{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:11:20Z","timestamp":1790356280497,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008349","name":"Universit\u00e4t Duisburg-Essen","doi-asserted-by":"publisher","award":["EH 100\/19-1"],"award-info":[{"award-number":["EH 100\/19-1"]}],"id":[{"id":"10.13039\/501100008349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008349","name":"Universit\u00e4t Duisburg-Essen","doi-asserted-by":"publisher","award":["SFB1430 - Project-ID 424228829"],"award-info":[{"award-number":["SFB1430 - Project-ID 424228829"]}],"id":[{"id":"10.13039\/501100008349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.jbc.2025.110729","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T20:54:38Z","timestamp":1758056078000},"page":"110729","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["The serine protease HTRA1 targets tau fibrils and provides a proteolytic barrier against pathogenic protein conformations"],"prefix":"10.1016","volume":"301","author":[{"given":"Birte","family":"Hagemeier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamilla","family":"Ripkens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5503-6218","authenticated-orcid":false,"given":"Nina","family":"Schulze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"Bluemke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Strzala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9506-5991","authenticated-orcid":false,"given":"Michelle","family":"Koci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farnusch","family":"Kaschani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6540-8520","authenticated-orcid":false,"given":"Markus","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Erkelenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Schluecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melisa","family":"Merdanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8304-4062","authenticated-orcid":false,"given":"Simon","family":"Poepsel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Hellerschmied","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1848-1853","authenticated-orcid":false,"given":"Steven G.","family":"Burston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ehrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2025.110729_bib1","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41586-023-06437-2","article-title":"Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids","volume":"621","author":"Scheres","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.110729_bib2","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/s41580-018-0060-8","article-title":"A new era for understanding amyloid structures and disease","volume":"19","author":"Iadanza","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2025.110729_bib3","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1126\/science.aat1780","article-title":"Near-atomic model of microtubule-tau interactions","volume":"360","author":"Kellogg","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.jbc.2025.110729_bib4","article-title":"Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases","volume":"8","author":"Zhang","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.jbc.2025.110729_bib5","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev-pathmechdis-051222-120750","article-title":"Neurodegenerative disease tauopathies","volume":"19","author":"Creekmore","year":"2024","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.jbc.2025.110729_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112725","article-title":"Super-resolution imaging unveils the self-replication of tau aggregates upon seeding","volume":"42","author":"Dimou","year":"2023","journal-title":"Cell Rep"},{"key":"10.1016\/j.jbc.2025.110729_bib7","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/nrm3065","article-title":"HTRA proteases: regulated proteolysis in protein quality control","volume":"12","author":"Clausen","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2025.110729_bib8","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.1128\/MCB.00035-09","article-title":"Serine protease HtrA1 associates with microtubules and inhibits cell migration","volume":"29","author":"Chien","year":"2009","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2025.110729_bib9","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1158\/1541-7786.MCR-09-0473","article-title":"The serine protease HtrA1 specifically interacts and degrades the Tuberous Sclerosis Complex 2 protein","volume":"8","author":"Campioni","year":"2010","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.jbc.2025.110729_bib10","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nchembio.1931","article-title":"Determinants of amyloid fibril degradation by the PDZ protease HTRA1","volume":"11","author":"Poepsel","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jbc.2025.110729_bib11","doi-asserted-by":"crossref","first-page":"20931","DOI":"10.1074\/jbc.M111.316232","article-title":"Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates","volume":"287","author":"Tennstaedt","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110729_bib12","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1002\/pmic.201600057","article-title":"Changes in the detergent-insoluble brain proteome linked to amyloid and tau in Alzheimer's disease progression","volume":"16","author":"Hales","year":"2016","journal-title":"Proteomics"},{"key":"10.1016\/j.jbc.2025.110729_bib13","doi-asserted-by":"crossref","first-page":"6021","DOI":"10.1073\/pnas.0501823102","article-title":"Implications of the serine protease HtrA1 in amyloid precursor protein processing","volume":"102","author":"Grau","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110729_bib14","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2113520119","article-title":"An allosteric HTRA1-calpain 2 complex with restricted activation profile","volume":"119","author":"Rey","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jbc.2025.110729_bib15","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1073\/pnas.1918721117","article-title":"Activation by substoichiometric inhibition","volume":"117","author":"Merdanovic","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110729_bib16","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/nsmb.2013","article-title":"Substrate-induced remodeling of the active site regulates human HTRA1 activity","volume":"18","author":"Truebestein","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.jbc.2025.110729_bib17","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1021\/acscentsci.9b00416","article-title":"PhoX: an IMAC-Enrichable cross-linking reagent","volume":"5","author":"Steigenberger","year":"2019","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.jbc.2025.110729_bib18","doi-asserted-by":"crossref","first-page":"5944","DOI":"10.1038\/s41467-024-49982-8","article-title":"Rational correction of pathogenic conformational defects in HTRA1","volume":"15","author":"Beaufort","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.110729_bib19","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1371\/journal.pbio.1000034","article-title":"Structural polymorphism of 441-residue tau at single residue resolution","volume":"7","author":"Mukrasch","year":"2009","journal-title":"Plos Biol."},{"key":"10.1016\/j.jbc.2025.110729_bib20","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1002\/rcm.8243","article-title":"Utilities for mass spectrometry analysis of proteins (UMSAP): fast post-processing of mass spectrometry data","volume":"32","author":"Bravo-Rodriguez","year":"2018","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.jbc.2025.110729_bib21","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41467-023-36058-2","article-title":"The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system","volume":"14","author":"Saha","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.110729_bib22","doi-asserted-by":"crossref","first-page":"9676","DOI":"10.1074\/jbc.RA120.013478","article-title":"Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species","volume":"295","author":"Nachman","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110729_bib23","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41580-019-0101-y","article-title":"The proteostasis network and its decline in ageing","volume":"20","author":"Hipp","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2025.110729_bib24","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.tibs.2018.02.003","article-title":"Protein disaggregation in multicellular organisms","volume":"43","author":"Nillegoda","year":"2018","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jbc.2025.110729_bib25","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1038\/s41467-024-46538-8","article-title":"HTRA1 disaggregates alpha-synuclein amyloid fibrils and converts them into non-toxic and seeding incompetent species","volume":"15","author":"Chen","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.110729_bib26","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1021\/cr040669e","article-title":"Proteases universally recognize beta strands in their active sites","volume":"105","author":"Tyndall","year":"2005","journal-title":"Chem. Rev."},{"key":"10.1016\/j.jbc.2025.110729_bib27","doi-asserted-by":"crossref","first-page":"7702","DOI":"10.1073\/pnas.0803392105","article-title":"Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins","volume":"105","author":"Krojer","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110729_bib28","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.4103\/1673-5374.385853","article-title":"Tau truncation in the pathogenesis of Alzheimer's disease: a narrative review","volume":"19","author":"Chu","year":"2024","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.jbc.2025.110729_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.702788","article-title":"Human tau isoforms and proteolysis for production of toxic tau fragments in neurodegeneration","volume":"15","author":"Boyarko","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.jbc.2025.110729_bib30","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00401-017-1707-9","article-title":"Roles of tau protein in health and disease","volume":"133","author":"Guo","year":"2017","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.jbc.2025.110729_bib31","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3762\/bjnano.8.40","article-title":"Uptake of the proteins HTRA1 and HTRA2 by cells mediated by calcium phosphate nanoparticles","volume":"8","author":"Rotan","year":"2017","journal-title":"Beilstein J. Nanotechnol."},{"key":"10.1016\/j.jbc.2025.110729_bib32","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.62659","article-title":"Cell non-autonomous regulation of health and longevity","volume":"9","author":"Miller","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.jbc.2025.110729_bib33","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a034074","article-title":"Cell-nonautonomous regulation of proteostasis in aging and disease","volume":"12","author":"Morimoto","year":"2020","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.jbc.2025.110729_bib34","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1186\/s12885-016-2425-8","article-title":"Epigenetic silencing of serine protease HTRA1 drives polyploidy","volume":"16","author":"Schmidt","year":"2016","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jbc.2025.110729_bib35","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s40478-018-0540-2","article-title":"Proteomics analysis identifies new markers associated with capillary cerebral amyloid angiopathy in Alzheimer's disease","volume":"6","author":"Hondius","year":"2018","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.jbc.2025.110729_bib36","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13024-018-0266-4","article-title":"Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer's disease-related proteins","volume":"13","author":"Rangaraju","year":"2018","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.jbc.2025.110729_bib37","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.neuron.2019.12.015","article-title":"Deep multilayer brain proteomics identifies molecular networks in Alzheimer's disease progression","volume":"105","author":"Bai","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.jbc.2025.110729_bib38","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.neurobiolaging.2021.04.012","article-title":"Synaptic proteins associated with cognitive performance and neuropathology in older humans revealed by multiplexed fractionated proteomics","volume":"105","author":"Carlyle","year":"2021","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.jbc.2025.110729_bib39","doi-asserted-by":"crossref","first-page":"9473","DOI":"10.1021\/jacs.6b03463","article-title":"HtrA1 proteolysis of ApoE in vitro is allele selective","volume":"138","author":"Chu","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.jbc.2025.110729_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0089970","article-title":"Impact of age on the cerebrovascular proteomes of wild-type and Tg-SwDI mice","volume":"9","author":"Searcy","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2025.110729_bib41","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.54083","article-title":"Fibrillar abeta triggers microglial proteome alterations and dysfunction in alzheimer mouse models","volume":"9","author":"Sebastian Monasor","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.jbc.2025.110729_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2023.106286","article-title":"Unbiased classification of the elderly human brain proteome resolves distinct clinical and pathophysiological subtypes of cognitive impairment","volume":"186","author":"Higginbotham","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jbc.2025.110729_bib43","doi-asserted-by":"crossref","first-page":"135","DOI":"10.15252\/embj.201695148","article-title":"VCP\/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy","volume":"36","author":"Papadopoulos","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2025.110729_bib44","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jbc.2025.110729_bib45","doi-asserted-by":"crossref","first-page":"3679","DOI":"10.1021\/pr500202e","article-title":"MS amanda, a universal identification algorithm optimized for high accuracy tandem mass spectra","volume":"13","author":"Dorfer","year":"2014","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jbc.2025.110729_bib46","first-page":"535","article-title":"apQuant: accurate label-free quantification by quality filtering","volume":"18","author":"Doblmann","year":"2019","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jbc.2025.110729_bib47","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature10098","article-title":"Global quantification of mammalian gene expression control","volume":"473","author":"Schwanhausser","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.110729_bib48","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1074\/mcp.M113.031591","article-title":"Accurate proteome-wide label-free quantification by delayed normalization and maximal peptide ratio extraction, termed MaxLFQ","volume":"13","author":"Cox","year":"2014","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.jbc.2025.110729_bib49","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1074\/mcp.T500030-MCP200","article-title":"Parts per million mass accuracy on an Orbitrap mass spectrometer via lock mass injection into a C-trap","volume":"4","author":"Olsen","year":"2005","journal-title":"Mol. Cell Proteomics"},{"key":"10.1016\/j.jbc.2025.110729_bib50","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1021\/pr101065j","article-title":"Andromeda: a peptide search engine integrated into the MaxQuant environment","volume":"10","author":"Cox","year":"2011","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jbc.2025.110729_bib51","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jbc.2025.110729_bib52","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1186\/s12859-021-04344-9","article-title":"CellProfiler 4: improvements in speed, utility and usability","volume":"22","author":"Stirling","year":"2021","journal-title":"Bmc Bioinformatics"},{"key":"10.1016\/j.jbc.2025.110729_bib53","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41592-020-01018-x","article-title":"Cellpose: a generalist algorithm for cellular segmentation","volume":"18","author":"Stringer","year":"2021","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jbc.2025.110729_bib54","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1038\/s41592-022-01639-4","article-title":"Omnipose: a high-precision morphology-independent solution for bacterial cell segmentation","volume":"19","author":"Cutler","year":"2022","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jbc.2025.110729_bib55","doi-asserted-by":"crossref","first-page":"D447","DOI":"10.1093\/nar\/gkv1145","article-title":"2016 update of the PRIDE database and its related tools","volume":"44","author":"Vizcaino","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2025.110729_bib56","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/pro.5560040301","article-title":"Structural basis of substrate specificity in the serine proteases","volume":"4","author":"Perona","year":"1995","journal-title":"Protein Sci."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925825025815?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925825025815?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T12:24:11Z","timestamp":1773145451000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925825025815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":56,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S0021925825025815"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2025.110729","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The serine protease HTRA1 targets tau fibrils and provides a proteolytic barrier against pathogenic protein conformations","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2025.110729","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology\u00e9","name":"copyright","label":"Copyright"}],"article-number":"110729"}}