{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:41:02Z","timestamp":1776904862548,"version":"3.51.2"},"reference-count":67,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100032559","name":"Breakthrough T1D","doi-asserted-by":"publisher","award":["JDRF2-SRA-2022-1105-S-B"],"award-info":[{"award-number":["JDRF2-SRA-2022-1105-S-B"]}],"id":[{"id":"10.13039\/100032559","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032559","name":"Breakthrough T1D","doi-asserted-by":"publisher","award":["JDRF 230620-01"],"award-info":[{"award-number":["JDRF 230620-01"]}],"id":[{"id":"10.13039\/100032559","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK136327"],"award-info":[{"award-number":["DK136327"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK133332"],"award-info":[{"award-number":["DK133332"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35 HL150809"],"award-info":[{"award-number":["R35 HL150809"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK137806"],"award-info":[{"award-number":["DK137806"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012636","name":"New York State Stem Cell Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["25CDA1444258"],"award-info":[{"award-number":["25CDA1444258"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["836459"],"award-info":[{"award-number":["836459"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020424","name":"Weill Cornell Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020424","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jbc.2025.110947","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T09:59:10Z","timestamp":1763373550000},"page":"110947","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Adenovirus E4ORF1 activates isoform-specific phosphatidylinositol 3-kinase signaling in human endothelial cells"],"prefix":"10.1016","volume":"302","author":[{"given":"Fuqiang","family":"Geng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0709-2468","authenticated-orcid":false,"given":"Yang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesus Maria","family":"Gomez-Salinero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominick","family":"Romano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Kanyo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Geng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Ginsberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Hung","family":"Shieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4850-3462","authenticated-orcid":false,"given":"TuKiet T.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arash","family":"Rafii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sina Y.","family":"Rabbany","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rapha\u00ebl","family":"Lis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahin","family":"Rafii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2025.110947_bib1","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1182\/blood.V93.9.2936.409a14_2936_2944","article-title":"E1(-)E4(+) adenoviral gene transfer vectors function as a \"pro-life\" signal to promote survival of primary human endothelial cells","volume":"93","author":"Ramalingam","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.jbc.2025.110947_bib2","doi-asserted-by":"crossref","first-page":"11760","DOI":"10.1074\/jbc.M312221200","article-title":"Adenovirus E4 gene promotes selective endothelial cell survival and angiogenesis via activation of the vascular endothelial-cadherin\/Akt signaling pathway","volume":"279","author":"Zhang","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110947_bib3","doi-asserted-by":"crossref","first-page":"19288","DOI":"10.1073\/pnas.0805980105","article-title":"Generation of a functional and durable vascular niche by the adenoviral E4ORF1 gene","volume":"105","author":"Seandel","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110947_bib4","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/ncb2108","article-title":"Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells","volume":"12","author":"Kobayashi","year":"2010","journal-title":"Nat. Cel. Biol."},{"key":"10.1016\/j.jbc.2025.110947_bib5","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature17040","article-title":"Angiocrine functions of organ-specific endothelial cells","volume":"529","author":"Rafii","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.110947_bib6","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/sj.onc.1206151","article-title":"Selective PDZ protein-dependent stimulation of phosphatidylinositol 3-kinase by the adenovirus E4-ORF1 oncoprotein","volume":"22","author":"Frese","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.jbc.2025.110947_bib7","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jdiacomp.2012.09.006","article-title":"Insulin sparing action of adenovirus 36 and its E4orf1 protein","volume":"27","author":"Dhurandhar","year":"2013","journal-title":"J. Diabetes Complications"},{"key":"10.1016\/j.jbc.2025.110947_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0208427","article-title":"E4orf1: a protein for enhancing glucose uptake despite impaired proximal insulin signaling","volume":"13","author":"Shastri","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2025.110947_bib9","doi-asserted-by":"crossref","first-page":"358","DOI":"10.2337\/db16-0876","article-title":"Hepatic expression of adenovirus 36 E4ORF1 improves glycemic control and promotes glucose metabolism through AKT activation","volume":"66","author":"McMurphy","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.jbc.2025.110947_bib10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41387-023-00242-6","article-title":"E4orf1 improves adipose tissue-specific metabolic risk factors and indicators of cognition function in a mouse model of Alzheimer's disease","volume":"13","author":"Khan","year":"2023","journal-title":"Nutr. Diabetes"},{"key":"10.1016\/j.jbc.2025.110947_bib11","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1016\/j.celrep.2016.11.082","article-title":"Adenovirus protein E4-ORF1 activation of PI3 kinase reveals differential regulation of downstream effector pathways in adipocytes","volume":"17","author":"Chaudhary","year":"2016","journal-title":"Cell. Rep."},{"key":"10.1016\/j.jbc.2025.110947_bib12","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/sj.emboj.7600597","article-title":"Adenoviral proteins mimic nutrient\/growth signals to activate the mTOR pathway for viral replication","volume":"24","author":"O'Shea","year":"2005","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2025.110947_bib13","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3390\/vaccines10020295","article-title":"E4orf1 suppresses E1B-Deleted adenovirus vaccine-induced immune responses","volume":"10","author":"Sangare","year":"2022","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.jbc.2025.110947_bib14","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.tibs.2014.12.003","article-title":"Synergy in activating class I PI3Ks","volume":"40","author":"Burke","year":"2015","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.jbc.2025.110947_bib15","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ceb.2017.02.007","article-title":"PI3K signaling in cancer: beyond AKT","volume":"45","author":"Lien","year":"2017","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.jbc.2025.110947_bib16","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cell.2017.04.001","article-title":"AKT\/PKB signaling: navigating the network","volume":"169","author":"Manning","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.110947_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105224","article-title":"PI3K signaling through a biochemical systems lens","volume":"299","author":"Madsen","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110947_bib18","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1158\/1541-7786.MCR-20-1066","article-title":"Emerging roles for AKT isoform preference in cancer progression pathways","volume":"19","author":"Degan","year":"2021","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.jbc.2025.110947_bib19","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1038\/sj.emboj.7601030","article-title":"Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressor","volume":"25","author":"Frese","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2025.110947_bib20","doi-asserted-by":"crossref","first-page":"4385","DOI":"10.1128\/jvi.71.6.4385-4394.1997","article-title":"Mutant adenovirus type 9 E4 ORF1 genes define three protein regions required for transformation of CREF cells","volume":"71","author":"Weiss","year":"1997","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110947_bib21","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1128\/JVI.75.2.557-568.2001","article-title":"Several E4 region functions influence mammary tumorigenesis by human adenovirus type 9","volume":"75","author":"Thomas","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110947_bib22","doi-asserted-by":"crossref","first-page":"4787","DOI":"10.1128\/JVI.02855-06","article-title":"A new crucial protein interaction element that targets the adenovirus E4-ORF1 oncoprotein to membrane vesicles","volume":"81","author":"Chung","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110947_bib23","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1038\/sj.onc.1210784","article-title":"Functionally distinct monomers and trimers produced by a viral oncoprotein","volume":"27","author":"Chung","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.jbc.2025.110947_bib24","doi-asserted-by":"crossref","first-page":"7031","DOI":"10.1038\/onc.2008.352","article-title":"Cell polarity proteins: common targets for tumorigenic human viruses","volume":"27","author":"Javier","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.jbc.2025.110947_bib25","doi-asserted-by":"crossref","DOI":"10.1242\/dev.196956","article-title":"Electrostatic plasma membrane targeting contributes to dlg function in cell polarity and tumorigenesis","volume":"148","author":"Lu","year":"2021","journal-title":"Development"},{"key":"10.1016\/j.jbc.2025.110947_bib26","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1083\/jcb.135.4.1125","article-title":"Two independent domains of hDlg are sufficient for subcellular targeting: the PDZ1-2 conformational unit and an alternatively spliced domain","volume":"135","author":"Lue","year":"1996","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.jbc.2025.110947_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004102","article-title":"The human adenovirus E4-ORF1 protein subverts discs large 1 to mediate membrane recruitment and dysregulation of phosphatidylinositol 3-kinase","volume":"10","author":"Kong","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jbc.2025.110947_bib28","doi-asserted-by":"crossref","first-page":"14268","DOI":"10.1128\/JVI.02324-14","article-title":"Hijacking Dlg1 for oncogenic phosphatidylinositol 3-kinase activation in human epithelial cells is a conserved mechanism of human adenovirus E4-ORF1 proteins","volume":"88","author":"Kumar","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110947_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0023394","article-title":"E4orf1: a novel ligand that improves glucose disposal in cell culture","volume":"6","author":"Dhurandhar","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2025.110947_bib30","doi-asserted-by":"crossref","first-page":"10774","DOI":"10.1128\/JVI.01463-15","article-title":"Adenovirus E4-ORF1 dysregulates epidermal growth factor and Insulin\/Insulin-like growth factor receptors to mediate constitutive Myc expression","volume":"89","author":"Kong","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.jbc.2025.110947_bib31","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.cmet.2014.03.009","article-title":"Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication","volume":"19","author":"Thai","year":"2014","journal-title":"Cell. Metab."},{"key":"10.1016\/j.jbc.2025.110947_bib32","doi-asserted-by":"crossref","first-page":"12067","DOI":"10.1523\/JNEUROSCI.0816-13.2013","article-title":"CASK regulates SAP97 conformation and its interactions with AMPA and NMDA receptors","volume":"33","author":"Lin","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jbc.2025.110947_bib33","doi-asserted-by":"crossref","first-page":"9392","DOI":"10.1074\/jbc.M610002200","article-title":"The stardust family protein MPP7 forms a tripartite complex with LIN7 and DLG1 that regulates the stability and localization of DLG1 to cell junctions","volume":"282","author":"Bohl","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110947_bib34","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.cub.2013.05.060","article-title":"DLin-7 is required in postsynaptic lamina neurons to prevent light-induced photoreceptor degeneration in Drosophila","volume":"23","author":"Soukup","year":"2013","journal-title":"Curr. Biol."},{"key":"10.1016\/j.jbc.2025.110947_bib35","doi-asserted-by":"crossref","first-page":"4067","DOI":"10.1038\/onc.2011.125","article-title":"Loss of PI3K blocks cell-cycle progression in a Drosophila tumor model","volume":"30","author":"Willecke","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.jbc.2025.110947_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1002440","article-title":"Kif13b regulates PNS and CNS myelination through the Dlg1 scaffold","volume":"14","author":"Noseda","year":"2016","journal-title":"PLoS Biol."},{"key":"10.1016\/j.jbc.2025.110947_bib37","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1073\/pnas.1110120109","article-title":"Scaffold protein Disc large homolog 1 is required for T-cell receptor-induced activation of regulatory T-cell function","volume":"109","author":"Zanin-Zhorov","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110947_bib38","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1126\/science.1187735","article-title":"Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination","volume":"328","author":"Cotter","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.jbc.2025.110947_bib39","doi-asserted-by":"crossref","first-page":"13046","DOI":"10.1074\/jbc.M112.441261","article-title":"Discs large 1 (Dlg1) scaffolding protein participates with clathrin and adaptator protein complex 1 (AP-1) in forming Weibel-Palade bodies of endothelial cells","volume":"288","author":"Philippe","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110947_bib40","doi-asserted-by":"crossref","first-page":"6406","DOI":"10.1074\/jbc.M108724200","article-title":"The distribution and function of alternatively spliced insertions in hDlg","volume":"277","author":"McLaughlin","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110947_bib41","doi-asserted-by":"crossref","first-page":"34445","DOI":"10.1074\/jbc.M305209200","article-title":"Protein 4.1-mediated membrane targeting of human discs large in epithelial cells","volume":"278","author":"Hanada","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110947_bib42","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1021\/acs.biochem.7b01074","article-title":"Structures of the L27 domain of disc large Homologue 1 protein illustrate a self-assembly module","volume":"57","author":"Ghosh","year":"2018","journal-title":"Biochemistry"},{"key":"10.1016\/j.jbc.2025.110947_bib43","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/s41556-020-00596-4","article-title":"Phosphatidylinositol-3-OH kinase signalling is spatially organized at endosomal compartments by microtubule-associated protein 4","volume":"22","author":"Thapa","year":"2020","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.jbc.2025.110947_bib44","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fcell.2015.00024","article-title":"Nuclear PI3K signaling in cell growth and tumorigenesis","volume":"3","author":"Davis","year":"2015","journal-title":"Front .Cell. Dev. Biol."},{"key":"10.1016\/j.jbc.2025.110947_bib45","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/S0960-9822(02)00972-7","article-title":"High-resolution structure of the pleckstrin homology domain of protein kinase b\/akt bound to phosphatidylinositol (3,4,5)-trisphosphate","volume":"12","author":"Thomas","year":"2002","journal-title":"Curr. Biol."},{"key":"10.1016\/j.jbc.2025.110947_bib46","doi-asserted-by":"crossref","first-page":"26364","DOI":"10.1074\/jbc.M116.752121","article-title":"IQGAP1 interaction with RHO family proteins revisited: kinetic and equilibrium evidence for multiple distinct binding sites","volume":"291","author":"Nouri","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110947_bib47","doi-asserted-by":"crossref","first-page":"4097","DOI":"10.1074\/jbc.M114.620377","article-title":"Hepatocyte growth factor-induced Asef-IQGAP1 complex controls cytoskeletal remodeling and endothelial barrier","volume":"290","author":"Tian","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110947_bib48","first-page":"4121","article-title":"Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway","volume":"126","author":"Jacquemet","year":"2013","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.jbc.2025.110947_bib49","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.cellsig.2011.12.005","article-title":"IQGAP1 and its binding proteins control diverse biological functions","volume":"24","author":"White","year":"2012","journal-title":"Cell. Signal."},{"key":"10.1016\/j.jbc.2025.110947_bib50","doi-asserted-by":"crossref","first-page":"12399","DOI":"10.1073\/pnas.0908278107","article-title":"Self-organization of the phosphatidylinositol lipids signaling system for random cell migration","volume":"107","author":"Arai","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110947_bib51","doi-asserted-by":"crossref","first-page":"568","DOI":"10.3390\/ijms23010568","article-title":"Tracking of endothelial cell migration and stiffness measurements reveal the role of cytoskeletal dynamics","volume":"23","author":"Romano","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbc.2025.110947_bib52","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1073\/pnas.0910715107","article-title":"Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein","volume":"107","author":"Hale","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110947_bib53","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1126\/science.1198701","article-title":"Scaffold proteins: hubs for controlling the flow of cellular information","volume":"332","author":"Good","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.jbc.2025.110947_bib54","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202205062","article-title":"The IQGAP scaffolds: critical nodes bridging receptor activation to cellular signaling","volume":"222","author":"Thines","year":"2023","journal-title":"J. Cell. Biol."},{"key":"10.1016\/j.jbc.2025.110947_bib55","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.cell.2013.04.031","article-title":"RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms","volume":"153","author":"Fritsch","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.110947_bib56","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2003264","article-title":"G protein-coupled receptor-mediated activation of p110beta by Gbetagamma is required for cellular transformation and invasiveness","volume":"5","author":"Dbouk","year":"2012","journal-title":"Sci. Signal."},{"key":"10.1016\/j.jbc.2025.110947_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2023.102718","article-title":"p85alpha regulatory subunit isoform controls PI3-kinase and TRPC6 membrane translocation","volume":"111","author":"Chaudhuri","year":"2023","journal-title":"Cell Calcium"},{"key":"10.1016\/j.jbc.2025.110947_bib58","doi-asserted-by":"crossref","first-page":"14194","DOI":"10.1073\/pnas.0606109103","article-title":"Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling","volume":"103","author":"Hale","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110947_bib59","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.molcel.2011.01.026","article-title":"Structure of lipid kinase p110beta\/p85beta elucidates an unusual SH2-domain-mediated inhibitory mechanism","volume":"41","author":"Zhang","year":"2011","journal-title":"Mol. Cell."},{"key":"10.1016\/j.jbc.2025.110947_bib60","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.trecan.2019.02.009","article-title":"The opposing roles of PIK3R1\/p85alpha and PIK3R2\/p85beta in cancer","volume":"5","author":"Vallejo-Diaz","year":"2019","journal-title":"Trends Cancer"},{"key":"10.1016\/j.jbc.2025.110947_bib61","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1111\/tra.12089","article-title":"Emerging role of the scaffolding protein Dlg1 in vesicle trafficking","volume":"14","author":"Walch","year":"2013","journal-title":"Traffic"},{"key":"10.1016\/j.jbc.2025.110947_bib62","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1146\/annurev-biophys-052118-115534","article-title":"Regulation of transmembrane signaling by phase separation","volume":"48","author":"Case","year":"2019","journal-title":"Annu. Rev. Biophys."},{"key":"10.1016\/j.jbc.2025.110947_bib63","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/s41392-020-00218-3","article-title":"PI3K activation is enhanced by FOXM1D binding to p110 and p85 subunits","volume":"5","author":"Wang","year":"2020","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.jbc.2025.110947_bib64","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.ccell.2017.04.013","article-title":"A pan-cancer proteogenomic Atlas of PI3K\/AKT\/mTOR pathway alterations","volume":"31","author":"Zhang","year":"2017","journal-title":"Cancer. Cell."},{"key":"10.1016\/j.jbc.2025.110947_bib65","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1172\/JCI107470","article-title":"Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria","volume":"52","author":"Jaffe","year":"1973","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jbc.2025.110947_bib66","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.celrep.2013.12.013","article-title":"RNAi factors are present and active in human cell nuclei","volume":"6","author":"Gagnon","year":"2014","journal-title":"Cell. Rep."},{"key":"10.1016\/j.jbc.2025.110947_bib67","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ymeth.2016.09.016","article-title":"TrackMate: an open and extensible platform for single-particle tracking","volume":"115","author":"Tinevez","year":"2017","journal-title":"Methods"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925825027991?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925825027991?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:19:30Z","timestamp":1773879570000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925825027991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S0021925825027991"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2025.110947","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adenovirus E4ORF1 activates isoform-specific phosphatidylinositol 3-kinase signaling in human endothelial cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2025.110947","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology\u00e9","name":"copyright","label":"Copyright"}],"article-number":"110947"}}