{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T15:35:11Z","timestamp":1786721711382,"version":"build-2736575974"},"reference-count":57,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["P50 HD113015"],"award-info":[{"award-number":["P50 HD113015"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01 HD111549"],"award-info":[{"award-number":["R01 HD111549"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["F31 HD105363"],"award-info":[{"award-number":["F31 HD105363"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jbc.2025.110889","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:25:29Z","timestamp":1762302329000},"page":"110889","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Biochemical characterization of the full-length isoform of soluble adenylyl cyclase"],"prefix":"10.1016","volume":"301","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2146-9732","authenticated-orcid":false,"given":"Jacob","family":"Ferreira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayden","family":"Belliveau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5204-6356","authenticated-orcid":false,"given":"Lonny R.","family":"Levin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Buck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2025.110889_bib1","doi-asserted-by":"crossref","first-page":"9017","DOI":"10.1074\/jbc.R800075200","article-title":"Cyclic nucleotide-regulated cation channels","volume":"284","author":"Biel","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110889_bib2","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/nrm1197","article-title":"Epac: a new cAMP target and new avenues in cAMP research","volume":"4","author":"Bos","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jbc.2025.110889_bib3","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1124\/molpharm.121.000315","article-title":"The tails of protein kinase A","volume":"101","author":"Taylor","year":"2022","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.jbc.2025.110889_bib4","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.pharmthera.2014.03.008","article-title":"cAMP signaling in subcellular compartments","volume":"143","author":"Lefkimmiatis","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jbc.2025.110889_bib5","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1146\/annurev.pa.36.040196.002333","article-title":"Complexity and diversity of mammalian adenylyl cyclases","volume":"36","author":"Sunahara","year":"1996","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.jbc.2025.110889_bib6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1073\/pnas.96.1.79","article-title":"Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals","volume":"96","author":"Buck","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"10.1016\/j.jbc.2025.110889_bib7","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.cmet.2009.01.012","article-title":"Cyclic AMP produced inside Mitochondria regulates oxidative phosphorylation","volume":"9","author":"Acin-Perez","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbc.2025.110889_bib8","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.cmet.2013.05.003","article-title":"Mitochondrial Ca(2+) uptake induces cyclic AMP generation in the matrix and modulates Organelle ATP levels","volume":"17","author":"Di Benedetto","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbc.2025.110889_bib9","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1083\/jcb.201303159","article-title":"The inner and outer compartments of mitochondria are sites of distinct cAMP\/PKA signaling dynamics","volume":"202","author":"Lefkimmiatis","year":"2013","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jbc.2025.110889_bib10","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1016\/j.bbadis.2014.05.035","article-title":"Role of soluble adenylyl cyclase in mitochondria","volume":"1842","author":"Valsecchi","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbc.2025.110889_bib11","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1096\/fj.02-0598fje","article-title":"Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains","volume":"17","author":"Zippin","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.jbc.2025.110889_bib12","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1083\/jcb.200311119","article-title":"Bicarbonate-responsive \"soluble\" adenylyl cyclase defines a nuclear cAMP microdomain","volume":"164","author":"Zippin","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jbc.2025.110889_bib13","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1126\/science.289.5479.625","article-title":"Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor","volume":"289","author":"Chen","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.jbc.2025.110889_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26136401","article-title":"Updating the mechanism of bicarbonate (HCO(3)(-)) activation of soluble adenylyl cyclase (sAC)","volume":"26","author":"Ferreira","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbc.2025.110889_bib15","doi-asserted-by":"crossref","first-page":"15922","DOI":"10.1074\/jbc.M212475200","article-title":"Kinetic properties of \"soluble\" adenylyl cyclase. Synergism between calcium and bicarbonate","volume":"278","author":"Litvin","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110889_bib16","doi-asserted-by":"crossref","first-page":"33283","DOI":"10.1074\/jbc.M113.510073","article-title":"CO2\/HCO3(-)- and calcium-regulated soluble adenylyl cyclase as a physiological ATP sensor","volume":"288","author":"Zippin","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110889_bib17","doi-asserted-by":"crossref","first-page":"C1305","DOI":"10.1152\/ajpcell.00584.2004","article-title":"Cloning and characterization of the human soluble adenylyl cyclase","volume":"288","author":"Geng","year":"2005","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.jbc.2025.110889_bib18","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/(SICI)1098-2795(200005)56:1<6::AID-MRD2>3.0.CO;2-M","article-title":"Specific expression of soluble adenylyl cyclase in male germ cells","volume":"56","author":"Sinclair","year":"2000","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.jbc.2025.110889_bib19","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.jmb.2006.07.045","article-title":"Molecular details of cAMP generation in Mammalian cells: a tale of two systems","volume":"362","author":"Kamenetsky","year":"2006","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jbc.2025.110889_bib20","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/ki.2011.95","article-title":"Intracellular cAMP signaling by soluble adenylyl cyclase","volume":"79","author":"Tresguerres","year":"2011","journal-title":"Kidney Int."},{"key":"10.1016\/j.jbc.2025.110889_bib21","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.pharmthera.2018.05.008","article-title":"Pharmacological modulation of the CO 2\/HCO 3\u2212\/pH-, calcium-, and ATP-sensing soluble adenylyl cyclase","volume":"190","author":"Wiggins","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.jbc.2025.110889_bib22","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1093\/humrep\/dez048","article-title":"ADCY10 frameshift variant leading to severe recessive asthenozoospermia and segregating with absorptive hypercalciuria","volume":"34","author":"Akbari","year":"2019","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.jbc.2025.110889_bib23","doi-asserted-by":"crossref","DOI":"10.1093\/molehr\/gaab054","article-title":"Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization","volume":"27","author":"Balbach","year":"2021","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.jbc.2025.110889_bib24","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1073\/pnas.0400050101","article-title":"Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect","volume":"101","author":"Esposito","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110889_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.953903","article-title":"Strategies to safely target widely expressed soluble adenylyl cyclase for contraception","volume":"13","author":"Ferreira","year":"2022","journal-title":"Front Pharmacol."},{"key":"10.1016\/j.jbc.2025.110889_bib26","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.devcel.2005.06.007","article-title":"The \"soluble\" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization","volume":"9","author":"Hess","year":"2005","journal-title":"Develop. Cell"},{"key":"10.1016\/j.jbc.2025.110889_bib27","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/168558c0","article-title":"Activation and the correlation between male and female elements in fertilization","volume":"168","author":"Austin","year":"1951","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.110889_bib28","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/168697b0","article-title":"Fertilizing capacity of spermatozoa deposited into the fallopian tubes","volume":"168","author":"Chang","year":"1951","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.110889_bib29","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1242\/dev.00353","article-title":"Bicarbonate actions on flagellar and Ca2+-channel responses: initial events in sperm activation","volume":"130","author":"Wennemuth","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.jbc.2025.110889_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.rbmo.2024.104481","article-title":"Novel biallelic ADCY10 variants cause asthenozoospermia with excessive residual cytoplasm and hydronephrosis in humans","volume":"50","author":"Zeb","year":"2025","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.jbc.2025.110889_bib31","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/s41467-023-36119-6","article-title":"On-demand male contraception via acute inhibition of soluble adenylyl cyclase","volume":"14","author":"Balbach","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.110889_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2024.101281","article-title":"The uniqueness of on-demand male contraception","volume":"97","author":"Sanchez","year":"2024","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.jbc.2025.110889_bib33","doi-asserted-by":"crossref","first-page":"31698","DOI":"10.1074\/jbc.M011698200","article-title":"Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase","volume":"276","author":"Jaiswal","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110889_bib34","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/mrd.20409","article-title":"Autoinhibitory regulation of soluble adenylyl cyclase","volume":"73","author":"Chaloupka","year":"2006","journal-title":"Mol. Reprod. Develop."},{"key":"10.1016\/j.jbc.2025.110889_bib35","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.str.2009.01.001","article-title":"Wheel of life, wheel of death: a mechanistic Insight into signaling by STAND proteins","volume":"17","author":"Danot","year":"2009","journal-title":"Structure"},{"key":"10.1016\/j.jbc.2025.110889_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jmb.2004.08.023","article-title":"STAND, a class of P-loop NTPases including animal and plant regulators of programmed cell death: multiple, complex domain architectures, unusual phyletic patterns, and evolution by horizontal gene transfer","volume":"343","author":"Leipe","year":"2004","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jbc.2025.110889_bib37","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1042\/BSR20120051","article-title":"Identification of a haem domain in human soluble adenylate cyclase","volume":"32","author":"Middelhaufe","year":"2012","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.jbc.2025.110889_bib38","doi-asserted-by":"crossref","first-page":"10676","DOI":"10.1073\/pnas.1831008100","article-title":"Calcium regulation of the soluble adenylyl cyclase expressed in mammalian spermatozoa","volume":"100","author":"Jaiswal","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110889_bib39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003251","article-title":"Somatic 'soluble' adenylyl cyclase isoforms are unaffected in Sacytm1Lex\/Sacytm1Lex 'knockout' mice","volume":"3","author":"Farrell","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2025.110889_bib40","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41586-020-2308-7","article-title":"The mutational constraint spectrum quantified from variation in 141,456 humans","volume":"581","author":"Karczewski","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.110889_bib41","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1085\/jgp.200709784","article-title":"Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP","volume":"130","author":"Schmid","year":"2007","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.jbc.2025.110889_bib42","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1073\/pnas.1322778111","article-title":"Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate","volume":"111","author":"Kleinboelting","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"10.1016\/j.jbc.2025.110889_bib43","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1124\/jpet.111.184135","article-title":"The soluble guanylyl cyclase activator YC-1 increases intracellular cGMP and cAMP via independent mechanisms in INS-1E cells","volume":"338","author":"Ramos-Espiritu","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jbc.2025.110889_bib44","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.RA120.015440","article-title":"PES inhibits human-inducible Hsp70 by covalent targeting of cysteine residues in the substrate-binding domain","volume":"296","author":"Yang","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110889_bib45","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1073\/pnas.72.3.1097","article-title":"Development of a Mn2+ sensitive, 'soluble' adenylate cyclase in rat testis","volume":"72","author":"Braun","year":"1975","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110889_bib46","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0005-2744(77)90155-3","article-title":"Mn2+-sensitive, soluble adenylate cyclase in rat testis. Differentiation from other testicular nucleotide cyclases","volume":"481","author":"Braun","year":"1977","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbc.2025.110889_bib47","doi-asserted-by":"crossref","first-page":"15208","DOI":"10.1021\/acs.jmedchem.2c01133","article-title":"Design, synthesis, and pharmacological evaluation of second-generation soluble adenylyl cyclase (sAC, ADCY10) inhibitors with slow dissociation rates","volume":"65","author":"Miller","year":"2022","journal-title":"J. Med. Chem."},{"issue":"12 Pt B","key":"10.1016\/j.jbc.2025.110889_bib48","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1016\/j.bbadis.2014.08.012","article-title":"Structure, mechanism, and regulation of soluble adenylyl cyclases - similarities and differences to transmembrane adenylyl cyclases","volume":"1842","author":"Steegborn","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jbc.2025.110889_bib49","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neulet.2014.07.019","article-title":"cAMP, cGMP, cCMP and cUMP concentrations across the tree of life: high cCMP and cUMP levels in astrocytes","volume":"579","author":"Hartwig","year":"2014","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jbc.2025.110889_bib50","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.bbrc.2014.04.099","article-title":"Soluble adenylyl cyclase accounts for high basal cCMP and cUMP concentrations in HEK293 and B103 cells","volume":"448","author":"Hasan","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jbc.2025.110889_bib51","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/cge.13927","article-title":"The sodium\/proton exchanger SLC9C1 (sNHE) is essential for human sperm motility and fertility","volume":"99","author":"Cavarocchi","year":"2021","journal-title":"Clin. Genet."},{"key":"10.1016\/j.jbc.2025.110889_bib52","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2513924122","article-title":"Formation of a complex between TMEM217 and the sodium-proton exchanger SLC9C1 is crucial for mouse sperm motility and male fertility","volume":"122","author":"Iida-Norita","year":"2025","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110889_bib53","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1073\/pnas.0911790107","article-title":"Bicarbonate-sensing soluble adenylyl cyclase is an essential sensor for acid\/base homeostasis","volume":"107","author":"Tresguerres","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"10.1016\/j.jbc.2025.110889_bib54","first-page":"35","article-title":"Adenylate cyclase assay","volume":"10","author":"Salomon","year":"1979","journal-title":"Adv. Cyclic Nucleotide Res."},{"key":"10.1016\/j.jbc.2025.110889_bib55","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.ade1516","article-title":"Mechanisms of ion selectivity and throughput in the mitochondrial calcium uniporter","volume":"8","author":"Delgado","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jbc.2025.110889_bib56","doi-asserted-by":"crossref","first-page":"5632","DOI":"10.1016\/j.jmb.2020.08.013","article-title":"Structure and reconstitution of an MCU-EMRE mitochondrial Ca(2+) uniporter Complex","volume":"432","author":"Wang","year":"2020","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jbc.2025.110889_bib57","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nsmb.1727","article-title":"Modulation of protein properties in living cells using nanobodies","volume":"17","author":"Kirchhofer","year":"2010","journal-title":"Nat. Struct. Mol. Biol."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925825027413?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925825027413?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T09:24:21Z","timestamp":1773912261000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925825027413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":57,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S0021925825027413"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2025.110889","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biochemical characterization of the full-length isoform of soluble adenylyl cyclase","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2025.110889","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology\u00e9","name":"copyright","label":"Copyright"}],"article-number":"110889"}}