization and plasma membrane interactions"],"prefix":"10.1016","volume":"301","author":[{"given":"Balindile B.","family":"Motsa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9139-6916","authenticated-orcid":false,"given":"Barsha","family":"Bhowal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4358-2912","authenticated-orcid":false,"given":"Yogesh B.","family":"Narkhede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9929-7574","authenticated-orcid":false,"given":"Ukesh","family":"Karki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina Toro","family":"Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel W.","family":"Eger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Wiest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prem P.","family":"Chapagain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5443-7863","authenticated-orcid":false,"given":"Robert V.","family":"Stahelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2025.110489_bib1","doi-asserted-by":"crossref","first-page":"e165","DOI":"10.1016\/S1473-3099(24)00673-X","article-title":"Ebola disease: bridging scientific discoveries and clinical application","volume":"25","author":"Rojek","year":"2025","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.jbc.2025.110489_bib2","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1136\/bmj.2.6086.541","article-title":"A case of Ebola virus infection","volume":"2","author":"Emond","year":"1977","journal-title":"Br. Med. J."},{"key":"10.1016\/j.jbc.2025.110489_bib3","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1038\/s41564-024-01703-z","article-title":"Molecular insights into the Ebola virus life cycle","volume":"9","author":"Bodmer","year":"2024","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.jbc.2025.110489_bib4","doi-asserted-by":"crossref","first-page":"5205","DOI":"10.1128\/JVI.75.11.5205-5214.2001","article-title":"Ebola virus VP40-induced particle formation and association with the lipid bilayer","volume":"75","author":"Jasenosky","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110489_bib5","doi-asserted-by":"crossref","first-page":"4855","DOI":"10.1128\/JVI.76.10.4855-4865.2002","article-title":"Ebola virus VP40 drives the formation of virus-like filamentous particles along with GP","volume":"76","author":"Noda","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110489_bib6","doi-asserted-by":"crossref","first-page":"7344","DOI":"10.1128\/JVI.78.14.7344-7351.2004","article-title":"Contribution of ebola virus glycoprotein, nucleoprotein, and VP24 to budding VP40 virus-like particles","volume":"78","author":"Licata","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110489_bib7","article-title":"Chaperone-mediated autophagy protein BAG3 negatively regulates Ebola and Marburg VP40-mediated egress","volume":"13","author":"Liang","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2025.110489_bib8","doi-asserted-by":"crossref","first-page":"9163","DOI":"10.1128\/JVI.01078-16","article-title":"ITCH E3 ubiquitin ligase interacts with Ebola virus VP40 to regulate budding","volume":"90","author":"Han","year":"2016","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110489_bib9","doi-asserted-by":"crossref","first-page":"8596","DOI":"10.1074\/jbc.AC120.013171","article-title":"Angiomotin regulates budding and spread of Ebola virus","volume":"295","author":"Han","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110489_bib10","doi-asserted-by":"crossref","first-page":"5779","DOI":"10.1074\/jbc.M112.443960","article-title":"The Ebola virus matrix protein penetrates into the plasma membrane: a key step in viral protein 40 (VP40) oligomerization and viral egress","volume":"288","author":"Adu-Gyamfi","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110489_bib11","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1128\/JVI.01087-15","article-title":"Host cell plasma membrane phosphatidylserine regulates the assembly and budding of Ebola virus","volume":"89","author":"Adu-Gyamfi","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110489_bib12","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202051709","article-title":"Phosphatidylserine clustering by the Ebola virus matrix protein is a critical step in viral budding","volume":"23","author":"Husby","year":"2022","journal-title":"EMBO Rep."},{"key":"10.1016\/j.jbc.2025.110489_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2024.100512","article-title":"PI(4,5)P2 binding sites in the ebola virus matrix protein modulate assembly and budding","volume":"65","author":"Johnson","year":"2024","journal-title":"J. Lipid. Res."},{"key":"10.1016\/j.jbc.2025.110489_bib14","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.antiviral.2008.12.003","article-title":"No exit: targeting the budding process to inhibit filovirus replication","volume":"81","author":"Harty","year":"2009","journal-title":"Antivir. Res."},{"key":"10.1016\/j.jbc.2025.110489_bib15","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1517\/14728222.2014.863877","article-title":"Could the Ebola virus matrix protein VP40 be a drug target?","volume":"18","author":"Stahelin","year":"2014","journal-title":"Expert Opin. Ther. Targ."},{"key":"10.1016\/j.jbc.2025.110489_bib16","first-page":"33193","article-title":"Development of a crystallographic screening to identify Sudan virus VP40 ligands","volume":"9","author":"Werner","year":"2024","journal-title":"ACS Omega"},{"key":"10.1016\/j.jbc.2025.110489_bib17","doi-asserted-by":"crossref","first-page":"4228","DOI":"10.1093\/emboj\/19.16.4228","article-title":"Crystal structure of the matrix protein VP40 from Ebola virus","volume":"19","author":"Dessen","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2025.110489_bib18","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1128\/JVI.79.3.1898-1905.2005","article-title":"VP40 octamers are essential for ebola virus replication","volume":"79","author":"Hoenen","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110489_bib19","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.cell.2013.07.015","article-title":"Structural rearrangement of Ebola virus VP40 begets multiple functions in the virus life cycle","volume":"154","author":"Bornholdt","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.110489_bib20","doi-asserted-by":"crossref","first-page":"3335","DOI":"10.1074\/jbc.M117.816280","article-title":"A cationic, C-terminal patch and structural rearrangements in Ebola virus matrix VP40 protein control its interactions with phosphatidylserine","volume":"293","author":"Del Vecchio","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110489_bib21","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1016\/j.bpj.2012.04.022","article-title":"Investigation of Ebola VP40 assembly and oligomerization in live cells using number and brightness analysis","volume":"102","author":"Adu-Gyamfi","year":"2012","journal-title":"Biophys. J."},{"key":"10.1016\/j.jbc.2025.110489_bib22","doi-asserted-by":"crossref","first-page":"19125","DOI":"10.1038\/srep19125","article-title":"The Ebola Virus matrix protein, VP40, requires phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) for extensive oligomerization at the plasma membrane and viral egress","volume":"6","author":"Johnson","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2025.110489_bib23","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.59225","article-title":"Ebola and Marburg virus matrix layers are locally ordered assemblies of VP40 dimers","volume":"9","author":"Wan","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.jbc.2025.110489_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.108986","article-title":"Cellular mRNA triggers structural transformation of Ebola virus matrix protein VP40 to its essential regulatory form","volume":"35","author":"Landeras-Bueno","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2025.110489_bib25","doi-asserted-by":"crossref","first-page":"4275","DOI":"10.1073\/pnas.1120453109","article-title":"Structural dissection of Ebola virus and its assembly determinants using cryo-electron tomography","volume":"109","author":"Bharat","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110489_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/pro.4978","article-title":"Computational and experimental identification of keystone interactions in Ebola virus matrix protein VP40 dimer formation","volume":"33","author":"Narkhede","year":"2024","journal-title":"Protein Sci."},{"key":"10.1016\/j.jbc.2025.110489_bib27","doi-asserted-by":"crossref","first-page":"6449","DOI":"10.1021\/acs.jpcb.3c01759","volume":"127","author":"Narkhede","year":"2023","journal-title":"J. Phys. Chem. B."},{"key":"10.1016\/j.jbc.2025.110489_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107213","article-title":"Minor electrostatic changes robustly increase VP40 membrane binding, assembly, and budding of Ebola virus matrix protein derived virus-like particles","volume":"300","author":"Motsa","year":"2024","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110489_bib29","doi-asserted-by":"crossref","first-page":"6732","DOI":"10.1093\/emboj\/19.24.6732","article-title":"Membrane association induces a conformational change in the Ebola virus matrix protein","volume":"19","author":"Scianimanico","year":"2000","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2025.110489_bib30","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1039\/D5CB00048C","article-title":"Design of a stapled peptide that binds to the Ebola virus matrix protein dimer interface","volume":"19","author":"Saxena","year":"2025","journal-title":"RSC Chem. Biol."},{"key":"10.1016\/j.jbc.2025.110489_bib31","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1126\/science.1259657","article-title":"Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak","volume":"345","author":"Gire","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.jbc.2025.110489_bib32","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.cell.2015.06.007","article-title":"Ebola virus epidemiology, transmission, and evolution during seven months in Sierra Leone","volume":"161","author":"Park","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.110489_bib33","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nature14612","article-title":"Distinct lineages of ebola virus in Guinea during the 2014 western Africa epidemic","volume":"525","author":"Simon-Loriere","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.110489_bib34","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nature14490","article-title":"Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone","volume":"524","author":"Tong","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.110489_bib35","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.3201\/eid2107.150522","article-title":"Monitoring of Ebola virus Makona through establishment of advanced genomic capability in Liberia","volume":"21","author":"Kugelman","year":"2015","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.jbc.2025.110489_bib36","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.1093\/bioinformatics\/bty407","article-title":"Nextstrain: real-time tracking of pathogen evolution","volume":"34","author":"Hadfield","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jbc.2025.110489_bib37","doi-asserted-by":"crossref","first-page":"e109","DOI":"10.1016\/S2666-5247(23)00259-8","article-title":"2020 Ebola virus disease outbreak in \u00c9quateur Province, Democratic Republic of Congo: a retrospective genomic characterisation","volume":"5","author":"Kingada-Lusamaki","year":"2024","journal-title":"Lancet Microbe"},{"key":"10.1016\/j.jbc.2025.110489_bib38","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1186\/s12879-024-09391-0","article-title":"Sudan virus disease super-spreading, Uganda, 2022","volume":"24","author":"Komakech","year":"2024","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.jbc.2025.110489_bib39","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1021\/acs.jpcb.4c07794","article-title":"Prospective evaluation of structure-based simulations reveal their ability to predict the impact of kinase mutations on inhibitor binding","volume":"129","author":"Singh","year":"2025","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.jbc.2025.110489_bib40","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1021\/acs.jcim.3c00344","article-title":"Integrative approach to dissect the drug resistance mechanism of the H172Y mutation of SARS-CoV-2 main protease","volume":"63","author":"Clayton","year":"2023","journal-title":"J. Chem. Inform. Mod."},{"key":"10.1016\/j.jbc.2025.110489_bib41","doi-asserted-by":"crossref","first-page":"4656","DOI":"10.1021\/acs.jcim.1c00783","article-title":"Computationally designed ACE2 decoy receptor binds SARS-CoV-2 spike (S) protein with tight nanomolar affinity","volume":"61","author":"Havranek","year":"2021","journal-title":"J. Chem. Inform. Mod."},{"key":"10.1016\/j.jbc.2025.110489_bib42","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1128\/JVI.02034-09","article-title":"Conserved motifs within Ebola and Marburg virus VP40 proteins are important for stability, localization, and subsequent budding of virus-like particles","volume":"84","author":"Liu","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110489_bib43","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1517\/17460441.2015.1032936","article-title":"The MM\/PBSA and MM\/GBSA methods to estimate ligand-binding affinities","volume":"10","author":"Genheden","year":"2015","journal-title":"Expt. Opin. Drug Discov."},{"key":"10.1016\/j.jbc.2025.110489_bib44","doi-asserted-by":"crossref","first-page":"5389","DOI":"10.1021\/acs.jpcb.7b11367","article-title":"Flex ddG: Rosetta ensemble-based estimation of changes in protein\u2013protein binding affinity upon mutation","volume":"122","author":"Barlow","year":"2018","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.jbc.2025.110489_bib45","series-title":"Methods in Enzymology","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/B978-0-12-381270-4.00019-6","article-title":"ROSETTA3: an object-oriented software suite for the simulation and design of macromolecules","volume":"487","author":"Leaver-Fay","year":"2011"},{"key":"10.1016\/j.jbc.2025.110489_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020161","article-title":"RosettaScripts: a scripting language interface to the Rosetta macromolecular modeling suite","volume":"6","author":"Fleishman","year":"2011","journal-title":"PloS one"},{"key":"10.1016\/j.jbc.2025.110489_bib47","series-title":"Schr\u00f6dinger Release 2024-1: Protein Preparation Workflow","year":"2024"},{"key":"10.1016\/j.jbc.2025.110489_bib48","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1021\/acs.jctc.8b01026","article-title":"OPLS3e: Extending force field coverage for drug-like small molecules","volume":"15","author":"Roos","year":"2019","journal-title":"J. Chem. Theor. Comput."},{"key":"10.1016\/j.jbc.2025.110489_bib49","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.str.2021.03.011","article-title":"Macromolecular refinement of X-ray and cryoelectron microscopy structures with Phenix\/OPLS3e for improved structure and ligand quality","volume":"29","author":"van Zundert","year":"2021","journal-title":"Structure"},{"key":"10.1016\/j.jbc.2025.110489_bib50","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1021\/acs.jctc.5b00255","article-title":"ff14SB: improving the accuracy of protein side chain and backbone parameters from ff99SB","volume":"11","author":"Maier","year":"2015","journal-title":"J. Chem. Theor. Comput."},{"key":"10.1016\/j.jbc.2025.110489_bib51","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1021\/ct200909j","article-title":"Routine microsecond molecular dynamics simulations with AMBER on GPUs. 1. Generalized born","volume":"8","author":"Gotz","year":"2012","journal-title":"J. Chem. Theor. Comput."},{"key":"10.1016\/j.jbc.2025.110489_bib52","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1021\/ct400314y","article-title":"Routine microsecond molecular dynamics simulations with AMBER on GPUs. 2. Explicit solvent particle mesh Ewald","volume":"9","author":"Salomon-Ferrer","year":"2013","journal-title":"J. Chem. Theor. Comput."},{"key":"10.1016\/j.jbc.2025.110489_bib53","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1021\/ct400341p","article-title":"PTRAJ and CPPTRAJ: software for processing and analysis of molecular dynamics trajectory data","volume":"9","author":"Roe","year":"2013","journal-title":"J. Chem. Theor. Comput."},{"key":"10.1016\/j.jbc.2025.110489_bib54","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/(SICI)1096-987X(19990130)20:2<217::AID-JCC4>3.0.CO;2-A","article-title":"Approximate atomic surfaces from linear combinations of pairwise overlaps (LCPO)","volume":"20","author":"Weiser","year":"1999","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.jbc.2025.110489_bib55","series-title":"R: A Language and Environment for Statistical Computing","year":"2021"},{"key":"10.1016\/j.jbc.2025.110489_bib56","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/wics.147","article-title":"ggplot2","volume":"3","author":"Wickham","year":"2011","journal-title":"Wiley Interdiscip. Rev. Comput. Stat."},{"key":"10.1016\/j.jbc.2025.110489_bib57","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1002\/jcc.20945","article-title":"CHARMM-GUI: a web-based graphical user Interface for CHARMM","volume":"29","author":"Jo","year":"2008","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.jbc.2025.110489_bib58","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1021\/acs.jctc.5b00935","article-title":"CHARMM-GUI input generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM\/OpenMM simulations using the CHARMM36 additive force field","volume":"12","author":"Lee","year":"2016","journal-title":"J. Chem. Theor. Comput."},{"key":"10.1016\/j.jbc.2025.110489_bib59","doi-asserted-by":"crossref","DOI":"10.1063\/5.0014475","article-title":"Scalable molecular dynamics on CPU and GPU architectures with NAMD","volume":"153","author":"Phillips","year":"2020","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.jbc.2025.110489_bib60","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nmeth.4067","article-title":"CHARMM36m: an improved force field for folded and intrinsically disordered proteins","volume":"14","author":"Huang","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jbc.2025.110489_bib61","doi-asserted-by":"crossref","first-page":"11335","DOI":"10.1021\/acs.jpcb.4c02700","article-title":"Ebola virus matrix protein VP40 single mutations G198R and G201R significantly enhance plasma membrane localizaion","volume":"128","author":"Cioffi","year":"2024","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.jbc.2025.110489_bib62","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1080\/00268978300102851","article-title":"Constant pressure molecular dynamics for molecular systems","volume":"50","author":"Nos\u00e9","year":"1983","journal-title":"Mol. Phys."},{"key":"10.1016\/j.jbc.2025.110489_bib63","doi-asserted-by":"crossref","first-page":"8577","DOI":"10.1063\/1.470117","article-title":"A smooth particle mesh Ewald method","volume":"103","author":"Essmann","year":"1995","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.jbc.2025.110489_bib64","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0021-9991(77)90098-5","article-title":"Numerical Integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes","volume":"23","author":"Ryckaert","year":"1977","journal-title":"J. Comput. Phys."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925825023397?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925825023397?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T16:44:35Z","timestamp":1772815475000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925825023397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":64,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S0021925825023397"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2025.110489","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Variants of the Ebola virus matrix protein VP40 have differential effects on oligomerization and plasma membrane interactions","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2025.110489","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology\u00e9","name":"copyright","label":"Copyright"}],"article-number":"110489"}}