{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:40:43Z","timestamp":1792176043084,"version":"4.4.0"},"reference-count":240,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"US Office of Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["PD220039"],"award-info":[{"award-number":["PD220039"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006309","name":"American Parkinson Disease Association","doi-asserted-by":"publisher","award":["1043097"],"award-info":[{"award-number":["1043097"]}],"id":[{"id":"10.13039\/100006309","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R00AG066862"],"award-info":[{"award-number":["R00AG066862"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30 AG072959"],"award-info":[{"award-number":["P30 AG072959"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017970","name":"Alzheimer's Disease Research Center, University of Pittsburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017970","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000040","name":"American Parkinson's Disease Foundation","doi-asserted-by":"publisher","award":["P30 AG072959"],"award-info":[{"award-number":["P30 AG072959"]}],"id":[{"id":"10.13039\/100000040","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jbc.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biological Chemistry"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jbc.2025.111039","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T02:54:46Z","timestamp":1765421686000},"page":"111039","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Sterile innate immune mechanisms in neurodegenerative diseases"],"prefix":"10.1016","volume":"302","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9262-9431","authenticated-orcid":false,"given":"Alyssa","family":"Ealy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda M.","family":"Serapiglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1752-4284","authenticated-orcid":false,"given":"Nikhil","family":"Panicker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jbc.2025.111039_bib1","doi-asserted-by":"crossref","DOI":"10.7189\/jogh.13.04160","article-title":"Global, regional, and national burden of neurological disorders in 204 countries and territories worldwide","volume":"13","author":"Huang","year":"2023","journal-title":"J. Glob. Health."},{"key":"10.1016\/j.jbc.2025.111039_bib2","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1002\/mds.21956","article-title":"The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years","volume":"23","author":"Hely","year":"2008","journal-title":"Mov Disord."},{"key":"10.1016\/j.jbc.2025.111039_bib3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1750-3639.2007.00052.x","article-title":"Hereditary frontotemporal dementia caused by Tau gene mutations","volume":"17","author":"van Swieten","year":"2007","journal-title":"Brain Pathol."},{"key":"10.1016\/j.jbc.2025.111039_bib4","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1749-6632.1988.tb27086.x","article-title":"Occurrence of HLA-DR reactive microglia in Alzheimer's disease","volume":"540","author":"McGeer","year":"1988","journal-title":"Ann. N. Y Acad. Sci."},{"key":"10.1016\/j.jbc.2025.111039_bib5","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1212\/WNL.38.8.1285","article-title":"Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains","volume":"38","author":"McGeer","year":"1988","journal-title":"Neurology"},{"issue":"7 Pt 1","key":"10.1016\/j.jbc.2025.111039_bib6","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1212\/WNL.30.7.778","article-title":"Glial fibrillary acidic protein and alzheimer-type senile dementia","volume":"30","author":"Duffy","year":"1980","journal-title":"Neurology"},{"key":"10.1016\/j.jbc.2025.111039_bib7","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/glia.440070114","article-title":"Microglia in degenerative neurological disease","volume":"7","author":"McGeer","year":"1993","journal-title":"Glia"},{"key":"10.1016\/j.jbc.2025.111039_bib8","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1159\/000322228","article-title":"Presence of reactive microglia and neuroinflammatory mediators in a case of frontotemporal dementia with P301S mutation","volume":"8","author":"Bellucci","year":"2011","journal-title":"Neurodegener Dis."},{"key":"10.1016\/j.jbc.2025.111039_bib9","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.msard.2018.11.032","article-title":"Cerebrospinal fluid biomarkers link toxic astrogliosis and microglial activation to multiple sclerosis severity","volume":"28","author":"Masvekar","year":"2019","journal-title":"Mult. Scler. Relat. Disord."},{"key":"10.1016\/j.jbc.2025.111039_bib10","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3389\/fneur.2018.00181","article-title":"Evaluation of microglial activation in multiple sclerosis patients using positron emission tomography","volume":"9","author":"Airas","year":"2018","journal-title":"Front Neurol."},{"key":"10.1016\/j.jbc.2025.111039_bib11","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1038\/s41380-023-02089-w","article-title":"Multi-ancestry meta-analysis and fine-mapping in Alzheimer's disease","volume":"28","author":"Lake","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.jbc.2025.111039_bib12","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/ng.803","article-title":"Common variants at ABCA7, MS4A6A\/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease","volume":"43","author":"Hollingworth","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbc.2025.111039_bib13","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJMoa1211851","article-title":"TREM2 variants in Alzheimer's disease","volume":"368","author":"Guerreiro","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jbc.2025.111039_bib14","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.tins.2023.07.009","article-title":"Inflammasome assembly in neurodegenerative diseases","volume":"46","author":"Singh","year":"2023","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.jbc.2025.111039_bib15","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2025.111039_bib16","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1002\/art.10509","article-title":"Association of mutations in the NALP3\/CIAS1\/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis","volume":"46","author":"Aganna","year":"2002","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jbc.2025.111039_bib17","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/ng756","article-title":"Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome","volume":"29","author":"Hoffman","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbc.2025.111039_bib18","doi-asserted-by":"crossref","first-page":"6329","DOI":"10.4049\/jimmunol.171.12.6329","article-title":"Cutting edge: CIAS1\/cryopyrin\/PYPAF1\/NALP3\/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties","volume":"171","author":"O'Connor","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.jbc.2025.111039_bib19","doi-asserted-by":"crossref","first-page":"787","DOI":"10.4049\/jimmunol.0901363","article-title":"Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression","volume":"183","author":"Bauernfeind","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.jbc.2025.111039_bib20","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.111039_bib21","doi-asserted-by":"crossref","first-page":"7611","DOI":"10.1073\/pnas.86.19.7611","article-title":"Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease","volume":"86","author":"Griffin","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.111039_bib22","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/ni.1636","article-title":"The NALP3 inflammasome is involved in the innate immune response to amyloid-beta","volume":"9","author":"Halle","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jbc.2025.111039_bib23","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1084\/jem.20021546","article-title":"CD36 mediates the innate host response to beta-amyloid","volume":"197","author":"El Khoury","year":"2003","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jbc.2025.111039_bib24","doi-asserted-by":"crossref","first-page":"47373","DOI":"10.1074\/jbc.M208788200","article-title":"A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid","volume":"277","author":"Moore","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.111039_bib25","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.4049\/jimmunol.1101121","article-title":"TLR2 is a primary receptor for Alzheimer's amyloid beta peptide to trigger neuroinflammatory activation","volume":"188","author":"Liu","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.jbc.2025.111039_bib26","doi-asserted-by":"crossref","first-page":"7254","DOI":"10.4049\/jimmunol.181.10.7254","article-title":"Fibrillar amyloid-beta peptides activate microglia via TLR2: implications for Alzheimer's disease","volume":"181","author":"Jana","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.jbc.2025.111039_bib27","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1074\/jbc.M508125200","article-title":"Activation of toll-like receptor 2 on microglia promotes cell uptake of Alzheimer disease-associated amyloid beta peptide","volume":"281","author":"Chen","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.111039_bib28","doi-asserted-by":"crossref","first-page":"5296","DOI":"10.1073\/pnas.94.10.5296","article-title":"Amyloid-beta peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease","volume":"94","author":"Du Yan","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.111039_bib29","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.neuron.2018.01.031","article-title":"TREM2 is a receptor for beta-amyloid that mediates microglial function","volume":"97","author":"Zhao","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.jbc.2025.111039_bib30","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature11729","article-title":"NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP\/PS1 mice","volume":"493","author":"Heneka","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.111039_bib31","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.bbi.2016.12.014","article-title":"Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-beta and cognitive function in APP\/PS1 mice","volume":"61","author":"Dempsey","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jbc.2025.111039_bib32","doi-asserted-by":"crossref","first-page":"3916","DOI":"10.1038\/s41467-018-06449-x","article-title":"Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer's disease mouse model","volume":"9","author":"Flores","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.111039_bib33","first-page":"195","article-title":"Interleukin-1beta in central nervous System injury and repair","volume":"1","author":"Hewett","year":"2012","journal-title":"Eur. J. Neurodegener. Dis."},{"issue":"6 Pt 1","key":"10.1016\/j.jbc.2025.111039_bib34","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1083\/jcb.127.6.1717","article-title":"Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis","volume":"127","author":"Estus","year":"1994","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jbc.2025.111039_bib35","doi-asserted-by":"crossref","first-page":"6482","DOI":"10.1523\/JNEUROSCI.5712-03.2004","article-title":"Cell type-specific interleukin-1beta signaling in the CNS","volume":"24","author":"Srinivasan","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jbc.2025.111039_bib36","doi-asserted-by":"crossref","first-page":"5053","DOI":"10.1523\/JNEUROSCI.4361-12.2013","article-title":"Sustained interleukin-1beta overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model","volume":"33","author":"Ghosh","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jbc.2025.111039_bib37","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/s12974-019-1645-7","article-title":"IL-1beta-driven amyloid plaque clearance is associated with an expansion of transcriptionally reprogrammed microglia","volume":"16","author":"Rivera-Escalera","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jbc.2025.111039_bib38","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nature25158","article-title":"Microglia-derived ASC specks cross-seed amyloid-beta in Alzheimer's disease","volume":"552","author":"Venegas","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.111039_bib39","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1016\/j.celrep.2020.02.025","article-title":"beta-Amyloid clustering around ASC fibrils boosts its toxicity in Microglia","volume":"30","author":"Friker","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2025.111039_bib40","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/cr.2015.139","article-title":"Gasdermin D is an executor of pyroptosis and required for interleukin-1beta secretion","volume":"25","author":"He","year":"2015","journal-title":"Cell Res."},{"key":"10.1016\/j.jbc.2025.111039_bib41","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0304-3940(02)00300-2","article-title":"Association of interleukin-1 beta polymorphisms with idiopathic Parkinson's disease","volume":"326","author":"McGeer","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jbc.2025.111039_bib42","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1742-2094-5-8","article-title":"Neuroinflammation mediated by IL-1beta increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease","volume":"5","author":"Koprich","year":"2008","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jbc.2025.111039_bib43","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1126\/science.1227157","article-title":"Pathological alpha-synuclein transmission initiates parkinson-like neurodegeneration in nontransgenic mice","volume":"338","author":"Luk","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.jbc.2025.111039_bib44","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aah4066","article-title":"Inflammasome inhibition prevents \u03b1-synuclein pathology and dopaminergic neurodegeneration in mice","volume":"10","author":"Gordon","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jbc.2025.111039_bib45","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12974-023-02709-w","article-title":"ASC specks exacerbate alpha-synuclein pathology via amplifying NLRP3 inflammasome activities","volume":"20","author":"Zheng","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jbc.2025.111039_bib46","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.neurobiolaging.2007.04.006","article-title":"Synuclein activates microglia in a model of Parkinson's disease","volume":"29","author":"Su","year":"2008","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.jbc.2025.111039_bib47","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1084\/jem.20182191","article-title":"Fyn kinase regulates misfolded \u03b1-synuclein uptake and NLRP3 inflammasome activation in microglia","volume":"216","author":"Panicker","year":"2019","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jbc.2025.111039_bib48","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1038\/ncomms2534","article-title":"Neuron-released oligomeric alpha-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia","volume":"4","author":"Kim","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.111039_bib49","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1038\/s41467-020-15119-w","article-title":"Microglia clear neuron-released alpha-synuclein via selective autophagy and prevent neurodegeneration","volume":"11","author":"Choi","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.111039_bib50","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/glia.22437","article-title":"Toll-like receptor 4 is required for alpha-synuclein dependent activation of microglia and astroglia","volume":"61","author":"Fellner","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.jbc.2025.111039_bib51","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.4049\/jimmunol.2100035","article-title":"Microglial NLRP3 inflammasome activation upon TLR2 and TLR5 ligation by distinct alpha-Synuclein assemblies","volume":"207","author":"Scheiblich","year":"2021","journal-title":"J. Immunol."},{"key":"10.1016\/j.jbc.2025.111039_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111401","article-title":"Interaction of RAGE with alpha-synuclein fibrils mediates inflammatory response of microglia","volume":"40","author":"Long","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2025.111039_bib53","first-page":"E1926","article-title":"alpha-Synuclein, a chemoattractant, directs microglial migration via H2O2-dependent Lyn phosphorylation","volume":"112","author":"Wang","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.111039_bib54","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1002\/glia.23970","article-title":"alpha-Synuclein evokes NLRP3 inflammasome-mediated IL-1beta secretion from primary human microglia","volume":"69","author":"Pike","year":"2021","journal-title":"Glia"},{"key":"10.1016\/j.jbc.2025.111039_bib55","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1016\/j.neuron.2022.05.009","article-title":"Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease","volume":"110","author":"Panicker","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.jbc.2025.111039_bib56","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/35097565","article-title":"From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS","volume":"2","author":"Cleveland","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jbc.2025.111039_bib57","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1016\/S0140-6736(15)00461-4","article-title":"Frontotemporal dementia","volume":"386","author":"Bang","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.jbc.2025.111039_bib58","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1016\/S0002-9440(10)63421-9","article-title":"Induction of inflammatory mediators and microglial activation in mice transgenic for mutant human P301S tau protein","volume":"165","author":"Bellucci","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jbc.2025.111039_bib59","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41586-019-1769-z","article-title":"NLRP3 inflammasome activation drives tau pathology","volume":"575","author":"Ising","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.111039_bib60","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s00401-018-01957-y","article-title":"Aggregated Tau activates NLRP3-ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo","volume":"137","author":"Stancu","year":"2019","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.jbc.2025.111039_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109720","article-title":"Proteopathic tau primes and activates interleukin-1beta via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway","volume":"36","author":"Jiang","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2025.111039_bib62","doi-asserted-by":"crossref","DOI":"10.1002\/alz.14418","article-title":"Microglia internalize tau monomers and fibrils using distinct receptors but similar mechanisms","volume":"21","author":"Falkon","year":"2025","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.jbc.2025.111039_bib63","doi-asserted-by":"crossref","DOI":"10.1172\/JCI161987","article-title":"Tau fibrils induce glial inflammation and neuropathology via TLR2 in Alzheimer's disease-related mouse models","volume":"133","author":"Dutta","year":"2023","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jbc.2025.111039_bib64","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.biopsych.2022.10.015","article-title":"Pathogenic role of RAGE in tau transmission and memory deficits","volume":"93","author":"Kim","year":"2023","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jbc.2025.111039_bib65","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.expneurol.2015.07.019","article-title":"TDP-43 activates microglia through NF-kappaB and NLRP3 inflammasome","volume":"273","author":"Zhao","year":"2015","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jbc.2025.111039_bib66","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1096\/fj.201601163R","article-title":"Extracellular TDP-43 aggregates target MAPK\/MAK\/MRK overlapping kinase (MOK) and trigger caspase-3\/IL-18 signaling in microglia","volume":"31","author":"Leal-Lasarte","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.jbc.2025.111039_bib67","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41593-021-00975-6","article-title":"TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration","volume":"25","author":"Xie","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jbc.2025.111039_bib68","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/glia.23728","article-title":"The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins","volume":"68","author":"Deora","year":"2020","journal-title":"Glia"},{"key":"10.1016\/j.jbc.2025.111039_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112133","article-title":"Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome","volume":"42","author":"Shu","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2025.111039_bib70","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.3390\/cells11193128","article-title":"C9-ALS-Associated proline-arginine dipeptide repeat protein induces activation of NLRP3 inflammasome of HMC3 microglia cells by binding of complement component 1 Q subcomponent-binding protein (C1QBP), and syringin prevents this effect","volume":"11","author":"Fu","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.jbc.2025.111039_bib71","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.3390\/antiox12101896","article-title":"Glycine-Alanine dipeptide repeat protein from C9-ALS interacts with sulfide quinone oxidoreductase (SQOR) to induce the activity of the NLRP3 inflammasome in HMC3 microglia: Irisflorentin reverses this interaction","volume":"12","author":"Fu","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.jbc.2025.111039_bib72","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.1007\/s12035-023-03315-w","article-title":"Inflammasome-Mediated neuronal-microglial crosstalk: a therapeutic substrate for the familial C9orf72 variant of frontotemporal Dementia\/Amyotrophic lateral sclerosis","volume":"60","author":"Trageser","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jbc.2025.111039_bib73","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s00401-022-02466-9","article-title":"Increased pyroptosis activation in white matter microglia is associated with neuronal loss in ALS motor cortex","volume":"144","author":"Van Schoor","year":"2022","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.jbc.2025.111039_bib74","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1002\/glia.22891","article-title":"NLRP3 inflammasome is expressed by astrocytes in the SOD1 mouse model of ALS and in human sporadic ALS patients","volume":"63","author":"Johann","year":"2015","journal-title":"Glia"},{"key":"10.1016\/j.jbc.2025.111039_bib75","doi-asserted-by":"crossref","first-page":"15811","DOI":"10.1523\/JNEUROSCI.4088-10.2010","article-title":"The inflammasome sensor, NLRP3, regulates CNS inflammation and demyelination via caspase-1 and interleukin-18","volume":"30","author":"Jha","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jbc.2025.111039_bib76","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.intimp.2017.08.007","article-title":"Progesterone therapy induces an M1 to M2 switch in microglia phenotype and suppresses NLRP3 inflammasome in a cuprizone-induced demyelination mouse model","volume":"51","author":"Aryanpour","year":"2017","journal-title":"Int. Immunopharmacol"},{"key":"10.1016\/j.jbc.2025.111039_bib77","doi-asserted-by":"crossref","first-page":"E6065","DOI":"10.1073\/pnas.1722041115","article-title":"Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis","volume":"115","author":"McKenzie","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.111039_bib78","doi-asserted-by":"crossref","first-page":"974","DOI":"10.4049\/jimmunol.0904145","article-title":"NLRP3 plays a critical role in the development of experimental autoimmune encephalomyelitis by mediating Th1 and Th17 responses","volume":"185","author":"Gris","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.jbc.2025.111039_bib79","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1007\/s12035-023-03618-y","article-title":"Inhibiting the NLRP3 inflammasome with MCC950 Alleviates neurological impairment in the brain of EAE mice","volume":"61","author":"Hou","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jbc.2025.111039_bib80","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nm.3806","article-title":"A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases","volume":"21","author":"Coll","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.jbc.2025.111039_bib81","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1093\/brain\/awaa084","article-title":"NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients","volume":"143","author":"Malhotra","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.jbc.2025.111039_bib82","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.4049\/jimmunol.1103308","article-title":"Inflammasome-derived IL-1beta regulates the production of GM-CSF by CD4(+) T cells and gammadelta T cells","volume":"188","author":"Lukens","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.jbc.2025.111039_bib83","doi-asserted-by":"crossref","first-page":"4610","DOI":"10.4049\/jimmunol.1000217","article-title":"Cutting edge: critical role for PYCARD\/ASC in the development of experimental autoimmune encephalomyelitis","volume":"184","author":"Shaw","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.jbc.2025.111039_bib84","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1084\/jem.20150237","article-title":"NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes","volume":"214","author":"Freeman","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jbc.2025.111039_bib85","doi-asserted-by":"crossref","first-page":"10480","DOI":"10.1073\/pnas.1201836109","article-title":"NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis","volume":"109","author":"Inoue","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"10.1016\/j.jbc.2025.111039_bib86","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/s41586-020-2174-3","article-title":"AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment","volume":"580","author":"Lammert","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.111039_bib87","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1186\/s12974-021-02327-4","article-title":"Downregulating expression of OPTN elevates neuroinflammation via AIM2 inflammasome- and RIPK1-activating mechanisms in APP\/PS1 transgenic mice","volume":"18","author":"Cao","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jbc.2025.111039_bib88","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14555","article-title":"Conditional knockout of AIM2 in microglia ameliorates synaptic plasticity and spatial memory deficits in a mouse model of Alzheimer's disease","volume":"30","author":"Ye","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.jbc.2025.111039_bib89","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/s41586-021-03231-w","article-title":"AIM2 in regulatory T cells restrains autoimmune diseases","volume":"591","author":"Chou","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.111039_bib90","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.155563","article-title":"The AIM2 inflammasome is activated in astrocytes during the late phase of EAE","volume":"7","author":"Barclay","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.jbc.2025.111039_bib91","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1126\/science.1232458","article-title":"Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway","volume":"339","author":"Sun","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.jbc.2025.111039_bib92","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.molcel.2013.05.022","article-title":"Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING","volume":"51","author":"Zhang","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2025.111039_bib93","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.molcel.2013.01.039","article-title":"STING recognition of cytoplasmic DNA instigates cellular defense","volume":"50","author":"Abe","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2025.111039_bib94","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1076784","article-title":"cGAS in nucleus: the link between immune response and DNA damage repair","volume":"13","author":"Song","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jbc.2025.111039_bib95","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.cell.2013.04.046","article-title":"Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase","volume":"153","author":"Gao","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.111039_bib96","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nature12306","article-title":"cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING","volume":"498","author":"Ablasser","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.111039_bib97","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/s41586-019-1000-2","article-title":"Structural basis of STING binding with and phosphorylation by TBK1","volume":"567","author":"Zhang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.111039_bib98","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/nature08476","article-title":"STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity","volume":"461","author":"Ishikawa","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.111039_bib99","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/s41586-019-1228-x","article-title":"A conserved PLPLRT\/SD motif of STING mediates the recruitment and activation of TBK1","volume":"569","author":"Zhao","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.111039_bib100","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaa2630","article-title":"Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation","volume":"347","author":"Liu","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.jbc.2025.111039_bib101","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.molcel.2013.07.004","article-title":"The cGAS-STING pathway for DNA sensing","volume":"51","author":"Xiao","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2025.111039_bib102","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.immuni.2020.06.009","article-title":"Interferon-Independent activities of Mammalian STING mediate antiviral response and tumor immune evasion","volume":"53","author":"Wu","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.jbc.2025.111039_bib103","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2002521","article-title":"STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway","volume":"5","author":"Tanaka","year":"2012","journal-title":"Sci. Signal"},{"key":"10.1016\/j.jbc.2025.111039_bib104","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ni921","article-title":"IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway","volume":"4","author":"Fitzgerald","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jbc.2025.111039_bib105","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s12943-019-1087-y","article-title":"STING: a master regulator in the cancer-immunity cycle","volume":"18","author":"Zhu","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.jbc.2025.111039_bib106","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature09907","article-title":"A diverse range of gene products are effectors of the type I interferon antiviral response","volume":"472","author":"Schoggins","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.111039_bib107","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41586-023-06373-1","article-title":"cGAS-STING drives ageing-related inflammation and neurodegeneration","volume":"620","author":"Gulen","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.111039_bib108","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s43587-022-00337-2","article-title":"Activation of innate immune cGAS-STING pathway contributes to Alzheimer's pathogenesis in 5xFAD mice","volume":"3","author":"Xie","year":"2023","journal-title":"Nat. Aging"},{"key":"10.1016\/j.jbc.2025.111039_bib109","article-title":"Microglial cGAS deletion protects against amyloid-beta induced Alzheimer's disease pathogenesis","author":"He","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.jbc.2025.111039_bib110","article-title":"Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model","author":"Carling","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.jbc.2025.111039_bib111","doi-asserted-by":"crossref","DOI":"10.1002\/alz.70305","article-title":"STING deletion protects against amyloid beta-induced Alzheimer's disease pathogenesis","volume":"21","author":"Thanos","year":"2025","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.jbc.2025.111039_bib112","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1038\/s12276-024-01295-y","article-title":"Blockade of STING activation alleviates microglial dysfunction and a broad spectrum of Alzheimer's disease pathologies","volume":"56","author":"Chung","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.jbc.2025.111039_bib113","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/s41593-023-01315-6","article-title":"Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience","volume":"26","author":"Udeochu","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jbc.2025.111039_bib114","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abd7695","article-title":"MEF2 is a key regulator of cognitive potential and confers resilience to neurodegeneration","volume":"13","author":"Barker","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jbc.2025.111039_bib115","article-title":"APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition","author":"Naguib","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.jbc.2025.111039_bib116","doi-asserted-by":"crossref","first-page":"6565","DOI":"10.1038\/s41467-021-26851-2","article-title":"Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation","volume":"12","author":"Jin","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.111039_bib117","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2118819119","article-title":"STING mediates neurodegeneration and neuroinflammation in nigrostriatal alpha-synucleinopathy","volume":"119","author":"Hinkle","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.111039_bib118","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1124\/jpet.112.192138","article-title":"Mitochondrial dysfunction in neurodegenerative diseases","volume":"342","author":"Johri","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.jbc.2025.111039_bib119","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13024-020-00367-7","article-title":"PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson's disease","volume":"15","author":"Ge","year":"2020","journal-title":"Mol. Neurodegener"},{"key":"10.1016\/j.jbc.2025.111039_bib120","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41586-018-0448-9","article-title":"Parkin and PINK1 mitigate STING-induced inflammation","volume":"561","author":"Sliter","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.111039_bib121","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.81943","article-title":"Constitutively active STING causes neuroinflammation and degeneration of dopaminergic neurons in mice","volume":"11","author":"Szego","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.jbc.2025.111039_bib122","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/j.neuron.2017.11.032","article-title":"Activation of the STING-Dependent type I interferon response reduces microglial reactivity and neuroinflammation","volume":"96","author":"Mathur","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.jbc.2025.111039_bib123","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.4049\/jimmunol.2001317","article-title":"STING agonist mitigates experimental autoimmune encephalomyelitis by stimulating type I IFN-Dependent and -Independent immune-regulatory pathways","volume":"206","author":"Johnson","year":"2021","journal-title":"J. Immunol."},{"key":"10.1016\/j.jbc.2025.111039_bib124","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/s41590-021-01105-x","article-title":"The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING-p53 signaling","volume":"23","author":"Concepcion","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jbc.2025.111039_bib125","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a032003","article-title":"Interferon beta for Multiple Sclerosis","volume":"8","author":"Jakimovski","year":"2018","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.jbc.2025.111039_bib126","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1016\/j.cell.2024.05.031","article-title":"STING orchestrates the neuronal inflammatory stress response in multiple sclerosis","volume":"187","author":"Woo","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.111039_bib127","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s00401-024-02688-z","article-title":"Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia","volume":"147","author":"Marques","year":"2024","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.jbc.2025.111039_bib128","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/s41556-023-01339-x","article-title":"Innate immune sensing of lysosomal dysfunction drives multiple lysosomal storage disorders","volume":"26","author":"Wang","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jbc.2025.111039_bib129","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nn.4000","article-title":"Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia","volume":"18","author":"Freischmidt","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jbc.2025.111039_bib130","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00401-015-1436-x","article-title":"Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease","volume":"130","author":"Pottier","year":"2015","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.jbc.2025.111039_bib131","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.cell.2020.09.020","article-title":"TDP-43 triggers mitochondrial DNA release via mPTP to activate cGAS\/STING in ALS","volume":"183","author":"Yu","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.111039_bib132","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.cell.2009.11.005","article-title":"Lipid droplets finally get a little R-E-S-P-E-C-T","volume":"139","author":"Farese","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.111039_bib133","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a040576","article-title":"Lipid metabolism","volume":"13","author":"Chandel","year":"2021","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.jbc.2025.111039_bib134","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.cmet.2017.07.012","article-title":"Triglyceride synthesis by DGAT1 protects adipocytes from lipid-induced ER stress during lipolysis","volume":"26","author":"Chitraju","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbc.2025.111039_bib135","doi-asserted-by":"crossref","first-page":"36312","DOI":"10.1074\/jbc.M109.049817","article-title":"DGAT1 expression increases heart triglyceride content but ameliorates lipotoxicity","volume":"284","author":"Liu","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.111039_bib136","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41574-023-00845-0","article-title":"Lipid droplet biogenesis and functions in health and disease","volume":"19","author":"Zadoorian","year":"2023","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jbc.2025.111039_bib137","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.devcel.2017.06.003","article-title":"DGAT1-Dependent lipid droplet biogenesis protects mitochondrial function during starvation-induced autophagy","volume":"42","author":"Nguyen","year":"2017","journal-title":"Dev. Cell"},{"key":"10.1016\/j.jbc.2025.111039_bib138","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1002\/glia.23978","article-title":"Astrocytes in stress accumulate lipid droplets","volume":"69","author":"Smolic","year":"2021","journal-title":"Glia"},{"key":"10.1016\/j.jbc.2025.111039_bib139","doi-asserted-by":"crossref","first-page":"7176","DOI":"10.1038\/ncomms8176","article-title":"AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation","volume":"6","author":"Herms","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.111039_bib140","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.cell.2019.04.001","article-title":"Neuron-Astrocyte metabolic coupling protects against activity-induced fatty acid toxicity","volume":"177","author":"Ioannou","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.111039_bib141","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/ca.980080612","article-title":"An English translation of Alzheimer's 1907 paper, \"Uber eine eigenartige Erkankung der Hirnrinde\"","volume":"8","author":"Alzheimer","year":"1995","journal-title":"Clin. Anat."},{"key":"10.1016\/j.jbc.2025.111039_bib142","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1749-6632.1985.tb11846.x","article-title":"Foam cells and atherogenesis","volume":"454","author":"Fowler","year":"1985","journal-title":"Ann. N. Y Acad. Sci."},{"key":"10.1016\/j.jbc.2025.111039_bib143","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1126\/science.aaf6659","article-title":"Senescent intimal foam cells are deleterious at all stages of atherosclerosis","volume":"354","author":"Childs","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.jbc.2025.111039_bib144","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cell.2014.12.019","article-title":"Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration","volume":"160","author":"Liu","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.111039_bib145","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/s41588-019-0358-2","article-title":"Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Abeta, tau, immunity and lipid processing","volume":"51","author":"Kunkle","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbc.2025.111039_bib146","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41593-019-0566-1","article-title":"Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain","volume":"23","author":"Marschallinger","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jbc.2025.111039_bib147","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/j.immuni.2025.04.029","article-title":"Amyloid-beta induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer's disease","volume":"58","author":"Prakash","year":"2025","journal-title":"Immunity"},{"key":"10.1016\/j.jbc.2025.111039_bib148","doi-asserted-by":"crossref","first-page":"598","DOI":"10.3389\/fphys.2020.00598","article-title":"Involvement of lipids in Alzheimer's Disease pathology and potential therapies","volume":"11","author":"Chew","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.jbc.2025.111039_bib149","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41586-021-03960-y","article-title":"Neurotoxic reactive astrocytes induce cell death via saturated lipids","volume":"599","author":"Guttenplan","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.111039_bib150","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201899553","article-title":"Lipid-induced lysosomal damage after demyelination corrupts microglia protective function in lysosomal storage disorders","volume":"38","author":"Gabande-Rodriguez","year":"2019","journal-title":"EMBO J."},{"key":"10.1016\/j.jbc.2025.111039_bib151","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41586-024-07185-7","article-title":"APOE4\/4 is linked to damaging lipid droplets in Alzheimer's disease microglia","volume":"628","author":"Haney","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.111039_bib152","doi-asserted-by":"crossref","first-page":"4402","DOI":"10.3390\/ijms22094402","article-title":"Senescent microglia: the key to the ageing brain?","volume":"22","author":"Greenwood","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jbc.2025.111039_bib153","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.stem.2022.07.005","article-title":"Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity","volume":"29","author":"Victor","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jbc.2025.111039_bib154","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2112095118","article-title":"Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease-associated genes","volume":"118","author":"Moulton","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.111039_bib155","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/s43587-021-00130-7","article-title":"Neuronal accumulation of peroxidated lipids promotes demyelination and neurodegeneration through the activation of the microglial NLRP3 inflammasome","volume":"1","author":"Wang","year":"2021","journal-title":"Nat. Aging"},{"key":"10.1016\/j.jbc.2025.111039_bib156","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.jbc.2025.111039_bib157","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1073\/pnas.90.5.1977","article-title":"Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease","volume":"90","author":"Strittmatter","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.111039_bib158","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.nbd.2014.08.025","article-title":"Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases","volume":"72","author":"Huang","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jbc.2025.111039_bib159","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.1523\/JNEUROSCI.5476-05.2006","article-title":"Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus","volume":"26","author":"Xu","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jbc.2025.111039_bib160","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.cmet.2017.08.024","article-title":"The Glia-Neuron lactate shuttle and elevated ROS promote lipid synthesis in neurons and lipid droplet accumulation in glia via APOE\/D","volume":"26","author":"Liu","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbc.2025.111039_bib161","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108572","article-title":"ApoE4 Impairs Neuron-Astrocyte coupling of Fatty acid metabolism","volume":"34","author":"Qi","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.jbc.2025.111039_bib162","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202305003","article-title":"APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size","volume":"223","author":"Windham","year":"2024","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jbc.2025.111039_bib163","first-page":"686","article-title":"Lipophagy: molecular mechanisms and implications in metabolic disorders","volume":"43","author":"Shin","year":"2020","journal-title":"Mol. Cells"},{"key":"10.1016\/j.jbc.2025.111039_bib164","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1080\/15548627.2023.2213984","article-title":"Impaired lipophagy induced-microglial lipid droplets accumulation contributes to the buildup of TREM1 in diabetes-associated cognitive impairment","volume":"19","author":"Li","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.jbc.2025.111039_bib165","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2022.167714","article-title":"Functional and pathological effects of alpha-Synuclein on synaptic SNARE complexes","volume":"435","author":"Gao","year":"2023","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jbc.2025.111039_bib166","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","article-title":"Mutation in the alpha-synuclein gene identified in families with Parkinson's disease","volume":"276","author":"Polymeropoulos","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.jbc.2025.111039_bib167","doi-asserted-by":"crossref","first-page":"6344","DOI":"10.1074\/jbc.M108414200","article-title":"Lipid droplet binding and oligomerization properties of the Parkinson's disease protein alpha-synuclein","volume":"277","author":"Cole","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jbc.2025.111039_bib168","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.molcel.2018.11.028","article-title":"Lipidomic analysis of alpha-Synuclein neurotoxicity identifies Stearoyl CoA desaturase as a target for parkinson treatment","volume":"73","author":"Fanning","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jbc.2025.111039_bib169","doi-asserted-by":"crossref","first-page":"E28","DOI":"10.1152\/ajpendo.90897.2008","article-title":"Biochemical and physiological function of stearoyl-CoA desaturase","volume":"297","author":"Paton","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.jbc.2025.111039_bib170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009921","article-title":"Abnormal accumulation of lipid droplets in neurons induces the conversion of alpha-Synuclein to proteolytic resistant forms in a Drosophila model of Parkinson's disease","volume":"17","author":"Girard","year":"2021","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jbc.2025.111039_bib171","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.3390\/cells11081261","article-title":"GBA variants and parkinson disease: mechanisms and treatments","volume":"11","author":"Smith","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.jbc.2025.111039_bib172","first-page":"773","article-title":"The GBA variant E326K is associated with alpha-synuclein aggregation and lipid droplet accumulation in human cell lines","volume":"32","author":"Smith","year":"2023","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jbc.2025.111039_bib173","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2103425118","article-title":"Wild-type GBA1 increases the alpha-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice","volume":"118","author":"Glajch","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.111039_bib174","doi-asserted-by":"crossref","first-page":"27646","DOI":"10.1073\/pnas.2003021117","article-title":"Cell type-specific lipid storage changes in Parkinson's disease patient brains are recapitulated by experimental glycolipid disturbance","volume":"117","author":"Brekk","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.111039_bib175","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/s42255-019-0065-4","article-title":"Gpnmb secreted from liver promotes lipogenesis in white adipose tissue and aggravates obesity and insulin resistance","volume":"1","author":"Gong","year":"2019","journal-title":"Nat. Metab."},{"key":"10.1016\/j.jbc.2025.111039_bib176","doi-asserted-by":"crossref","DOI":"10.1126\/science.abk0637","article-title":"GPNMB confers risk for Parkinson's disease through interaction with alpha-synuclein","volume":"377","author":"Diaz-Ortiz","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.jbc.2025.111039_bib177","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.674739","article-title":"The role of GPNMB in inflammation","volume":"12","author":"Saade","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jbc.2025.111039_bib178","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aay1809","article-title":"APOE4 exacerbates alpha-synuclein pathology and related toxicity independent of amyloid","volume":"12","author":"Zhao","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jbc.2025.111039_bib179","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aay3069","article-title":"APOE genotype regulates pathology and disease progression in synucleinopathy","volume":"12","author":"Davis","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jbc.2025.111039_bib180","article-title":"Multiple pathways of lipid dysregulation in amyotrophic lateral sclerosis","volume":"5","author":"Phan","year":"2023","journal-title":"Brain Commun."},{"key":"10.1016\/j.jbc.2025.111039_bib181","doi-asserted-by":"crossref","first-page":"773","DOI":"10.3233\/JAD-170660","article-title":"Lipid metabolism and survival across the frontotemporal dementia-amyotrophic lateral sclerosis spectrum: relationships to eating behavior and cognition","volume":"61","author":"Ahmed","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.jbc.2025.111039_bib182","doi-asserted-by":"crossref","first-page":"554","DOI":"10.3390\/metabo12060554","article-title":"Lipid metabolism is dysregulated in the motor Cortex White matter in amyotrophic lateral sclerosis","volume":"12","author":"Sadler","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.jbc.2025.111039_bib183","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1101\/gad.315564.118","article-title":"A C9orf72-CARM1 axis regulates lipid metabolism under glucose starvation-induced nutrient stress","volume":"32","author":"Liu","year":"2018","journal-title":"Genes Dev."},{"key":"10.1016\/j.jbc.2025.111039_bib184","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1038\/s41593-022-01199-y","article-title":"TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury","volume":"25","author":"Zambusi","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jbc.2025.111039_bib185","doi-asserted-by":"crossref","first-page":"5197","DOI":"10.1038\/s41467-023-40927-1","article-title":"Microglial REV-ERBalpha regulates inflammation and lipid droplet formation to drive tauopathy in male mice","volume":"14","author":"Lee","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jbc.2025.111039_bib186","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.nbd.2017.02.007","article-title":"Loss of spatacsin function alters lysosomal lipid clearance leading to upper and lower motor neuron degeneration","volume":"102","author":"Branchu","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jbc.2025.111039_bib187","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.cmet.2024.03.014","article-title":"Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK","volume":"36","author":"Li","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.jbc.2025.111039_bib188","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1212\/WNL.62.10.1758","article-title":"Increased lipid peroxidation in sera of ALS patients: a potential biomarker of disease burden","volume":"62","author":"Simpson","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.jbc.2025.111039_bib189","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00415-010-5805-z","article-title":"Patients with elevated triglyceride and cholesterol serum levels have a prolonged survival in amyotrophic lateral sclerosis","volume":"258","author":"Dorst","year":"2011","journal-title":"J. Neurol."},{"key":"10.1016\/j.jbc.2025.111039_bib190","article-title":"Microglial phenotypes and functions in multiple sclerosis","volume":"8","author":"O'Loughlin","year":"2018","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.jbc.2025.111039_bib191","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0044998","article-title":"Myelin-derived lipids modulate macrophage activity by liver X receptor activation","volume":"7","author":"Bogie","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jbc.2025.111039_bib192","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/s41586-021-03892-7","article-title":"A lymphocyte-microglia-astrocyte axis in chronic active multiple sclerosis","volume":"597","author":"Absinta","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.111039_bib193","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1126\/science.aan4183","article-title":"Defective cholesterol clearance limits remyelination in the aged central nervous system","volume":"359","author":"Cantuti-Castelvetri","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.jbc.2025.111039_bib194","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s00018-022-04547-0","article-title":"Perilipin-2 limits remyelination by preventing lipid droplet degradation","volume":"79","author":"Loix","year":"2022","journal-title":"Cell. Mol. Life. Sci"},{"issue":"Pt 2","key":"10.1016\/j.jbc.2025.111039_bib195","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/brain\/awh707","article-title":"Myelin-laden macrophages are anti-inflammatory, consistent with foam cells in multiple sclerosis","volume":"129","author":"Boven","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.jbc.2025.111039_bib196","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20210227","article-title":"TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination","volume":"218","author":"Gouna","year":"2021","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jbc.2025.111039_bib197","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13024-023-00679-4","article-title":"Alzheimer's genes in microglia: a risk worth investigating","volume":"18","author":"Sudwarts","year":"2023","journal-title":"Mol. Neurodegener"},{"key":"10.1016\/j.jbc.2025.111039_bib198","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.neuron.2019.12.007","article-title":"TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge","volume":"105","author":"Nugent","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.jbc.2025.111039_bib199","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1111\/j.1471-4159.2009.06042.x","article-title":"A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia","volume":"109","author":"Hsieh","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jbc.2025.111039_bib200","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.neuron.2018.02.018","article-title":"TREM2 and amyloid beta: a love-hate relationship","volume":"97","author":"Udeochu","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.jbc.2025.111039_bib201","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1523\/JNEUROSCI.2110-16.2016","article-title":"Disease progression-dependent effects of TREM2 deficiency in a mouse model of Alzheimer's Disease","volume":"37","author":"Jay","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jbc.2025.111039_bib202","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.cell.2015.01.049","article-title":"TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model","volume":"160","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.111039_bib203","doi-asserted-by":"crossref","first-page":"10425","DOI":"10.1096\/fj.201900527R","article-title":"Microglial Trem2 induces synaptic impairment at early stage and prevents amyloidosis at late stage in APP\/PS1 mice","volume":"33","author":"Sheng","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.jbc.2025.111039_bib204","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113506","article-title":"TREM2 overexpression rescues cognitive deficits in APP\/PS1 transgenic mice by reducing neuroinflammation via the JAK\/STAT\/SOCS signaling pathway","volume":"336","author":"Ruganzu","year":"2021","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.jbc.2025.111039_bib205","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1093\/hmg\/ddaa209","article-title":"Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions","volume":"29","author":"Liu","year":"2020","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jbc.2025.111039_bib206","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1084\/jem.20142322","article-title":"TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models","volume":"212","author":"Jay","year":"2015","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jbc.2025.111039_bib207","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13024-017-0216-6","article-title":"TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy","volume":"12","author":"Bemiller","year":"2017","journal-title":"Mol. Neurodegener"},{"key":"10.1016\/j.jbc.2025.111039_bib208","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.neuron.2021.02.010","article-title":"Trem2 restrains the enhancement of tau accumulation and neurodegeneration by beta-amyloid pathology","volume":"109","author":"Lee","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.jbc.2025.111039_bib209","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/s41593-019-0433-0","article-title":"TREM2 function impedes tau seeding in neuritic plaques","volume":"22","author":"Leyns","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jbc.2025.111039_bib210","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.neuron.2022.10.022","article-title":"TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4","volume":"111","author":"Gratuze","year":"2023","journal-title":"Neuron"},{"key":"10.1016\/j.jbc.2025.111039_bib211","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/s12974-022-02581-0","article-title":"Comparative analysis of transcriptome remodeling in plaque-associated and plaque-distant microglia during amyloid-beta pathology progression in mice","volume":"19","author":"Hemonnot-Girard","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jbc.2025.111039_bib212","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.7150\/ijbs.81900","article-title":"beta-amyloid binds to microglia Dectin-1 to induce inflammatory response in the pathogenesis of Alzheimer's disease","volume":"19","author":"Zhao","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jbc.2025.111039_bib213","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1016\/j.cell.2022.09.030","article-title":"SYK coordinates neuroprotective microglial responses in neurodegenerative disease","volume":"185","author":"Ennerfelt","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.111039_bib214","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1016\/j.cell.2022.09.033","article-title":"TREM2 drives microglia response to amyloid-beta via SYK-dependent and -independent pathways","volume":"185","author":"Wang","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.jbc.2025.111039_bib215","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/j.ebiom.2015.09.053","article-title":"Stress granules modulate SYK to cause microglial cell dysfunction in Alzheimer's Disease","volume":"2","author":"Ghosh","year":"2015","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jbc.2025.111039_bib216","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13623","article-title":"Amyloid-beta activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk-AMPK pathway","volume":"21","author":"Jung","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.jbc.2025.111039_bib217","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nature04926","article-title":"Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity","volume":"442","author":"Gross","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jbc.2025.111039_bib218","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2303760120","article-title":"CARD9 attenuates Abeta pathology and modifies microglial responses in an Alzheimer's disease mouse model","volume":"120","author":"Ennerfelt","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jbc.2025.111039_bib219","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/s41590-019-0377-2","article-title":"CARD9(+) microglia promote antifungal immunity via IL-1beta- and CXCL1-mediated neutrophil recruitment","volume":"20","author":"Drummond","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jbc.2025.111039_bib220","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.neuron.2013.04.014","article-title":"Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta","volume":"78","author":"Griciuc","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.jbc.2025.111039_bib221","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s12035-013-8536-1","article-title":"CD33 in Alzheimer's disease","volume":"49","author":"Jiang","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jbc.2025.111039_bib222","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.neuron.2019.06.010","article-title":"TREM2 acts downstream of CD33 in modulating microglial pathology in Alzheimer's Disease","volume":"103","author":"Griciuc","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.jbc.2025.111039_bib223","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1002\/glia.23968","article-title":"Deletion of Alzheimer's disease-associated CD33 results in an inflammatory human microglia phenotype","volume":"69","author":"Wissfeld","year":"2021","journal-title":"Glia"},{"key":"10.1016\/j.jbc.2025.111039_bib224","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1002\/alz.12849","article-title":"INPP5D deficiency attenuates amyloid pathology in a mouse model of Alzheimer's disease","volume":"19","author":"Lin","year":"2023","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.jbc.2025.111039_bib225","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ng.2802","article-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease","volume":"45","author":"Lambert","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jbc.2025.111039_bib226","doi-asserted-by":"crossref","first-page":"69225","DOI":"10.18632\/oncotarget.12648","article-title":"INPP5D rs35349669 polymorphism with late-onset Alzheimer's disease: a replication study and meta-analysis","volume":"7","author":"Jing","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.jbc.2025.111039_bib227","article-title":"INPP5D\/SHIP1 regulates inflammasome activation in human microglia","author":"Chou","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/j.jbc.2025.111039_bib228","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105303","article-title":"INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia","volume":"153","author":"Tsai","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.jbc.2025.111039_bib229","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.1002\/alz.14078","article-title":"Inpp5d haplodeficiency alleviates tau pathology in the PS19 mouse model of Tauopathy","volume":"20","author":"Soni","year":"2024","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.jbc.2025.111039_bib230","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.238030","article-title":"Pan-SHIP1\/2 inhibitors promote microglia effector functions essential for CNS homeostasis","volume":"133","author":"Pedicone","year":"2020","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.jbc.2025.111039_bib231","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1002\/alz.12821","article-title":"Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer's disease","volume":"19","author":"Castranio","year":"2023","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.jbc.2025.111039_bib232","doi-asserted-by":"crossref","first-page":"4908","DOI":"10.1002\/alz.13089","article-title":"The Alzheimer's disease risk factor INPP5D restricts neuroprotective microglial responses in amyloid beta-mediated pathology","volume":"19","author":"Samuels","year":"2023","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.jbc.2025.111039_bib233","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1750-1326-8-19","article-title":"TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease","volume":"8","author":"Rayaprolu","year":"2013","journal-title":"Mol. Neurodegener"},{"key":"10.1016\/j.jbc.2025.111039_bib234","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1001\/jamaneurol.2013.6237","article-title":"TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis","volume":"71","author":"Cady","year":"2014","journal-title":"JAMA Neurol."},{"issue":"Pt 11","key":"10.1016\/j.jbc.2025.111039_bib235","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1093\/brain\/awn217","article-title":"Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation","volume":"131","author":"Piccio","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.jbc.2025.111039_bib236","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00401-020-02193-z","article-title":"TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis","volume":"140","author":"Cignarella","year":"2020","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.jbc.2025.111039_bib237","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1002\/eji.200636837","article-title":"Blockade of TREM-2 exacerbates experimental autoimmune encephalomyelitis","volume":"37","author":"Piccio","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jbc.2025.111039_bib238","doi-asserted-by":"crossref","first-page":"12164","DOI":"10.1096\/fj.201900992R","article-title":"TREM2 deficiency aggravates alpha-synuclein-induced neurodegeneration and neuroinflammation in Parkinson's disease models","volume":"33","author":"Guo","year":"2019","journal-title":"FASEB J."},{"issue":"Pt 2","key":"10.1016\/j.jbc.2025.111039_bib239","article-title":"TREM2 signaling in Parkinson's disease: regulation of microglial function and alpha-synuclein pathology","volume":"143","author":"Yin","year":"2024","journal-title":"Int. Immunopharmacol"},{"key":"10.1016\/j.jbc.2025.111039_bib240","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.celrep.2017.07.004","article-title":"The lifespan and turnover of microglia in the human brain","volume":"20","author":"Reu","year":"2017","journal-title":"Cell Rep."}],"container-title":["Journal of Biological Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925825028911?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021925825028911?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T20:10:12Z","timestamp":1773951012000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021925825028911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":240,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S0021925825028911"],"URL":"https:\/\/doi.org\/10.1016\/j.jbc.2025.111039","relation":{},"ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sterile innate immune mechanisms in neurodegenerative diseases","name":"articletitle","label":"Article Title"},{"value":"Journal of Biological Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jbc.2025.111039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.","name":"copyright","label":"Copyright"}],"article-number":"111039"}}