{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:29:40Z","timestamp":1777602580580,"version":"3.51.4"},"reference-count":77,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08 NS102509"],"award-info":[{"award-number":["K08 NS102509"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31 NS105404"],"award-info":[{"award-number":["F31 NS105404"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS131402"],"award-info":[{"award-number":["R01 NS131402"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35 NS122306"],"award-info":[{"award-number":["R35 NS122306"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["390713860"],"award-info":[{"award-number":["390713860"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["450648163"],"award-info":[{"award-number":["450648163"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jbc.2025.110991","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:16:16Z","timestamp":1764634576000},"page":"110991","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Profiling the TRPV4 ankyrin repeat domain interactome and its disruption by neuromuscular disease-causing mutations"],"prefix":"10.1016","volume":"302","author":[{"given":"Alexis K.","family":"Loder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gage P.","family":"Kosmanopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William H.","family":"Aisenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7691-4835","authenticated-orcid":false,"given":"Eric","family":"Cox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis R.","family":"Meeker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1338-8476","authenticated-orcid":false,"given":"Seth","family":"Blackshaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9177-054X","authenticated-orcid":false,"given":"Rachelle","family":"Gaudet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7162-285X","authenticated-orcid":false,"given":"Ute A.","family":"Hellmich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brett A.","family":"McCray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte J.","family":"Sumner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy M.","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2025.110991_bib1","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1110\/ps.03554604","article-title":"The ankyrin repeat as molecular architecture for protein recognition","volume":"13","author":"Mosavi","year":"2004","journal-title":"Protein Sci."},{"key":"10.1016\/j.jbc.2025.110991_bib2","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1039\/B801481G","article-title":"A primer on ankyrin repeat function in TRP channels and beyond","volume":"4","author":"Gaudet","year":"2008","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.jbc.2025.110991_bib3","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.264","article-title":"Ankyrin domains across the tree of life","volume":"2","author":"Jernigan","year":"2014","journal-title":"PeerJ"},{"key":"10.1016\/j.jbc.2025.110991_bib4","doi-asserted-by":"crossref","first-page":"840","DOI":"10.3390\/biom11060840","article-title":"Folding and stability of ankyrin repeats control biological protein function","volume":"11","author":"Kumar","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.jbc.2025.110991_bib5","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/ng.512","article-title":"Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C","volume":"42","author":"Landour\u00e9","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbc.2025.110991_bib6","doi-asserted-by":"crossref","first-page":"25006","DOI":"10.1074\/jbc.C600153200","article-title":"Structure of the N-terminal ankyrin repeat domain of the TRPV2 ion channel","volume":"281","author":"Jin","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110991_bib7","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.neuron.2007.05.027","article-title":"The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity","volume":"54","author":"Lishko","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.jbc.2025.110991_bib8","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1021\/bi702109w","article-title":"Structural analyses of the ankyrin repeat domain of TRPV6 and related TRPV ion channels","volume":"47","author":"Phelps","year":"2008","journal-title":"Biochemistry"},{"key":"10.1016\/j.jbc.2025.110991_bib9","doi-asserted-by":"crossref","first-page":"6195","DOI":"10.1021\/bi300279b","article-title":"Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel","volume":"51","author":"Inada","year":"2012","journal-title":"Biochemistry"},{"key":"10.1016\/j.jbc.2025.110991_bib10","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1212\/NXG.0000000000000029","article-title":"Novel mutations highlight the key role of the ankyrin repeat domain in TRPV4-mediated neuropathy","volume":"1","author":"Sullivan","year":"2015","journal-title":"Neurol. Genet."},{"key":"10.1016\/j.jbc.2025.110991_bib11","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1093\/brain\/awq109","article-title":"Dominant mutations in the cation channel gene transient receptor potential vanilloid 4 cause an unusual spectrum of neuropathies","volume":"133","author":"Zimon","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.jbc.2025.110991_bib12","doi-asserted-by":"crossref","first-page":"3732","DOI":"10.1038\/s41467-023-39345-0","article-title":"TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease","volume":"14","author":"Kwon","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.110991_bib13","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1152\/physrev.00016.2015","article-title":"TRPV4: molecular conductor of a diverse orchestra","volume":"96","author":"White","year":"2016","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.jbc.2025.110991_bib14","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/ng.509","article-title":"Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4","volume":"42","author":"Deng","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbc.2025.110991_bib15","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/ng.508","article-title":"Alterations in the ankyrin domain of TRPV4 cause congenital distal SMA, scapuloperoneal SMA and HMSN2C","volume":"42","author":"Auer-Grumbach","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbc.2025.110991_bib16","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1212\/WNL.0b013e3181ffe4bb","article-title":"CMT2C with vocal cord paresis associated with short stature and mutations in the TRPV4 gene","volume":"75","author":"Chen","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.jbc.2025.110991_bib17","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.jocn.2011.12.003","article-title":"TRPV4 axonal neuropathy spectrum disorder","volume":"19","author":"McEntagart","year":"2012","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.jbc.2025.110991_bib18","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1212\/WNL.0000000000000450","article-title":"Phenotypic spectrum and incidence of TRPV4 mutations in patients with inherited axonal neuropathy","volume":"82","author":"Echaniz-Laguna","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.jbc.2025.110991_bib19","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1212\/WNL.0b013e31825f04b2","article-title":"Exome sequencing identifies a novel TRPV4 mutation in a CMT2C family","volume":"79","author":"Landour\u00e9","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.jbc.2025.110991_bib20","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1093\/brain\/awae201","article-title":"TRPV4 neuromuscular disease registry highlights bulbar, skeletal and proximal limb manifestations","volume":"148","author":"Kosmanopoulos","year":"2025","journal-title":"Brain"},{"key":"10.1016\/j.jbc.2025.110991_bib21","doi-asserted-by":"crossref","first-page":"4165","DOI":"10.1038\/s41467-023-39808-4","article-title":"Crosstalk between regulatory elements in disordered TRPV4 N-terminus modulates lipid-dependent channel activity","volume":"14","author":"Goretzki","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.110991_bib22","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.1038\/s41467-023-39346-z","article-title":"Structure of human TRPV4 in complex with GTPase RhoA","volume":"14","author":"Nadezhdin","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.110991_bib23","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.3390\/ijms21103556","article-title":"The zinc-finger domain containing protein ZC4H2 interacts with TRPV4, enhancing channel activity and turnover at the plasma membrane","volume":"21","author":"Vangeel","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbc.2025.110991_bib24","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/embor.2012.219","article-title":"The puzzle of TRPV4 channelopathies","volume":"14","author":"Nilius","year":"2013","journal-title":"EMBO Rep."},{"key":"10.1016\/j.jbc.2025.110991_bib25","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/acn3.51523","article-title":"TRPV4 mutations causing mixed neuropathy and skeletal phenotypes result in severe gain of function","volume":"9","author":"Taga","year":"2022","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.jbc.2025.110991_bib26","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/brain\/awae243","article-title":"Combined clinical, structural and cellular studies discriminate pathogenic and benign TRPV4 variants","volume":"148","author":"Berth","year":"2025","journal-title":"Brain"},{"key":"10.1016\/j.jbc.2025.110991_bib27","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/s41594-018-0037-5","article-title":"Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms","volume":"25","author":"Deng","year":"2018","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.jbc.2025.110991_bib28","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1038\/s41467-021-21699-y","article-title":"Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension","volume":"12","author":"McCray","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.110991_bib29","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/j.str.2018.08.002","article-title":"Structural basis of TRPV4 N terminus interaction with Syndapin\/PACSIN1-3 and PIP2","volume":"26","author":"Goretzki","year":"2018","journal-title":"Structure"},{"key":"10.1016\/j.jbc.2025.110991_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.101826","article-title":"Multiubiquitination of TRPV4 reduces channel activity independent of surface localization","volume":"298","author":"Aisenberg","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110991_bib31","doi-asserted-by":"crossref","first-page":"18753","DOI":"10.1074\/jbc.M602452200","article-title":"PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4","volume":"281","author":"Cuajungco","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110991_bib32","first-page":"7","article-title":"Interaction between PSD 95 and TRPV4 through PDZ domain controls TRPV4\u2019s localization and activity","volume":"6","author":"Lee","year":"2024","journal-title":"J. Anal. Tech. Res."},{"key":"10.1016\/j.jbc.2025.110991_bib33","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bbrc.2015.01.087","article-title":"Hippocampal neuronal maturation triggers post-synaptic clustering of brain temperature-sensor TRPV4","volume":"458","author":"Shibasaki","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jbc.2025.110991_bib34","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/978-3-319-49674-0_3","article-title":"Functional and structural roles of coiled coils","volume":"82","author":"Hartmann","year":"2017","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.jbc.2025.110991_bib35","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/cbic.200300781","article-title":"Coiled coil domains: stability, specificity, and biological implications","volume":"5","author":"Mason","year":"2004","journal-title":"Chembiochem"},{"key":"10.1016\/j.jbc.2025.110991_bib36","doi-asserted-by":"crossref","first-page":"12413","DOI":"10.1073\/pnas.94.23.12413","article-title":"Dystrobrevin and dystrophin: an interaction through coiled-coil motifs","volume":"94","author":"Sadoulet-Puccio","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110991_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081075","article-title":"Structure of a highly conserved domain of Rock1 required for Shroom-mediated regulation of cell morphology","volume":"8","author":"Mohan","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2025.110991_bib38","first-page":"18","article-title":"Physiological functions of the ubiquitin ligases Nedd4-1 and Nedd4-2","volume":"39","author":"Rotin","year":"2024","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.jbc.2025.110991_bib39","doi-asserted-by":"crossref","first-page":"4875","DOI":"10.1038\/s41467-025-60207-4","article-title":"Structural basis of ubiquitin ligase Nedd4-2 autoinhibition and regulation by calcium and 14-3-3 proteins","volume":"16","author":"Janosev","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.110991_bib40","doi-asserted-by":"crossref","first-page":"12279","DOI":"10.1074\/jbc.M109.086405","article-title":"Calcium activates Nedd4 E3 ubiquitin ligases by releasing the C2 domain-mediated auto-inhibition","volume":"285","author":"Wang","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110991_bib41","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.molcel.2009.09.043","article-title":"Ubiquitin ligase Nedd4L targets activated Smad2\/3 to limit TGF-beta signaling","volume":"36","author":"Gao","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2025.110991_bib42","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/sj.embor.7400201","article-title":"Crystal structure of human otubain 2","volume":"5","author":"Nanao","year":"2004","journal-title":"EMBO Rep."},{"key":"10.1016\/j.jbc.2025.110991_bib43","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1007\/s00415-011-5947-7","article-title":"Reduced penetrance in hereditary motor neuropathy caused by TRPV4 Arg269Cys mutation","volume":"258","author":"Berciano","year":"2011","journal-title":"J. Neurol."},{"key":"10.1016\/j.jbc.2025.110991_bib44","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1055\/s-0035-1554100","article-title":"Long-term observations in an affected family with neurogenic scapuloperoneal syndrome caused by mutation R269C in the TRPV4 gene","volume":"46","author":"Vill","year":"2015","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.jbc.2025.110991_bib45","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1002\/ajmg.a.34327","article-title":"Striking phenotypic variability in familial TRPV4-axonal neuropathy spectrum disorder","volume":"155A","author":"Aharoni","year":"2011","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.jbc.2025.110991_bib46","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ajhg.2009.01.021","article-title":"Mutations in the gene encoding the calcium-permeable ion channel TRPV4 produce spondylometaphyseal dysplasia, Kozlowski type and metatropic dysplasia","volume":"84","author":"Krakow","year":"2009","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jbc.2025.110991_bib47","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1212\/WNL.0000000000003772","article-title":"Genetic heterogeneity of motor neuropathies","volume":"88","author":"Bansagi","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.jbc.2025.110991_bib48","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/210401","article-title":"Genetic diagnosis of Charcot-Marie-Tooth disease in a population by next-generation sequencing","volume":"2014","author":"H\u00f8yer","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.jbc.2025.110991_bib49","doi-asserted-by":"crossref","DOI":"10.1212\/NXG.0000000000000335","article-title":"Oligogenic basis of sporadic ALS: the example of SOD1 p.Ala90Val mutation","volume":"5","author":"Kuuluvainen","year":"2019","journal-title":"Neurol. Genet."},{"key":"10.1016\/j.jbc.2025.110991_bib50","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1086\/378159","article-title":"Slowed conduction and thin myelination of peripheral nerves associated with mutant rho Guanine-nucleotide exchange factor 10","volume":"73","author":"Verhoeven","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jbc.2025.110991_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004635","article-title":"An ARHGEF10 deletion is highly associated with a juvenile-onset inherited polyneuropathy in leonberger and saint bernard dogs","volume":"10","author":"Ekenstedt","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jbc.2025.110991_bib52","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1097\/00001756-199109000-00002","article-title":"Embryonic mouse spinal cord motor neuron hybrid cells","volume":"2","author":"Salazar-Grueso","year":"1991","journal-title":"Neuroreport"},{"key":"10.1016\/j.jbc.2025.110991_bib53","doi-asserted-by":"crossref","first-page":"E1184","DOI":"10.1073\/pnas.1114124108","article-title":"Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli","volume":"108","author":"Cordero-Morales","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110991_bib54","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/j.cell.2015.08.024","article-title":"Ankyrin repeats convey force to gate the NOMPC mechanotransduction channel","volume":"162","author":"Zhang","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.110991_bib55","doi-asserted-by":"crossref","first-page":"25665","DOI":"10.1074\/jbc.M311515200","article-title":"Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity","volume":"279","author":"Morenilla-Palao","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110991_bib56","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1074\/jbc.M109.052548","article-title":"Differential regulation of TRPV1, TRPV3, and TRPV4 sensitivity through a conserved binding site on the ankyrin repeat domain","volume":"285","author":"Phelps","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110991_bib57","doi-asserted-by":"crossref","first-page":"9553","DOI":"10.1073\/pnas.1220231110","article-title":"Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli","volume":"110","author":"Garcia-Elias","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.110991_bib58","doi-asserted-by":"crossref","first-page":"6","DOI":"10.4161\/21541248.2014.968004","article-title":"Toward understanding RhoGTPase specificity: structure, function and local activation","volume":"5","author":"Schaefer","year":"2014","journal-title":"Small GTPases"},{"key":"10.1016\/j.jbc.2025.110991_bib59","doi-asserted-by":"crossref","first-page":"27884","DOI":"10.1074\/jbc.M109.028803","article-title":"Activation of the TRPV4 ion channel is enhanced by phosphorylation","volume":"284","author":"Fan","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110991_bib60","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1016\/j.bbrc.2009.12.140","article-title":"Identification of a protein kinase C-dependent phosphorylation site involved in sensitization of TRPV4 channel","volume":"391","author":"Peng","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jbc.2025.110991_bib61","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1074\/jbc.M805357200","article-title":"Tyrosine phosphorylation modulates the activity of TRPV4 in response to defined stimuli","volume":"284","author":"Wegierski","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110991_bib62","doi-asserted-by":"crossref","first-page":"11520","DOI":"10.1074\/jbc.M211061200","article-title":"Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress","volume":"278","author":"Xu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110991_bib63","doi-asserted-by":"crossref","first-page":"5659","DOI":"10.1038\/sj.emboj.7601429","article-title":"The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels","volume":"25","author":"Wegierski","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2025.110991_bib64","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s44321-025-00206-6","article-title":"Deubiquitination of RIPK3 by OTUB2 potentiates neuronal necroptosis after ischemic stroke","volume":"17","author":"Mei","year":"2025","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.jbc.2025.110991_bib65","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.molcel.2018.10.030","article-title":"OTUB2 promotes cancer metastasis via hippo-independent activation of YAP and TAZ","volume":"73","author":"Zhang","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2025.110991_bib66","article-title":"KIF26B promotes bladder cancer progression via activating Wnt\/beta-catenin signaling in a TRAF2-dependent pathway","volume":"44","author":"Wang","year":"2025","journal-title":"Cell Rep"},{"key":"10.1016\/j.jbc.2025.110991_bib67","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00210-006-0083-0","article-title":"Gef10--the third member of a rho-specific guanine nucleotide exchange factor subfamily with unusual protein architecture","volume":"373","author":"Mohl","year":"2006","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.jbc.2025.110991_bib68","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202002783RR","article-title":"Tumor necrosis factor-induced ArhGEF10 selectively activates RhoB contributing to human microvascular endothelial cell tight junction disruption","volume":"35","author":"Khan","year":"2021","journal-title":"FASEB J."},{"key":"10.1016\/j.jbc.2025.110991_bib69","doi-asserted-by":"crossref","first-page":"29511","DOI":"10.1074\/jbc.M111.236810","article-title":"Identification of a negative regulatory region for the exchange activity and characterization of T332I mutant of Rho guanine nucleotide exchange factor 10 (ARHGEF10)","volume":"286","author":"Chaya","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.110991_bib70","doi-asserted-by":"crossref","first-page":"3620","DOI":"10.1242\/jcs.186817","article-title":"ARHGEF10 directs the localization of Rab8 to Rab6-positive executive vesicles","volume":"129","author":"Shibata","year":"2016","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.jbc.2025.110991_bib71","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/ana.24265","article-title":"Sequencing of Charcot-Marie-Tooth disease genes in a toxic polyneuropathy","volume":"76","author":"Beutler","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jbc.2025.110991_bib72","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jns.2015.06.056","article-title":"Association of the Charcot-Marie-Tooth disease gene ARHGEF10 with paclitaxel induced peripheral neuropathy in NCCTG N08CA (Alliance)","volume":"357","author":"Boora","year":"2015","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jbc.2025.110991_bib73","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.O111.016253","article-title":"Rapid identification of monospecific monoclonal antibodies using a human proteome microarray","volume":"11","author":"Jeong","year":"2012","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.jbc.2025.110991_bib74","doi-asserted-by":"crossref","first-page":"D394","DOI":"10.1093\/nar\/gkaa1106","article-title":"PANTHER version 16: a revised family classification, tree-based classification tool, enhancer regions and extensive API","volume":"49","author":"Mi","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2025.110991_bib75","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/pro.4218","article-title":"PANTHER: making genome-scale phylogenetics accessible to all","volume":"31","author":"Thomas","year":"2022","journal-title":"Protein Sci."},{"key":"10.1016\/j.jbc.2025.110991_bib76","doi-asserted-by":"crossref","first-page":"D730","DOI":"10.1093\/nar\/gkae1113","article-title":"The STRING database in 2025: protein networks with directionality of regulation","volume":"53","author":"Szklarczyk","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jbc.2025.110991_bib77","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1074\/mcp.RA117.000014","article-title":"Global identification of small ubiquitin-related modifier (SUMO) substrates reveals crosstalk between SUMOylation and phosphorylation promotes cell migration","volume":"17","author":"Uzoma","year":"2018","journal-title":"Mol. Cell. Proteomics"}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925825028431?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925825028431?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T20:58:17Z","timestamp":1777409897000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925825028431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":77,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S0021925825028431"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2025.110991","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Profiling the TRPV4 ankyrin repeat domain interactome and its disruption by neuromuscular disease-causing mutations","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2025.110991","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology\u00e9","name":"copyright","label":"Copyright"}],"article-number":"110991"}}