{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T16:22:12Z","timestamp":1773332532328,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017700","name":"Henan Provincial Science and Technology Research Project","doi-asserted-by":"publisher","award":["252102310403"],"award-info":[{"award-number":["252102310403"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009019","name":"Shenzhen University","doi-asserted-by":"publisher","award":["2025-HY004"],"award-info":[{"award-number":["2025-HY004"]}],"id":[{"id":"10.13039\/501100009019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32200438"],"award-info":[{"award-number":["32200438"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Shenzhen Science and Technology Innovation Commission","doi-asserted-by":"publisher","award":["JCYJ20240813142003005"],"award-info":[{"award-number":["JCYJ20240813142003005"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jbc.2025.110812","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T23:28:05Z","timestamp":1760398085000},"page":"110812","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long non-coding RNA enhances SARS-CoV-2-mediated apoptosis through epigenetic repression of angiotensin-converting enzyme 2"],"prefix":"10.1016","volume":"301","author":[{"given":"Weijie","family":"Liao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxing","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songmao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaou","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2025.110812_bib1","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.cell.2020.06.043","article-title":"Tracking changes in SARS-CoV-2 spike: evidence that D614G increases infectivity of the COVID-19 virus","volume":"182","author":"Korber","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.110812_bib2","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0140-6736(20)30557-2","article-title":"SARS-CoV-2 is an appropriate name for the new coronavirus","volume":"395","author":"Wu","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jbc.2025.110812_bib3","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1126\/science.abn8863","article-title":"Structures of the omicron spike trimer with ACE2 and an anti-Omicron antibody","volume":"375","author":"Yin","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.jbc.2025.110812_bib4","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/S1473-3099(21)00751-9","article-title":"Efficacy and safety of two neutralising monoclonal antibody therapies, sotrovimab and BRII-196 plus BRII-198, for adults hospitalised with COVID-19 (TICO): a randomised controlled trial","volume":"22","year":"2022","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.jbc.2025.110812_bib5","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41586-020-2180-5","article-title":"Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor","volume":"581","author":"Lan","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.110812_bib6","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.cell.2020.03.045","article-title":"Structural and functional basis of SARS-CoV-2 entry by using human ACE2","volume":"181","author":"Wang","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.110812_bib7","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1126\/science.abb2762","article-title":"Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2","volume":"367","author":"Yan","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jbc.2025.110812_bib8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s40249-020-00662-x","article-title":"Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues","volume":"9","author":"Li","year":"2020","journal-title":"Infect. Dis. Poverty"},{"key":"10.1016\/j.jbc.2025.110812_bib9","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.pharmthera.2010.06.003","article-title":"Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters","volume":"128","author":"Kuba","year":"2010","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jbc.2025.110812_bib10","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1161\/CIRCRESAHA.120.317015","article-title":"Angiotensin-Converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin System: celebrating the 20th anniversary of the discovery of ACE2","volume":"126","author":"Gheblawi","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.jbc.2025.110812_bib11","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.110812_bib12","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1161\/CIRCRESAHA.121.318902","article-title":"SARS-CoV-2 spike protein impairs endothelial function via downregulation of ACE 2","volume":"128","author":"Lei","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.jbc.2025.110812_bib13","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1126\/science.abc8665","article-title":"Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2","volume":"369","author":"Thoms","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.jbc.2025.110812_bib14","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202256660","article-title":"Interferon-induced transmembrane protein 3 (IFITM3) limits lethality of SARS-CoV-2 in mice","volume":"24","author":"Kenney","year":"2023","journal-title":"EMBO Rep."},{"key":"10.1016\/j.jbc.2025.110812_bib15","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.molcel.2011.08.018","article-title":"Molecular mechanisms of long noncoding RNAs","volume":"43","author":"Wang","year":"2011","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2025.110812_bib16","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev-biochem-051410-092902","article-title":"Genome regulation by long noncoding RNAs","volume":"81","author":"Rinn","year":"2012","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.jbc.2025.110812_bib17","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/s41392-023-01669-0","article-title":"Non-coding RNAs expression in SARS-CoV-2 infection: pathogenesis, clinical significance, and therapeutic targets","volume":"8","author":"Liu","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.jbc.2025.110812_bib18","doi-asserted-by":"crossref","first-page":"760","DOI":"10.3390\/genes11070760","article-title":"Protein coding and long noncoding RNA (lncRNA) transcriptional landscape in SARS-CoV-2 infected bronchial epithelial cells highlight a role for interferon and inflammatory response","volume":"11","author":"Vishnubalaji","year":"2020","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.jbc.2025.110812_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.590870","article-title":"The neat dance of COVID-19: NEAT1, DANCR, and Co-Modulated cholinergic RNAs link to inflammation","volume":"11","author":"Meydan","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jbc.2025.110812_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.699","article-title":"Persistent high glucose induced EPB41L4A-AS1 inhibits glucose uptake via GCN5 mediating crotonylation and acetylation of histones and non-histones","volume":"12","author":"Liao","year":"2022","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.jbc.2025.110812_bib21","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ebiom.2019.01.035","article-title":"LncRNA EPB41L4A-AS1 regulates glycolysis and glutaminolysis by mediating nucleolar translocation of HDAC2","volume":"41","author":"Liao","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jbc.2025.110812_bib22","article-title":"Overexpression of lncRNA EPB41L4A-AS1 induces metabolic reprogramming in trophoblast cells and placenta tissue of miscarriage","volume":"36","author":"Zhu","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.jbc.2025.110812_bib23","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jconrel.2022.06.063","article-title":"Peritoneal M2 macrophage-derived extracellular vesicles as natural multitarget nanotherapeutics to attenuate cytokine storms after severe infections","volume":"349","author":"Wang","year":"2022","journal-title":"J. Control Release"},{"key":"10.1016\/j.jbc.2025.110812_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.723585","article-title":"Different profiles of antibodies and cytokines were found between severe and moderate COVID-19 patients","volume":"12","author":"Guo","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jbc.2025.110812_bib25","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/bph.17392","article-title":"Plasma miR-1-3p levels predict severity in hospitalized COVID-19 patients","volume":"182","author":"Di Pietro","year":"2025","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jbc.2025.110812_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231810242","article-title":"miR-142 targets TIM-1 in human endothelial cells: potential implications for stroke, COVID-19, zika, Ebola, Dengue, and other viral infections","volume":"23","author":"Kansakar","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbc.2025.110812_bib27","first-page":"9","article-title":"miR-24 targets the transmembrane glycoprotein Neuropilin-1 in human brain Microvascular endothelial cells","volume":"7","author":"Mone","year":"2021","journal-title":"Noncoding RNA"},{"key":"10.1016\/j.jbc.2025.110812_bib28","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s10020-025-01154-0","article-title":"miR-27a-5p, miR-21-5p, miR-1246 and miR-4508: a candidate microRNA signature in the protection and regulation of viral infection in mild COVID-19","volume":"31","author":"Gajate-Arenas","year":"2025","journal-title":"Mol. Med."},{"key":"10.1016\/j.jbc.2025.110812_bib29","first-page":"48","article-title":"Circulating miRNAs in the plasma of Post-COVID-19 patients with typical recovery and those with Long-COVID symptoms: regulation of immune response-associated pathways","volume":"10","author":"Timofeeva","year":"2024","journal-title":"Noncoding RNA"},{"key":"10.1016\/j.jbc.2025.110812_bib30","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1080\/15384101.2024.2340859","article-title":"Discovery of common molecular signatures and drug repurposing for COVID-19\/Asthma comorbidity: ACE2 and multi-partite networks","volume":"23","author":"Xu","year":"2024","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jbc.2025.110812_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-75740-3","article-title":"Data normalization of plasma miRNA profiling from patients with COVID-19","volume":"14","author":"Siguemoto","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2025.110812_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.102151","article-title":"Transcriptomic profiling of SARS-CoV-2 infected human cell lines identifies HSP90 as target for COVID-19 therapy","volume":"24","author":"Wyler","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.jbc.2025.110812_bib33","doi-asserted-by":"crossref","first-page":"7052","DOI":"10.1038\/s41598-021-86002-x","article-title":"Comprehensive transcriptomic analysis of COVID-19 blood, lung, and airway","volume":"11","author":"Daamen","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jbc.2025.110812_bib34","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.cell.2020.10.030","article-title":"Identification of required host factors for SARS-CoV-2 infection in human cells","volume":"184","author":"Daniloski","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.110812_bib35","article-title":"Modulating the transcriptional landscape of SARS-CoV-2 as an effective method for developing antiviral compounds","author":"Hoagland","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.jbc.2025.110812_bib36","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1128\/JVI.02520-12","article-title":"Release of severe acute respiratory syndrome coronavirus nuclear import block enhances host transcription in human lung cells","volume":"87","author":"Sims","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110812_bib37","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00165-13","article-title":"Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus","volume":"4","author":"Josset","year":"2013","journal-title":"mBio"},{"key":"10.1016\/j.jbc.2025.110812_bib38","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01174-14","article-title":"Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses","volume":"5","author":"Menachery","year":"2014","journal-title":"mBio"},{"key":"10.1016\/j.jbc.2025.110812_bib39","doi-asserted-by":"crossref","first-page":"7531","DOI":"10.1073\/pnas.1402393111","article-title":"In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics","volume":"111","author":"Lao","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110812_bib40","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.csbj.2020.12.016","article-title":"Host transcriptomic profiling of COVID-19 patients with mild, moderate, and severe clinical outcomes","volume":"19","author":"Jain","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.jbc.2025.110812_bib41","doi-asserted-by":"crossref","DOI":"10.1093\/pnasnexus\/pgad029","article-title":"Elucidation of the liver pathophysiology of COVID-19 patients using liver-on-a-chips","volume":"2","author":"Deguchi","year":"2023","journal-title":"PNAS Nexus"},{"key":"10.1016\/j.jbc.2025.110812_bib42","doi-asserted-by":"crossref","first-page":"W242","DOI":"10.1093\/nar\/gkab418","article-title":"GEPIA2021: integrating multiple deconvolution-based analysis into GEPIA","volume":"49","author":"Li","year":"2021","journal-title":"Nucleic Acids Res."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582502664X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002192582502664X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:19:33Z","timestamp":1773289173000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002192582502664X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":42,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S002192582502664X"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2025.110812","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long non-coding RNA enhances SARS-CoV-2-mediated apoptosis through epigenetic repression of angiotensin-converting enzyme 2","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2025.110812","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology\u00e9","name":"copyright","label":"Copyright"}],"article-number":"110812"}}